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25

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8931L	ICCB-19 hydrochloride ICCB-19 HCl（750621-52-4 free base）	Apoptosis; Others; Autophagy; RIP kinase	Apoptosis; Autophagy; NF-κB; Others
	ICCB-19 hydrochloride (ICCB-19 HCl) 是RIPK1激酶活性的间接抑制剂。它是一种 TRADD 抑制剂，可与 TRADD 的 N 端结构域结合，破坏其与 TRADD-C 和 TRAF2 的结合，诱导自噬和长寿命蛋白质的降解。
T3726	Erdafitinib 厄达替尼,JNJ-42756493	Apoptosis; FGFR	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Erdafitinib (JNJ-42756493) 是一种喹喔啉衍生物，是一种具有口服活性的FGFR 家族抑制剂，抑制FGFR1/2/3/4活性的IC50分别为1.2、 2.5、3.0和5.7 nM。
T20642	Laurdan 6-十二酰基-N,N-二甲基-2-萘胺,6-Dodecanoyl-2-dimethylaminonaphthalene	Others	Others
	Laurdan (6-Dodecanoyl-2-dimethylaminonaphthalene) 是膜透性荧光探针。它的广义极化 (GP) 定量可用于磷脂相的鉴定，对与之结合的细胞膜磷脂相具有光谱敏感性。
T17284	Zardaverine BY 290,B 84290	PDE	Metabolism
	Zardaverine (BY 290) 是一种可口服且具有选择性和有效性的 PDE3/4 抑制剂，具有支气管扩张活性和抗肝癌活性。Zardaverine 在血小板中的作用是通过PDE III同工酶介导，可用于研究急性肾衰竭呵呵慢性气流阻塞。
T6189	Mirdametinib PD325901,PD0325901	Apoptosis; MEK; Autophagy	Apoptosis; Autophagy; MAPK
	Mirdametinib (PD325901) 是一种 MEK 抑制剂 (IC50=0.33 nM)，具有选择性、非 ATP 竞争性和口服活性。Mirdametinib 具有抗肿瘤活性，可以抑制 p-ERK1/2 的表达并诱导细胞凋亡。
T32191	Irdabisant CEP-26401,CEP 26401,CEP26401	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Irdabisant (CEP-26401) 是选择性、口服活性和血脑屏障渗透性的组胺 H3 受体 (histamine H3 receptor, H3R) 拮抗剂/逆激动剂。Irdabisant 显示人 H3R 和大鼠 H3R 的 Ki 分别为 2.0 nM 和 7.2 nM。Irdabisant 抑制 hERG 电流的活性相对较低 (IC50= 13.8 μM)。在大鼠社会认知模型中，Irdabisant 具有认知增强和唤醒作用。Irdabisant 可用于研究精神分裂症或认知障碍。
T37555	Cardanol triene
	Cardanol triene is a phenol found in cashew nut shell liquid that reversibly inhibits tyrosinase with an IC50 value of 40.5 μM in vitro. A mixture of cardanol mono-, di-, and triene is used to synthesize cardanol-metal complexes that inhibit uropathogenic E. coli biofilm formation.
T36477	Urdamycin A
	Urdamycin A is a bacterial metabolite originally isolated fromS. fradiaethat has antibacterial and anticancer activities.1,2It is active against a variety of Gram-positive and Gram-negative bacteria, includingB. subtilisand strains ofArthrobacterandStreptomyces, but not the fungusS. cerevisiae, in a disc assay when used at a concentration of 1 mg/ml.2Urdamycin A is cytotoxic to L1210 and HT-29, but not A549, cancer cells (IC50s = 7.5, 5, and >10 μg/ml, respectively).1
T126318	Sordariol
	Sordariol 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126318，CAS号为 115873-03-5。
T26318	Verdantiol Butylphenyl methylpropional methyl anthranilate
	Verdantiol is a flavanol.
T30669	C.I. Mordant Brown 1 NSC-326197,NSC 326197,NSC326197
	C.I. Mordant Brown 1 是一种偶氮染料，λmax 为 373 nm、487 nm (2nd)。C.I. Mordant Brown 1 也可以抑制CD40-CD154 共刺激蛋白-蛋白互作。
T36539	Nocardamine
	Nocardamine is a ferrioxamine siderophore that has been found inStreptomycesand has diverse biological activities.1,2,3,4It chelates iron in a chrome azurol S assay (IC50= 9.9 μM).1Nocardamine inhibitsM. smegmatisandM. bovisbiofilm formation (MIC = 10 μM for both), an effect that can be reversed by iron.2It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 μM, respectively).3Nocardamine also induces morphological changes in BM-N4 insect cells.4 1.Lo...
T36434	Sordarin sodium
	Sordarin is an inhibitor of fungal protein synthesis originally isolated from S. araneosa.[1] It binds to elongation factor 2 (EF-2) in the presence of ribosomes and inhibits the uncoupled GTPase activity of equimolar mixtures of EF-2 and ribosomes from C. albicans (IC50 = 0.1 μM). Sordarin inhibits protein synthesis in cell-free lysates of C. albicans, C. glabrata, and C. neoformans (IC50s = 0.01, 0.2, and 0.06 μg/ml, respectively) but not in rabbit reticulocytes (IC50 = >100 μg/ml).[1] [2] It...
T131401	Halfordamine
	Halfordamine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131401。
T125463	12-O-Methylsordariol
	12-O-Methylsordariol 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125463，CAS号为 1938054-84-2。
T71813	Cardanol diene
	Cardanol diene is a phenol found in cashew nut shell liquid that inhibits tyrosinase with an IC50 value of 52.5 μM in vitro. Cardanol diene is also used to synthesize cardanol-metal complexes that inhibit uropathogenic E. coli biofilm formation.
T69413	Primordazine B
	Primordazine B is a selective inhibitor of primordial germ cell (PGC) development which targets poly(A)-tail-independent noncanonical translation (PAINT).
T125499	Piperdardine
	Piperdardine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125499。
T34133	Primordazine NC-6364997 Primordazine NC 6364997,Primordazine NC6364997
	Primordazine NC-6364997 is a negative control for Primordazine A and Primordazine B.
T126401	Cordatin
	Cordatin 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126401，CAS号为 110382-43-9。
T61197	Irdabisant hydrochloride
	Irdabisant (CEP-26401) hydrochloride 是一种选择性、口服活性的组胺H3受体拮抗剂/逆激动剂，具备良好的血脑屏障渗透性。该化合物对大鼠和人类的H3受体具有高亲和力，其Ki值分别为7.2 nM和2.0 nM。此外，Irdabisant hydrochloride在抑制hERG电流方面表现出较低的活性，IC50为13.8 μM。在大鼠社会认知模型中，它展现了认知增强和唤醒的效果，可作为精神分裂症或认知障碍研究的潜在工具。
T10795	Chlordantoin Clodantoin,氯登妥因	Others	Others
	Chlordantoin is an antifungal agent with the potential for vaginal candidiasis treatment.
T80447	Pardaxin P5
	Pardaxin P5，一种抗菌肽，其对大肠杆菌的最小抑制浓度（MIC）为13 μM。
T33483	Mordant red 19 NSC-326195,NSC 326195,Acid Chrome Red 5G,Superchrome Red G,NSC326195
	Mordant red 19 is an azo dye.
T23399	STEARDA	Others	Others
	STEARDA potentiates TRPV1-mediated effects of NADA.

