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35

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T20600	Kaolin Clay 347,Hydrated aluminum silicate,Bolus alba,HSDB 630,Altowhite,China clay,高岭土	Others	Others
	Kaolin (Bolus alba) 是一种以高岭石族矿物为主的粘土。 Kaolin 提高了这种监测血友病治疗方法的敏感性。
T19084	1-Naphthyl acetate	AChE	Neuroscience
	1-Naphthyl acetate 是一种有吸引力的生色底物，用于检测红细胞乙酰胆碱酯酶的活性。它具有检测有机磷农药中毒的潜力。
T20000	I-XW-053 4-(4,5-二苯基-1H-咪唑-2-基)苯甲酸	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	I-XW-053 是一种针对衣壳的 HIV-1 复制抑制剂，使用基于混合结构的方法以微摩尔亲和力阻断 CA N 末端结构域之间的界面（NTD-NTD 界面）。
T19080	DOPE 1,2-二油酰-SN-甘油-3-磷酰乙醇胺	Others	Others
	DOPE (DOPE) 是一种阳离子脂质体的中性辅助脂质 (helper lipid)，能够与阳离子磷脂结合，增强裸 siRNA 的转染效率。
T19027	Methyl Blue	Others	Others
	Methyl blue 是一种三氨基三苯甲烷染料。它在多色染色法中被广泛用作抗菌染料，并能够应用于组织学和微生物学染色溶液。它已被用作研究各种催化剂对染料光降解影响的模型。
TP1606L	NLS PKKKRKV acetate(95088-49-6 free base)	Others	Others
	NLS PKKKRKV acetate(95088-49-6 free base) 是从大猿病毒40肿瘤抗原（SV40大T 抗原）衍生的肽，是基因转移研究领域中增强核入口的一种方法。
T70885	R419
	R419 is an indirect activator of AMPK with potential application as a method of glucose regulation.
T40874	2-Nitrobenzaldehyde semicarbazone 13C,15N2 2-Nitrobenzaldehyde semicarbazone 13C,15N2
	2-Nitrobenzaldehyde semicarbazone (13C, 15N2) is utilized in the LC-MS/MS method for semicarbazide analysis.
T10982	ddATP 2',3'-Dideoxyadenosine 5'-triphosphate	Others	Others
	ddATP is a dideoxynucleotide, used as a chain extension inhibitor for DNA polymerase, and used for DNA sequencing by the Sanger method.
T31172	DA 3505 DA-3505,DA3505
	DA 3505 is one of feprazone metabolite. Limits of detection are 0.1 microgram feprazone per ml plasma and 0.2 microgram of its metabolite per ml plasma using the HPLC method. Concentration down to about 0.5 microgram/ml plasma of both compounds can be det
T20584	Octanophenone Heptyl phenyl ketone,Caprylophenone
	Octanophenone can be analyzed by reverse phase (RP) HPLC method with simple conditions. The phosphoric acid needs to be replaced with formic acid for Mass-Spec (MS) compatible applications. For fast UPLC applications, smaller 3 µm particles columns is av
T81250	Ru(bpy)2(dcbpy)NHS dihexafluorophosphate
	Ru(bpy)2(dcbpy)NHS (dihexafluorophosphate)与金纳米颗粒结合, 可构建用于电化学发光检测溶菌酶的扩增系统。
TP1606	NLS (PKKKRKV) NLS PKKKRKV
	NLS (PKKKRKV) is a peptide derived from the 40 tumor antigen of the great ape virus (SV40 big T antigen), which is a method to enhance the nuclear portal in the research field of gene transfer.
T27376	FR-186054 FR186054,FR 186054
	FR-186054 is a new, potent inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT) and has oral activity. Compared to other ACAT inhibitors, this compound displayed excellent in vitro efficacy, irrespective of dosing method, indicating superior charact
T38902	Cyanine 5 Tyramide Tyramide-Cy5
	Cyanine 5 Tyramide (Tyramide-Cy5), a red fluorescent dye, serves as a reporter fluorescent substrate in horseradish peroxidase (HRP)-catalyzed deposition, a signal amplification method employed in immunoassays and in situ hybridization of nucleic acids.
T75108	LNP Lipid-1
	LNP Lipid-1 (Method B) 为一种脂质化合物，用于脂质纳米颗粒组合物的合成中。该化合物可作为小分子活性分子、蛋白质及核酸等生物活性物质的运输载体，具有潜在应用价值。
T39547	Naph-EA-mal Thiol-green 1,Naph-EA-mal
	Naph-EA-mal (Thiol-green 1) is a highly efficient and quick-responding thiol fluorescence probe specifically designed for protein labeling and bioimaging applications. This compound offers a rapid detection method and exhibits ultrafast turn-on fluorescence upon interaction with thiols. Naph-EA-mal (Thiol-green 1) enables the detection of thiols in live cells, facilitates the labeling of protein thiols, enables quantification of total thiol concentration in cell lysate, and allows for the determ...
T35602	O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine
