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28

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TQ0179	PAP-1 5-(4-Phenoxybutoxy)psoralen	Potassium Channel	Membrane transporter/Ion channel
	PAP-1 (5-(4-Phenoxybutoxy)psoralen) 是口服活性的Kv1.3选择性阻滞剂 (EC50=2 nM)。它依赖性阻止 Kv1.3，并优先与通道的 C 型失活状态结合来发挥作用。
T81547	PAP-IN-2
	PAP-IN-2 (Compound 35)，作为紫色酸性磷酸酶（PAP）的抑制剂，其抑制常数（Ki）为186 nM，适用于开发治疗骨质疏松的化合物。
T81548	PAP-IN-1
	PAP-IN-1（化合物28）为紫色酸性磷酸酶（PAP）的抑制剂，后者是一种普遍存在的双核金属水解酶。该抑制剂对哺乳动物PAP显示出较强的抑制活性，具有Ki值为168 nM；对猪PAP的抑制活性亦显著，具有Kic值为0.17 μM。此类PAP抑制剂主要用于抗骨质疏松药物研究。
T81550	PAP 248–286 Prostatic Acid Phosphatase(248-286)
	PAP 248–286是一种精液衍生的生物活性肽，也称为前列腺酸性磷酸酶 (248-286) 或PAP (248-286) 肽，属于精液中的精液衍生病毒感染增强子 (SEVI) 因子。该肽能显著增强HIV病毒颗粒与靶细胞间的附着，从而增加HIV感染率。
T70211	CAM741
	CAM741 is a novel selective inhibitor of vascular cell adhesion molecule 1 (VCAM1) synthesis in endothelial cells, blocking the process of cotranslational translocation, which is dependent on the signal peptide of VCAM1.
T83735	Pap12-6 TFA
	Pap12-6是一种从蝶类P. xuthus幼虫中发现的papiliocin十二个N-端氨基酸衍生的抗菌肽。它对包括E. coli、P. aeruginosa和S. syphimurium在内的八种革兰氏阴性细菌（MIC50s = 4-8 µM）以及革兰氏阳性细菌S. aureus、耐甲氧西林的S. aureus 3126（MRSA-3126）、B. subtilis和S. epidermidis（MIC50s = 4-8 µM）具有活性，但在25 µM浓度下不影响人类红细胞、小鼠RAW 264.7巨噬细胞、人类HaCaT角质形成细胞或人类HEK293肾细胞的活性。Pap12-6在4和8 µM浓度下可引起E. coli的膜去极化。Pap12-6（10 µM）预处理可降低LPS刺激的RAW 264.7巨噬细胞中一氧化氮（NO2-）、Tnf-α和Il-6的分泌水平。在体内，Pap12-6（10 mg/kg）可以提高感染E. coli的小鼠的存活率，并且在剂量为1 mg/kg时减少感染E. coli小鼠的肺、肝和肾中菌落形成单位（CFUs）的数量。Pap12-6（1 mg/kg）在E. co...
T12359	Paprotrain (alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile	Kinesin	Cytoskeletal Signaling
	Paprotrain ((alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile) 是可渗透细胞的 kinesin MKLP-2的抑制剂，抑制 MKLP-2 的 ATPase 活性，IC50值为 1.35 μM，Ki 值为 3.36 μM。它对 DYRK1A 有中等的抑制作用，IC50值为 5.5 μM。
T74048	PAPA NONOate	Endogenous Metabolite; NO Synthase	Immunology/Inflammation; Metabolism
	PAPA NONOate 是一种依赖于 pH 调节的 NO 供体。PAPA NONOate 具有潜在的抗肿瘤活性，通过增加伤口部位的胶原合成率，可用于研究糖尿病伤口愈合障碍。
T21521L	Papain Inhibitor acetate 乙氨酸-乙氨酸-酪氨酸-精氨酸,GGYR,Gly-Gly-Tyr-Arg,Papain Inhibitor acetate （70195-20-9 free base)	Others	Others
	Papain Inhibitor acetate (Gly-Gly-Tyr-Arg) 是木瓜蛋白酶的亲和配体。
T33880	PAPS
	PAPS is a product of mitosomal sulfate activation which is translocated to the cytosol, then becomes a substrate for SULTs.
TP1595	Human Papillomavirus (HPV) E7 protein (49-57) Human Papillomavirus (HPV) E7 protein 49-57
	Human Papillomavirus (HPV) E7 protein (49-57) is the H-2d-restricted human papillomavirus (HPV) E749-57 epitope.
T38274	Papyracillic Acid
	Papyracillic acid is a fungal metabolite and a derivative of penicillic acid originally isolated fromL. papyraceumand has antibiotic, antifungal, and phytotoxic activities.1,2It is active against the bacteriaX. campestrisandB. subtilisand the fungusC. tropicalisin a disc assay when used at a concentration of 5 μg/disc.2Papyracillic acid (1 mg/ml) induces necrotic lesion formation in a panel of 10 plants. 1.Shan, R., Anke, H., Stadler, M., et al.Papyracillic acid, a new penicillic acid analogue f...
