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Search Results for " alkylating "

94

抑制剂 & 化合物

1

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Cat. No.	Product Name	Target	Signaling Pathways
T8897	2-Iodoacetamide 碘乙酰胺,2-碘乙酰胺,Iodoacetamide	Others	Others
	2-Iodoacetamide (Iodoacetamide) 是常用的烷基化剂之一，能够在蛋白质组学样品制备过程中，将半胱氨酸烷基化。
T8380	Bendamustine SDX105,宾达氮芥	Apoptosis; Others; DNA Alkylator/Crosslinker	Apoptosis; DNA Damage/DNA Repair; Others
	Bendamustine (SDX105) 是一种嘌呤类似物，是一种 DNA 交联剂，具有烷基化、抗癌和抗代谢作用。它可激活 DNA 损伤反应和细胞凋亡。
T4169	N-Nitroso-N-methylurea 1-甲基-1-亚硝基脲,1-Methyl-1-nitrosourea,N-Methyl-N-nitrosourea,Methylnitrosourea	Others; DNA Alkylator/Crosslinker	DNA Damage/DNA Repair; Others
	N-Nitroso-N-methylurea (Methylnitrosourea) 是一种具有烷基化、致癌和致突变特性的亚硝基脲化合物。它靶向多种动物器官，可引起各种癌症和变性疾病，可用于重氮甲烷合成。
T0095	Bendamustine hydrochloride SDX-105,SDX-105 (Cytostasane) HCl,Bendamustine HCl,EP-3101,盐酸苯达莫司汀	Apoptosis; DNA Alkylator/Crosslinker; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Bendamustine hydrochloride (EP-3101) 是一种嘌呤类似物，是一种 DNA 交联剂。它可激活 DNA 损伤反应和细胞凋亡，有烷基化，抗癌和抗代谢作用。
T1250	Thio-TEPA Tiofosyl,Triethylenethiophosphoramide,三亚乙基硫代磷酰胺,Tiofosfamid	DNA Alkylator/Crosslinker; DNA Alkylation; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Thio-TEPA (Tiofosyl) 是一种具有抗肿瘤作用的 DNA 烷化剂。
T1601	Lomustine CCNU,NSC 79037,洛莫司汀	Apoptosis; Others; DNA Alkylator/Crosslinker; DNA Alkylation; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Others
	Lomustine (NSC-79037) 是一种具有抗肿瘤活性的 DNA 烷化剂。
T26978	CEP-40125 RXDX-107	DNA Alkylation	DNA Damage/DNA Repair
	CEP-40125 (RXDX-107) 是一种 DNA 烷基剂，可用于研究晚期实体瘤。
T1241	Altretamine Hexamethylmelamine,NSC13875,六甲蜜胺,RB-1515,ENT-50852,WR-95704	DNA Alkylator/Crosslinker; DNA Alkylation	DNA Damage/DNA Repair
	Altretamine (ENT-50852) 是一种具有抗肿瘤活性的烷化剂。
T19736	Aniline mustard Mesylerythrol,NSC-18429,N,N-双(2-氯乙基)苯胺,Lymphocin	Others	Others
	Aniline mustard (Mesylerythrol) 是具有抗肿瘤活性的烷基化芥末。
T17159	Treosulfan NSC 39069,曲奥舒凡,Treosulphan	DNA Alkylator/Crosslinker; DNA Alkylation	DNA Damage/DNA Repair
	Treosulfan (Treosulphan) 是一种双功能的烷化剂，对卵巢癌及其他的实体瘤都有抑制效果。
T3091	Carmustine bis-chloroethylnitrosourea,Nitrumon,卡莫司汀,Gliadel,BCNU,BiCNU,Carmubris	DNA Alkylator/Crosslinker; DNA Alkylation	DNA Damage/DNA Repair
	Carmustine (bis-chloroethylnitrosourea) 是一种细胞周期性非特异性烷基化抗肿瘤剂。
T13689	Ethylene dimethanesulfonate	Apoptosis	Apoptosis
	Ethylene dimethanesulfonate 是温和的烷基化乙二醇非挥发性甲烷磺酸二酯，对 LC 具有选择性的促凋亡作用。
T17212	VAL-083 1,2:5,6-二脱水半乳糖醇,Dianhydrogalactitol,去水卫矛醇,Dianhydrodulcitol	DNA Alkylator/Crosslinker; DNA Alkylation	DNA Damage/DNA Repair
	VAL-083 (Dianhydrogalactitol) 是一种烷化剂，具有抗肿瘤活性，可在 DNA 上产生 N7 甲基化。
T0707	Cyclophosphamide hydrate 环磷酰胺一水物,Cyclophosphamide monohydrate,环磷酰胺水合物	DNA Alkylator/Crosslinker; DNA; MRP	DNA Damage/DNA Repair; Immunology/Inflammation
	Cyclophosphamide hydrate 是一种 DNA 烷化剂，一种 DNA 合成抑制剂。Cyclophosphamide hydrate 具有抗肿瘤活性、免疫抑制活性等。
T0707L	Cyclophosphamide	DNA Alkylator/Crosslinker; DNA; MRP	DNA Damage/DNA Repair; Immunology/Inflammation
	Cyclophosphamide 是一种烷化剂，具有抗肿瘤及免疫抑制活性，用于治疗多种癌症。
T16871	Semustine	DNA Alkylator/Crosslinker	DNA Damage/DNA Repair
	Semustine 是一种 DNA 烷化剂，是一种癌症化疗化合物，在接受辅助化疗的恶性黑色素瘤患者中具有肾毒性，可用于辅助治疗白血病。
T21463	Temozolomide Acid TMZA,3,4-二氢-3-甲基-4-氧代咪唑并[5,1-D]-1,2,3,5-四嗪-8-甲酰胺酸	Others	Others
	Temozolomide Acid (TMZA) 是 temozolomide (TMZ) 的代谢物。TMZ 在体外具有抗癌活性。TMZ 是一种口服烷化剂，用于治疗多形性胶质母细胞瘤 (GBM) 和星形细胞瘤。
T28663	Sarmustine NSC-364432,SarCNU,Sarcosinamide,NSC 364432,NSC364432