	O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine is a major metabolite of the calcium channel inhibitor amlodipine .1 1.Taguchi, R., Naito, T., Sato, H., et al.Validated LC-MS/MS method for the simultaneous determination of amlodipine and its major metabolites in human plasma of hypertensive patientsTher. Drug Monit.39(6)625-631(2017)
T37161	8-hydroxy Amoxapine
	8-hydroxy Amoxapine is a metabolite of the tetracyclic antidepressant amoxapine .1,2 1.Johnson, S.M., Nygard, G., and Khalil, S.K.Isocratic liquid chromatographic method for the determination of amoxapine and its metabolitesJ. Pharm. Sci.73(5)696-699(1984) 2.Tasset, J.J., and Pesce, A.J.Amoxapine in human overdoseJ. Anal. Toxicol.8(3)124-128(1984)
T63116	TXA6101
	TXA6101 是一种细菌蛋白 FtsZ (丝状温度敏感蛋白 Z) 抑制剂。TXA6101 能够抑制细菌的分裂，对表达 G193D 或 G196S 突变体 FtsZ 的 MRSA 分离株的抗菌活性 MIC 值都为 1 μg/mL，对 TXA707 抗性 FtsZ 突变体保留显着活性。TXA6101 能用做潜在的抵抗革兰氏阴性菌感染方法。
T83929	(+)-JQ1 maleimide
	(+)-JQ1 maleimide是一种探针，由一个与BRD4配体JQ1通过PEG2连接器相连的含有活性的maleimide组成。它可用于COFFEE方法（COvalent Functionalization Followed by E3 Electroporation），在该方法中，(+)-JQ1 maleimide与VHL共价连接后通过电穿孔导入活细胞。E3连接酶在细胞内与BRD4形成复合物，引导其降解。
T75837	Spantide I TFA
	Spantide I TFA 是substance P 的类似物，是选择性的神经激肽-1 受体 (NK1receptor) 的拮抗剂，其对NK1和NK2受体的Ki 值分别为 230 nM 和8150 nM。Spantide I 可减少感染角膜的1型细胞因子和增强2型细胞因子IL-10，从而显著减少角膜穿孔。
T35575	Aldehyde Reactive Probe (trifluoroacetate salt)
	DNA is continually damaged by endogenous and environmental agents leading to the formation of abasic (apurinic/apyrimidinic, AP) sites that are disruptive to DNA synthesis. Aldehyde Reactive Probe (ARP) is a biotinylated reagent for the detection and quantification of AP sites in damaged DNA. ARP reacts with aldehyde groups formed when reactive oxygen species depurinate DNA, resulting in covalent linkage of biotin to these AP sites. The biotin-tagged DNA can then be detected using common avidin-...
T35435	β-D-Ribofuranose 1,2,3,5-tetraacetate
	β-D-Ribofuranose 1,2,3,4-tetraacetate is a precursor in the synthesis of nucleosides with antiproliferative activity against cancer cells.1,2 1.Furukawa, Y., and Honjo, M.A novel method for the synthesis of purine nucleosides using Friedel-Crafts catalystsChem. Pharm. Bull. (Tokyo)16(6)1076-1080(1968) 2.Wicke, L., Engels, J.W., Gambari, R., et al.Synthesis and antiproliferative activity of quinolone nucleosides against the human myelogenous leukemia k-562 cell lineArch. Pharm. (Weinheim)346(10)7...
T38222	N-(α-Linolenoyl) Tyrosine
	Certain chronic neurologic disorders, such as Parkinson's disease, are caused by an insufficiency of the neurotransmitter dopamine secondary to the degeneration of substantia nigra dopaminergic neurons. N-(α-Linolenoyl) tyrosine (NALT) is a simple α-amide conjugate between the ω-3 essential fatty acid α-linolenate and the amino acid tyrosine. α-Linolenate is an important precursor to docosahexaenoic acid (DHA), a prominent brain polyunsaturated fatty acid, while tyrosine is the metabolic precurs...
T75337	Cy5.5-SE (DIPEA)
	Cy5.5-SE (Cyanine5.5 NHS ester) DIPEA 是一种以奇数个甲基单位连接两个氮原子的花菁(Cyanine)染料。该染料特点包括长波长、可调吸收发射、高消光系数、良好水溶性及合成相对简单。常用于蛋白、抗体和小分子化合物的标记，特别是蛋白抗体的标记，通过简单混合反应即可完成结合。储存应避光。
T36027	DEPMPO-biotin
	DEPMPO is a nitrone that is used to spin trap reactive O-, N-, S-, and C-centered radicals and allow their characterization when used in association with electron spin resonance. It is noted for the stability of adducts formed. DEPMPO can be used in vitro or in vivo, as it crosses lipid bilayer membranes and is a good trapping agent in biological systems. DEPMPO-biotin is a biotinylated form of DEPMPO which retains the outstanding persistency of its adducts. The biotin moiety offers an effective...
T74120	Cy5 maleimide
	Cy5 maleimide 是一种 CY 染料。CY 为花菁 (Cyanine) 的缩写，是由奇数个甲基单位连接的两个氮原子组成的化合物。菁类化合物具有波长长、吸收和发射可调、消光系数高、水溶性好、合成相对简单等特点。CY 系类染料常被用于蛋白，抗体以及小分子化合物的标记，对于蛋白抗体的标记，可以通过简单的混合反应来完成结合，以下我们介绍了蛋白抗体标记的标记方法，具有一定的参考意义。储存方式：避光。
