搜索结果

Search Results for " tnf-α-in-9 "

抑制剂 & 化合物

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T77494	TNF-α-IN-9	TNF	Apoptosis
	TNF-α-IN-9 是一种 NDM-1 inhibitor-3类似物，是一种 TNF-α 抑制剂。TNF-α-IN-9 显示低抑制活性。
T15017	CU-T12-9	TLR	Immunology/Inflammation
	CU-T12-9 是特异性 TLR1/2激动剂，可激活先天免疫系统和适应性免疫系统。它选择性激活 TLR1/2 异二聚体，可通过促进 TLR1 和 TLR2 二聚而激活 NF-κB 信号，引起下游 TNF-α、IL-10 和 iNOS 增加。
T4383	GSK-J4 Hydrochloride GSK J4 HCl,GSK J4 HCl (1373423-53-0 free base)	Histone Demethylase	Chromatin/Epigenetic
	GSK-J4 Hydrochloride (GSK J4 HCl) 是 H3K27me3/me2 去甲基化酶 JMJD3/KDM6B 和 UTX/KDM6A 双抑制剂，IC50分别为 8.6 和 6.6 μM。它是 GSK-J1 的乙酯衍生物，体外 IC50 值大于 50 μM。它抑制 LPS 诱导的人原代巨噬细胞产生 TNF-α，IC50值为 9 μM。
T3100	GSK-J4 GSK J4 HCl	Apoptosis; Histone Demethylase	Apoptosis; Chromatin/Epigenetic
	GSK-J4 (GSK J4 HCl) 是 H3K27me3/me2 去甲基化酶JMJD3/KDM6B 和UTX/KDM6A 双抑制剂，IC50分别为 8.6 μM 和 6.6 μM。它是 GSK-J1 的细胞通透性前药，可诱导内质网应激相关的细胞凋亡。它抑制 LPS 诱导的人原代巨噬细胞产生 TNF-α，IC50值为 9 μM。
T37726	MMP-9 Inhibitor I
	MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNF-α converting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 μM). MMP-9 inhibitor I decreases TNF-α secretion stimulated by LPS in BV-2 microglial cells when used at concentrations of 50 and 100 μM.
T72102	Glucocorticoid receptor modulator 1
	Glucocorticoid receptor modulator1 是一种高效且具有口服活性的 NF-κB 和 AP-1抑制剂，IC50分别为 9 nM 和 130 nM。Glucocorticoid receptor modulator1 可有效降低炎症因子 IL-6、IL-1β、TNF-α 的表达，可缓解小鼠皮炎。
T78548	3-Hydroxyxanthone 3-Hydroxy-xanthen-9-one	Integrin	Cytoskeletal Signaling
	3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one) 是一种具有抗炎活性的氧杂蒽酮化合物。它能抑制人脐静脉内皮细胞（HUVEC）中NADPH催化的脂质过氧化，并且阻止TNF-α所诱导的ICAM-1表达。
T35854	9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)
	9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid that has been found in beef and milk fat.1It binds to peroxisome proliferator-activated receptor α (PPARα; IC50= 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARα when used at a concentration of 100 μM.29(Z),11(E)-Conjugated linoleic acid inhibits TNF-α-inducedGLUT4expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes.3Dietary administration of 9(Z)11(E)-co...

化合物

Synonym: GSK J4 HCl,GSK J4 HCl (1373423-53-0 free base)

Target: Histone Demethylase

GSK-J4

Cat.No: T3100

Synonym: GSK J4 HCl

Target: Apoptosis, Histone Demethylase

Glucocorticoid receptor modulator 1

Synonym: 3-Hydroxy-xanthen-9-one

Target: Integrin

9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)

Cat.No: T35854

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
TN2075	Pimaric acid	MMP; p38 MAPK; NF-κB	MAPK; NF-κB; Proteases/Proteasome
	Pimaric acid has potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α±-induced human aortic smooth muscle cells.