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Search Results for " anti-mitotic "

19

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9595	LP-261	Microtubule Associated	Cytoskeletal Signaling
	LP-261 是一种新型的微管蛋白靶向抗癌剂，可与微管蛋白上的秋水仙碱位点结合，诱导 G2/M 期阻滞，其EC50为 3.2 μM。它可抑制人非小细胞肺癌的生长，可用于癌症研究。
T8492	BO-264	Apoptosis; FGFR	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	BO-264 是一种有口服活性的转化酸性卷曲螺旋 3 抑制剂，可特异性阻断 FGFR3-TACC3融合蛋白的功能。它诱导纺锤体检查点依赖的有丝分裂阻滞，DNA 损伤和细胞凋亡，具有广谱抗肿瘤活性。
T3330L	cis-trismethoxy Resveratrol (Z)-3,5,4'-Trimethoxystilbene,顺式白藜芦醇三甲醚	Microtubule Associated	Cytoskeletal Signaling
	cis-trismethoxy Resveratrol ((Z)-3,5,4'-Trimethoxystilbene) 抑制微管蛋白聚合 (IC50 = 4 μM) 并具有抗有丝分裂作用。
T20506	Maleuric acid N-Carbamoylmaleamic acid,AI3 32778,AI3-32778,AI332778	Others	Others
	Maleuric acid (N-Carbamoylmaleamic acid) 可抗有丝分裂，可与放射自显影技术结合起来用于生物研究。Maleuric acid 可用于改善动植物的生长和繁殖力以及治疗乳清酸缺乏症。
T34787	TAS-119 TAS119,TAS2104,TAS 2104,TAS-2104,TAS 119	Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	TAS-119 (TAS-2104) 是一种可口服且具有选择性和有效性的 Aurora A 抑制剂，IC50为1.0 nM。TAS-119 对 Aurora B 也具有抑制作用，IC50 为 95 nM。TAS-119 对 Aurora A 的亲和力比 Aurora B高。TAS-119 具有有效的抗肿瘤活性和潜在的抗有丝分裂活性。
T36674	DMU-212	Apoptosis; ERK	Apoptosis; MAPK
	DMU-212 是具有口服活性的白藜芦醇的甲基化衍生物，表现出抗分裂、抗增殖、抗氧化和促进细胞凋亡的活性。它通过诱导凋亡和激活ERK1/2蛋白阻止有丝分裂。
T10215	AAPK-25	Apoptosis; PLK; Aurora Kinase	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic
	AAPK-25 是选择性的Aurora/PLK 激酶双重抑制剂，显示出抗肿瘤活性。它可造成有丝分裂延迟并阻滞前中期细胞，通过生物标志物组蛋白 H3Ser10磷酸化反应，导致细胞凋亡激增。
T40232	KIF18A-IN-1 KIF18A-IN-1
	KIF18A-IN-1 is a potent inhibitor of the mitotic kinesin KIF18A. This compound demonstrates significant anti-tumor properties.
T13227	Tubulin inhibitor 1	Microtubule Associated	Cytoskeletal Signaling
	Tubulin inhibitor 1 is an inhibitor of tubulin, inhibits tubulin polymerization, with potent anti-tumor activity, induces cellular apoptosis causes and cellular mitotic arrest in the G2/M phase.
T18679	SC-VC-PAB-MMAE	Others	Others
	SC-VC-PAB-MMAE is a potent antitumor drug-linker conjugate for antibody-drug conjugates (ADCs), comprising the anti-mitotic agent monomethyl auristatin E (MMAE, a tubulin inhibitor) connected through the cleavable linker SC-VC-PAB[1].
T39307	Azido-PEG4-Val-Cit-PAB-MMAE Azido-PEG4-Val-Cit-PAB-MMAE
	Azido-PEG4-Val-Cit-PAB-MMAE is a drug-linker conjugate for antibody-drug conjugates (ADCs), comprising the anti-mitotic agent monomethyl auristatin E (MMAE, a tubulin inhibitor), connected through the cleavable linker Azido-PEG4-Val-Cit-PAB-OH.
T18736	SuO-Val-Cit-PAB-MMAE	Others	Others
	SuO-Val-Cit-PAB-MMAE is an ADC (antibody-drug conjugate) linker comprising the anti-mitotic monomethyl auristatin E (MMAE, a tubulin inhibitor) connected through the SuO-Val-Cit-PAB peptide.
T40596	Tasisulam sodium LY 573636 sodium,Tasisulam sodium
	Tasisulam is an anti-cancer compound that induces apoptosis through the intrinsic pathway, leading to the release of cytochrome c and caspase-dependent cell death. Additionally, tasisulam inhibits mitotic progression and triggers vascular normalization.
T78771	Tubulin inhibitor 36
	Tubulin inhibitor 36 (Compound 10) 是新型高效微管蛋白抑制剂，可阻止微管蛋白聚合并诱发细胞凋亡，IC50值为1.5±0.1 μM。该化合物在抗有丝分裂中表现出显著活性，并对胶质母细胞瘤（GBM）细胞线有效，适用于胶质母细胞瘤（GBM）的抗肿瘤研究。
T62118	KIF18A-IN-4
	KIF18A-IN-4 是一种中度有效的 ATP 和微管 (microtubule) 非竞争性 KIF18A 抑制剂，其 IC50 值为 6.16 μM。KIF18A-IN-4 能够选择性的作用于大量有丝分裂驱动蛋白和激酶，对微管蛋白组装无直接影响。KIF18A-IN-4 显示出抗肿瘤作用。
T68860	Iso-Fludelone
	Iso-Fludelone is the third-generation epothilone B analogue with potential anti-mitotic and antineoplastic activites. Iso-fludelone binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to other generations of epothilones, iso-fludelone exhibits increased stability, water solubility, potency, duration of action, tumor penetration as we...
T68273	BNC105P
	BNC105P is a benzofuran-based vascular disrupting agent (VDA) prodrug with potential anti-vascular and antineoplastic activities. Upon administration vascular disrupting agent BNC105P, the disodium phosphate ester of BNC105, is rapidly converted to BNC105; in activated endothelial cells, BNC105 binds to tubulin and inhibits its polymerization, which may result in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. Hypoxic conditions ensue, deprivi...
T68480	4SC-207
	4SC-207 is a novel microtubule inhibitor , which shows strong anti-proliferative activity in a large panel of tumor cell lines with an average GI50 of 11 nM. In particular, 4SC-207 is active in multi-drug resistant cell lines, such as HCT-15 and ACHN, suggesting that it is a poor substrate for drug efflux pumps. 4SC-207 inhibits microtubule growth in vitro and in vivo and promotes, in a dose dependent manner, a mitotic delay/arrest, followed by apoptosis or aberrant divisions due to chromosome a...
T71082	DW532
	DW532 is one of simplified analogues of hematoxylin that has shown broad-spectrum inhibition on tyrosine kinases and in vitro anti-cancer activities. DW532 inhibited EGFR and VEGFR2 in vitro kinase activity (the IC50 values were 4.9 and 5.5 μmol/L, respectively), and suppressed their downstream signaling. DW532 dose-dependently inhibited tubulin polymerization via direct binding to tubulin, thus disrupting the mitotic spindle assembly and leading to abnormal cell division. In a panel of human ca...