T37403	O-desmethyl Brinzolamide (hydrochloride)
	O-desmethyl Brinzolamide is an active metabolite of the carbonic anhydrase (CA) inhibitor brinzolamide .1,2It inhibits CAII and CAIV (IC50s = 0.136 and 165 nM, respectively).1 1.Huang, Q., Rui, E.Y., Cobbs, M., et al.Design, synthesis, and evaluation of NO-donor containing carbonic anhydrase inhibitors to lower intraocular pressureJ. Med. Chem.58(6)2821-2833(2015) 2.Lo Faro, A.F., Tini, A., Gottardi, M., et al.Development and validation of a fast ultra-high-performance liquid chromatography tand...
T37344	5,6-dimethyl-2-Thiouracil
	5,6-dimethyl-2-Thiouracil is a heterocyclic building block that has been used in the synthesis of anti-HIV-1 pyrimidinones.1 It has also been used as an internal standard for the quantification of thyreostats, including 2-thiouracil, in bovine plasma.2 \|1. Navrotskii, M.B. Synthesis and anti-HIV-1 activity of new 2-[(2-phthalimidoethyl)thio]-4(3H)-pyrimidinone derivatives. Pharm. Chem. J. 39(9), 466-467 (2005).\|2. Schmidt, K.S. In-house validation and factorial effect analysis of a liquid chroma...
T37246	Palonosetron N-oxide
	Palonosetron N-oxide is a metabolite of the serotonin (5-HT) receptor subtype 5-HT3antagonist palonosetron .1It is also a potential impurity in palonosetron preparations.2Palonosetron N-oxide is a degradation product formed by exposure to oxidative stress. 1.Stoltz, R.A., Cyong, J.-C., Shah, A., et al.Pharmacokinetic and safety evaluation of palonosetron, a 5-hydroxytryptamine-3 receptor antagonist, in U.S. and Japanese healthy subjectsJ. Clin. Pharmacol.44(5)520-531(2004) 2.Vishnu Murthy, M., S...
T37002	7-Fluoro-2,1,3-benzoxadiazole-4-sulfonate (ammonium salt)
	7-Fluoro-2,1,3-benzoxadiazole-4-sulfonate (SBD-F) is a thiol-reactive fluorogenic probe.1It has been used to quantify the levels of homocysteine, cysteine, and cysteamine in human plasma.2SBD-F displays excitation/emission maxima of 380/515 nm, respectively.1 1.Imai, K., Toyo’oka, T., and Watanabe, Y.A novel fluorogenic reagent for thiols: Ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonateAnal. Biochem.128(2)471-473(1983) 2.Ichinose, S., Nakamura, M., Maeda, M., et al.A validated HPLC-fluoresc...
T35929	O-Demethyl Apremilast
	O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast .1It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-α production in isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 8.3 and 5.6 μM, respectively). O-Demethyl apremilast is also an oxidative degradation product of apremilast.2,3 1.Hoffmann, M., Kumar, G., Schafer, P., et al.Disposition, metabolism and mass balance of [14C]apremilast following oral admi...
T36929	Pal-KTTKS (acetate)
	Pal-KTTKS is a lipidated pentapeptide consisting of a fragment of the type I collagen C-terminal propeptide conjugated to palmitic acid .1 It increases collagen production in human corneal and dermal fibroblasts when used at concentrations of 0.002, 0.004, and 0.008 wt%.2 Following topical administration, pal-KTTKS (50 μg/cm2) is found in the stratum corneum, epidermis, and dermis of isolated hairless mouse skin.1 It can self-assemble into flat tapes and extended fibrillar structures.3 Pal-KTTKS...
T35568	BODIPY-aminoacetaldehyde diethyl acetal
	BODIPY-aminoacetaldehyde diethyl acetal (BAAA-DA) is a stable precursor to BODIPY-aminoacetaldehyde, a cell-permeable fluorescent substrate for aldehyde dehydrogenase (ALDH).1,2BODIPY-aminoacetaldehyde diethyl acetal is converted under acidic conditions to BODIPY-aminoacetaldehyde (BAAA).2BAAA is cell-permeant and is converted intracellularly by ALDH to BODIPY aminoacetate (BAA), which is retained by cells and can be used to identify cells with high ALDH activity.1BAA is a substrate for the effl...