	Sarmustine (SarCNU) 是一种具有抗癌活性的烷化剂，通过 p53 依赖性和 p53 非依赖性途径抑制前列腺癌细胞的生长。Sarmustine 在体外介导 P140K 甲基鸟嘌呤-DNA-甲基转移酶转导的人 CD34(+)细胞的选择。
T0164	Oxaliplatin L-OHP,奥沙利铂	DNA Alkylator/Crosslinker; DNA/RNA Synthesis; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Oxaliplatin (L-OHP) 是一种 DNA 烷化剂，一种 DNA 合成抑制剂。Oxaliplatin 会导致 DNA 交联损伤，阻止 DNA 复制和转录并导致细胞死亡。Oxaliplatin 可以诱导细胞自噬。
T1178	Temozolomide NSC 362856,替莫唑胺,TZM,CCRG 81045,TMZ	Apoptosis; DNA Alkylator/Crosslinker; DNA/RNA Synthesis; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Temozolomide (TMZ) 是一种 DNA 烷基化剂，具有血脑屏障渗透性和口服活性。Temozolomide 具有抗肿瘤活性和抗血管生成活性，还可以诱导细胞凋亡和自噬。
T15771	Lobaplatin D-19466,络铂	DNA Alkylation	DNA Damage/DNA Repair
	Lobaplatin (D-19466) 是一种铂 (II) 复合物的非对映混合物，是一种有前途的抗肿瘤化疗药物，在多种肿瘤类型的患者中具有活性。
T4469	Nemorubicin Methoxymorpholinyldoxorubicin,PNU-152243A,PNU 152243,奈莫柔比星	Others	Others
	Nemorubicin (PNU 152243) 是一种 Doxorubicin 衍生物，具有抗肿瘤活性。它需要完整的核苷酸切除修复系统才能发挥活性。它对多药耐药表型的多种肿瘤细胞系具有细胞毒性。
T61487	APE1-IN-1	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	APE1-IN-1 是一种可透过血脑屏障且有效的无嘌呤/嘧啶内切酶 1 (APE1) 抑制剂，具有潜在的抗肿瘤活性，可增强烷基化剂甲基甲烷磺酸盐对癌细胞的细胞毒性。
T6798	Tretazicar 5-Aziridino-2,4-dinitrobenzamide,CB1954,NSC 115829	DNA Alkylator/Crosslinker; DNA Alkylation	DNA Damage/DNA Repair
	Tretazicar (NSC-115829) 是一种抗肿瘤前药，由 NAD(P)H 醌氧化还原酶 2 激活。它在酶促活化后生成细胞毒性双功能烷基剂，可以形成 DNA-DNA 链间交联。
T21320	Methoxyamine HCl 甲氧基胺盐酸盐,TRC102,TRC 102,Methoxyamine,TRC-102	Others	Others
	Methoxyamine HCl (Methoxyamine) 与脱嘌呤/脱嘧啶 (AP) DNA 损伤位点共价结合并抑制碱基切除修复 (BER)，这可能导致 DNA 链断裂和细胞凋亡增加。 Methoxyamine 是一种具有潜在佐剂活性的口服生物可利用的小分子抑制剂。该药剂可增强烷化剂的抗肿瘤活性。
T3615	Evofosfamide 艾伏磷酰胺,TH-302	Apoptosis; Others	Apoptosis; Others
	Evofosfamide (TH-302) 是一种缺氧激活前药，在缺氧 (N2) 和常氧 (21% O2) 环境下，IC50分别为 10 μM 和 1000 μM。
T4570	Pipobroman Vercyte,A-8103,Amedel,哌泊溴烷	Others; DNA Alkylator/Crosslinker	DNA Damage/DNA Repair; Others
	Pipobroman (Vercyte) 是一种烷基化剂，是哌嗪的溴化衍生物。它通过抑制 DNA 和 RNA 聚合酶或减少嘧啶核苷酸掺入 DNA 发挥其作用。它在真性红细胞增多症和原发性血小板增多症中具有良好的临床活性，可用于癌症研究。
T21306	Glyfosfin
	Glyfosfin is a DNA cross-linking agent and an alkylating agent with anticancer activity.
T11046	Dimethyl-SGD-1882 Dimethyl-PBD dimer	Others	Others
	Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly efficient DNA alkylating agent used as antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylating agent that inhibits DNA replication.
T34424	RSU 1164 RSU-1164,RSU1164
	RSU 1164 is an electron affinic agent that contains a nitro group and a weakly basic alkylating aziridine moiety.
T12586	Py-MPB-amino-C3-PBD	Others	Others
	Py-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group,with antimicrobial activity.
T68622	Ditiomustine
	Ditiomustine is a nitrosourea compound with alkylating activity. Ditiomustine crosslinks DNA, resulting in the inhibition of DNA replication and eventually cellular proliferation. It was developed as antineoplastic agent.
T34474	S-23906-1 S239061
	S-23906-1 is a potential alkylating agent for solid tumors.
T34927	Triaziquone Trenimone,A 163,Trenimon
	Triaziquone is an alkylating agent that can react with DNA to form intrastrand crosslinks.
T41074	MB-VC-MGBA
	MB-VC-MGBA is a potent antitumor drug-linker conjugate for antibody-drug conjugates (ADC), utilizing the minor-groove-binding DNA-alkylating agent (MGBA), connected through the ADC linker MB-VC.
T21133	Decane, 1,10-dibromo- Decamethylene dibromide,1,10-Dibromodecane
	Decane, 1,10-dibromo- is used as synthetic organic intermediate and as an alkylating agent.