T28156	Nepaprazole TY-11345,TY11345,TY 11345
	Nepaprazole is a proton pump inhibitor. TY-11345 potently inhibited H+/K(+)-ATPase activity in isolated rabbit gastric mucosal microsomes, and the inhibitory effect was enhanced under weak acid conditions, the IC50 being 5.8 microM and 9.9 microM at pH 6.
T70135	Nepaprazole sodium dihydrate
	Nepaprazole sodium dihydrate is a proton pump inhibitor potentially for treatment of gastric ulcers.
T81413	pppApG
	pppApG是vRNA（病毒RNA）及cRNA（互补RNA）合成的初始产物，常用于流感病毒相关研究。
T24095	PAPD5-IN-1 GNE9278,GNE 9278,GNE-9278
	GNE-9278 is an NMDA receptor positive allosteric modulator. It acts via the transmembrane domain.
T70428	Nepaprazole sodium
	Nepaprazole Na is the salt form of Nepaprazole Free Base, also known as TY-11345, is a proton pump inhibitor potentially for treatment of gastric ulcer. TY-11345 potently inhibited H+/K(+)-ATPase activity in isolated rabbit gastric mucosal microsomes; and the inhibitory effect was enhanced under weak acid conditions, the IC50 (concentrations that inhibit the enzyme activity by 50%) being 5.8 microM and 9.9 microM at pH 6.0 and pH 7.4, respectively. TY-11345 should be useful for the clinical tre...
T33879	Papaveraldine Xanthaline
	Papaveraldine is a benzylisoquinoline alkaloid that papaverine degradation product.
T66037	(R)-Tetrahydropapaverine hydrochloride
	(R)-Tetrahydropapaverine hydrochloride 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66037，CAS号为 54417-53-7。
T34960	Tropapride
	Tropapride is a benzamide derivative.
T35422	5'-pApA (sodium salt)
	5'-pApA is a linearized form of cyclic di-AMP, a bacterial second messenger that activates the host innate immune system through stimulator of interferon genes (STING).1,2,3,4It is a metabolite of cyclic di-AMP formedviahydrolysis by various phosphodiesterases (PDEs).55'-pApA is intended for use as a negative control for cyclic di-AMP signaling. 1.Burdette, D.L., Monroe, K.M., Sotelo-Troha, K., et al.STING is a direct innate immune sensor of cyclic-di-GMPNature478(7370)515-518(2011) 2.Parvatiyar...
T74464	m7GpppApG
	m7GpppApG 是一个三核苷酸，mRNA 5' 帽子的类似物，可以用于体外 RNA 合成。
T81549	Papilostatin-2
	Papilostatin-2为抗血管生成肽，适用于抗血管生成研究。
TP2216	alpha-1 antitrypsin fragment 235-243 [Homo sapiens]/[Papio hamadryas]/[Cercopithecus aethiops]	Others	Others
	Protease inhibitor
T83734	PapRIV TFA
	PapRIV是最初从B. cereus分离出的一种群体感应七肽。它被转译为一个48-氨基酸多肽，由NprB蛋白酶在细胞外分泌和加工形成活性七肽。PapRIV（1-25 µM）在BV-2微胶质细胞中诱导IL-6和TNF-α的产生，并促使NF-κB转移。
T81042	Taplitumomab paptox
	Taplitumomab paptox为针对CD19的单克隆抗体，主要应用于癌症研究领域。
T34785	TAPAP 3-Tapap
	TAPAP binds to thrombin and trypsin.
T24664	Propaphos Kayaphos,丙虫磷,Kayphosnac	Others	Others
	Propaphos (Kayaphos) 是一种有机磷类杀虫剂。

