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Search Results for " p8 "

27

抑制剂 & 化合物

2

天然产物

12

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP2389	Laminin B1 octapeptide P-8 Asp-pro-gln-tyr-ile-gln-ser-arg,Dpgyigsr
	Laminin B1 octapeptide P-8 is a synthetic laminin B1 chain octapeptide with laminin receptor binding ability.
T67876	USP8-IN-2	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	USP8-IN-2 是一种有效的去泛素化酶 USP7和USP8 抑制剂，对USP8D 的IC50为4.0 μM。USP8-IN-2是治疗癌症和病毒感染的潜在化合物。
T39615L	P8RI acetate	Integrin	Cytoskeletal Signaling
	P8RI acetate 是 CD31 的仿生肽和 CD3 的激动剂。 P8RI acetate 通过恢复 CD31 抑制途径显示出免疫抑制作用。
T14987	CMP8	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	CMP8 是一种雌激素受体的选择性配体，可结合到雌激素受体配体结合域。它能够作用于突变型 MGERα (IC50:29 nM)、MGRERα (IC50:41 nM)和野生型 hERα (IC50:1100 nM)、hERβ (IC50:2200 nM)。
T72784	OTUB1/USP8-IN-1	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	OTUB1/USP8-IN-1 是一种高效的 OTUB1/USP8 抑制剂，具有潜在的抗癌活性，对 OTUB1 和 USP8 的 IC50 值分别为 0.17 和 0.28 nM。OTUB1/USP8-IN-1 可用于研究非小细胞肺癌。
T67873	USP8-IN-3	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	USP8-IN-3 是一种有效的去泛素化酶 USP7和USP8 抑制剂，对USP8D 的IC50为4.0 μM。USP8-IN-3 对GH3 和 H1957 细胞的增殖有抑制作用，GI50 分别为 37.03 μM 和 6.01 μM。USP8-IN-3是治疗癌症和病毒感染的潜在化合物。
TP1893L1	[D-Trp8]-γ-MSH acetate(321351-81-9 free base)	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	[D-Trp8]-γ-MSH acetate(321351-81-9 free base) 是选择性黑皮质素 3 (MC3) 受体激动剂（对人 MC3、MC5 和 MC4 受体的 IC50 值分别为 6.7、340 和 600 nM）。显示有抗炎功效。
T60146	USP8-IN-1	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	USP8-IN-1 是USP8的抑制剂，IC50为 1.9 μM。USP8-IN-1 抑制 H1975 细胞生长，GI50为 82.04 μM。
T6990L	SNAP8 Acetate(868844-74-0,free base)	Others	Others
	SNAP8 Acetate(868844-74-0,free base) 减少皱纹出现。
T2469	TP808 TP-808,TP 808	Others	Others
	TP808是一种高度通用的中间体，可用于多种四环素类抗生素的构建。
T69769	BDP8900
	BDP8900 is a potent and selective MRCK inhibitor, reducing substrate phosphorylation. BDP8900 leads to morphological changes in cancer cells along with inhibition of their motility and invasive character.
T124885	Antibiotic LL-P880y
	Antibiotic LL-P880y 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T124885，CAS号为 41206-21-7。
T72784L	OTUB1/USP8-IN-1 HCl OTUB1/USP8-IN-1 HCl（2858800-98-1 Free base）	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	OTUB1/USP8-IN-1 HCL 是一种高效的 OTUB1和 USP8 双重抑制剂，具有潜在的抗肿瘤活性，抑制 OTUB1 和 USP8 的活性。OTUB1/USP8-IN-1 可用于研究白血病。
T83494	[D-Trp8,Tyr11] Somatostatin
	[D-Trp8,Tyr11] Somatostatin是一种somatostatin的类似物，后者是一种调节多种身体机能的激素。在该化合物中，DTrp8残基的加入可以提高其稳定性。
T64001	MAP855
	MAP855 是一种高效的、选择性的、口服具有活力的具、 ATP 竞争性的 MEK1/2 激酶抑制剂，对 MEK1 ERK2 cascade 的 IC50 值为 3 nM，pERKEC50 值为 5 nM。MAP855 对野生型和突变型 MEK1/2 表现出同等的抑制效果。
T80135	Tyr-(D-Dab4,Arg5,D-Trp8)-cyclo-Somatostatin-14 (4-11)
	Tyr-(D-Dab4,Arg5,D-Trp8)-cyclo-Somatostatin-14 (4-11)，一种生长抑素激动剂，用于癌症研究。
T35137	WP814 WP 814,WP-814
	WP814 is a bioactive chemical.
T16878	SHP836	Others	Others
	SHP836 is an inhibitor of SHP2 allosteric (IC50: 12 μM for the full-length SHP2).
T6990	SNAP8 Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-Nh2,SNAP 8,SNAP-8	Others	Others
	SNAP8 (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-Nh2) 是 SNAP-25 N 末端的模拟物，它与 SNAP-25 竞争 SNARE 复合物中的位置，从而调节其形成。
T27851	LP8 LP 8,LP-8
	LP8 is a novel inhibitor of Trypanosoma cruzi CYP51.
T73477	SHP844
	SHP844为一SHP2抑制剂，IC50值为18.9 µM。SHP2为蛋白酪氨酸磷酸酶(PTP)，调控酪氨酸磷酸化水平，影响细胞增殖、分化及存活。
TP1893	[D-Trp8]-γ-MSH
	[D-Trp8]-γ-MSH is a selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively). [D-Trp8]-γ-MSH displays anti-inflammatory efficacy.
T83546	(D-Trp8,D-Cys14)-Somatostatin-14
	"(D-Trp8,D-Cys14)-Somatostatin-14"为一种生长抑素合成类似物，主要用于代谢相关疾病研究。
T83493	[D-Trp8] Somatostatin-14
	[D-Trp8] Somatostatin-14为一种十四肽生长抑素类似物，其活性优于天然Somatostatin。
T39615	P8RI D-P8RI
	P8RI (D-P8RI) is a CD31 biomimetic peptide and agonist that specifically targets the juxtamembrane amino acid sequence of the ectodomain of CD31. By restoring the CD31 inhibitory pathway, P8RI exhibits immunosuppressive properties.
T75854	[D-Trp8]-γ-MSH TFA
	[D-Trp8]-γ-MSH TFA 是一种有效的、选择性的黑皮质素3 (MC3)受体激动剂，在 CHO 细胞中，抑制 hMC3，hMC4和 hMC5的 IC50值分别为 6.7 nM，600 nM 和 340 nM。[D-Trp8]-γ-MSH TFA 显示出对多种炎症性疾病(如类风湿关节炎和结肠炎)的保护作用。
T76612	(D-Phe5,Cys6,11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide
	(D-Phe5,Cys6,11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide (Compound 4) 是一种生长抑素类似物，对 SSTR5、SSTR3、SSTR2、SSTR1和 SSTR4的Kd 分别为 0.61、11.05、23.5、1200 和 >1000 nM。

