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Cat. No. | Product Name | Target | Signaling Pathways |
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T4384 |
Halofenozide
|
Others | Others |
Halofenozide 是一种新的昆虫生长调节剂 (IGR),具有苯甲酰肼结构,也是一种蜕皮激素 (ecdysteroid) 激动剂。可模拟天然昆虫蜕皮激素 20-羟基蜕皮激素的作用, | |||
T7556 |
Fadrozole hydrochloride
CGS 16949A,盐酸法倔唑 |
Aromatase | Endocrinology/Hormones |
Fadrozole hydrochloride (CGS 16949A) 是一种选择性的、有效,和非甾体类的芳香化酶抑制剂(IC50:6.4 nM)。 | |||
T5700 |
PDD00017273
|
Others | Others |
PDD00017273 是一种有效的放射增敏作用(二磷酸腺苷核糖)的水解酶 (PARG) 抑制剂,具有抗肿瘤或活性。PDD00017273 具有放射增敏作用,可用于研究上皮性卵巢。 | |||
T5317L |
Cridanimod sodium
XBIO-101,XBIO 101,Cycloferon,Sodium Cridanimod,Cridanimod Na,XBIO101 |
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Cridanimod can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Cridanimod is able to induce the expression of PR in endometrial cancer. In combination with a progestin, cancer cells could be eradicated thro | |||
T76566 |
Fsh receptor-binding inhibitor fragment(bi-10)
|
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FSHreceptor-binding inhibitor fragment(bi-10) 是一种有效的 FSH 拮抗剂。FSHreceptor-binding inhibitor fragment(bi-10) 阻断 FSH 与 FSHR 的结合,并在受体水平上改变 FSH 的作用。FSHreceptor-binding inhibitor fragment(bi-10) 导致小鼠排卵抑制和卵泡闭锁。FSHreceptor-binding inhibitor fragment(bi-10) 通过下调卵巢中 FSHR 和 ERβ的过度表达来抑制卵巢癌发生。 | |||
T83666 |
Kisspeptin-10 (zebrafish) TFA
Tyr-Asn-Leu-Asn-Ser-Phe-Gly-Leu-Arg-Tyr-NH2,Kp-10 |
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Kisspeptin-10是一种在斑马鱼的大脑、卵巢和睾丸中表达的神经肽,参与性腺发育和类固醇表达。在10 ng/ml的浓度下使用时,能提高孤立的斑马鱼卵巢滤泡中编码黄体生成素(luteinizing hormone, Lh)受体,以及孕酮受体a (Progestin receptor a, Pra)和Prb的mRNA水平。在0.1和1 µg/g的剂量下给予时,Kisspeptin-10能在雌性金鱼中增加黄体生成素的血清水平,但在雄性金鱼中则不会。 | |||
T36701 | Phosphoramide mustard (cyclohexanamine) | ||
Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA damage and elicits the ovarian DNA repair response[1][2]. Phosphoramide mustard cyclohexanamine causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication[1].Phosphoramide mustard cyclohexanamine destroys rapidly dividing ce... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T20597 |
Alginic acid
Protanal LF,褐藻酸,Snow acid algin G,Kelacid,Sazzio,Norgine |
Apoptosis; Autophagy; Histamine Receptor | Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Alginic acid (Snow acid algin G) 是一种从褐海藻中提取的天然多糖,具有抗过敏和抗炎活性。 Alginic acid 抑制组胺释放,可用于食品工业。 | |||
T0419 |
Testosterone propionate
|
Others; Androgen Receptor; Transferase | Endocrinology/Hormones; Metabolism; Others |
Testosterone Propionate is a short acting oil-based injectable formulation of testosterone. Testosterone inhibits gonadotropin secretion from the pituitary gland and ablates estrogen production in the ovaries, thereby decreasing endogenous estrogen levels. | |||
T3405 |
[6]-Gingerol
6-Gingerol,gingerol,(S)-(+)-[6]Gingerol,6-姜酚 |
Apoptosis; AMPK | Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
[6]-Gingerol ((S)-(+)-[6]Gingerol) 是一种从生姜中分离的活性物质,具有抗癌,抗炎和抗氧化活性。 | |||
T1009 |
Estrone
Oestrone,雌酮,Fluoroethyl,Aquacrine |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Estrone (Aquacrine) 是内源性雌激素的主要代表,由多种组织产生,尤其是脂肪组织。它是脂肪细胞中雄烯二酮芳构化过程的结果。 |