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18

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T2649	Menin-MLL inhibitor MI-2 Menin-MLL Inhibitor,MI2,MI-2,Menin-MLL inhibitor 2,MI 2	Apoptosis; Epigenetic Reader Domain; Histone Methyltransferase	Apoptosis; Chromatin/Epigenetic
	Menin-MLL inhibitor MI-2 (MI2) 抑制Menin-MLL 相互作用，IC50为 446±28 nM。
T28036	MI-2-2 MI22,MI 2 2	Histone Methyltransferase	Chromatin/Epigenetic
	MI-2-2 是一种抑制 menin 和 MLL 之间二价蛋白质-蛋白质相互作用的抑制剂，IC50 为 46 nM。 MI-2-2 与 menin 结合，Kd 为 22 nM。
T2350	MALT1 inhibitor MI-2 MALT1 inhibitor,MI 2,MI 2 (MALT1 inhibitor)	MALT	Immunology/Inflammation
	MI 2 (MALT1 inhibitor) 是一种MALT1抑制剂 (IC50=5.84 μM)，对动物无毒性。它能够直接与 MALT1 结合，不可逆地抑制蛋白酶功能，并伴有 NF-κB 报告子活性抑制、c-REL 核定位抑制和 NF-κB 靶基因下调。
T22978	MI-2 (hydrochloride)	Others	Others
	MI-2 (Menin-MLL Inhibitor) is an effective menin-MLL interaction inhibitor (IC50: 446 ± 28 nM).
T6585	SAR405838 MI773,MI 773,MI-77301,MI-773	Mdm2; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	SAR405838 (MI 773) 是 MI-773 的类似物，具有抗肿瘤活性。它是一种高效、选择性的MDM2-p53相互作用抑制剂，与 MDM2 结合的Ki 值为 0.88 nM。
T28029	Methylisothiazolinone hydrochloride N-Methylisothiazolin-3-one,MI,2-甲基-4-异噻唑啉-3-酮盐酸盐,KB-838,Methylisothiazolinone HCl
	Methylisothiazolinone is a powerful synthetic biocide and preservative.
T13748	L-2-Hydroxyglutaric acid disodium S-2-羟基戊二酸,(S)-2-Hydroxyglutaric acid disodium	Histone Demethylase; Mitochondrial Metabolism	Chromatin/Epigenetic; Metabolism
	L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) 是一种表观遗传修饰因子，是肾癌中的表观遗传修饰剂和推定的癌代谢物，可用于肾癌的相关研究。它抑制线粒体肌酸激酶活性，Km 和 Ki 分别为 2.52 mM 和11.13 mM。它可抑制组蛋白去甲基化酶，从而促进组蛋白甲基化。
T69524	MI-09
	MI-09 is a SARS-CoV-2 Protease inhibitor (IC50 = 15.2 nM). In a transgenic mouse model of SARS-CoV-2 infection, oral or intraperitoneal treatment with MI-09 significantly reduced lung viral loads and lung lesions.
T69640	MI-1851
	MI-1851 is a potent peptidomimetic inhibitor. MI-1851could prevent proteolytic processing of the S protein from SARSCoV-2 by endogenous furin in HEK293 cells.
T69541	MI-23
	MI-23 is a SARS-CoV-2 Protease inhibitor (IC50 = 7.6 nM).
T69540	MI-30
	MI-30 is a SARS-CoV-2 Protease inhibitor (IC50 = 17.2 nM). In a transgenic mouse model of SARS-CoV-2 infection, oral or intraperitoneal treatment, MI-30 significantly reduced lung viral loads and lung lesions.
T68394	MI-219
	MI-219 is a human double minute 2 (HDM2) inhibitor.
T21898	MI-192
	MI-192 是一种选择性 HDAC2和 HDAC3抑制剂，IC50分别为 30 nM 和 16 nM。MI-192 比其他 HDAC 异构体对 HDAC2/3 具有更高选择性。MI-192 诱导髓系白血病细胞凋亡 (apoptosis)。抗癌和神经保护活性。
T71223	SR-33805
	SR-33805 is a calcium channel antagonist potentially for the treatment of atherosclerosis and heart failure. SR-33805 restored the MI-altered cell shortening without affecting the Ca(2+) transient amplitude, suggesting an increase of myofilament Ca(2+) sensitivity in MI myocytes. A SR33805-induced sensitization of myofilament activation was found to be associated with a slight increase in myosin light chain-2 phosphorylation and a more significant decrease on troponin I (TnI) phosphorylation. D...
T73661	Delcasertib hydrochloride
	Delcasertib (KAI-9803) hydrochloride 是有效，选择性的 δ 蛋白激酶 C (δPKC) 抑制剂。Delcasertib (KAI-9803) hydrochloride 可改善急性心肌梗死动物模型的缺血再灌注损伤。
T78887	ROS-IN-2	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	ROS-IN-2 (compound 85) 为次狼烷三萜衍生物，具有抑制细胞内过量ROS及其他氧化应激源生成的作用，从而保护线粒体避免受损。该化合物在心肌缺血/再灌注（MI/R）损伤研究中具有潜在应用价值。
T74247	TPE-MI
	TPE-MI（Tetraphenylethene maleimide）在与马来酰亚胺与硫醇反应前不具荧光性。在与游离的半胱氨酸硫醇标记时，其荧光被激活，后者多在球形蛋白质的核心，仅在展开时显露。TPE-MI适用于测量细胞中未折叠蛋白质的负荷，并能在亨廷顿病诱导的多能干细胞模型中监测蛋白质平衡失衡，以及在形成可见聚合体之前，监测转染突变亨廷顿外显子1的细胞的状况。此外，TPE-MI用于检测双氢青蒿素处理后疟疾寄生虫的蛋白质损伤。应暗处储存。
T37963	Methylchloroisothiazolinone/Methylisothiazolinone Mixture
	Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) is a mixture of isothiazolinone-derived biocides.1,2It is effective against Gram-positive and Gram-negative bacteria with MIC values of 0.0002, 0.0002, 0.00005, and 0.00005% (w/w) forS. aureus,P. aeruginosa,A. niger, andC. albicans, respectively.2MCIT/MIT can elicit contact sensitization.3Formulations containing MCIT/MIT have been used for controlling microbial growth in industrial and household products. 1.Frenzel, E., Schmidt...