化合物

ICCB-19 hydrochloride

Cat.No: T8931L

Synonym: ICCB-19 HCl（750621-52-4 free base）

Target: Apoptosis, Others, Autophagy, RIP kinase

Cat.No: T3726

Synonym: 厄达替尼,JNJ-42756493

Target: Apoptosis, FGFR

Cat.No: T20642

Synonym: 6-十二酰基-N,N-二甲基-2-萘胺,6-Dodecanoyl-2-dimethylaminonaphthalene

Target: Others

Cat.No: T17284

Synonym: BY 290,B 84290

Target: PDE

Cat.No: T6189

Synonym: PD325901,PD0325901

Target: Apoptosis, MEK, Autophagy

Cat.No: T32191

Synonym: CEP-26401,CEP 26401,CEP26401

Target: Histamine Receptor

Cardanol triene

Cat.No: T37555

Cat.No: T36477

Cat.No: T126318

Cat.No: T26318

Synonym: Butylphenyl methylpropional methyl anthranilate

C.I. Mordant Brown 1

Cat.No: T30669

Synonym: NSC-326197,NSC 326197,NSC326197

Cat.No: T36539

Sordarin sodium

Cat.No: T36434

Cat.No: T131401

12-O-Methylsordariol

Cat.No: T125463

Cat.No: T71813

Cat.No: T69413

Cat.No: T125499

Primordazine NC-6364997

Cat.No: T34133

Synonym: Primordazine NC 6364997,Primordazine NC6364997

Cat.No: T126401

Irdabisant hydrochloride

Cat.No: T61197

Cat.No: T10795

Synonym: Clodantoin,氯登妥因

Target: Others

Cat.No: T80447

Cat.No: T33483

Synonym: NSC-326195,NSC 326195,Acid Chrome Red 5G,Superchrome Red G,NSC326195

Cat.No: T23399

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TJS0328	Nordalbergin 6,7-dihydroxy-4-phenylcoumarin,6,7-Dihydroxy-4-Phenylchromen-2-One,6,7-二羟基-4苯基香豆素	Others	Others
	Nordalbergin 是一种香豆素，分离自Dalbergia sissoo 的木皮中。它能够显著性的诱导 HL-60 细胞的分化。
TN3594	Cardanol (C15:1)	Apoptosis; Others	Apoptosis; Others
	Cardanol (C15:1) 存在于腰果壳液中，可诱导人黑色素瘤细胞线粒体相关的细胞凋亡。
T2994	(E)-Cardamonin Alpinetin chalcone,Cardamomin,小豆蔻明,Cardamonin,(E)-Cardamoni,豆蔻明	Apoptosis; TRP/TRPV Channel	Apoptosis; Membrane transporter/Ion channel
	(E)-Cardamonin (Alpinetin chalcone) 是一种新型hTRPA1阳离子通道拮抗剂，IC50值为454 nM。
T66078	Cardamonin
	Cardamonin, a chalcone extracted from cardamom spice with anti-inflammatory and anti-tumor activities. Cardamonin decreased viability of NPC(Nasopharyngeal carcinoma ) cells in a concentration-dependent manner. The IC50 values were 16.22 μM(CNE-1), 14.34 μM (CNE-2), 16.50 μM (HONE-1), and 68.12 μM (SUNE-1). Moreover, the expression level of the proapoptotic effector protein Bax and Bid was also markedly increased after treatment with cardamonin（15μM） in CNE-2 cells.In vivo, cardamonin (25 mg/kg ...

天然产物

Cat.No: TJS0328

Synonym: 6,7-dihydroxy-4-phenylcoumarin,6,7-Dihydroxy-4-Phenylchromen-2-One,6,7-二羟基-4苯基香豆素

Target: Others

Cardanol (C15:1)

Cat.No: TN3594

Target: Apoptosis, Others

Cat.No: T2994

Synonym: Alpinetin chalcone,Cardamomin,小豆蔻明,Cardamonin,(E)-Cardamoni,豆蔻明

Target: Apoptosis, TRP/TRPV Channel

Cat.No: T66078

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