化合物

Laminin B1 octapeptide P-8

Cat.No: TP2389

Synonym: Asp-pro-gln-tyr-ile-gln-ser-arg,Dpgyigsr

Cat.No: T67876

Target: DUB

Cat.No: T39615L

Target: Integrin

Cat.No: T14987

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

OTUB1/USP8-IN-1

Cat.No: T72784

Target: DUB

Cat.No: T67873

Target: DUB

[D-Trp8]-γ-MSH acetate(321351-81-9 free base)

Cat.No: TP1893L1

Target: Melanocortin Receptor

Cat.No: T60146

Target: DUB

SNAP8 Acetate(868844-74-0,free base)

Cat.No: T6990L

Target: Others

Cat.No: T2469

Synonym: TP-808,TP 808

Target: Others

Cat.No: T69769

Antibiotic LL-P880y

Cat.No: T124885

OTUB1/USP8-IN-1 HCl

Cat.No: T72784L

Synonym: OTUB1/USP8-IN-1 HCl（2858800-98-1 Free base）

Target: DUB

[D-Trp8,Tyr11] Somatostatin

Cat.No: T83494

Cat.No: T64001

Tyr-(D-Dab4,Arg5,D-Trp8)-cyclo-Somatostatin-14 (4-11)

Cat.No: T80135

Cat.No: T35137

Synonym: WP 814,WP-814

Cat.No: T16878

Target: Others

Cat.No: T6990

Synonym: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-Nh2,SNAP 8,SNAP-8

Target: Others

Cat.No: T27851

Synonym: LP 8,LP-8

Cat.No: T73477

[D-Trp8]-γ-MSH

Cat.No: TP1893

(D-Trp8,D-Cys14)-Somatostatin-14

Cat.No: T83546

[D-Trp8] Somatostatin-14

Cat.No: T83493

Cat.No: T39615

Synonym: D-P8RI

[D-Trp8]-γ-MSH TFA

Cat.No: T75854

(D-Phe5,Cys6,11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide

Cat.No: T76612

Cat. No.	Product Name	Target	Signaling Pathways
TN2376	Fructo-oligosaccharide DP8/GF7 蔗果八糖,Fructo-oligosaccharide DP8 / GF7	Others	Others
	Fructo-oligosaccharide DP8/GF7 (Fructo-oligosaccharide DP8 / GF7) 是一种聚果糖，聚合度(DP=8)。Fructo-oligosaccharides 由 7 个果糖单元通过 (2→1)-β-糖苷键连接，并在非还原性末端具有 1 个 D-葡萄糖单元。
T32808	LL P880 beta LL-P880 beta,LL-P880beta,LL-P880-beta,LLP880 beta
	LL P880 beta is a fungal metabolite.

