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Targets Recommended: Others Ligand for E3 Ligase

7

抑制剂 & 化合物

25

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T23371	SMER3 SMER 3	Others; Ligand for E3 Ligase	Others; PROTAC
	SMER3 是选择性的 Skp1-Cullin-F-box (SCF)Met30泛素连接酶抑制剂。SMER 3 通过抑制 SCFMet30来增强 Rapamycin 的生长抑制作用。
T72043	SCFSkp2-IN-2	Apoptosis; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	SCFSkp2-IN-2 是一种 Skp2抑制剂，其 KD 为 28.77 μM。AAA-237 诱导 NSCLC 细胞凋亡 (apoptosis)，显示出抗肿瘤活性。
T3452	ISCK03	c-Kit	Tyrosine Kinase/Adaptors
	ISCK03 是一种特异性的 SCF/c-Kit 抑制剂。
T17065	TFMB-(R)-2-HG	Others	Others
	TFMB-(R)-2-HG 是一种具有细胞膜渗透性的 (R)-2-HG，急性髓细胞性白血病的致癌因子。它能够响应雌激素戒断损害 SCF ER-Hoxb8 细胞分化。
T3317	SZL P1-41	Apoptosis; Others; E1/E2/E3 Enzyme	Apoptosis; Others; Ubiquitination
	SZL P1-41 是 Skp2 抑制剂，可以阻止 Skp2-Skp1 复合物的组装。它选择性地抑制 Skp2 SCF E3 连接酶活性，还在体内外抑制 Skp2 介导的 p27 和 Akt 泛素化。它通过触发细胞衰老和抑制糖酵解来抑制 Y 细胞和 Y 干细胞的存活，有抗肿瘤作用。
T76919	Barzolvolimab
	Barzolvolimab (CDX 0159)为人源化抗KIT IgG1单克隆抗体。其特异性地抑制KIT激活，有效降低慢性诱导性荨麻疹中皮肤肥大细胞数量及疾病活动程度。
T71654	APcK110
	APcK110 is a novel Kit inhibitor . APcK110 inhibits proliferation of the mastocytosis cell line HMC1.2 and the SCF-responsive cell line OCI/AML3 in a dose-dependent manner . APcK110 is a more potent inhibitor of OCI/AML3 proliferation than the clinically used Kit inhibitors imatinib and dasatinib and at least as potent as cytarabine. APcK110 inhibits the phosphorylation of Kit, Stat3, Stat5, and Akt in a dose-dependent fashion, showing activity of APcK110 on Kit and its downstream signaling path...

