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35

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12225L	Nevanimibe hydrochloride PD-132301 hydrochloride,ATR101 hydrochloride	Apoptosis; Acyltransferase	Apoptosis; Metabolism
	Nevanimibe hydrochloride (PD-132301 hydrochloride) 是一种口服有效的，选择性酰基辅酶 A：胆固醇 O-酰基转移酶 1 抑制剂，EC50为 9 nM。它抑制 ACAT2，EC50为 368 nM。它诱导细胞凋亡，具有抗肾上腺皮质癌的潜力。
T76124	Acyl coenzyme A synthetase
	Acyl coenzyme A synthetase (ACS)，一种生化研究中常用的酶，主要通过两步硫酯化反应激活脂肪酸与辅酶A结合，形成酰基辅酶A。该过程为脂质代谢中的多种合成与分解代谢途径，以及参与TCA循环中的有氧呼吸提供了关键中间物。
T30961	CL 277082 CL277082,CL-277082,Ddpmhu	Others	Others
	CL 277082 (Ddpmhu) 是一种酰基辅酶A：胆固醇O-酰基转移酶抑制剂，抑制肉芽肿组织 ACAT 活性。
T25651	Lecimibide DuP128,DuP-128,DuP 128	Acyltransferase	Metabolism
	Lecimibide (DuP 128) 是一种有效且具有选择性的酰辅酶 A 胆固醇酰基转移酶(ACAT)抑制剂，可用于研究由于高脂带来的疾病。
T8314	RP-64477 RP64477	Acyltransferase	Metabolism
	RP-64477 是有效的胆固醇酯化酶酰基辅酶 A：胆固醇 O-酰基转移酶 (ACAT) 抑制剂。
T23550	YM-750 YM 750	Acyltransferase	Metabolism
	YM-750 是一种有效的酰基:胆固醇酰基转移酶(ACAT)抑制剂，IC50为0.18 μM。
T27245L	Eflucimibe L0081,F-12511	Acyltransferase	Metabolism
	Eflucimibe (L0081) 是一种酰基辅酶A：胆固醇酰基转移酶抑制剂，可用于治疗心血管疾病和内分泌与代谢疾病，可用于研究动脉粥样硬化和高脂血症。
T2753	Avasimibe PD-148515,阿伐麦布,CI-1011	P450; Acyltransferase	Metabolism
	Avasimibe (PD-148515) 是一种口服有效的酰基辅酶 A: 胆固醇酰基转移酶 (ACAT) 抑制剂，对 ACAT1和 ACAT2的 IC50分别为 24 和 9.2 µM。Avasimibe 在前列腺癌中有研究的价值。
T70300	Avasimibe sodium
	Avasimibe sodium is an acyl coenzyme A: cholesterol acyltransferase (ACAT) inhibitor.
T32768	Linoleoyl-coenzyme A Coenzyme A,linoleoyl-
	Linoleoyl-coenzyme A is a substrate used to investigate the specificity and kinetics of acyl-CoA.
T39415	ACAT-IN-9
	ACAT-IN-9, acts as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). By doing so, it effectively suppresses NF-κB mediated transcription.
T40552	ACAT-IN-10
	ACAT-IN-10 is an acyl-Coenzyme A: cholesterol acyltransferase (ACAT) inhibitor. It inhibits NF-κB mediated transcription with a weak activity.
T12225	Nevanimibe ATR-101,PD-132301	Others	Others
	Nevanimibe is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50 of 9 nM).
T40553	ACAT-IN-6
	ACAT-IN-6, an acyl-Coenzyme A: cholesterol acyltransferase (ACAT) inhibitor, displays potent inhibition of NF-κB mediated transcription.
T74043	Hexanoyl coenzyme A trilithium
	Hexanoyl coenzyme A trilithium 是一种以己酰为酰基的中链脂肪酰辅酶 A，存在于所有生物体中。Hexanoyl coenzyme A trilithium 可以作为大麻素生物合成前体。可以作为一种竞争性抑制剂，作用于中链酰基辅酶A 脱氢酶 (MCAD)。
T40551	ACAT-IN-3
	ACAT-IN-3, a potent inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT), effectively suppresses NF-κB dependent transcription.
T39412	ACAT-IN-5
	ACAT-IN-5 (example 19) is a compound that functions as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). By inhibiting ACAT, this compound effectively suppresses the transcription mediated by NF-κB.
T64276	Octanoyl coenzyme A lithium
	Octanoyl coenzyme A lithium 是一种脂肪酸酰基辅酶 A 的衍生物。Octanoyl coenzyme A lithium 能够抑制柠檬酸合成酶和谷氨酸脱氢酶 (IC50: 0.4-1.6 mM)。
T39417	ACAT-IN-2
	ACAT-IN-2 is a potent inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). This compound effectively blocks NF-κB mediated transcription.
T35984	CAY10485
	Acyl-coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10485 inhibits human ACAT-1 and ACAT-2 with an IC50 values of 95 and 81 μM, respectively. It also inhibits copper-mediated oxidation of low density lipoproteins by 91% at a concentration of 2 μM.
T74039	Arachidonoyl coenzyme A lithium
	Arachidonoyl coenzyme A lithium是一种由辅酶A的硫醇基与花生四烯酸的羧基缩合生成的不饱和脂肪酰基辅酶A。
T39414	ACAT-IN-7
	ACAT-IN-7 is a compound that acts as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT) enzyme. It effectively suppresses the transcription process mediated by NF-κB.
T39416	ACAT-IN-4 hydrochloride