天然产物

Fructo-oligosaccharide DP8/GF7

Cat.No: TN2376

Synonym: 蔗果八糖,Fructo-oligosaccharide DP8 / GF7

Target: Others

Cat.No: T32808

Synonym: LL-P880 beta,LL-P880beta,LL-P880-beta,LLP880 beta

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01356	S100A8 Protein, Human, Recombinant (His) 60B8AG,MRP-8,MA387,NIF,L1Ag,S100 calcium binding protein A8,...	Human	Baculovirus Insect Cells
	S100A8 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 12.2 kDa and the accession number is P05109.
TMPY-03556	S100A8 Protein, Mouse, Recombinant (His) p8,S100 calcium binding protein A8,Caga,60B8Ag,B8Ag...	Mouse	E. coli
	S100A8 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.3 kDa and the accession number is P27005.
TMPY-06416	SARS-CoV-2 NSP8 Protein	SARS-CoV-2	E. coli
	NSP8 is a nonstructural protein of coronavirus. NSP8 acts as a primase in RNA synthesis. NSP8 and NSP7 are essential co-factors of NSP12 (the catalytic subunit with RNA-dependent RNA polymerase activity) that can remarkably stimulate RdRp activity. The nsp12-nsp7-nsp8 subcomplex is defined as the minimal core component for mediating coronavirus RNA synthesis. SARS-CoV-2 NSP8 Protein is expressed in E. coli expression system. The predicted molecular weight is 22.04 kDa and the accession number is...
TMPJ-00120	NKp80/KLRF1 Protein, Human, Recombinant (His) Lectin-like receptor F1,C-type lectin domain family 5 member...	Human	HEK293 Cells
	Killer cell lectin-like receptor subfamily F member 1 (KLRF1) is known as NKp80. Human NKp80, a member of the C-type lectin family of proteins (1 - 3), is 231 aa in length with a 38 amino acid (aa) cytoplasmic region, a 21 aa transmembrane region, and a 172 aa extracellular domain (ECD). The protein strongly expressed in peripheral blood leukocytes and spleen, with weaker expression in lymph node and adult liver, and no expression detected in bone marrow, thymus, and fetal liver. Its' function i...
TMPJ-01278	SENP8 Protein, Human, Recombinant (His) DEN1,Protease Cysteine 2,NEDP1,Sentrin-Specific Protease 8,D...	Human	E. coli
	Sentrin-Specific Protease 8 (SENP8) mediates the reversible covalent modification of proteins by NEDD8. SENP8 catalyzes the full-length NEDD8 to generate its mature form and deconjugation of NEDD8 from targeted proteins such as CUL2 , CUL4A in vivo, or p53. but it does not show activity against ubiquitin or SUMO proteins.
TMPK-00116	NKp80/KLRF1 Protein, Human, Recombinant (hFc) NKp80,KLRF1,Lectin-like receptor F1,CLEC5C,ML	Human	HEK293 Cells
	NKp80, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on essentially all human natural killer (NK) cells and stimulates their cytotoxicity and cytokine release.
TMPH-03526	Cap8A Protein, S. aureus, Recombinant (His) MAGEB2,MAGE XP-2 antigen,DAM6,MAGE-B2 antigen,Melanoma-assoc...	Staphylococcus aureus	E. coli
	May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Cap8A Protein, S. aureus, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 26.4 kDa and the accession number is O15479.
TMPY-05749	SARS-CoV-2 NSP8 Protein (Avi)	SARS-CoV-2	E. coli
	NSP8 is a nonstructural protein of coronavirus. NSP8 acts as a primase in RNA synthesis. NSP8 and NSP7 are essential co-factors of NSP12 (the catalytic subunit with RNA-dependent RNA polymerase activity) that can remarkably stimulate RdRp activity. The nsp12-nsp7-nsp8 subcomplex is defined as the minimal core component for mediating coronavirus RNA synthesis. SARS-CoV-2 NSP8 Protein (Avi) is expressed in E. coli expression system. The predicted molecular weight is 24.17 kDa and the accession num...
