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Search Results for " microtubule inhibitor 2 "

21

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T61749	Microtubule inhibitor 2
	Microtubule inhibitor 2 is a highly potent and selective microtubule inhibitor, which is orally active. It induces cell death via ferroptosis, and exhibits notable antitumor activity [1].
T60026	KIF18A-IN-2	Microtubule Associated	Cytoskeletal Signaling
	KIF18A-IN-2 是有丝分裂驱动蛋白 Kif18A 的抑制剂，IC50 为 28 nM，可用于染色体不稳定性相关漏洞的研究。
T50005	Sertaconazole	Antifungal	Microbiology/Virology
	Sertaconazole 是一种广谱抗真菌药。
T13298	Verubulin hydrochloride MPC-6827 hydrochloride,N-(4-甲氧基苯基)-N,2-二甲基-4-喹唑啉胺盐酸盐	Microtubule Associated	Cytoskeletal Signaling
	Verubulin hydrochloride (MPC-6827 hydrochloride) 是一种血脑屏障渗透性微管破坏剂，具有强效和广谱的细胞毒活性，在人 MX-1 乳腺癌和其他小鼠异种移植癌模型中具有有效的抗癌活性。
T15576	Indibulin 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺,ZIO 301,D 24851	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Indibulin (D 24851) 是一种口服有效的微管蛋白合成抑制剂，具有抗有丝分裂和抗肿瘤活性，且神经毒性小。它降低了肌间神经张力，产生异常的纺锤体，激活有丝分裂检查点蛋白 Mad2 和 BubR1，并诱导有丝分裂停滞和细胞凋亡。
T6665	Sertaconazole nitrate FI-7045,Ginedermofix,FI7056,Ertaczo,硝酸舍他康唑	Antibiotic; Antifungal	Microbiology/Virology
	Sertaconazole nitrate (FI-7045) 是一种局部广谱抗真菌药，可用于治疗浅表皮肤和粘膜感染。
T35548	Dynapyrazole A	Dynamin	Cytoskeletal Signaling
	Dynapyrazole A 是微管动力蛋白的特异性抑制剂，对动力蛋白 1 和动力蛋白 2 依赖性微管滑动的 IC50 分别为 2.3 和 2.6 μM。 Dynapyrazole A 抑制 Hedgehog 信号传导，IC50 为 1.9 μM。
T15612	JH-VIII-157-02	Microtubule Associated; ALK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	JH-VIII-157-02 是一种 ALK 抑制剂，可抑制棘皮动物微管相关蛋白样 4-ALK (EML4-ALK)，对EML4-ALK G1202R、EML4-ALKwt、EML4-ALK C1156Y、EML4-ALK F1174L 和 EML4-ALK F1174L 的 IC50 均为 2 nM。
T15183	Dynarrestin	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	Dynarrestin 是一种细胞质动力蛋白 1 和 2的氨基噻唑抑制剂。它能够快速的、可逆的抑制动力蛋白 1 驱动的微管在体外滑动和细胞内动力蛋白 1 和 2 依赖性过程，且不影响 ATP 水解和干扰纤毛发生。它可抑制神经元前体和肿瘤细胞的刺猬因子依赖性增殖。
T62642	Microtubule inhibitor 4
	Microtubule inhibitor 4 (compound 2) 是一种有效的 microtubule 抑制剂。Microtubule inhibitor 4 对 NCI-H460 (IC50s: 4.0 nM)、BxPC-3 (IC50s: 3.2 nM)、HT-29 (IC50s: 2.1 nM) 细胞具有细胞毒性。Microtubule inhibitor 4 能够抑制微管蛋白聚合。
T11946	MARK-IN-2	Others	Others
	MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).
T18871	VCP-Eribulin	Others	Others
	VCP-Eribulin, an Eribulin-based drug for antibody conjugates[1], combines the VCP (ADCs linker) with Eribulin, a distinct microtubule inhibitor used in cancer treatments[2].
T81850	MASTL-IN-2
	MASTL-IN-2为MASTL（microtubule-associated Ser/Thr kinase-like）抑制剂，能够抑制人上皮MIA PaCa癌细胞的增殖，其IC50值为2.8 nM。
T37037	Vinflunine ditartrate
	Vinflunine ditartrate, a fluorinated microtubule inhibitor and member of the Vinca alkaloids family, exhibits anti-angiogenic, vascular-disrupting, and anti-metastatic properties. It presents a potential avenue for studying transitional cell carcinoma of the urothelial tract, non-small cell lung cancer, and breast carcinoma[1][2].
T68401	IG-105
	IG-105 is a potent microtubule inhibitor with potential anticancer activity. IG-105 inhibits microtubule assembly by binding at colchicine pocket. IG-105 shows a potent anticancer activity in vitro and in vivo and has good safety in mice. IG-105 showed a potent activity against human leukemia and solid tumors in breast, liver, prostate, lung, skin, colon, and pancreas with IC(50) values between 0.012 and 0.298 mumol/L. It was also active in drug-resistant tumor cells and not a P-glycoprotein sub...
T79232	MARK4 inhibitor 2	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	MARK4 inhibitor 2作为MARK4的高效抑制剂，展现出对微管亲和调节激酶 4 (MARK4) 的Km值为6.3×10^7，及IC50为0.82 μM的特异性。它能够抑制癌细胞生长，适用于癌症的科学研究。
T60402	Tubulin inhibitor 14
	Tubulin inhibitor 14 是一种有效的 NQO2（醌氧化还原酶 2）抑制剂，IC50 为 1.0 μM，也抑制微管蛋白聚合和内皮细胞毛细管样管的形成。Tubulin inhibitor 14 是一种微管去稳定剂，具有潜在的肿瘤选择性以及抗血管生成和血管破坏的功能[1]。
T62847	AMXI-5001
	AMXI-5001 是一种有效的、口服具有活力的 parp1/2 和微管聚合抑制剂。MXI-5001 对多种人类癌细胞显示出选择性抗肿瘤细胞毒性，其 IC50s 远低于现有的临床 PARP1/2 抑制剂。AMXI-5001 能够诱导已建立的肿瘤（包括很大的肿瘤）完全消退。
T63328	AMXI-5001 hydrochloride
	AMXI-5001 hydrochloride 是口服具有活力的、有效的 parp1/2 和微管聚合抑制剂，且IC50 值明显低于现有的临床 PARP1/2 抑制剂。MXI-5001 hydrochloride 对多种人类癌细胞表现出选择性抗肿瘤细胞毒性，能够诱导已建立的肿瘤，包括较大的肿瘤完全消退。
T70006	DHA-paclitaxel
	DHA-paclitaxel, also know as Taxoprexin, is prodrug comprised of the naturally occurring omega-3 fatty acid docosahexaenoic acid (DHA) covalently conjugated to the anti-microtubule agent paclitaxel. Because tumor cells take up DHA, DHA-paclitaxel is delivered directly to tumor tissue, where the paclitaxel moiety binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. Paclitaxel also induces apoptosis by binding to and blocking the func...
T71217	MPT0B214
	MPT0B214 is a novel and potent microtubule inhibitor with potential anticancer activity. MPT0B214 inhibited tubulin polymerization through strongly binding to the tubulin's colchicine-binding site and had cytotoxic activity in a variety of human tumor cell lines. After treatment with MPT0B214, KB cells were arrested in the G2-M phase before cell death occurred, which were associated with upregulation of cyclin B1, dephosphorylation of Cdc2, phosphorylation of Cdc25C and elevated expression of th...

