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Search Results for " lovo "

14

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T41248	Thiocolchicine	Microtubule Associated	Cytoskeletal Signaling
	Thiocolchicine 是一种有效的微管蛋白聚合抑制剂，IC50 为 2.5 µM，Ki 为 0.7 µM。 Thiocolchicine 诱导细胞凋亡。 Thiocolchicine 可用作 ADC 技术中的 ADC 细胞毒素。
T4435	E7820 ER68203-00	Integrin	Cytoskeletal Signaling
	E7820 (ER68203-00) 是具有口服活性芳香族磺酰胺衍生物，是一种血管生成抑制剂，可抑制内皮上整合素 α2 亚基的表达。它调节 α1，α2，α3 和 α5 整联素 mRNA 表达，具有抗血管生成和抗肿瘤活性。它抑制大鼠主动脉血管生成，IC50为 0.11 μg/ml。
T27047	Clovoxamine fumarate DU23811 fumarate,DU 23811 fumarate,DU-23811 fumarate	5-HT Receptor; Serotonin Transporter; Norepinephrine	GPCR/G Protein; Neuroscience
	Clovoxamine fumarate (DU 23811 fumarate) 是一种 5-羟色胺再摄取、血清素和去甲肾上腺素抑制剂，具有抗抑郁和抗惊厥活性。
T61808	ATR-IN-14
	ATR-IN-14 (compound 1) is a powerful ATR kinase inhibitor that significantly inhibits ATR signaling pathways following CHKI protein phosphorylation, demonstrating a remarkable inhibition rate of 98.03% at 25 nM. Moreover, ATR-IN-14 exhibits notable anticancer efficacy in LoVo cells, displaying an IC50 value of 64 nM [1].
T61432	ATR-IN-16
	ATR-IN-16 (compound 46) is a highly effective ATR kinase inhibitor, exhibiting considerable anticancer activity in LoVo cells, as demonstrated by its IC 50 value of 410 nM [1].
T62548	ATR-IN-17
	ATR-IN-17 是一种 ATR 激酶的有效抑制剂，在 LoVo 细胞中具有良好的抗癌效果 (IC50: 1 nM)。
T63604	ATR-IN-18
	ATR-IN-18 是口服具有活力的 ATR 激酶抑制剂 (IC50: 0.69 nM)。ATR-IN-18 在 LoVo 细胞中表现出抗增殖效果 (IC50: 37.34 nM)。ATR-IN-18 显示出抗肿瘤作用。
T22490	2,3-DCPE hydrochloride	Others	Others
	Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways. IC50 values are 0.89 and 12.6 μM for LoVo human colon cancer cell line and normal human fibroblasts respectively.
T74771	Diaporthein B
	Diaporthein B 是氧化程度极高的 pimarane 二萜之一。Diaporthein B 表现出抗结核分枝杆菌的活性，MIC 为 3.1 μg/mL。Diaporthein B 显示对 HCT 116 和 LoVo 结肠癌细胞的 IC50为 1.5-3 μM/L。
T78959	ATR-IN-23	ATM/ATR	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	ATR-IN-23 (Compound 34) 是一种选择性ATR抑制剂，其IC50为 1.5 nM。该化合物对LoVo细胞表现出抗增殖活性，并对HT-29细胞产生合成致死效果，适用于研究DNA损伤反应(DDR)缺陷癌症。
T61587	ATR-IN-15
	ATR-IN-15 (compound 1) is a highly potent and orally active inhibitor of ATR kinase with an IC50 of 8 nM. Additionally, ATR-IN-15 demonstrates inhibitory activity against several targets, including human colon tumor cells LoVo, DNA-PK, and PI3K, with IC50 values of 47, 663, and 5131 nM, respectively [1].
T63521	Bcl-2-IN-7
	Bcl-2-IN-7 是 Bcl-2(b 细胞淋巴瘤 -2) 的有效抑制剂，能够下调 Bcl-2 的表达，提高 p53、Bax、caspase-7 mRNA 的表达，能够诱导乳腺癌 MCF-7 细胞周期阻滞和凋亡。Bcl-2-IN-7 对 MCF-7 细胞 (IC50: 20.17 μM)、LoVo 细胞 (IC50: 22.64 μM)、HepG2 细胞 (IC50:45.57 μM) 和 A549 细胞 (IC50: 51.50 μM)均表现出良好的抗肿瘤活性。
T63676	Bcl-2-IN-6
	Bcl-2-IN-6 是 Bcl-2 (b 细胞淋巴瘤-2) 的有效抑制剂，可下调 Bcl-2 的表达，并提高 p53、Bax、caspase-7 mRNA 的表达。Bcl-2-IN-7 能够诱导乳腺癌 MCF-7 细胞周期阻滞和凋亡。Bcl-2-IN-7 能够作用于 MCF-7 细胞 (IC50: 20.91 μM)、LoVo 细胞 (IC50: 22.30 μM)、HepG2 细胞 (IC50: 42.29 μM) 和 A549 细胞 (IC50: 48.00 μM) 均显示出良好的抗肿瘤效果。
T35897	ASK120067
	ASK120067 is a potent and orally active inhibitor of EGFRT790M (IC50:0.3 nM) with selectivity over EGFRWT (IC50:6.0 nM). ASK120067 is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC)[1]. In the in vitro kinase assay ASK120067 potently inhibits the EGFR L858R/T790M and EGFR T790M resistant mutants with IC50 values of 0.3 nM and 0.5 nM, respectively, as well as the EGFRexon19del sensitizing mutant (IC50= 0.5 nM). The 50 of ASK120067 against wild-type EGFR (EGFRWT...

化合物

Cat.No: T41248

Target: Microtubule Associated

Cat.No: T4435

Synonym: ER68203-00

Target: Integrin

Clovoxamine fumarate

Cat.No: T27047

Synonym: DU23811 fumarate,DU 23811 fumarate,DU-23811 fumarate

Target: 5-HT Receptor, Serotonin Transporter, Norepinephrine

Cat.No: T61808

Cat.No: T61432

Cat.No: T62548

Cat.No: T63604

2,3-DCPE hydrochloride

Cat.No: T22490

Target: Others

Cat.No: T74771

Cat.No: T78959

Target: ATM/ATR

Cat.No: T61587

Cat.No: T63521

Cat.No: T63676

Cat.No: T35897

Cat. No.	Product Name	Target	Signaling Pathways
TN3920	Effusanin A	Raf; Antifection	MAPK; Microbiology/Virology
	Effusanin A 是一种存在于Isodon rugosus 之中的天然产物。它具有 DNA 损伤和抗菌作用。
T36886	Pestalotin
	Pestalotin is a fungal metabolite originally isolated from P. cryptomeriaecola with diverse biological activities. It induces reducing sugar release in embryoless rice endosperms when used at concentrations ranging from 3 to 100 mg/L and enhances growth of rice seedlings (O. sativa) when used in combination with gibberellin A3 at concentrations ranging from 30 to 500 mg/L. Pestalotin has antifungal activity, reducing the growth of C. albicans, C. neoformans, T. rubrum, and A. fumigatus (MICs = 1...

天然产物

Cat.No: TN3920

Target: Raf, Antifection

Cat.No: T36886

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