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抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T39913	TMX-4100
	TMX-4100 is a potent degrader of phosphodiesterase 6D (PDE6D), exhibiting high degradation selectivity towards PDE6D with DC50 values below 200 nM in MOLT4, Jurkat, and MM.1S cells. This compound holds significant potential for research pertaining to multiple myeloma.
T0773	Febuxostat 非布索坦,TMX 67,非布司他,TEI 6720	ROS; Xanthine Oxidase	Immunology/Inflammation; Metabolism
	Febuxostat (TEI 6720) 是一种选择性黄嘌呤氧化酶(XO)抑制剂，Ki=0.6 nM。
T67949	TMX-2164
	TMX-2164 是高效、不可逆的 B 细胞淋巴瘤 6 (BCL6) 抑制剂，IC50 为 152 nM，展现出持续的细胞内靶向作用及抗增殖活性。
T61754	TMX-4116
	TMX-4116为酪蛋白激酶1α (CK1α) 降解剂，具有显著的选择性，尤其是在MOLT4、Jurkat 和 MM.1S 细胞系中，其对CK1α的降解活性强，DC50值低于200 nM。因此，TMX-4116被用于多发性骨髓瘤相关研究。
T60740	TMX-4113
	TMX-4113 具有癌症研究的潜力，它是磷酸二酯酶 6D (PDE6D) 和酪蛋白激酶 1α (CK1α) 的降解剂。
T74870	TMX-201
	TMX-201，一种TLR7配体-磷脂共轭物，表现出显著的免疫刺激活性，适用于乳腺癌与黑色素瘤的研究。
T80974	TMX-4153	Ligands for Target Protein for PROTAC	PROTAC
	TMX-4153 是一种二价降解剂，能快速选择性地募集 Von Hippel-Lindau (VHL) E3 ubiquitin ligase complex 来降解内源性 PIP4K2C，KD 值为 42 nM。此化合物适用于 PROTAC 的合成。
T75139	TMX1
	TMX1 是一种 BRD4共价分子胶降解剂。TMX1 选择性地将 DCAF16 招募到 BRD4BD2 上，导致 BRD4的降解。
T4281	Endoxifen (E/Z)-N-desmethyl-4-hydroxy Tamoxifen,N-去甲基-4-羟基-,(E/Z)-Endoxifen	Estrogen Receptor/ERR; Aromatase; Estrogen/progestogen Receptor; Parasite; Drug Metabolite	Endocrinology/Hormones; Metabolism; Microbiology/Virology
	Endoxifen ((E/Z)-Endoxifen) 是 Tamoxifen 的关键活性代谢物，能抑制芳香酶的活性，与雌激素受体有较高的亲和力和特异性。它有潜力研究乳腺癌。
T33876	panomifene GYKI13504,GYKI 13504,EGIS5650,EGIS-5650,EGIS 5650,GYKI-13504
	Panomiphene (Gyki-13504, EGIS-5650) is an anti-estrogen drug that is a tamoxifen (TMX) analogue.

化合物

Synonym: 非布索坦,TMX 67,非布司他,TEI 6720

Target: ROS, Xanthine Oxidase

Target: Ligands for Target Protein for PROTAC

Synonym: (E/Z)-N-desmethyl-4-hydroxy Tamoxifen,N-去甲基-4-羟基-,(E/Z)-Endoxifen

Target: Estrogen Receptor/ERR, Aromatase, Estrogen/progestogen Receptor, Parasite, Drug Metabolite

panomifene

Cat.No: T33876

Synonym: GYKI13504,GYKI 13504,EGIS5650,EGIS-5650,EGIS 5650,GYKI-13504

Target:

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05058	TMX1 Protein, Human, Recombinant (mFc) thioredoxin-related transmembrane protein 1,PDIA11,TXNDC,TXN...	Human	HEK293 Cells
	As a thiol-based tumor suppressor, TMX1 increases mitochondrial ATP production and apoptosis progression. TMX1 is the first example of a topology-specific client protein redox catalyst acting both in the folding and in the degradative pathways.
TMPJ-01404	TMX2 Protein, Human, Recombinant (His) Cell proliferation-inducing gene 26 protein,TMX2,Th...	Human	E. coli
	TMX2 is a single-pass type I membrane protein and contains 1 thioredoxin domain. Thioredoxin plays an important role in various cellular processes through redox regulation. The Molecular Cloning and characterization of one member of the thioredoxin superfamily, designated as TMX2.The TMX2 cDNA consists of 1644 nucleotides and contains an open reading frame encoding a protein of 372 amino acids with a predicted molecular mass of 42.5 kDa and an isoelectric point of 8.94. The TMX2 protein may pos...

重组蛋白

TMX1 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05058

Species: Human

Expression System: HEK293 Cells

TMX2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01404

Species: Human

Expression System: E. coli

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