T24453	Metamelfalan NSC-67781,Metamelfalanum,NSC67781,NSC 67781,m-L-Sarcolysin
	Metamelfalan is an alkylating nitrogen mustard with potential antineoplastic activity. It causes crosslinking of DNA, thereby preventing DNA replication and eventually cellular proliferation.
T32376	Kenazepine
	Kenazepine is a benzodiazepine cpd containing functional alkylating moiety.
T72217	Altretamine hydrochloride RB-1515 hydrochloride,ENT-50852 hydrochloride ; RB-1515 hydrochloride ; WR-95704 hydrochloride,ENT-50852 hydrochloride,WR-95704 hydrochloride
	Altretamine hydrochloride 是一种烷化剂 (alkylator)，具有抗肿瘤活性。
T25299	Degranol NSC 9698,NSC-9698,NSC9698
	Degranol is a nitrogen mustard derivative alkylating agent utilized as antineoplastic. It causes severe bone marrow depression and is a powerful vesicant.
T68715	Anaxirone
	Anaxirone is a synthetic triepoxide alkylating agent with potential antineoplastic activity. Anaxirone alkylates DNA via actual or derived epoxide groups, resulting in inhibition of DNA synthesis. This agent has been shown to exhibit a broad spectrum of antineoplastic activity against experimental tumors, including those resistant to other alkylating agents.
T10974	DC41	Others	Others
	DC41 is a derivative of DC1. DC1 is a simplified analogue of CC-1065, an antibody conjugate of cytotoxic DNA alkylating agents, used for targeted treatment of cancer.
T28418	Piposulfan Ancyte,A-20968,A 20968,A20968
	Piposulfan, a water-insoluble alkylating agent, is used as an antineoplastic and anti-tumor agent.
T34523	Sarcolysine hydrochloride DL-Phenylalanine mustard hydrochloride,Melphalan,DL-Sarcolysine hydrochloride,DL-Sarcolysin monohydrochloride,AI3-52155,Alkeran
	Sarcolysine hydrochloride, also known as Melphalan HCl, is a nitrogen mustard and alkylating agent that has been studied for use in multiple myeloma therapy.
T25816	Mitolactol NSC 104800,NSC-104800,NSC104800
	Mitolactol is an alkylating antineoplastic toxic to bone marrow; utilized in breast cancer, also in combination with other drugs. Mitolactol is able to cross bloodbrain barrier, consequently could control certain brain tumors.
T29851	Aldoifosfamide UNII-S1JX147O5E,Mitoxana,Ifex
	Aldoifosfamide is a metabolite of ifosfamide. Ifosfamide (also marketed as Mitoxana and Ifex) is a nitrogen mustard alkylating agent used in the treatment of cancer. It is sometimes abbreviated 'IFO''.
T37108	Carboxyphosphamide
	Carboxyphosphamide is an inactive metabolite of the alkylating agent cyclophosphamide .1It is formed from cyclophosphamideviaoxidation of the intermediate metabolite aldophosphamide by aldehyde dehydrogenase. 1.Manthey, C.L., and Sladek, N.E.Kinetic characterization of the catalysis of activated" cyclophosphamide (4-hydroxycyclophosphamide/aldophosphamide) oxidation to carboxyphosphamide by mouse hepatic aldehyde dehydrogenasesBiochem. Pharmacol.37(14)2781-2790(1988)"
T11116	Duocarmycin MA	Others	Others
	Duocarmycin MA can be used against multi-drug resistant cell lines.Duocarmycin MA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove.
T22388	OBI-3424	Others	Others
	OBI-3424, a highly selective prodrug, is converted by aldo-keto reductase family 1 member C3 (AKR1C3) to a potent DNA-alkylating agent.
T11119	Duocarmycin DM free base Duocarmycin	Others	Others
	Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug–antibody conjugates (ADCs) . Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity.