化合物

Cat.No: T23371

Synonym: SMER 3

Target: Others, Ligand for E3 Ligase

Cat.No: T72043

Target: Apoptosis, E1/E2/E3 Enzyme

Cat.No: T3452

Target: c-Kit

Cat.No: T17065

Target: Others

Cat.No: T3317

Target: Apoptosis, Others, E1/E2/E3 Enzyme

Cat.No: T76919

Cat.No: T71654

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02105	SCF Protein, Mouse, Recombinant (His) Gb,Kitlg,SF,Clo,Mgf,SLF,Sl,KIT ligand,SCF,Con	Mouse	Baculovirus Insect Cells
	SCF Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 19.7 kDa and the accession number is P20826-1.
TMPJ-01470	SCF Protein, Human, Recombinant Mast Cell Growth Factor,c-Kit ligand,KITLG,MGF,Stem Cell Fac...	Human	E. coli
	Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures and has been shown to act synergistically with colony stimulating factors.
TMPJ-00166	SCF Protein, Mouse, Recombinant SCF,Hematopoietic growth factor KL,MGF,Steel factor...	Mouse	E. coli
	Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the ...
TMPY-02170	SCF Protein, Human, Recombinant (aa 1-189, His) DCUA,Kitl,FPHH,SCF,KL-1,SF,FPH2,MGF,SHEP7,C-kit lig...	Human	Baculovirus Insect Cells
	SCF Protein, Human, Recombinant (aa 1-189, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 19.9 kDa and the accession number is P21583-1.
TMPY-05135	SCF Protein, Mouse, Recombinant (His), Biotinylated Con,SLF,SF,Mgf,Gb,Clo,KIT ligand,Sl,Kitlg,SCF	Mouse	Baculovirus Insect Cells
	SCF Protein, Mouse, Recombinant (His), Biotinylated is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 19.7 kDa and the accession number is P20826-1.
TMPJ-00894	SCF Protein, Rat, Recombinant (His) Hematopoietic growth factor KL,Steel factor,Stem cell factor...	Rat	E. coli
	Stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase...
TMPJ-00895	SCF Protein, Rat, Recombinant (HEK293, His) steel factor,Mast cell growth factor,SLF,MGFSHEP7,SCF	Rat	HEK293 Cells
	SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. In phase I/II...
TMPJ-00402	CD117 Protein, Human, Recombinant (hFc) KIT,CD117,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncog...	Human	HEK293 Cells
	C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing sti...
TMPH-02651	Fbxo3 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.
TMPH-01326	FBXO44 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. FBXO44 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 37.2 kDa and the accession number is Q9H4M3.
TMPJ-01133	NEDD8 Protein, Human, Recombinant (His & SUMO) Neddylin,Ubiquitin-like protein Nedd8,NEDD8,Neural precursor...	Human	E. coli
	Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation. NEDD8 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHi...
TMPJ-01132	NEDD8 Protein, Human, Recombinant Ubiquitin-like protein Nedd8,NEDD8,Neddylin,Neural precursor...	Human	E. coli
	Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation. NEDD8 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular...
TMPY-02240	STAT1 Protein, Human, Recombinant (His & GST) IMD31A,IMD31B,IMD31C,STAT91,CANDF7,signal transducer and act...	Human	Baculovirus Insect Cells
	STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by various ligands, including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. It is a signal transducer and transcription activator that mediates cellular responses to interferons (IFNs),...
TMPJ-01249	ASB13 Protein, Human, Recombinant (His) ASB13,Ankyrin repeat and SOCS box protein 13	Human	E. coli
	Ankyrin repeat and SOCS box protein 13(ASB13) is a member of the ankyrin repeat and SOCS box-containing (ASB) family. ASB13 contain six ankyrin repeats sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. ASB13 may be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex...
TMPK-00045	SKP1 Protein, Human, Recombinant (His, Avi), Biotinylated SIII,OCP-2,TCEB1L,EMC19,OCP-II,OCP2,SKP1A,p19A	Human	HEK293 Cells
	The S-phase Kinase-Associated Protein 1 (SKP1) is a core component of the SKP1, Cullin 1, F-box protein (SCF) complex, an E3 ubiquitin ligase that serves to poly-ubiquitinate a vast array of protein targets as a signal for their proteasomal degradation, thereby playing a critical role in the regulation of downstream biological processes. SKP1 Protein, Human, Recombinant (His, Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His and C-Avi tag. The predicted molecular weight is 21....
TMPH-02136	SPSB1 Protein, Human, Recombinant (His)	Human	E. coli
	Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5.
TMPK-00044	SKP1 Protein, Human, Recombinant (His, Avi) OCP-II,TCEB1L,SIII,p19A,OCP-2,EMC19,OCP2,SKP1A	Human	HEK293 Cells
	The S-phase Kinase-Associated Protein 1 (SKP1) is a core component of the SKP1, Cullin 1, F-box protein (SCF) complex, an E3 ubiquitin ligase that serves to poly-ubiquitinate a vast array of protein targets as a signal for their proteasomal degradation, thereby playing a critical role in the regulation of downstream biological processes. SKP1 Protein, Human, Recombinant (His, Avi) is expressed in HEK293 mammalian cells with N-His and C-Avi tag. The predicted molecular weight is 21.43 kDa and the...
TMPJ-00331	IFNAR1 Protein, Rhesus macaque, Recombinant (His) IFN-al,CRF2-1,IFN-alpha/beta receptor 1,human interferon-α r...	Rhesus	HEK293 Cells
	Interferon‑alpha/beta receptor 1 (IFN‑ alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphory...
TMPH-02632	TRIM21 Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr...
TMPH-02633	TRIM21 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus Insect Cells
	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr...
TMPH-02131	SKP2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UB...
TMPJ-01418	CSF1R Protein, Cynomolgus, Recombinant (hFc) M-CSF-R,CSF1R,CSF-1-R,CSF-1 receptor,CSF-1R,Macrophage colon...	Cynomolgus	HEK293 Cells
	Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region. CSF1R is expressed primarily on cells of the monocyte/macrophage lineage, dendritic cells, stem cells and in the developing placenta. CSF1 and its receptor (CSF1R, product of ...
TMPJ-01419	CSF1R Protein, Cynomolgus, Recombinant (His) CSF-1-R,CSF-1 receptor,Proto-oncogene c-Fms,M-CSF-R,Macropha...	Cynomolgus	HEK293 Cells
	Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region. CSF1R is expressed primarily on cells of the monocyte/macrophage lineage, dendritic cells, stem cells and in the developing placenta. CSF1 and its receptor (CSF1R, product of ...
TMPY-03968	Secretogranin II Protein, Human, Recombinant (His) EM66,SgII,SN,CHGC,secretogranin II	Human	HEK293 Cells
	Kit ligand, also known as Hematopoietic growth factor KL, Mast cell growth factor, Steel factor, Stem cell factor, c-Kit ligand, Kitlg and KITL, is a single-pass type I membrane protein that belongs to the SCF family. KITL / kit ligand also belongs to the family of dimeric transmembrane growth factors. The soluble form of KIT ligand is a secreted protein. Mast cells are thought to participate in a variety of immune responses, such as parasite resistance and the allergic reaction. Mast cell devel...
TMPH-01692	MAPK3 Protein, Human, Recombinant (His)	Human	E. coli
	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, c...