TMPY-03623	NKp80/KLRF1 Protein, Cynomolgus, Recombinant (hFc) killer cell lectin like receptor F1,KLRF1	Cynomolgus	HEK293 Cells
	NKp80, also known as KLRF1, is an activating homodimeric C-type lectin-like receptor that is expressed on nearly all-natural killer cells and stimulates their cytotoxicity and cytokine release. NKp80 stimulates cytotoxicity upon engagement of its genetically linked ligand: myeloid-specific CTLR activation-induced C-type lectin (AICL). NKp80, but not NKp80 mutated at tyrosine 7 (NKp80/Y7F), is tyrosine phosphorylated. Accordingly, NKp80/Y7F, but not NKp80/Y3F or NKp80/Y37F, failed to induce cytot...
TMPY-03416	TNFAIP8 Protein, Human, Recombinant (His) GG2-1,tumor necrosis factor, alpha-induced protein 8,SCCS2,S...	Human	E. coli
	Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8) family is a newly identified protein with vital roles in maintaining immune homeostasis. Tumor necrosis factor-alpha-inducible protein 8 (TNFAIP8) is a TNF-alpha inducible anti-apoptotic protein with multiple roles in tumor growth and survival. by the creation of cellular autophagy events, TNFAIP8 promotes cell survival and drug resistance in prostate cancer cells. TNFAIP8 regulates Hippo pathway through interacting with LATS1 to prom...
TMPJ-01428	SARS-CoV-2 NSP8 Protein (His) SARS-CoV 2 nsp8	SARS-CoV-2	E. coli
	Cleavage by the viral main protease, 3CLpro results in generating the nsp8 protein, The nsp8 protein has been shown to associate with several other nsps and to colocalize with these nsps in cytoplasmic complexes that are important for viral RNA synthesis. It forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.Nsp8 was shown to have RNA-dependen...
TMPY-06123	SARS-CoV-2 Nucleocapsid Protein (P80R, His)	SARS-CoV-2	E. coli
	SARS-CoV-2 Nucleocapsid Protein (P80R, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 46.7 kDa and the accession number is P0DTC9.

重组蛋白

S100A8 Protein, Human, Recombinant (His)

Cat.No: TMPY-01356

Species: Human

Expression System: Baculovirus Insect Cells

S100A8 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03556

Species: Mouse

Expression System: E. coli

SARS-CoV-2 NSP8 Protein

Cat.No: TMPY-06416

Species: SARS-CoV-2

Expression System: E. coli

NKp80/KLRF1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00120

Species: Human

Expression System: HEK293 Cells

SENP8 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01278

Species: Human

Expression System: E. coli

NKp80/KLRF1 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00116

Species: Human

Expression System: HEK293 Cells

Cap8A Protein, S. aureus, Recombinant (His)

Cat.No: TMPH-03526

Species: Staphylococcus aureus

Expression System: E. coli

SARS-CoV-2 NSP8 Protein (Avi)

Cat.No: TMPY-05749

Species: SARS-CoV-2

Expression System: E. coli

NKp80/KLRF1 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPY-03623

Species: Cynomolgus

Expression System: HEK293 Cells

TNFAIP8 Protein, Human, Recombinant (His)

Cat.No: TMPY-03416

Species: Human

Expression System: E. coli

SARS-CoV-2 NSP8 Protein (His)

Cat.No: TMPJ-01428

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 Nucleocapsid Protein (P80R, His)

Cat.No: TMPY-06123

Species: SARS-CoV-2

Expression System: E. coli

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