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Search Results for " nifedipine "

12

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1146	Nifedipine BAY-a-1040,Procardia XL,Procardia,硝苯地平,Adalat	CaMK; Potassium Channel; Calcium Channel; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Nifedipine (Procardia) 是一种二氢吡啶类钙通道阻滞剂，可抑制细胞外钙离子跨膜流入心肌和血管平滑肌细胞，导致主要冠状动脉和全身动脉扩张，降低心肌收缩力。它常用于心肌功能不全的相关研究。
T36665	Dehydro Nifedipine BAY-b 4759
	Dehydro Nifedipine (BAY-b 4759) 是人血浆中硝苯地平的主要代谢物。Dehydro Nifedipine 抑制PC-12细胞葡萄糖摄取，IC50值为130 μM，硝苯地平是一种钙通道阻滞剂，用于治疗高血压和心绞痛。当硝苯地平被细胞色素P450 (CYP)异构体CYP3A4和CYP3A5代谢时形成脱氢硝苯地平。
T12222	Nifedipine-d6 硝苯地平 D6,Nifedipine D6,BAY-a-1040 D6	Others	Others
	Nifedipine D6 is deuterium labeled nifedipine which is a potent blocker of calcium channel.
T69021	Nifedipine HCl
	Nifedipine HCl is a potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
T35584	Hydroxydehydro Nifedipine Carboxylate
	Hydroxydehydro nifedipine carboxylate is a metabolite of nifedipine .1 1.Roosemalen, M.C.M., Soons, P.A., Funaki, T., et al.High-performance liquid chromatographic determination of the polar metabolites of nifedipine in plasma, blood and urineJ. Chromatogr.565(1-2)516-522(1991)
T11926	m-Nifedipine	Others	Others
	m-Nifedipine, an impurity of Nifedipine, serves as a potent calcium channel blocker and the preferred treatment option for cardiac insufficiencies.
T1215	Nicardipine hydrochloride 盐酸尼卡地平,RS-69216,Nicardipine HCl,YC-93 Hydrochloride	Calcium Channel; Adrenergic Receptor; AChR; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Nicardipine hydrochloride (YC-93 Hydrochloride) 是一种钙通道阻滞剂，IC50为 1 μM。它可阻断某些细胞壁中的钙离子并抑制冠状动脉和外周动脉的收缩，从而降低对氧气的需求心肌和减少动脉收缩和痉挛。它在临床上用作脑和冠状血管扩张剂。
T0119	Nitrendipine BAY-E-5009,Bayotensin,尼群地平	Calcium Channel; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism
	Nitrendipine (BAY-E-5009) 是 Nifedipine 的类似物，是一种钙通道阻滞剂，具有显着的血管扩张作用。它是一种有效的抗高血压药且不会降低肾小球滤过率，并且具有轻微的利钠作用。
T68972	FR-7534
	FR-7534 is a calcium antagonist structurally similar to nifedipine.
T25010	AK-2-38 AK -2-38,AK2-38
	AK-2-38 is a nifedipine analogue with potent smooth muscle calcium antagonist action and partial agonist effects on isolated guinea pig left atrium.
T33673	Niludipine Niludipina,BAY-a 7168,Bay a 7168,Niludipinum
	Nirudipine is a double (2-propoxyethyl) analogist of nifedipine and a calcium channel blocker, which is also a safe anti-angina Ca2+ antagonist with a broad range of efficacy for all types of angina. At the same time, Niludipine is a highly effective drug
T36070	(±)5(6)-EET
	5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-δ-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5(6)-EET has been implicated in the mobilization of calcium and hormone secretion. 5(6)-EET is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhib...

化合物

Cat.No: T1146

Synonym: BAY-a-1040,Procardia XL,Procardia,硝苯地平,Adalat

Target: CaMK, Potassium Channel, Calcium Channel, Autophagy

Dehydro Nifedipine

Cat.No: T36665

Synonym: BAY-b 4759

Nifedipine-d6

Cat.No: T12222

Synonym: 硝苯地平 D6,Nifedipine D6,BAY-a-1040 D6

Target: Others

Nifedipine HCl

Cat.No: T69021

Hydroxydehydro Nifedipine Carboxylate

Cat.No: T35584

Cat.No: T11926

Target: Others

Nicardipine hydrochloride

Cat.No: T1215

Synonym: 盐酸尼卡地平,RS-69216,Nicardipine HCl,YC-93 Hydrochloride

Target: Calcium Channel, Adrenergic Receptor, AChR, Autophagy

Cat.No: T0119

Synonym: BAY-E-5009,Bayotensin,尼群地平

Target: Calcium Channel, Autophagy

Cat.No: T68972

Cat.No: T25010

Synonym: AK -2-38,AK2-38

Cat.No: T33673

Synonym: Niludipina,BAY-a 7168,Bay a 7168,Niludipinum

Cat.No: T36070

Cat. No.	Product Name	Target	Signaling Pathways
TN3135	5-O-Methylnaringenin	Others	Others
	5-O-Methylnaringenin is a marker, reduced MS detection of 5-O-methylnaringenin indicated that nifedipine may preferably remove a proton from the 5-position OH group in the A ring of the flavonoid skeleton.
TN3147	6',7'-Dihydroxybergamottin	P450	Metabolism
	6',7'-Dihydroxybergamottin(DHB), a well-known inhibitor of CYP3A4, the inhibition of CYP3A4 activity by DHB includes the inhibition of POR activity, DHB can inhibit nifedipine oxidation in a concentration-dependent manner.

天然产物

5-O-Methylnaringenin

Cat.No: TN3135

Target: Others

6',7'-Dihydroxybergamottin

Cat.No: TN3147

Target: P450

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