重组蛋白

SCF Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02105

Species: Mouse

Expression System: Baculovirus Insect Cells

SCF Protein, Human, Recombinant

Cat.No: TMPJ-01470

Species: Human

Expression System: E. coli

SCF Protein, Mouse, Recombinant

Cat.No: TMPJ-00166

Species: Mouse

Expression System: E. coli

SCF Protein, Human, Recombinant (aa 1-189, His)

Cat.No: TMPY-02170

Species: Human

Expression System: Baculovirus Insect Cells

SCF Protein, Mouse, Recombinant (His), Biotinylated

Cat.No: TMPY-05135

Species: Mouse

Expression System: Baculovirus Insect Cells

SCF Protein, Rat, Recombinant (His)

Cat.No: TMPJ-00894

Species: Rat

Expression System: E. coli

SCF Protein, Rat, Recombinant (HEK293, His)

Cat.No: TMPJ-00895

Species: Rat

Expression System: HEK293 Cells

CD117 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00402

Species: Human

Expression System: HEK293 Cells

Fbxo3 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02651

Species: Mouse

Expression System: E. coli

FBXO44 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01326

Species: Human

Expression System: E. coli

NEDD8 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPJ-01133

Species: Human

Expression System: E. coli

NEDD8 Protein, Human, Recombinant

Cat.No: TMPJ-01132

Species: Human

Expression System: E. coli

STAT1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02240

Species: Human

Expression System: Baculovirus Insect Cells

ASB13 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01249

Species: Human

Expression System: E. coli

SKP1 Protein, Human, Recombinant (His, Avi), Biotinylated

Cat.No: TMPK-00045

Species: Human

Expression System: HEK293 Cells

SPSB1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02136

Species: Human

Expression System: E. coli

SKP1 Protein, Human, Recombinant (His, Avi)

Cat.No: TMPK-00044

Species: Human

Expression System: HEK293 Cells

IFNAR1 Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPJ-00331

Species: Rhesus

Expression System: HEK293 Cells

TRIM21 Protein, Mouse, Recombinant (E. coli, His)

Cat.No: TMPH-02632

Species: Mouse

Expression System: E. coli

TRIM21 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02633

Species: Mouse

Expression System: Baculovirus Insect Cells

SKP2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02131

Species: Human

Expression System: E. coli

CSF1R Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPJ-01418

Species: Cynomolgus

Expression System: HEK293 Cells

CSF1R Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-01419

Species: Cynomolgus

Expression System: HEK293 Cells

Secretogranin II Protein, Human, Recombinant (His)

Cat.No: TMPY-03968

Species: Human

Expression System: HEK293 Cells

MAPK3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01692

Species: Human

Expression System: E. coli

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