化合物

Cat.No: TQ0179

Synonym: 5-(4-Phenoxybutoxy)psoralen

Target: Potassium Channel

Cat.No: T81547

Cat.No: T81548

PAP 248–286

Cat.No: T81550

Synonym: Prostatic Acid Phosphatase(248-286)

Cat.No: T70211

Cat.No: T83735

Cat.No: T12359

Synonym: (alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile

Target: Kinesin

Cat.No: T74048

Target: Endogenous Metabolite, NO Synthase

Papain Inhibitor acetate

Cat.No: T21521L

Synonym: 乙氨酸-乙氨酸-酪氨酸-精氨酸,GGYR,Gly-Gly-Tyr-Arg,Papain Inhibitor acetate （70195-20-9 free base)

Target: Others

Cat.No: T33880

Human Papillomavirus (HPV) E7 protein (49-57)

Cat.No: TP1595

Synonym: Human Papillomavirus (HPV) E7 protein 49-57

Papyracillic Acid

Cat.No: T38274

Cat.No: T28156

Synonym: TY-11345,TY11345,TY 11345

Nepaprazole sodium dihydrate

Cat.No: T70135

Cat.No: T81413

Cat.No: T24095

Synonym: GNE9278,GNE 9278,GNE-9278

Nepaprazole sodium

Cat.No: T70428

Papaveraldine

Cat.No: T33879

Synonym: Xanthaline

(R)-Tetrahydropapaverine hydrochloride

Cat.No: T66037

Cat.No: T34960

5'-pApA (sodium salt)

Cat.No: T35422

Cat.No: T74464

Papilostatin-2

Cat.No: T81549

alpha-1 antitrypsin fragment 235-243 [Homo sapiens]/[Papio hamadryas]/[Cercopithecus aethiops]

Cat.No: TP2216

Target: Others

Cat.No: T83734

Taplitumomab paptox

Cat.No: T81042

Cat.No: T34785

Synonym: 3-Tapap

Cat.No: T24664

Synonym: Kayaphos,丙虫磷,Kayphosnac

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T6004	Tetrahydropapaverine hydrochloride Tetrahydropapaverine HCl,Norlaudanosine HCl,Tetrahydroalkali hydrochloride,四氢罂粟碱盐酸盐	Hydroxylase	Metabolism
	Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) 是一种四氢异喹啉类药物。它对多巴胺神经元有神经毒性作用。
T19503	Papain	Others; Cysteine Protease	Others; Proteases/Proteasome
	Papain 是一种半胱氨酸蛋白酶，是肽酶 C1 家族中一员，在食品、医药、化妆品、纺织等具有广泛的应用。
T5S0273	Hypaphorine Lenticin,Glyyunnanenine,Tryptophan Betaine,刺桐碱	Others	Others
	Hypaphorine (Lenticin) 是一种提取自 Pisolithus tinctorius 中的吲哚类生物碱，对啮齿动物具有有神经学影响降糖活性。
T0256	Citric acid trilithium salt tetrahydrate Lithium citrate tribasic tetrahydrate,柠檬酸三锂盐四水合物,Trilithium citrate tetrahydrate	Dehydrogenase; GSK-3; HIF/HIF Prolyl-Hydroxylase; Antibacterial; GluR	Chromatin/Epigenetic; Metabolism; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells
	Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) 是一种用于治疗精神疾病的药物。它也是一种医药和建筑材料, 可用于氨基酸定量分析时的梯度洗脱。

天然产物

Tetrahydropapaverine hydrochloride

Cat.No: T6004

Synonym: Tetrahydropapaverine HCl,Norlaudanosine HCl,Tetrahydroalkali hydrochloride,四氢罂粟碱盐酸盐

Target: Hydroxylase

Cat.No: T19503

Target: Others, Cysteine Protease

Cat.No: T5S0273

Synonym: Lenticin,Glyyunnanenine,Tryptophan Betaine,刺桐碱

Target: Others

Citric acid trilithium salt tetrahydrate

Cat.No: T0256

Synonym: Lithium citrate tribasic tetrahydrate,柠檬酸三锂盐四水合物,Trilithium citrate tetrahydrate

Target: Dehydrogenase, GSK-3, HIF/HIF Prolyl-Hydroxylase, Antibacterial, GluR

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