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Search Results for " aglycone "

11

抑制剂 & 化合物

23

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19214	Bredinin aglycone 5-Hydroxy-1H-imidazole-4-carboxamide,5-羟基-1H-咪唑-4-甲酰胺,SM-108	Others	Others
	Bredinin aglycone (SM-108) 是嘌呤核苷酸类似物，可用于嘌呤核苷酸类似物催化剂的制作效率的检测。
T35733	Doramectin aglycone
	Doramectin aglycone is an acid degradation product of doramectin , a disaccharide-containing anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes, and its acid-catalyzed hydrolysis product doramectin monosaccharide . Doramectin undergoes one round of acid-catalyzed hydrolysis to form doramectin monosaccharide which is then hydrolyzed again to remove the remaining saccharide unit and form doramectin aglycone.
T26256	Teicoplanin aglycone TD-A3
	Teicoplanin aglycone is an antibacterial glycopeptide antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria, including Enterococcus faecalis and methicillin-resistant Staphylococcus aureus.
T35755	Avermectin B1a aglycone
	Avermectin B1a aglycone is an aglycone form of the anthelmintic and insecticide avermectin B1a . It hyperpolarizes P. crassipes muscle fibers with a minimum active concentration (MAC) value of 0.1 μM. Avermectin B1a aglycone decreases survival of C. elegans (MAC = 0.1 μM). In vivo, avermectin B1a aglycone prevents seizures induced by pentylenetetrazole in mice (ED50 = 43.9 mg/kg) without inducing deficits in rotarod performance.
T12916	Silvestrol aglycone	Others	Others
	Silvestrol aglycone is an analogue of Silvestrol, inhibits protein translation initiation in cancer cells(EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively), with nti-cancer activity.
T29483	7-Deoxyadriamycinol aglycone
	7-Deoxyadriamycinol aglycone is an adriamycin metabolite.
T12915	Silvestrol aglycone (enantiomer)	Others	Others
	Silvestrol aglycone (enantiomer) is a cyclopenta benzofuran core phenol.
T29673	Doxorubicinone Adriamycinone,Adriamycin Aglycone,Doxorubicin Aglycone
	Adriamycin Aglycone, also known as Doxorubicinone, is an oncolytic agent. It is a metabolite of Doxorubicin which binds to the DNA minor-groove.
T125057	Oleuropein aglycone
	Oleuropein aglycone 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125057。
T32323	Jurubidine
	Jurubidine is a type of cyclised aglycone from Jurubine.
T70904	Tylogenin
	Tylogenin, a steroidal aglycone generated by acid hydrolysis from two seasonal glycosides occurring in Tylophora sylvatica, inhibits IgE-induced basophil mediator release for allergic reactions. In the rabbit basophil-dependent serotonin release (BDSR) assay system, the inhibitory activity of tylogenin was significantly greater than that of its parent glycosides, tylophoroside and acetyltylophoroside, and that of dexamethasone. The activity of tylogenin was found to increase with the incubation ...

化合物

Bredinin aglycone

Cat.No: T19214

Synonym: 5-Hydroxy-1H-imidazole-4-carboxamide,5-羟基-1H-咪唑-4-甲酰胺,SM-108

Target: Others

Doramectin aglycone

Cat.No: T35733

Teicoplanin aglycone

Cat.No: T26256

Synonym: TD-A3

Avermectin B1a aglycone

Cat.No: T35755

Silvestrol aglycone

Cat.No: T12916

Target: Others

7-Deoxyadriamycinol aglycone

Cat.No: T29483

Silvestrol aglycone (enantiomer)

