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Cat. No. | Product Name | Target | Signaling Pathways |
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T78362 |
Transglutaminase
TG |
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Transglutaminase (TG) 是一种硫醇酶,促使蛋白质分子间交联,通过催化谷氨酰胺残基的γ-羧酰胺基团与其他化合物的一级ε-胺基团形成异肽键。该酶在包括凝血、抗菌免疫反应和光合作用在内的多种生理过程中发挥作用。 | |||
T3968 |
GK921
|
Glutaminase | Proteases/Proteasome |
GK921 是一种转谷氨酰胺酶2 抑制剂,对人类重组TGase2的IC50=为7.71 μM。 | |||
T17289 |
ZED-1227
ZED-101,TAK-227 |
Others; Glutaminase | Others; Proteases/Proteasome |
ZED-1227 (TAK-227) 是一种具有口服活性、选择性和高效性的转谷氨酰胺酶 2 (TG2) 抑制剂,具有抗癌活性,能阻塞炎症诱导的 TG2 表达和激活,可用于治疗乳糜泻。 | |||
T15035 |
Cystamine
2,2'-Disulfanediyldiethanamine |
Caspase | Apoptosis; Proteases/Proteasome |
Cystamine (2,2'-Disulfanediyldiethanamine) 是一种转谷氨酰胺酶抑制剂,可抑制 caspase-3,IC50 值为 23.6 μM。 Cystamine 可用于亨廷顿氏病的研究。 | |||
T6145 |
ZM39923 hydrochloride
JAK3 Inhibitor IV,ZM 39923 HCl |
EGFR; Others; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Others; Stem Cells; Tyrosine Kinase/Adaptors |
ZM39923 hydrochloride (JAK3 Inhibitor IV) 是一种 JAK3抑制剂,pIC50值为 7.1。它也抑制组织型转谷氨酞胺酶 (TGM2) 的活性,IC50值为 10 nM。 | |||
T26494 |
AA10 TG2 inhibitor
AA 10,AA10,AA-10 |
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AA10 is an irreversible inhibitor of transglutaminase 2 (TG2). | |||
T28137 |
NC9 TG2 inhibitor
NC 9,NC-9 TG2 inhibitor,NC9 |
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NC9 is an irreversible inhibitor of transglutaminase 2 (TG2) and also inhibits Factor XIIIA (FXIIIA). | |||
T27717 |
KCC009
KCC-009,KCC 009 |
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KCC009 is a potent and selective Transglutaminase 2 Inhibitor. | |||
T69878 |
AA9 TG2 inhibitor
|
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AA9 is a novel transglutaminase (TG2) inhibitor. | |||
T26265 |
TG53
TG-53,TG 53 |
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TG53 is a tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction inhibitor. | |||
T17295 | ZM39923 | Others | Others |
ZM39923 is a JAK3 inhibitor (pIC50: 7.1). ZM39923 also effectively inhibits tissue transglutaminase (IC50: 10 nM). | |||
T70413 | TG2-IN-3h | ||
TG2-IN-3h is a highly selective, potent, cell-permeable fluorescent irreversible tissue transglutaminase (tg2) inhibitor | |||
T76951 | Zampilimab | ||
Zampilimab (UCB-7858),一种转谷氨酰胺酶 2 (TG2) 单克隆抗体,具有肾移植潜在应用。 | |||
T60274 |
TG-2-IN-1
|
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TG-2-IN-1 (Compound D003) 是一种转谷氨酰胺酶-2 (TGM-2) 抑制剂,可用于近视研究。 | |||
T2460 |
JAK 3 inhibitor IV
ZM 39923 hydrochloride,Jak3 inhibitor IV |
EGFR; Others; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Others; Stem Cells; Tyrosine Kinase/Adaptors |
JAK 3 inhibitor IV (ZM 39923 hydrochloride) 是一种 JAK1/3 抑制剂,pIC50 为 4.4/7.1,对 JAK2 几乎没有活性,对 EGFR 有适度的作用;还发现对转谷氨酰胺酶敏感。 | |||
T39168L |
Epsilon-(gamma-glutamyl)-lysine acetate (17105-15-6 Free base)
|
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Epsilon-(gamma-glutamyl)-lysine acetate (17105-15-6 Free base) 是一种 N(6)-酰基-L-赖氨酸衍生物,可在组织转谷氨酰胺酶的帮助下在细胞外基质 (ECM) 成分之间形成键 (tTg)。 这些键与某些疾病(如非糖尿病肾病和青光眼滤过)的发病机制有关。 | |||
T79315 |
PROTAC TG2 degrader-2
|
PROTACs | PROTAC |
PROTACTG2 degrader-2(compound 7)是一种针对Transglutaminase 2(TG2)的选择性竞争性降解剂,其Kd值大于100 μM。该化合物能有效抑制卵巢癌细胞的迁移,并降低其TG2表达水平,因此可作为卵巢癌研究的工具。 | |||
T63248 | NTU281 | ||
NTU281 是转谷氨酰胺酶-2 (transglutaminase-2) 的有效抑制剂,能够减少糖尿病大鼠血清肌酐和蛋白尿的升高,并降低肾小球 I 型胶原积累、Hic-5 和α-SMA 表达,以及减少细胞凋亡 (apoptosis),能够用于糖尿病引起的肾小球硬化的研究。 | |||
T73760 |
Epsilon-(gamma-glutamyl)-lysine TFA
|
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Epsilon-(gamma-glutamyl)-lysine (H-Glu(H-Lys-OH)-OH) TFA 为 N(6)-acyl-L-lysine 的衍生物,其在特定疾病中(如非糖尿病肾病、青光眼)通过组织转谷氨酰胺酶(tTg)作用,促进ECM成分间Epsilon-(gamma-glutamyl)-lysine键形成,从而增加。 | |||
T79505 |
PROTAC TG2 degrader-1
|
PROTACs | PROTAC |
PROTACTG2 degrader-1(化合物 11)是一种靶向组织转谷氨酰胺酶 (TG2) 的VHL基PROTAC,具有68.9 μM的KD值。该化合物通过蛋白酶体途径降低卵巢癌细胞中TG2的水平。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T39168 |
Epsilon-(gamma-glutamyl)-lysine
Epsilon-(gamma-glutamyl)-lysine,γ-Glu-ε-Lys,H-Glu(H-Lys-OH)-OH |
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Epsilon-(gamma-glutamyl)-lysine is an N(6)-acyl-L-lysine derivative that forms bonds between extracellular matrix (ECM) components with the assistance of the enzyme tissue transglutaminase (tTg). These bonds are implicated in the pathogenesis of certain diseases like non-diabetic kidney and glaucoma filtration. |