化合物

Cat.No: T20600

Synonym: Clay 347,Hydrated aluminum silicate,Bolus alba,HSDB 630,Altowhite,China clay,高岭土

Target: Others

1-Naphthyl acetate

Cat.No: T19084

Target: AChE

Cat.No: T20000

Synonym: 4-(4,5-二苯基-1H-咪唑-2-基)苯甲酸

Target: HIV Protease

Cat.No: T19080

Synonym: 1,2-二油酰-SN-甘油-3-磷酰乙醇胺

Target: Others

Cat.No: T19027

Target: Others

NLS PKKKRKV acetate(95088-49-6 free base)

Cat.No: TP1606L

Target: Others

Cat.No: T70885

2-Nitrobenzaldehyde semicarbazone 13C,15N2

Cat.No: T40874

Synonym: 2-Nitrobenzaldehyde semicarbazone 13C,15N2

Cat.No: T10982

Synonym: 2',3'-Dideoxyadenosine 5'-triphosphate

Target: Others

Cat.No: T31172

Synonym: DA-3505,DA3505

Cat.No: T20584

Synonym: Heptyl phenyl ketone,Caprylophenone

Ru(bpy)2(dcbpy)NHS dihexafluorophosphate

Cat.No: T81250

Cat.No: TP1606

Synonym: NLS PKKKRKV

Cat.No: T27376

Synonym: FR186054,FR 186054

Cyanine 5 Tyramide

Cat.No: T38902

Synonym: Tyramide-Cy5

Cat.No: T75108

Cat.No: T39547

Synonym: Thiol-green 1,Naph-EA-mal

O-Des[2-aminoethyl]-O-carboxymethyl dehydroamlodipine

Cat.No: T35602

8-hydroxy Amoxapine

Cat.No: T37161

Cat.No: T63116

(+)-JQ1 maleimide

Cat.No: T83929

Cat.No: T75837

Aldehyde Reactive Probe (trifluoroacetate salt)

Cat.No: T35575

β-D-Ribofuranose 1,2,3,5-tetraacetate

Cat.No: T35435

N-(α-Linolenoyl) Tyrosine

Cat.No: T38222

Cy5.5-SE (DIPEA)

Cat.No: T75337

Cat.No: T36027

Cat.No: T74120

O-desmethyl Brinzolamide (hydrochloride)

Cat.No: T37403

5,6-dimethyl-2-Thiouracil

Cat.No: T37344

Palonosetron N-oxide

Cat.No: T37246

7-Fluoro-2,1,3-benzoxadiazole-4-sulfonate (ammonium salt)

Cat.No: T37002

O-Demethyl Apremilast

Cat.No: T35929

Pal-KTTKS (acetate)

