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Cat. No. | Product Name | ||
---|---|---|---|
DO1200 | 药物靶点库 | 53200 compounds | |
数量多,含53200种小分子化合物,是高通量筛选的有力工具; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1493L1 |
PSA1 141-150 acetate
PSA1 141-150 acetate(160215-60-1 free base) |
Others | Others |
PSA1 141-150 acetate 用于癌症实验的免疫治疗,它是一种前列腺特异性抗原 1 肽。 | |||
TP1493 |
PSA1 (141-150)
PSA1 141-150 |
||
This Prostate Specific Antigen 1 peptide was used in the immunotherapy of cancer experiments. | |||
T5092 |
AIM-100
AIM100 |
ACK | Tyrosine Kinase/Adaptors |
AIM-100 是选择性的 Ack1 抑制剂 (IC50:21.58 nM)。它还抑制 Tyr267磷酸化,但不抑制其他激酶,包括 PI3K 和 AKT 亚家族成员。它具有抗癌活性。 | |||
T19379 |
Ipsalazide
|
Autophagy | Autophagy |
Ipsalazide 是一种新型柳氮磺吡啶类似物,可用于治疗炎症性肠病。 | |||
T22871 |
Ipsapirone
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
Ipsapirone 是 5-HT1A 受体的部分激动剂,在高剂量时对 5-HT2 和 α1-肾上腺素能功能产生抑制作用。 | |||
T13237L |
Ropsacitinib
Tyk2-IN-8,PF-06826647 |
Tyrosine Kinases | Tyrosine Kinase/Adaptors |
Ropsacitinib (PF-06826647) 是一种选择性TYK2抑制剂。Ropsacitinib 与Tyk2催化活性JH1结构域结合(IC50:17nM)。 | |||
T39349 |
Vocacapsaicin hydrochloride
CA-008 hydrochloride |
TRP/TRPV Channel | Membrane transporter/Ion channel |
Vocacapsaicin hydrochloride (CA-008 hydrochloride) 是非阿片类 TRPV1 激动剂,是辣椒素的原料,可用于缓解疼痛。 | |||
T1109 |
(Z)-Capsaicin
Zucapsaicin,Civamide,cis-Capsaicin,珠卡赛辛,(Z)-辣椒素 |
TRP/TRPV Channel; HSV | Membrane transporter/Ion channel; Microbiology/Virology |
(Z)-Capsaicin (Zucapsaicin) 是天然辣椒素的合成顺式异构体,用于治疗膝骨关节炎。它是一种可口服的 TRPV1激动剂,可研究神经性疼痛。 | |||
T80966 |
Topsalysin
PRX-302 |
||
Topsalysin为PSA激活的前体蛋白质,同时是与人前列腺特异性抗原融合的孔隙形成蛋白(合成原气溶素)。研究显示Topsalysin能够抑制小鼠模型中的肿瘤生长。 | |||
TP1063 |
Psalmotoxin 1
PcTx1,Psalmopoeus cambridgei toxin-1 |
||
Psalmotoxin 1 is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker. | |||
T28459 |
Psammaplysene A
|
||
Psammaplysene A is a FOXO1a nuclear export inhibitor. | |||
T124402 |
7-O-Acetyllycopsamine N-oxide
|
||
7-O-Acetyllycopsamine N-oxide 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124402。 | |||
T28460 |
Psammaplysene B
|
||
Psammaplysene B is a FOXO1a nuclear export inhibitor. | |||
T16273 |
Napsagatran hydrate
Ro 46-6240/010 hydrate,Ro 46-6240 hydrate |
Others | Others |
Napsagatran hydrate is a novel and specific inhibitor of thrombin. | |||
T39348 |
Vocacapsaicin
CA-008,Vocacapsaicin |
||
Vocacapsaicin (CA-008), a prodrug of Capsaicin and a first-in-class non-opioid TRPV1 agonist, offers significant and enduring pain relief. | |||
T23912 |
CPSA
|
||
CPSA is an effective and selective AKR1C1 inhibitor. | |||
T123864 |
Lycopsamine N-oxide
|
||
Lycopsamine N-oxide 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T123864。 | |||
T8683 |
Mipsagargin
G-202 |
Others | Others |
Mipsagargin (G-202) 是一种抑制 DNA 生物合成的新型抗生素。 | |||
T82645 |
Cyclic PSAP peptide
|
||
Cyclic PSAP peptide(DWLPK)是一种环五肽,具有活性分子特性,在体内能够抑制肿瘤转移扩散和发展。 | |||
T27623 |
Ipsapirone hydrochloride
BAY q 7821,BAY q-7821,BAY q7821,Ipsapirone HCl |
||
Ipsapirone, a pyrimidinylpiperazine ligand, is potent and specific for 5-HT1A receptors and has potential therapeutic use in affective disorders. | |||
T125760 |
Dipsacussaponin C
|
||
Dipsacussaponin C 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T125760。 | |||
T29110 |
VPC-13163
2,3-dihydro-2,3'-Bi-1H-indole,VPC13163,NSC52361,NSC 52361,VPC 13163 |
Others | Others |
VPC-13163 (NSC-52361) 对 LNCaP 和耐恩杂鲁胺的前列腺癌细胞系 (MR49F) 具有很强的抗增殖活性,而它不影响 AR 独立 PC3 细胞系的生长。它还抑制 LNCaP 和 MR49F 中的前列腺特异性抗原 (PSA) 并降低 AR 靶基因 PSA 和 TMPRSS2 的表达。这些发现表明 VPC-13566 表现出 AR BF3 特定的作用机制。 | |||
