Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T22406 |
Prazosin
哌唑嗪,Prazosine,Furazosin,Prazocin |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Prazosin (Prazosine) 是一种 α1 受体阻滞剂,是一种 α1 肾上腺素能受体的反向激动剂,用于治疗高血压。 | |||
T1050 |
Prazosin hydrochloride
Prazosin hydrochloride,哌唑嗪盐酸盐,Prazosin HCl,cp-12299-1,Peripress,Vasoflex,盐酸哌唑嗪,Minipress |
Potassium Channel; MRP; Adrenergic Receptor; ABC; Autophagy | Autophagy; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience |
Prazosin hydrochloride (Vasoflex) 是一种选择性肾上腺素能 α-1 拮抗剂,可降低外周阻力并放松血管平滑肌。 它可用于研究高血压和酒精使用障碍。 它是一种合成哌嗪衍生物,具有降压抗肾上腺素能特性。它抑制有机阳离子转运蛋白 OCT-1 和 OCT-3,IC50分别为 1.8 和 13 μM 。 | |||
T63980 |
BODIPY FL prazosin
|
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BODIPY FL prazosin 是荧光 α1-肾上腺素 α1-adrenergic 拮抗剂,能够作用于 α1a-AR (Ki: 14.5 nM)和 α1b-AR (Ki: 43.3 nM)。BODIPY FL prazosin 是一种荧光配体,激发和发射波长分别为 485 和 535 nm。BODIPY FL prazosin 能够用于 α1-肾上腺素受体亚型的亚细胞定位差异的研究。 | |||
T10998 |
Deriglidole
SL 86-0715 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Deriglidole (SL 86-0715) 是一种外周肾上腺素能受体拮抗剂,是一种具有选择性的α2受体抑制剂。 Deriglidole 对可乐定和 Idazoxan 有抑制作用而对哌唑嗪与大鼠皮质和人血小板α2-肾上腺素能受体不显示活性。 | |||
T0993 |
Methoxamine hydrochloride
Methoxamine HCl,盐酸甲氧明 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Methoxamine hydrochloride (Methoxamine HCl) 是一种 alpha1 肾上腺素能受体的选择性激动剂。它通过 Prazosin 敏感机制在兔肺动脉显著增加 ATP、ADP 和 AMP 的溢出,但不增加腺苷的溢出。它引起血管收缩和外周血管阻力增加。 | |||
T22232 |
Alfuzosin
|
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Alfuzosin 是选择性和竞争性的α1肾上腺素受体拮抗剂,可用于良性前列腺增生(BPH)的研究。 | |||
T25793 |
Metazosin
Kenosin |
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Metazosin is an antihypertensive agent that replaces 3H-prazosin from its bond to alpha-1 receptors of the cerebral cortex. | |||
T31022 |
CP 59430
CP-59430,CP59430 |
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CP 59430 is an azide analogue of prazosin. Prazosin is a highly selective α 1-adrenergic receptor antagonist. | |||
T67790 |
Biricodar dicitrate
VX 710,VX 710-3 |
NF-κB; AChR | Neuroscience; NF-κB |
Biricodar dicitrate (VX-710)是一种 有效的 MDR 抑制剂没具有抗癌活性,可用于研究前列腺癌。 | |||
T62476 |
Trimazosin
|
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Trimazosin 是一种口服具有活力的 quinazoline 衍生物,结构与 prazosin 有关。Trimazosin 能够选择性阻断α1肾上腺素受体 (α1-adrenoceptors),具有降压 (hypotensive) 活性。 | |||
T71122 |
Carsatrin (free base)
|
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Carsatrin is purinylpiperazine derivative. as cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle without affecting the Na+, K+-ATPase, adenylyl cyclase, phosphodiesterase isozymes, or cardiac myofilaments. Carsatrin’s positive inotropic effect can be prevented by tetrodotoxin but not by the adrenergic antagonists timolol, yohimbine, or prazosin | |||
T70975 |
Carsatrin succinate
|
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Carsatrin succinate is the salt form of Carsatin, a purinylpiperazine derivative used as a cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle without affecting the Na+, K+-ATPase, adenylyl cyclase, phosphodiesterase isozymes, or cardiac myofilaments. Carsatrin’s positive inotropic effect can be prevented by tetrodotoxin but not by the adrenergic antagonists timolol, yohimbi... | |||
T22680 |
CP-100356 hydrochloride
CP-100356 HCl,CP 100356 hydrochloride |
BCRP | Membrane transporter/Ion channel |
CP-100356 hydrochloride 是一种具有口服活性和低微摩尔的 MDR1 (P-gp) 和 BCRP 双重抑制剂,是核苷酸衍生的底物类似物,对 MDR1 介导的 Calcein-AM 转运 和 BCRP 介导的 Prazosin 转运有抑制作用。CP-100356 抑制 OATP1B1,可在黑暗中诱导气孔张开。 |