化合物

Microtubule inhibitor 2

Cat.No: T61749

Cat.No: T60026

Target: Microtubule Associated

Cat.No: T50005

Target: Antifungal

Verubulin hydrochloride

Cat.No: T13298

Synonym: MPC-6827 hydrochloride,N-(4-甲氧基苯基)-N,2-二甲基-4-喹唑啉胺盐酸盐

Target: Microtubule Associated

Cat.No: T15576

Synonym: 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺,ZIO 301,D 24851

Target: Apoptosis, Microtubule Associated

Sertaconazole nitrate

Cat.No: T6665

Synonym: FI-7045,Ginedermofix,FI7056,Ertaczo,硝酸舍他康唑

Target: Antibiotic, Antifungal

Cat.No: T35548

Target: Dynamin

Cat.No: T15612

Target: Microtubule Associated, ALK

Cat.No: T15183

Target: Hedgehog/Smoothened

Microtubule inhibitor 4

Cat.No: T62642

Cat.No: T11946

Target: Others

Cat.No: T18871

Target: Others

Cat.No: T81850

Vinflunine ditartrate

Cat.No: T37037

Cat.No: T68401

MARK4 inhibitor 2

Cat.No: T79232

Target: AMPK

Tubulin inhibitor 14

Cat.No: T60402

Cat.No: T62847

AMXI-5001 hydrochloride

Cat.No: T63328

Cat.No: T70006

Cat.No: T71217

Cat. No.	Product Name	Target	Signaling Pathways
T2220	2-Methoxyestradiol 2-甲氧雌二醇,二甲氧基雌二醇,NSC-659853,2-MeOE2,2-ME2	Apoptosis; Reactive Oxygen Species; Microtubule Associated; Endogenous Metabolite; HIF; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB
	2-Methoxyestradiol (2-ME2) 是一种口服生物可利用的雌二醇代谢物，具有抗肿瘤活性。它通过减少内皮细胞增殖和诱导内皮细胞凋亡来抑制血管生成，也可破坏微管的稳定。它可诱导半胱天冬酶活化，导致细胞周期停滞在 G2 期、DNA 断裂和细胞凋亡。
T1034	Docetaxel 多西他赛,NSC 628503,RP-56976,多烯紫杉醇	Apoptosis; Microtubule Associated; Endogenous Metabolite	Apoptosis; Cytoskeletal Signaling; Metabolism
	Docetaxel (RP-56976) 是紫杉醇的半合成类似物，是一种微管解聚抑制剂 (IC50=0.2 μM)。Docetaxel 可以减弱 bcl-2 和 bcl-xL 基因表达的影响，具有诱导凋亡、抗肿瘤活性。
T74761	Eleutherobin
	Eleutherobin 是一种有效的 β 微管蛋白 (β-microtubule)，IC50为 2 μM。Eleutherobin 可从海洋软珊瑚中提取。Eleutherobin 对癌细胞的细胞毒活性具有与紫杉醇 (Paclitaxel)) 相似的效力。具有抗癌活性。
T75521	PM050489
	PM050489 是一种有效的聚酮类微管/微管蛋白 (Microtubule/Tubulin) 抑制剂，可从马达加斯加海绵Lithoplocamia lithistoides 中分离。PM050489 抑制有丝分裂，IC50值为 26.4 nM。PM050489 具有抗肿瘤活性，能用于癌症研究。

天然产物

2-Methoxyestradiol

Cat.No: T2220

Synonym: 2-甲氧雌二醇,二甲氧基雌二醇,NSC-659853,2-MeOE2,2-ME2

Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated, Endogenous Metabolite, HIF, Autophagy

Cat.No: T1034

Synonym: 多西他赛,NSC 628503,RP-56976,多烯紫杉醇

Target: Apoptosis, Microtubule Associated, Endogenous Metabolite

Cat.No: T74761

Cat.No: T75521

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