T77574 |
ROS inducer 1
|
ROS; Antibiotic | Immunology/Inflammation; Microbiology/Virology |
ROS inducer 1 是一种具有杀菌作用的小分子化合物,对 Xanthomonas axonopodis pv. citri (Xac)、Xanthomonas oryzae pv. oryzae (Xoo)和 Pseudomonas syringae pv. actinidiae (Psa) 具有抑制作用。ROS inducer 1 诱 Xanthomonas 细胞内 ROS 的产生可用于研究农作物细菌感染。 | |||
T80552 |
Prostate Specific Antigen Substrate
|
||
Prostate Specific Antigen Substrate为前列腺特异性抗原(PSA)的荧光底物,专用于检测PSA的酶活性。 | |||
T78976 | Antibacterial agent 141 | ||
Antibacterialagent 141(Compound B14)针对四种植物病原体Xoo、Xac、Psa与Cmm展现出了抗菌效果,其EC50值为1.28 μM。该化合物能够抑制细胞膜形成并改变细胞透性。 | |||
T76675 | Clazakizumab | ||
Clazakizumab是一种具有高亲和力和特异性的单克隆抗体,针对IL-6(白细胞介素-6)细胞因子。它可能对抑制COVID-19中因SARS-CoV-2引起的细胞因子反应有帮助。此外,Clazakizumab也被用于研究银屑病关节炎(PsA)和肾抗体介导的排斥反应。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7177 |
Capsazepine
|
Apoptosis; TRP/TRPV Channel | Apoptosis; Membrane transporter/Ion channel |
Capsazepine 是一种 TRPV1 受体的拮抗剂, IC50值为 562 nM。 它可阻断由激活 TRPV1 离子通道的辣椒素引起的热痛感,是辣椒素拮抗剂。 | |||
T2163 |
Dihydrocapsaicin
CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide |
Others; TRP/TRPV Channel | Membrane transporter/Ion channel; Others |
Dihydrocapsaicin (CCRIS1589) 是一种天然来源的辣椒素,是TRPV1的选择性激动剂,同时可以增加 p-Akt 水平。它可以增强低温诱导的神经保护。 | |||
TN1739 |
Homodihydrocapsaicin I
高二氢辣椒素,高二氢辣椒素I |
Others | Others |
Homodihydrocapsaicin I 是一种辣椒素,分离自辣椒果实中。 | |||
T3372 |
Dipsacoside B
|
Others | Others |
Dipsacoside B 是主要的具有生物活性的皂素,可用作标志物。 | |||
T3421 |
Nordihydrocapsaicin
|
Others | Others |
Nordihydrocapsaicin(诺地氢辣椒碱)是Capsaicin(辣椒素)的模拟物和同源物,属于在Capsicum(辣椒)中发现的Capsaicinoid(辣椒素类)化合物。 | |||
T1062 |
Capsaicin
Qutenza,8-Methyl-N-vanillyl-trans-6-nonenamide,天然辣椒素,Vanilloid,辣椒素,(E)-Capsaicin,Zostrix |
Apoptosis; TRP/TRPV Channel; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel |
Capsaicin ((E)-Capsaicin) 属于天然产物,提取自辣椒,是一种 TRPV1 激动剂 (EC50=0.29 μM)。Capsaicin 具有抗肿瘤、抗炎、抗氧化、神经保护等活性。 | |||
T39018 | Capsaicin β-D-glucopyranoside | ||
Capsaicin β-D-glucopyranoside, a glucoside converted by Capsaicin, is the bioactive compound found in chili peppers responsible for their characteristic pungent flavor. | |||
T36303 |
Psammaplin A
|
||
Psammaplin A, a marine metabolite, functions as a robust inhibitor of HDAC and DNA methyltransferases, displaying notable potency and selectivity as a DAC1 inhibitor, with an IC50 value of 0.9 nM. It exhibits antimicrobial effects against Gram-positive bacteria and inhibits both DNA synthesis and DNA gyrase activity, also demonstrating antitumor activity[1][2]. | |||
T33029 |
7-Acetyllycopsamine
Lycopsamine `1-acetate,7-乙酰基环磷酰胺 |
||
Lycopsamine `1-acetate is a bioactive chemical. | |||
TN1122 |
Dipsanoside A
|
Others | Others |
Dipsanoside A is a natural product | |||
T82187 |
Homocapsaicin II
|
||
Homocapsaicin II, 提取自Capsicum annuum L果实,为一种辣椒素类化合物。 | |||
TN1123 |
Dipsanoside B
续断苷 B,续断苷B |
Others | Others |
Dipsanoside B is a natural product | |||
TN3588 |
Capsanthin
|
Others | Others |
Capsanthin 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3588,CAS号为 465-42-9。 | |||
T22729 |
Dipsacobioside
|
Others | Others |
Dipsacobioside is extracted from Anemone hupehensis. | |||
T33028 | Lycopsamine | ||
Lycopsamine is a bioactive chemical. | |||
T83309 |
5,22-Dioxokopsane
|
||
5,22-Dioxokopsane为源自Kopsia officinalis的单萜类吲哚生物碱。 | |||
TN5878 |
7,2',4'-Trihydroxy-5-methoxy-3-phenylcoumarin
|
||
7,2',4'-Trihydroxy-5-methoxy-3-arylcoumarin shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells. | |||
TN3416 |
Angelol M
|
Others | Others |