	ACAT-IN-4 hydrochloride (Example 208) is a hydrochloride salt of a potent inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). This compound effectively hinders NF-κB mediated transcription.
T32598	Lauroyl-coenzyme A Dodecanoyl-coa,Coenzyme A, lauroyl-,Lauroyl-coa
	Lauroyl-coenzyme A can function as an acyl group carrier, acetyl-CoA. It can be used as an intermediate in lipid metabolism and is involved in lipid biosynthesis and fatty acid transport.
T39411	ACAT-IN-10 dihydrochloride
	ACAT-IN-10 dihydrochloride is a compound that serves as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT).ACAT-IN-10 dihydrochloride effectively hampers NF-κB mediated transcription, albeit to a lesser extent.
T36549	CAY10486
	Acyl-Coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis. CAY10486 inhibits human ACAT-1 and ACAT-2 equally with an IC50 value of approximately 60 μM. It also inhibits copper-mediated oxidation of low density lipoproteins by about 28% at a concentration of 3 μM.
T37405	Octanoyl Coenzyme A (sodium salt)
	Octanoyl coenzyme A (octanoyl-CoA) is a medium-chain acyl CoA and a metabolic intermediate in mitochondrial fatty acid β-oxidation. Levels of octanoyl-CoA are increased in the liver of patients with Reye's syndrome and β-oxidation of octanoyl-CoA by medium-chain acyl CoA dehydrogenase (MCADH) is decreased in patients with MCADH deficiency (MCD). Octanoyl-CoA inhibits citrate synthase and glutamate dehydrogenase.
T40554	ACAT-IN-4
	ACAT-IN-4 (Example 208) is a chemical compound that functions as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). Additionally, ACAT-IN-4 effectively inhibits the transcription process mediated by NF-κB.
T73918	Lauroyl coenzyme A lithium
	Lauroyl coenzyme A lithium salt 是一种辅酶 A。辅酶 A 作为酰基载体，即乙酰辅酶 A。十二烷酰辅酶 A (C12-CoA) 是一种长链 (C-12) 饱和脂肪酰辅酶 A，用作脂质代谢的中间体，参与脂质生物合成和脂肪酸转运。月桂酰辅酶 A 是底物用于 FAM34A 蛋白和萤火虫荧光素酶的产物。
T39413	ACAT-IN-8
	ACAT-IN-8 (example 206) is a compound that functions as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT), an enzyme involved in cholesterol modulation. This compound also possesses the ability to inhibit transcription mediated by NF-κB.
T74038	Palmitoyl coenzyme A lithium
	Palmitoyl coenzyme A lithium，一种酰基-CoA 硫酯，通过肉碱穿梭系统转运至线粒体基质，参与β-氧化，亦作为鞘氨醇生物合成底物。
T36842	Isobutyryl Coenzyme A (sodium salt)
	Isobutyryl coenzyme A (isobutyryl-CoA) is a short-chain branched acyl CoA. Isobutyryl-CoA is a substrate for isobutyryl-CoA dehydrogenase (IBDH) in the catabolism of valine and an intermediate in the synthesis of isobutyryl-L-carnitine , which accumulates in IBDH deficiency.
T38025	Cyclohexanoyl Coenzyme A
	Cyclohexanoyl coenzyme A (CHCoA) is an acyl CoA that contains a cyclohexane group. It is the activated form of cyclohexane carboxylic acid (CHC) in R. palustris. CHC is converted to CHCoA by a succinyl-CoA CHC CoA transferase, and CHCoA is then degraded by a dehydrogenase. CHCoA is converted to hippuric acid in submitochondrial fractions isolated from guinea pig liver.
T62726	Phenylpyropene C
	Phenylpyropene C (S14-95) 是一种 JAK/STAT 通路抑制剂，对 IFN-γ 介导的报告基因表达表现出抑制作用 (IC50:5.4~10.8 μM)。Phenylpyropene C 也是一种酰基辅酶 A 的抑制剂 (IC50: 16.0 μM)。
T37407	Arachidonoyl-L-carnitine (chloride) C20:4 Carnitine,Arachidonoyl-L-carnitine (chloride)
	Carnitine facilitates the transport of fatty acids into the mitochondria to be used in fatty acid metabolism. It does so by accepting acyl groups from fatty acids complexed with coenzyme A, which yields esterified carnitine or acylcarnitines that enable the transport of fatty acyl groups into the inner mitochondrial matrix. β-Oxidation of fatty acids in mitochondria is inhibited by uncoupling conditions, thus changes in circulating levels of various acylcarnitines have been used to identify alte...