化合物

Cat.No: T9595

Target: Microtubule Associated

Cat.No: T8492

Target: Apoptosis, FGFR

cis-trismethoxy Resveratrol

Cat.No: T3330L

Synonym: (Z)-3,5,4'-Trimethoxystilbene,顺式白藜芦醇三甲醚

Target: Microtubule Associated

Cat.No: T20506

Synonym: N-Carbamoylmaleamic acid,AI3 32778,AI3-32778,AI332778

Target: Others

Cat.No: T34787

Synonym: TAS119,TAS2104,TAS 2104,TAS-2104,TAS 119

Target: Aurora Kinase

Cat.No: T36674

Target: Apoptosis, ERK

Cat.No: T10215

Target: Apoptosis, PLK, Aurora Kinase

Cat.No: T40232

Synonym: KIF18A-IN-1

Tubulin inhibitor 1

Cat.No: T13227

Target: Microtubule Associated

Cat.No: T18679

Target: Others

Azido-PEG4-Val-Cit-PAB-MMAE

Cat.No: T39307

Synonym: Azido-PEG4-Val-Cit-PAB-MMAE

SuO-Val-Cit-PAB-MMAE

Cat.No: T18736

Target: Others

Tasisulam sodium

Cat.No: T40596

Synonym: LY 573636 sodium,Tasisulam sodium

Tubulin inhibitor 36

Cat.No: T78771

Cat.No: T62118

Cat.No: T68860

Cat.No: T68273

Cat.No: T68480

Cat.No: T71082

Cat. No.	Product Name	Target	Signaling Pathways
T6213	Vinorelbine ditartrate Vinorelbine Tartrate,Nor-5'-anhydrovinblastine ditartrate,KW-2307,Navelbine tartrate,长春瑞滨酒石酸盐,酒石酸长春瑞滨	Microtubule Associated; Autophagy	Autophagy; Cytoskeletal Signaling
	Vinorelbine ditartrate (KW-2307)是一种抗有丝分裂剂，能够抑制 Hela 细胞的增殖，IC50值为 1.25 nM。
T0968	Paclitaxel Taxol,紫杉醇,NSC 125973	Apoptosis; Microtubule Associated; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling
	Paclitaxel (Taxol) 属于天然产物，是一种微管聚合物稳定剂。Paclitaxel 具有抗肿瘤活性；通过诱导有丝分裂停滞、细胞凋亡、细胞自噬等，导致细胞死亡。
T6718	Zingerone Gingerone,Vanillylacetone,姜酮,NSC 15335	NF-κB	NF-κB
	Zingerone (Vanillylacetone) 是一种从生姜中得到的无毒的甲氧基苯酚，具有抗炎、抗糖尿病、抗脂质过敏、抗腹泻、抗痉挛和抗肿瘤等活性。它作为抗有丝分裂剂，能够抑制神经母细胞瘤的生长。它能够缓解氧化应激和炎症，下调 NF-κB 介导的信号通路。
TQ0112	Tubulysin A TubA	Microtubule Associated	Cytoskeletal Signaling
	Tubulysin A is a natural product from myxobacterial. It has many function in vitro assays, including anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, and anti-angiogenic.

天然产物

Vinorelbine ditartrate

Cat.No: T6213

Synonym: Vinorelbine Tartrate,Nor-5'-anhydrovinblastine ditartrate,KW-2307,Navelbine tartrate,长春瑞滨酒石酸盐,酒石酸长春瑞滨

Target: Microtubule Associated, Autophagy

Cat.No: T0968

Synonym: Taxol,紫杉醇,NSC 125973

Target: Apoptosis, Microtubule Associated, Autophagy

Cat.No: T6718

Synonym: Gingerone,Vanillylacetone,姜酮,NSC 15335

Target: NF-κB

Cat.No: TQ0112

Synonym: TubA

Target: Microtubule Associated

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