Angelol M shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells. | |||
T75468 | Asperglaucin B | ||
Asperglaucin B 是一种来自真菌Aspergillus chevalieriSQ-8 的烷基化水杨醛衍生物,具有抗菌活性。Asperglaucin B 对两种植物病原体Pseudomonas syringae pv actinidae(Psa)和Bacillus cereus 显示出有效的抗菌活性,MIC 值为 6.25 μM。 | |||
T75467 | Asperglaucin A | ||
Asperglaucin A 代表一种不寻常的类苯酞衍生物。Asperglaucin A 对两种植物病原体Pseudomonas syringae pv actinidae(Psa) 和Bacillus cereus 具有有效的抗菌活性,MIC 值为 6.25 μM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02258 |
Kallikrein 3/KLK3 Protein, Human, Recombinant (His)
APS,KLK2A1,PSA,kallikrein related peptidase 3,Hk3 |
Human | HEK293 Cells |
KLK3 (Kallikrein Related Peptidase 3) is a Protein Coding gene. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease that is synthesized in the epithelial cells of the prostate gland and is present in seminal plasma. KLK3, also known as Prostate Specific Antigen (PSA), kallikrein-related peptidase 3, Gamma-seminoprotein, is a secreted protein of the glandular kallikrein subfamily of serine proteases.... | |||
TMPY-03848 |
Protein S/PROS1 Protein, Human, Recombinant (His)
PS21,PSA,PS23,PS22,THPH6,PS25,Protein S,THPH5,prote... |
Human | HEK293 Cells |
Protein S/PROS1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 74.1 kDa and the accession number is P07225. | |||
TMPJ-01204 |
TPSAB1 Protein, Human, Recombinant (His)
TPS1,tryptase alpha/beta 1,TPS2,tryptase α/β1,tryptase α/β 1... |
Human | HEK293 Cells |
Tryptases are serine proteases with trypsin-like specificity. Together with chymases and Cathepsin G, tryptases are important players in mast cell mediation of inflammatory and allergic responses. Tryptase alpha/beta-1(TPSAB1), also known as mast cell protease 7 (MCPT7), it exhibits anticoagulant activity due to its ability to degrade fibrinogen in the presence of a diverse array of protease inhibitors in plasma. The two Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and s... | |||
TMPH-02802 |
Napsin-A/NAPSA Protein, Mouse, Recombinant (His)
|
Mouse | E. coli |
May be involved in processing of pneumocyte surfactant precursors. Napsin-A/NAPSA Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 40.5 kDa and the accession number is O09043. | |||
TMPH-02957 |
TPSAB1 Protein, Mouse, Recombinant (His)
|
Mouse | E. coli |
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. TPSAB1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 30.1 kDa and the accession number is Q02844. | |||
TMPH-01750 |
Napsin-A/NAPSA Protein, Human, Recombinant (His)
|
Human | E. coli |
May be involved in processing of pneumocyte surfactant precursors. Napsin-A/NAPSA Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 42.5 kDa and the accession number is O96009. | |||
TMPH-03589 |
PsaA Protein, S. oralis, Recombinant (His & Myc)
|
Streptococcus oralis | E. coli |
Part of an ATP-driven transport system. PsaA Protein, S. oralis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 40.1 kDa and the accession number is Q9L5W9. | |||
TMPK-01303 |
TPSAB1 protein, Cynomolgus, Recombinant (His)
Tryptase alpha/beta-1,TPSB1,Tryptase I,TPS2,TPS1,Tryptase al... |
Cynomolgus | E. coli |
TPSAB1, namely tryptase alpha/beta-1, is a serine protease with trypsinlike activity. TPSAB1 is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. It may play a role in innate immunity. Diseases associated with TPSAB1 include mastocytosis and systemic mastocytosis. | |||
TMPH-03590 |
PsaA Protein, S. pneumoniae (strain ATCC BAA-255/R6), Recombinant (His & Myc)
|
Streptococcus pneumoniae | E. coli |