化合物

Nevanimibe hydrochloride

Cat.No: T12225L

Synonym: PD-132301 hydrochloride,ATR101 hydrochloride

Target: Apoptosis, Acyltransferase

Acyl coenzyme A synthetase

Cat.No: T76124

Cat.No: T30961

Synonym: CL277082,CL-277082,Ddpmhu

Target: Others

Cat.No: T25651

Synonym: DuP128,DuP-128,DuP 128

Target: Acyltransferase

Cat.No: T8314

Synonym: RP64477

Target: Acyltransferase

Cat.No: T23550

Synonym: YM 750

Target: Acyltransferase

Cat.No: T27245L

Synonym: L0081,F-12511

Target: Acyltransferase

Cat.No: T2753

Synonym: PD-148515,阿伐麦布,CI-1011

Target: P450, Acyltransferase

Avasimibe sodium

Cat.No: T70300

Linoleoyl-coenzyme A

Cat.No: T32768

Synonym: Coenzyme A,linoleoyl-

Cat.No: T39415

Cat.No: T40552

Cat.No: T12225

Synonym: ATR-101,PD-132301

Target: Others

Cat.No: T40553

Hexanoyl coenzyme A trilithium

Cat.No: T74043

Cat.No: T40551

Cat.No: T39412

Octanoyl coenzyme A lithium

Cat.No: T64276

Cat.No: T39417

Cat.No: T35984

Arachidonoyl coenzyme A lithium

Cat.No: T74039

Cat.No: T39414

ACAT-IN-4 hydrochloride

Cat.No: T39416

Lauroyl-coenzyme A

Cat.No: T32598

Synonym: Dodecanoyl-coa,Coenzyme A, lauroyl-,Lauroyl-coa

ACAT-IN-10 dihydrochloride

Cat.No: T39411

Cat.No: T36549

Octanoyl Coenzyme A (sodium salt)

Cat.No: T37405

Cat.No: T40554

Lauroyl coenzyme A lithium

Cat.No: T73918

Cat.No: T39413

Palmitoyl coenzyme A lithium

Cat.No: T74038

Isobutyryl Coenzyme A (sodium salt)