化合物

2-Iodoacetamide

Cat.No: T8897

Synonym: 碘乙酰胺,2-碘乙酰胺,Iodoacetamide

Target: Others

Cat.No: T8380

Synonym: SDX105,宾达氮芥

Target: Apoptosis, Others, DNA Alkylator/Crosslinker

N-Nitroso-N-methylurea

Cat.No: T4169

Synonym: 1-甲基-1-亚硝基脲,1-Methyl-1-nitrosourea,N-Methyl-N-nitrosourea,Methylnitrosourea

Target: Others, DNA Alkylator/Crosslinker

Bendamustine hydrochloride

Cat.No: T0095

Synonym: SDX-105,SDX-105 (Cytostasane) HCl,Bendamustine HCl,EP-3101,盐酸苯达莫司汀

Target: Apoptosis, DNA Alkylator/Crosslinker, DNA/RNA Synthesis

Cat.No: T1250

Synonym: Tiofosyl,Triethylenethiophosphoramide,三亚乙基硫代磷酰胺,Tiofosfamid

Target: DNA Alkylator/Crosslinker, DNA Alkylation, Antibacterial, Antibiotic

Cat.No: T1601

Synonym: CCNU,NSC 79037,洛莫司汀

Target: Apoptosis, Others, DNA Alkylator/Crosslinker, DNA Alkylation, Autophagy

Cat.No: T26978

Synonym: RXDX-107

Target: DNA Alkylation

Cat.No: T1241

Synonym: Hexamethylmelamine,NSC13875,六甲蜜胺,RB-1515,ENT-50852,WR-95704

Target: DNA Alkylator/Crosslinker, DNA Alkylation

Aniline mustard

Cat.No: T19736

Synonym: Mesylerythrol,NSC-18429,N,N-双(2-氯乙基)苯胺,Lymphocin

Target: Others

Cat.No: T17159

Synonym: NSC 39069,曲奥舒凡,Treosulphan

Target: DNA Alkylator/Crosslinker, DNA Alkylation

Cat.No: T3091

Synonym: bis-chloroethylnitrosourea,Nitrumon,卡莫司汀,Gliadel,BCNU,BiCNU,Carmubris

Target: DNA Alkylator/Crosslinker, DNA Alkylation

Ethylene dimethanesulfonate

Cat.No: T13689

Target: Apoptosis

Cat.No: T17212

Synonym: 1,2:5,6-二脱水半乳糖醇,Dianhydrogalactitol,去水卫矛醇,Dianhydrodulcitol

Target: DNA Alkylator/Crosslinker, DNA Alkylation

Cyclophosphamide hydrate

Cat.No: T0707

Synonym: 环磷酰胺一水物,Cyclophosphamide monohydrate,环磷酰胺水合物

Target: DNA Alkylator/Crosslinker, DNA, MRP

Cyclophosphamide

Cat.No: T0707L

Target: DNA Alkylator/Crosslinker, DNA, MRP

Cat.No: T16871

Target: DNA Alkylator/Crosslinker

Temozolomide Acid

Cat.No: T21463

Synonym: TMZA,3,4-二氢-3-甲基-4-氧代咪唑并[5,1-D]-1,2,3,5-四嗪-8-甲酰胺酸

Target: Others

Cat.No: T28663

Synonym: NSC-364432,SarCNU,Sarcosinamide,NSC 364432,NSC364432

Cat.No: T0164

Synonym: L-OHP,奥沙利铂

Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis, Autophagy

Cat.No: T1178

Synonym: NSC 362856,替莫唑胺,TZM,CCRG 81045,TMZ

Target: Apoptosis, DNA Alkylator/Crosslinker, DNA/RNA Synthesis, Autophagy

Cat.No: T15771

Synonym: D-19466,络铂

Target: DNA Alkylation

