Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13824 |
PP58
|
FGFR; p38 MAPK; TNF; PDGFR; Src | Angiogenesis; Apoptosis; MAPK; Tyrosine Kinase/Adaptors |
PP58 是 PDGFR、FGFR 和 Src 家族的抑制剂。 | |||
T2414 |
Torkinib
PP 242 |
Apoptosis; Mitophagy; PI3K; mTOR; Autophagy | Apoptosis; Autophagy; PI3K/Akt/mTOR signaling |
Torkinib (PP 242) 是一种选择性,ATP 竞争型的mTOR 抑制剂,IC50为 8 nM。它也抑制mTORC1和mTORC2,IC50分别为 30 nM 和 58 nM。 | |||
T71933 |
GNE-3500
|
||
GNE-3500 is a Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C (RORc or RORγ) Inverse Agonist. Retinoic acid receptor-related orphan receptor C (RORc, RORγ, or NR1F3) is a nuclear receptor that plays a major role in the production of interleukin (IL)-17. Considerable efforts have been directed toward the discovery of selective RORc inverse agonists as potential treatments of inflammatory diseases such as psoriasis and rheumatoid arthritis. GNE-3500 poss... |