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Search Results for " pd-l2 "

Targets Recommended: PD-1/PD-L1

11

抑制剂 & 化合物

18

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T77075	Spartalizumab PDR001	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	Spartalizumab (PDR001) 是一种人源化的免疫球蛋白 4 单克隆抗体，在低浓度下选择性与 PD-1结合显示出较高活性。Spartalizumab 阻断与 PD-L1 和 PD-L2 的相互作用，可用于研究甲状腺未分化癌 (ATC)。
T9902	Atezolizumab 阿特朱单抗,阿特珠单抗	Apoptosis; PD-1/PD-L1; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; Immunology/Inflammation
	Atezolizumab 是一种人源化单克隆抗体 IgG1，能抵抗程序性死亡因子配体1 ，可用于癌症研究。
T35394	Sintilimab (anti-PD-1) IBI308,Sintilimab (anti-PD-1)	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	Sintilimab (IBI308) 是一种人源化的 IgG4 单克隆抗体，具有显著的抗肿瘤活性，通过与 PD-1 结合从而阻断 PD-1 与其配体 (PD-L1 和 PL-L2) 的相互作用，进而恢复内源性抗肿瘤 T 细胞反应。Sintilimab 联合其他化合物来治疗经典霍奇金淋巴瘤、非小细胞肺癌和食管癌。
T76850	Dostarlimab
	Dostarlimab (TSR-042) 是一种人源化抗PD-1单克隆抗体。Dostarlimab 与人PD-1具有高亲和力，并竞争性地抑制其与其配体PD-L1和 PD-L2 的相互作用，IC50s 分别为 1.8 nM 和 1.5 nM。
T77023	Geptanolimab
	Geptanolimab (CBT-501) 为一种针对程序性死亡-1 (PD-1) 的人源化 IgG4κ 单克隆抗体。通过竞争性抑制 PD-L1/L2 与 PD-1 的结合，Geptanolimab 在癌症研究中发挥作用。
TP1075	AUNP-12 TFA (1353563-85-5 free base) AUNP-12 TFA,NP-12 TFA
	AUNP-12 TFA (NP-12 TFA) is a polypeptide antagonist in the pd-1 signaling pathway, which has the same antagonistic effect on pd-l1 and pd-l2, and can protect the proliferation and effector function of lymphocytes.
T77003	Ezabenlimab
	Ezabenlimab (BI-754091) 是一种抗PD-1单克隆抗体，结合PD-1的 Kd 为 6 nM (CHO 细胞)。Ezabenlimab 能够阻断PD-1与PD-L1和PD-L2的相互作用。Ezabenlimab 还增加 T 细胞内的 γ 干扰素分泌，抑制体内肿瘤生长。
T76985	Tebotelimab
	Tebotelimab (MGD-013) 是一种人源的 IgG4κ 双特异性 PD-1/LAG-3双亲和再靶向 (DART) 抗体。Tebotelimab 结合 NS0 细胞表面表达的 PD-1和 LAG-3，EC50分别为 1.65 nM 和 0.41 nM。Tebotelimab 阻断 PD-1/PD-L1、PD-1/PD-L2 和 LAG-3/HLA (MHC-II) 相互作用和 PD-1信号。Tebotelimab 可恢复耗尽的 T 细胞功能并增强抗肿瘤免疫力。
T76945	Cetrelimab
	Cetrelimab (JNJ 63723283; JNJ 3283) 为人源化IgG4κ单克隆抗体，专门针对PD-1。其与PD-1的结合Kd值为1.72 nM（在HEK293细胞中测得）。Cetrelimab有效阻断PD-1与其配体PD-L1和PD-L2的结合，其IC50值分别为111.7 ng/mL与138.6 ng/mL。此外，Cetrelimab能激活外周T细胞，提升细胞因子（IFN-γ, IL-2, TNF-α）的表达水平，进而抑制肿瘤在体内的生长。
T76020	AUNP-12 TFA
	AUNP-12 (NP-12) TFA 是 PD-1信号通路的一种多肽拮抗剂，在抑制淋巴细胞增殖和效应功能方面对 PD-L1和 PD-L2 具有等效的拮抗作用。AUNP-12 TFA 具有免疫激活作用、良好的抗肿瘤活性，具有更好的研究免疫相关不良事件 (irAEs) 的潜力。
T35396	Spartalizumab (anti-PD-1)	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	Spartalizumab (anti-PD-1)是一种针对PD-1的人源IgG4抗体，抑制PD-L1和PD-L2与PD-1的结合。PDR001可与PD-1以高亲和力结合，抑制其生物活性；MW: 145.8 KD。