Cat.No: T36929

BODIPY-aminoacetaldehyde diethyl acetal

Cat.No: T35568

Cat. No.	Product Name	Target	Signaling Pathways
T8067	Methyl Nonadecanoate Nonadecanoic Acid methyl ester,正十九酸甲酯	Others	Others
	Methyl Nonadecanoate (Nonadecanoic Acid methyl ester)是一种内标物，能够用于生物柴油中脂肪酸甲酯含量的测定。
TN1084	1,3,5,8-Tetrahydroxyxanthone Desmethylbellidifolin,去甲基雏叶龙胆酮	Anti-infection	Microbiology/Virology
	1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) 是一种天然黄酮，从 Gentianella acuta 中提取得到。它具有镇痉作用和抗炎作用。
T4869	D-Allose 阿洛糖,β-D-Allopyranose,D-(+)-ALLOSE	Others; Endogenous Metabolite	Metabolism; Others
	D-Allose (β-D-Allopyranose) 是内源性代谢产物的一种。
T4S0094	Hydroxygenkwanin 羟基芫花素,Luteolin 7-methylether,7-O-Methylluteolin	Antioxidant	oxidation-reduction
	Hydroxygenkwanin (Luteolin 7-methylether) 是一种丁香达芙妮的主要成分，是一种天然的类黄酮化合物。它具有抗氧化，抗神经胶质瘤能力和抗癌作用。
T5S2254	Swertianolin Bellidifolin-8-O-Glucoside,当药醇苷	Others; HBV; Antibacterial; AChE	Microbiology/Virology; Neuroscience; Others
	Swertianolin (Bellidifolin-8-O-Glucoside) 是从Gentianella Acuta 分离得到的一种黄酮，具有抗 HBV 和抗菌活性，可抑制乙酰胆碱酯酶。
T0194	Chloroquine phosphate Chloroquine diphosphate,Aralen phosphate,磷酸氯喹,Chingamin phosphate	SARS-CoV; TLR; HIV Protease; Antibiotic; Parasite; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Chloroquine phosphate (Aralen phosphate) 是广泛用于疟疾和类风湿性关节炎的抗疟疾和抗炎剂。它是autophagy 和toll-like receptors 抑制剂，有效抑制SARS-CoV-2(COVID-19) 感染 (EC50=1.13 μM)。
TN4650	Nervogenic acid	Antifection	Microbiology/Virology
	Nervogenic acid has antioxidative, pro-coagulant, and antibacterial activities, it exhibits higher activity than that of t-butyl-4- hydroxyanisole (BHA) using the ferric thiocyanate method.
T66903	Gallic Acid Monohydrate
	Gallic acid may be used as a standard in the photometric determination of total phenolics content by Folin-Ciocalteu method with potential role in epigenetic therapy of human cancers.
TN5240	Vitedoin A	Others	Others
	Vitedoin A shows stronger antioxidative activity than alpha-tocopherol using the ferric thiocyanate method, it also shows higher radical-scavenging effect on the stable free radical, 1,1-diphenyl-2-picrylhydrazyl, than L-cysteine.
T10194	7-Methylguanine	Others	Others
	7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents and used as a probe of DNA–protein interactions and a key component of the DNA sequencing method.
TN3741	Cyclocurcumin	TNF; ROS	Apoptosis; Immunology/Inflammation
	Cyclocurcumin, a curcumin derivative, exhibits anticancer, anti-inflammatory, and immune-modulating abilities and is a potential compound for the treatment of rheumatoid arthritis as predicted by the MM-PBSA method. It may have a therapeutic potential as

天然产物

Methyl Nonadecanoate

Cat.No: T8067

Synonym: Nonadecanoic Acid methyl ester,正十九酸甲酯

Target: Others

1,3,5,8-Tetrahydroxyxanthone

Cat.No: TN1084

Synonym: Desmethylbellidifolin,去甲基雏叶龙胆酮

Target: Anti-infection

Cat.No: T4869

Synonym: 阿洛糖,β-D-Allopyranose,D-(+)-ALLOSE

Target: Others, Endogenous Metabolite

Hydroxygenkwanin

Cat.No: T4S0094

Synonym: 羟基芫花素,Luteolin 7-methylether,7-O-Methylluteolin

Target: Antioxidant

Cat.No: T5S2254

Synonym: Bellidifolin-8-O-Glucoside,当药醇苷

Target: Others, HBV, Antibacterial, AChE

Chloroquine phosphate

Cat.No: T0194

Synonym: Chloroquine diphosphate,Aralen phosphate,磷酸氯喹,Chingamin phosphate

Target: SARS-CoV, TLR, HIV Protease, Antibiotic, Parasite, Autophagy

Nervogenic acid

Cat.No: TN4650

Target: Antifection

Gallic Acid Monohydrate

Cat.No: T66903

Cat.No: TN5240

Target: Others

7-Methylguanine

Cat.No: T10194

Target: Others

Cat.No: TN3741

Target: TNF, ROS

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