Part of an ATP-driven transport system. PsaA Protein, S. pneumoniae (strain ATCC BAA-255/R6), Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 40.0 kDa and the accession number is P0A4G3. | |||
TMPY-00209 |
PSAP/Prosaposin Protein, Rat, Recombinant (His)
prosaposin |
Rat | HEK293 Cells |
Prosaposin (PSAP) gene mutations, affecting saposin B (Sap-B) domain, cause a rare metachromatic leukodystrophy (MLD) variant in which arylsulfatase A (ARSA) activity is normal. The human prosaposin gene (PSAP) was previously localized to 10q21-->q22 by isotopic in situ hybridization using a human prosaposin cDNA as a probe. Using fluorescence in situ hybridization with a mouse genomic prosaposin fragment as probe, confirms the localization of PSAP and precisely maps it to band 10q22.1. PSAP/Pro... | |||
TMPH-00856 |
RPSA Protein, Human, Recombinant (His & Myc)
|
Human | E. coli |
RPSA Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 37.7 kDa and the accession number is P08865. | |||
TMPH-03396 |
TPSAB1 Protein, Rat, Recombinant (His & Myc & SUMO)
|
Rat | E. coli |
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. TPSAB1 Protein, Rat, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 47.4 kDa and the accession number is P27435. | |||
TMPH-03591 |
PsaA Protein, S. pneumoniae, Recombinant (His & Myc)
|
Streptococcus pneumoniae | E. coli |
Part of an ABC transporter complex involved in manganese import. PsaA Protein, S. pneumoniae, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.9 kDa and the accession number is P42363. | |||
TMPY-04510 |
PSAP/Prosaposin Protein, Human, Recombinant (His)
prosaposin,SAP1,GLBA |
Human | HEK293 Cells |
Prosaposin (PSAP) gene mutations, affecting saposin B (Sap-B) domain, cause a rare metachromatic leukodystrophy (MLD) variant in which arylsulfatase A (ARSA) activity is normal. The human prosaposin gene (PSAP) was previously localized to 10q21-->q22 by isotopic in situ hybridization using a human prosaposin cDNA as a probe. Using fluorescence in situ hybridization with a mouse genomic prosaposin fragment as probe, confirms the localization of PSAP and precisely maps it to band 10q22.1. PSAP/Pro... | |||
TMPK-01057 |
CLEC9A Protein, Human, Recombinant (hFc)
CD370,UNQ9341,DNGR-1,HEEE9341,9830005G06Rik,CLEC9A |
Human | HEK293 Cells |
CLEC9A expression was significantly higher in psoriatic skin compared with healthy donor. In psoriatic skin and PsA ST, CLEC9A() cells were in close proximity to TUNEL() cells. SF CLEC9A levels were significantly lower compared with paired PsA serum. Adalimumab treatment did not affect CLEC9A serum level and skin expression. The downregulation of synovial CLEC9A might be associated with a novel mechanism by which anti-TNF therapy might reduce CD8-mediated inflammation in PsA patients. | |||
TMPH-02078 |
Semenogelin-1/SEMG1 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.; Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone. Sem... | |||
TMPJ-00482 |
SEMG1 Protein, Human, Recombinant (His)
SGI,SEMG,Semenogelin-1,Seminal Basic Protein,Alpha-Inhibin-3... |
Human | HEK293 Cells |
Semenogelin-1 (SEMG1) is the predominant protein in semen; it is a secretory protein involved in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes SEMG1 into smaller peptides, each possibly having a separate function. In the proteolysis process, Alpha-inhibin-92 and alpha-inhibin-31 are produced; they inhibit the secretion of pituitary follicle-stimulating hormone. At the same time, it breaks... |