化合物

Cat.No: T77075

Synonym: PDR001

Target: PD-1/PD-L1

Cat.No: T9902

Synonym: 阿特朱单抗,阿特珠单抗

Target: Apoptosis, PD-1/PD-L1, Autophagy

Sintilimab (anti-PD-1)

Cat.No: T35394

Synonym: IBI308,Sintilimab (anti-PD-1)

Target: PD-1/PD-L1

Cat.No: T76850

Cat.No: T77023

AUNP-12 TFA (1353563-85-5 free base)

Cat.No: TP1075

Synonym: AUNP-12 TFA,NP-12 TFA

Cat.No: T77003

Cat.No: T76985

Cat.No: T76945

Cat.No: T76020

Spartalizumab (anti-PD-1)

Cat.No: T35396

Target: PD-1/PD-L1

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04957	PD-L2 Protein, Human, Recombinant (His), Biotinylated B7DC,Btdc,B7-DC,bA574F11.2,PDL2,programmed...	Human	HEK293 Cells
	PD-L2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is Q9BQ51-1.
TMPY-05827	PD-L2 Protein, Human, Recombinant (mFc) PDCD1L2,bA574F11.2,Btdc,B7-DC,PD-...	Human	HEK293 Cells
	PD-L2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 48.93 kDa and the accession number is Q9BQ51-1.
TMPY-04346	PD-L2 Protein, Human, Recombinant (His) PD-L2,B7-DC,CD273,Btdc,PDCD1L...	Human	HEK293 Cells
	PD-L2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is Q9BQ51-1.
TMPY-02436	PD-L2 Protein, Mouse, Recombinant (hFc) F730015O22Rik,Btdc,PD-L2,programmed cell d...	Mouse	HEK293 Cells
	PD-L2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.5 kDa and the accession number is Q9WUL5.
TMPY-02352	PD-L2 Protein, Mouse, Recombinant (His) programmed cell death 1 ligand 2,Btdc,F730015O22Rik,B7-DC,	Mouse	HEK293 Cells
	PD-L2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is Q9WUL5.
TMPY-05282	PD-L2 Protein, Mouse, Recombinant (His), Biotinylated PD-L2,programmed cell death 1 ligand 2,B7-...	Mouse	HEK293 Cells
	PD-L2 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is Q9WUL5.
TMPY-00120	PD-L2 Protein, Human, Recombinant (hFc) Btdc,B7-DC,programmed cell death 1 ligand 2,B7DC,PD...	Human	HEK293 Cells
	PD-L2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.3 kDa and the accession number is Q9BQ51-1.
TMPK-00166	PD-L2 Protein, Human, Recombinant (His & Avi) PDL2,Btdc,Butyrophilin B7-DC,PDCD...	Human	HEK293 Cells
	PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4 T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals. PD-L2 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.3 kDa and the accession nu...
TMPK-01290	PD-L2 Protein, Cynomolgus, Recombinant (aa 20-220, His) B7DC,PDL2,CD273, PDCD1 ligand 2,B...	Cynomolgus	HEK293 Cells
	PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4 T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals. PD-L2 Protein, Cynomolgus, Recombinant (aa 20-220, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 23.73 kDa and the acces...
TMPY-06281	PD-L2 Protein, Human, Recombinant (hFc & Avi), Biotinylated bA574F11.2,B7DC,B7-DC,PDCD1L2,programmed c...	Human	HEK293 Cells
	PD-L2 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 51.09 kDa and the accession number is Q9BQ51-1.
TMPY-05613	PD-L2 Protein, Human, Recombinant (His & Avi), Biotinylated bA574F11.2,programmed cell death 1 ligand 2,Btdc,PD...	Human	HEK293 Cells
	PD-L2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 25.8 kDa and the accession number is Q9BQ51-1.
TMPY-04223	PD-L2 Protein, Rat, Recombinant (hFc) programmed cell death 1 ligand 2	Rat	HEK293 Cells
	PD-L2 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.2 kDa and the accession number is D4AAV6.
TMPY-03738	PD-L2 Protein, Cynomolgus, Recombinant (His) programmed cell death 1 ligand 2	Cynomolgus	HEK293 Cells
	PD-L2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is A4GW30.
TMPY-04225	PD-L2 Protein, Rat, Recombinant (His) programmed cell death 1 ligand 2	Rat	HEK293 Cells
	PD-L2 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.9 kDa and the accession number is D4AAV6.
TMPY-03404	PD-L2 Protein, Cynomolgus, Recombinant (hFc) programmed cell death 1 ligand 2	Cynomolgus	HEK293 Cells
	PD-L2 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.6 kDa and the accession number is A4GW30.
TMPY-06819	PD-L2 Protein, Rhesus, Recombinant (hFc) programmed cell death 1 ligand 2	Rhesus	HEK293 Cells
	PD-L2 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.6 kDa and the accession number is A4GW30.
TMPY-06838	PD-L2 Protein, Rhesus, Recombinant (His) programmed cell death 1 ligand 2	Rhesus	HEK293 Cells
	PD-L2 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is NP_001077068.1.
TMPJ-00181	PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated Programmed cell death protein 1,PDCD1,CD279,hPD...	Human	HEK293 Cells
	Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been sugg...