Cat.No: T12915

Target: Others

Cat.No: T29673

Synonym: Adriamycinone,Adriamycin Aglycone,Doxorubicin Aglycone

Oleuropein aglycone

Cat.No: T125057

Cat.No: T32323

Cat.No: T70904

Cat. No.	Product Name	Target	Signaling Pathways
T35743	Ivermectin B1a aglycone
	Ivermectin B1a aglycone is an acid degradation product produced by hydrolysis of the disaccharide unit of ivermectin. It can inhibit nematode larval development, but does not cause paralytic activity.
T36337	Burnettramic Acid A aglycone
	Burnettramic acid A aglycone is a fungal metabolite and an aglycone form of burnettramic acid A originally isolated fromA. burnettiithat has anticancer activity.1It is cytotoxic to NS-1 murine myeloma cells but not neonatal foreskin fibroblasts (IC50s = 8.4 and >100 μg/ml, respectively). 1.Li, H., Gilchrist, C.L.M., Lacey, H.J., et al.Discovery and heterologous biosynthesis of the burnettramic acids: Rare PKS-NRPS-derived bolaamphiphilic pyrrolizidinediones from an Australian fungus, Aspergillus...
TN5385	Plucheoside B aglycone
	Plucheoside B aglycone 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5385，CAS号为 393862-19-6。
TN3775	Daturataturin A aglycone	Others	Others
	Daturataturin A aglycone 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3775，CAS号为 904665-71-0。
TN1944	Momordicoside I aglycone	Others	Others
	Momordicoside I aglycone is a natural product
T79962	Aloenin aglycone	Others	Others
	Aloenin aglycone (compound 13) 作为一种NF-κB抑制剂，可从芦荟渗出液中提取。它在抑制TNFα引发的NF-κB转录活性方面表现显著（IC50: 18.7 μM）。当HepG2细胞经10 ng/mL TNFα处理时，以10 μM Aloenin aglycone处理能有效下调诱导型一氧化氮合酶（iNOS）及细胞间粘附分子1（ICAM-1）的基因表达。
T7024	Qingyangshengenin 青阳参甙元,Qingyangshengenin A,Cynanchagenin	Others	Others
	Qingyangshengenin (Cynanchagenin) 是一种孕烷糖苷，是一种分离自Cychuchumot ophyllum(Asclepiadaceae) 的根中的 C21 类固醇糖苷配基。它具有抗癌作用。
T0228	Methyl-Hesperidin 甲基橙皮甙	Akt; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Methyl hesperidin 是一种血管扩张剂。
T3371	Quillaic Acid S,皂皮酸	Others	Others
	Quillaic Acid 是一种天然产物，可用于研究疼痛的缓解。
T5792	Rebaudioside M 瑞鲍迪苷M,瑞鲍迪甙M	Others	Others
	Rebaudioside M 是一种天然无热量甜味剂，是戊二烯二萜苷元的糖苷，提取自 Stevia rebaudianaBertoni 中。
TCS1188	Mogroside III	Others	Others
	Mogroside III 是一种三萜糖苷和非糖甜味剂。 Mogroside III 被人体肠道细菌转化，释放出次生Mogroside IIA1 和苷元莫格罗。
T2210	Genipin 京尼平,(+)-Genipin	Others; Autophagy	Autophagy; Others
	Genipin ((+)-Genipin) 是衍生自黄栀果实的天然交联剂，可抑制细胞中的 UCP2 (解偶联蛋白 2)。它有蛋白质调节、抗肿瘤、抗炎症、免疫抑制、抗血栓形成和对海马神经元保护的多种生物活性，可研究 2 型糖尿病。
T6S1485	Ginsenoside Rh4 人参皂苷Rh4	Others	Others
	Ginsenoside Rh4 可以安全地用作佐剂，具有低溶血作用或无溶血作用。它具有细胞毒活性，其苷元对癌细胞系具有杀伤作用。
T2827	Asiatic acid Asiantic acid,Dammarolic acid,积雪草酸	Apoptosis; p38 MAPK; Parasite	Apoptosis; MAPK; Microbiology/Virology
	Asiatic acid (Dammarolic acid) 是在Centella asiatica 中发现的一种五环三萜，有抗炎活性，可诱导黑色素瘤细胞的凋亡，有可能治疗皮肤癌。
T3325	Liquiritigenin 4',7-Dihydroxyflavanone,甘草素	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	Liquiritigenin (4',7-Dihydroxyflavanone) 是一种黄烷酮，从甘草中分离得到，是高度选择性的雌激素受体β 激动剂，用于活化 ERE tk-Luc 的 EC50值为36.5 nM。
T2957	Arctigenin 牛蒡苷元,牛蒡子苷元,(-)-Arctigenin	Apoptosis; MMP; Influenza Virus; Autophagy	Apoptosis; Autophagy; Microbiology/Virology; Proteases/Proteasome
	Arctigenin ((-)-Arctigenin) 是一种存在于牛蒡中的木脂素，具有抗氧化、抗肿瘤、抗炎和抗病毒活性。它可研究代谢紊乱和中枢神经系统功能障碍。
T4S0969	Obtusifolin 决明蒽醌,决明蒽醌；美决明子素	Antioxidant; NF-κB	NF-κB; oxidation-reduction
	Obtusifolin 是分离自决明子的种子中，能够抑制NF-kB 通路，调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。它通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。
T33926	Penupogenin
	Penupogenin is a steroidal aglycone isolated from the roots of Cynanchum auriculatum.
T38589	Neopanaxadiol
	Neopanaxadiol, an aglycone derived from protopanaxadiol type ginsenosides, exhibits promising potential for Alzheimer's disease research.
TN1431	Baohuoside VII 宝藿苷,宝藿苷VII	Others	Others
	Baohuoside aglycone possesses cardioprotective effect in prevention of ischemia/ reperfusion injury and reduce the myocardial infraction, the mechnism is due to the reduction of the injury of free radicals. Baohuoside VII in vivo exhibits significant anti
T19880	Friedelinol Friedelan-3alpha-ol,Friedelan-3-ol,NSC 407041,epi-Friedelinol,Epifriedelanol
	Friedelinol is a pentacyclic trierpene plant as the free acid or the aglycone for many saponins. Friedelinol can rearrange to the isomer, ursolic acid, or be oxidized to taraxasterol and amyrin.
T82285	Glycyrrhizin-6′,6′′-dimethylester
	Glycyrrhizin-6′,6′′-dimethylester (compound 23) 是一种从甘草根中提取的甘草皂苷，具有作为糖苷配基的能力，参与葡萄糖醛酸甲酯的生成，其结果是产生具有相似阈值的甜味、甘草味和苦味。
T82284	Glycyrrhizin-6′′-methylester
	Glycyrrhizin-6′′-methylester (compound 22) 是从甘草根中分离的一种甘草皂苷，能参与葡萄糖醛酸甲酯的生成，赋予其甜味和甘草特有风味，但不具苦味。该化合物的研究强调了糖苷锥结合葡萄糖醛酸的游离羧基在形成天然甜味和甘草味觉中的关键作用。

