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Cat. No. | Product Name | Target | Signaling Pathways |
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T22889 |
KF38789
KF 38789 |
Others | Others |
KF38789 特异性的抑制P-selectin 与PSGL-1结合。它对 U937 细胞与 P-selectin 免疫球蛋白 G 嵌合蛋白 (P-selectin-Ig) 的结合具有抑制作用 (IC50:1.97 μM) 。 | |||
T16676 |
PSI-697
P-Selectin Inhibitor |
Others | Others |
PSI-697 is an inhibitor of oral P-selectin (IC50: 125 μM). | |||
T78288 |
Inclacumab
Anti-Human selectin P Recombinant Antibody |
||
Inclacumab(Anti-HumanselectinP Recombinant Antibody)是一种人源化IgG4单克隆抗体,专一性靶向P-selectin,Kd为9.9 nM。该抗体能够抑制P-selectin糖蛋白配体1(PSGL-1)模拟肽与P-selectin的结合,其IC50为1.9 µg/mL,且显著抑制细胞粘附。 | |||
T1893 |
Parmodulin 2
ML 161 |
Protease-activated Receptor | GPCR/G Protein |
Parmodulin 2 (ML 161) 是一种蛋白酶激活受体 1(PAR1) 变构抑制剂,IC50为 0.26 μM。它是蛋白酶激活受体 1 (PAR1) 介导的血小板活化的抑制剂,可以抑制体外血小板聚集和体内血小板血栓形成。 | |||
T77399 |
Crizanlizumab
ADAKVEO,SEG-101 |
Others | Others |
Crizanlizumab(Adakveo)是一种针对 P-选择素的人源化单克隆抗体,用于预防镰状细胞病的疼痛危象。 | |||
T14573 |
Bimosiamose disodium
TBC-1269Z |
Integrin | Cytoskeletal Signaling |
Bimosiamose disodium has anti-inflammatory effects[1]. Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. | |||
T14574 |
Bimosiamose
TBC-1269 |
Integrin | Cytoskeletal Signaling |
Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively. | |||
T24144 | HMCEF | ||
HMCEF is a P-selectin inhibitor that acts by intercalating into calf thymus DNA, cutting off DNA pBR22. It also inhibits the proliferation of cancer cells. | |||
T39121 |
Odatroltide
DHDMIQK(KAP),Odatroltide |
||
Odatroltide is a nanoscale P-selectin inhibitor that serves as a nano-delivery system for 6,7-dihydroxyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and KPAK to specifically target the thrombus. | |||
T25911 |
Oxycinchophen
Magnophenyl,Sintofene,Reumartril,Chinoxone |
||
Oxycinchophen 是一种喹啉类的有机物,抗风湿病的化合物。它已被用于研究 P- 选择素拮抗活性,DHOD 抑制活性,以及抗炎药对血管平滑肌的作用。 | |||
T71472 |
LN6023
|
||
LN6023 is a ACKR3/CXCR7 Superagonist for Platelet Degranulation Modulation. LN6023 effectively reduced P-selectin expression by up to 97%, suggesting to be a potential candidate for the treatment of platelet-mediated thrombosis. | |||
T35884 |
Sialyl-Lewis X
|
||
Sialyl-Lewis X (sLeX), a sialylated fucosylated tetrasaccharide and endogenous antigen, serves as a high-affinity ligand for selectins (E-, P-, and L-selectin)[1]. It interacts with ELAM-1 and CD62, consequently inhibiting CD62-mediated neutrophil recruitment to inflammation sites[2]. | |||
T60303 |
Collagen-IN-1
|
||
Collagen-IN-1 (compound 3) is an ortho-carbonyl hydroquinone derivative exhibiting selective inhibition of collagen. It non-competitively inhibits agonist-induced platelet aggregation, with an IC50 value of 1.77 μM. Collagen-IN-1 effectively reduces the expression of P-selectin, activation of glycoprotein IIb/IIIa, and release of adenosine triphosphate and CD63 from platelets. This compound holds promise for research into platelet-related thrombosis diseases [1]. | |||
T36221 |
2-chloro Palmitic Acid
|
||
2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endot... | |||
T35494 | (±)11(12)-EET | ||
(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.[1][2][3[]A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET.[3]11(12)-EET has been shown, along with 8(9)-EET to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells[4] It also inhibits basolateral 18-pS potassium channels in t... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3S0645 |
N-trans-Feruloyltyramine
Feruloyltyramine,N-Feruloyltyramine,Moupinamide,N-反式阿魏酰酪胺 |
Others; COX | Immunology/Inflammation; Neuroscience; Others |
N-trans-Feruloyltyramine (Feruloyltyramine) 是从大麻中分离得到的一种生物碱,是COX1和COX2的抑制剂,具有抗氧化和抗炎活性。 | |||
T4S0498 |
Glaucocalyxin A
蓝萼甲素,Wangzaozin B,Leukamenin F |
Apoptosis; Akt; Caspase; PI3K | Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜,具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位,诱导骨肉瘤凋亡。 |