Cat.No: T36842

Cyclohexanoyl Coenzyme A

Cat.No: T38025

Phenylpyropene C

Cat.No: T62726

Arachidonoyl-L-carnitine (chloride)

Cat.No: T37407

Synonym: C20:4 Carnitine,Arachidonoyl-L-carnitine (chloride)

Cat. No.	Product Name	Target	Signaling Pathways
T10857	Coenzyme A	Endogenous Metabolite	Metabolism
	Coenzyme A 是所有活细胞中必需的辅助因子，由泛酸，三磷酸腺苷和半胱氨酸合成的。Coenzyme A 与过氧化物酶 5 共价结合导致其过氧化物酶活性完全抑制，通过 DTT 还原能够逆转。Coenzyme A 及其硫酯衍生物是主要分解代谢，合成代谢途径和基因表达调控的关键参与者。
T4867	Erucic acid Prifac 2990,芥酸,13(Z)-Docosenoic Acid,cis-13-docosenoic acid	PI3K; Endogenous Metabolite	Metabolism; PI3K/Akt/mTOR signaling
	Erucic acid (13(Z)-Docosenoic Acid) 是单不饱和脂肪酸，分离自萝卜的种子。Erucic acid 可以容易地穿过血脑屏障，使大脑中长链脂肪酸的积累正常化。Erucic acid 能够改善认知障碍并有效预防痴呆。
T12592	Pyripyropene A	Others	Others
	Pyripyropene A is a potent and selective inhibitor of sterol O-acyltransferase 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)(IC50 of 0.07 µM).
T75552	Pomonic acid
	Pomonic酸，作为一种三萜化合物，能显著抑制胆固醇酯的积累，并降低酰基辅酶A：胆固醇酰基转移酶（ACAT）的活性。
T36776	Terpendole C
	Terpendole C is an indole diterpene alkaloid fungal metabolite originally isolated from A. yamanashiensis and an inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 2.1 μM in rat liver microsomes). It also inhibits ACAT in J774 macrophages (IC50 = 0.46 μM) without affecting cell growth.
T36931	Penicillide
	Penicillide is a fungal metabolite originally isolated from Penicillium that has diverse biological activities. It is an inhibitor of calpain 2/m-calpain (IC50 = 7.1 μM) and acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 22.9 μM). It is also an antagonist of oxytocin receptors (IC50 = 67 μM). Penicillide inhibits RNA synthesis in P388 murine leukemia cells.
T36226	Beauveriolide I
	Beauveriolide I is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.78 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide I also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 6 μM).2 1.Namatame, I., Tomoda, H., Si, S., et al.Beauveriolides, specific i...
T37690	Phenylpyropene A
	Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 0.8 μM).1 Phenylpyropene A inhibits diacylglycerol acyltransferase (DGAT) in rat liver microsomes (IC50 = 78.7 μM). It induces mortality in 100% of M. persicae when used at a concentration of 5 ppm.3 \|1. Kwon, O.E., Rho, M.C., Song, H.Y., et al. Phenylpyropene A and B, new inhibitors of ...
T36227	Beauveriolide III
	Beauveriolide III is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.41 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide III also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 5.5 μM).2Beauveriolide III (25 and 50 mg/kg) reduces the size of aortic ...
T36329	Terpendole I
	Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml).1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3 \|1. Tomoda, H., Tabata, N., Yang, D.-J., et al. Ter...

天然产物

Cat.No: T10857

Target: Endogenous Metabolite

Cat.No: T4867

Synonym: Prifac 2990,芥酸,13(Z)-Docosenoic Acid,cis-13-docosenoic acid

Target: PI3K, Endogenous Metabolite

Cat.No: T12592

Target: Others

Cat.No: T75552

Cat.No: T36776

Cat.No: T36931

Beauveriolide I

Cat.No: T36226

Phenylpyropene A

Cat.No: T37690

Beauveriolide III

Cat.No: T36227

Cat.No: T36329

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