Cat.No: T4469

Synonym: Methoxymorpholinyldoxorubicin,PNU-152243A,PNU 152243,奈莫柔比星

Target: Others

Cat.No: T61487

Target: DNA/RNA Synthesis

Cat.No: T6798

Synonym: 5-Aziridino-2,4-dinitrobenzamide,CB1954,NSC 115829

Target: DNA Alkylator/Crosslinker, DNA Alkylation

Methoxyamine HCl

Cat.No: T21320

Synonym: 甲氧基胺盐酸盐,TRC102,TRC 102,Methoxyamine,TRC-102

Target: Others

Cat.No: T3615

Synonym: 艾伏磷酰胺,TH-302

Target: Apoptosis, Others

Cat.No: T4570

Synonym: Vercyte,A-8103,Amedel,哌泊溴烷

Target: Others, DNA Alkylator/Crosslinker

Cat.No: T21306

Dimethyl-SGD-1882

Cat.No: T11046

Synonym: Dimethyl-PBD dimer

Target: Others

Cat.No: T34424

Synonym: RSU-1164,RSU1164

Py-MPB-amino-C3-PBD

Cat.No: T12586

Target: Others

Cat.No: T68622

Cat.No: T34474

Synonym: S239061

Cat.No: T34927

Synonym: Trenimone,A 163,Trenimon

Cat.No: T41074

Decane, 1,10-dibromo-

Cat.No: T21133

Synonym: Decamethylene dibromide,1,10-Dibromodecane

Cat.No: T24453

Synonym: NSC-67781,Metamelfalanum,NSC67781,NSC 67781,m-L-Sarcolysin

Cat.No: T32376

Altretamine hydrochloride

Cat.No: T72217

Synonym: RB-1515 hydrochloride,ENT-50852 hydrochloride ; RB-1515 hydrochloride ; WR-95704 hydrochloride,ENT-50852 hydrochloride,WR-95704 hydrochloride

Cat.No: T25299

Synonym: NSC 9698,NSC-9698,NSC9698

Cat.No: T68715

Cat.No: T10974

Target: Others

Cat.No: T28418

Synonym: Ancyte,A-20968,A 20968,A20968

Sarcolysine hydrochloride

Cat.No: T34523

Synonym: DL-Phenylalanine mustard hydrochloride,Melphalan,DL-Sarcolysine hydrochloride,DL-Sarcolysin monohydrochloride,AI3-52155,Alkeran

Cat.No: T25816

Synonym: NSC 104800,NSC-104800,NSC104800

Cat.No: T29851

Synonym: UNII-S1JX147O5E,Mitoxana,Ifex

Carboxyphosphamide

Cat.No: T37108

Cat.No: T11116

Target: Others

Cat.No: T22388

Target: Others

Duocarmycin DM free base

Cat.No: T11119

Synonym: Duocarmycin

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T15467	Helenalin	Others	Others
	Helenalin is a selective inhibitor of transcription factor NF-κB by direct targeting of p65. It is an anti-inflammatory sesquiterpene lactone compound with alkylating activity. Through its ability to target the cysteine sulfhydryl groups in the p65 subunit of NF-κB, helenalin effectively inhibits its DNA binding.

天然产物

Cat.No: T15467

Target: Others

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