天然产物

Ivermectin B1a aglycone

Cat.No: T35743

Burnettramic Acid A aglycone

Cat.No: T36337

Plucheoside B aglycone

Cat.No: TN5385

Daturataturin A aglycone

Cat.No: TN3775

Target: Others

Momordicoside I aglycone

Cat.No: TN1944

Target: Others

Aloenin aglycone

Cat.No: T79962

Target: Others

Qingyangshengenin

Cat.No: T7024

Synonym: 青阳参甙元,Qingyangshengenin A,Cynanchagenin

Target: Others

Methyl-Hesperidin

Cat.No: T0228

Synonym: 甲基橙皮甙

Target: Akt, PKC

Cat.No: T3371

Synonym: S,皂皮酸

Target: Others

Cat.No: T5792

Synonym: 瑞鲍迪苷M,瑞鲍迪甙M

Target: Others

Cat.No: TCS1188

Target: Others

Cat.No: T2210

Synonym: 京尼平,(+)-Genipin

Target: Others, Autophagy

Ginsenoside Rh4

Cat.No: T6S1485

Synonym: 人参皂苷Rh4

Target: Others

Cat.No: T2827

Synonym: Asiantic acid,Dammarolic acid,积雪草酸

Target: Apoptosis, p38 MAPK, Parasite

Cat.No: T3325

Synonym: 4',7-Dihydroxyflavanone,甘草素

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Cat.No: T2957

Synonym: 牛蒡苷元,牛蒡子苷元,(-)-Arctigenin

Target: Apoptosis, MMP, Influenza Virus, Autophagy

Cat.No: T4S0969

Synonym: 决明蒽醌,决明蒽醌；美决明子素

Target: Antioxidant, NF-κB

Cat.No: T33926

Cat.No: T38589

Cat.No: TN1431

Synonym: 宝藿苷,宝藿苷VII

Target: Others

Cat.No: T19880

Synonym: Friedelan-3alpha-ol,Friedelan-3-ol,NSC 407041,epi-Friedelinol,Epifriedelanol

Glycyrrhizin-6′,6′′-dimethylester

Cat.No: T82285

Glycyrrhizin-6′′-methylester

Cat.No: T82284

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