重组蛋白

PD-L2 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-04957

Species: Human

Expression System: HEK293 Cells

PD-L2 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05827

Species: Human

Expression System: HEK293 Cells

PD-L2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04346

Species: Human

Expression System: HEK293 Cells

PD-L2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02436

Species: Mouse

Expression System: HEK293 Cells

PD-L2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02352

Species: Mouse

Expression System: HEK293 Cells

PD-L2 Protein, Mouse, Recombinant (His), Biotinylated

Cat.No: TMPY-05282

Species: Mouse

Expression System: HEK293 Cells

PD-L2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00120

Species: Human

Expression System: HEK293 Cells

PD-L2 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00166

Species: Human

Expression System: HEK293 Cells

PD-L2 Protein, Cynomolgus, Recombinant (aa 20-220, His)

Cat.No: TMPK-01290

Species: Cynomolgus

Expression System: HEK293 Cells

PD-L2 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPY-06281

Species: Human

Expression System: HEK293 Cells

PD-L2 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-05613

Species: Human

Expression System: HEK293 Cells

PD-L2 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-04223

Species: Rat

Expression System: HEK293 Cells

PD-L2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-03738

Species: Cynomolgus

Expression System: HEK293 Cells

PD-L2 Protein, Rat, Recombinant (His)

Cat.No: TMPY-04225

Species: Rat

Expression System: HEK293 Cells

PD-L2 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPY-03404

Species: Cynomolgus

Expression System: HEK293 Cells

PD-L2 Protein, Rhesus, Recombinant (hFc)

Cat.No: TMPY-06819

Species: Rhesus

Expression System: HEK293 Cells

PD-L2 Protein, Rhesus, Recombinant (His)

Cat.No: TMPY-06838

Species: Rhesus

Expression System: HEK293 Cells

PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00181

Species: Human

Expression System: HEK293 Cells

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