化合物

Menin-MLL inhibitor MI-2

Cat.No: T2649

Synonym: Menin-MLL Inhibitor,MI2,MI-2,Menin-MLL inhibitor 2,MI 2

Target: Apoptosis, Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: T28036

Synonym: MI22,MI 2 2

Target: Histone Methyltransferase

MALT1 inhibitor MI-2

Cat.No: T2350

Synonym: MALT1 inhibitor,MI 2,MI 2 (MALT1 inhibitor)

Target: MALT

MI-2 (hydrochloride)

Cat.No: T22978

Target: Others

Cat.No: T6585

Synonym: MI773,MI 773,MI-77301,MI-773

Target: Mdm2, E1/E2/E3 Enzyme

Methylisothiazolinone hydrochloride

Cat.No: T28029

Synonym: N-Methylisothiazolin-3-one,MI,2-甲基-4-异噻唑啉-3-酮盐酸盐,KB-838,Methylisothiazolinone HCl

L-2-Hydroxyglutaric acid disodium

Cat.No: T13748

Synonym: S-2-羟基戊二酸,(S)-2-Hydroxyglutaric acid disodium

Target: Histone Demethylase, Mitochondrial Metabolism

Cat.No: T69524

Cat.No: T69640

Cat.No: T69541

Cat.No: T69540

Cat.No: T68394

Cat.No: T21898

Cat.No: T71223

Delcasertib hydrochloride

Cat.No: T73661

Cat.No: T78887

Target: Reactive Oxygen Species

Cat.No: T74247

Methylchloroisothiazolinone/Methylisothiazolinone Mixture

Cat.No: T37963

Cat. No.	Product Name	Target	Signaling Pathways
T13749	L-2-Hydroxyglutaric acid (S)-2-Hydroxyglutaric acid	Others	Others
	L-2-Hydroxyglutaric acid, an epigenetic modifier and potential oncometabolite in renal cancer, impedes mitochondrial creatine kinase (Mi-CK) activity, exhibiting Km and Ki values of 2.52 mM and 11.13 mM, respectively. Additionally, it obstructs histone demethylases, thereby encouraging histone methylation.

天然产物

L-2-Hydroxyglutaric acid

Cat.No: T13749

Synonym: (S)-2-Hydroxyglutaric acid

Target: Others

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