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Cat. No.	Product Name	Target	Signaling Pathways
T0468	Lidocaine Lignocaine,Alphacaine,Xylocaine,利多卡因	Apoptosis; ERK; NF-κB; MEK; Sodium Channel; Histamine Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; Membrane transporter/Ion channel; Neuroscience; NF-κB
	Lidocaine (Alphacaine) 是一种酰胺衍生物，抑制涉及复杂电压和依赖性的钠通道，可用于研究室性心律失常。它通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长，迁移和侵袭。
T1144	Lidocaine hydrochloride Lidocaine HCL,盐酸利多卡因,Lignocaine hydrochloride,Xyloneural,Lidothesin	Apoptosis; ERK; NF-κB; MEK; Sodium Channel	Apoptosis; MAPK; Membrane transporter/Ion channel; NF-κB
	Lidocaine hydrochloride (Lignocaine hydrochloride) 抑制涉及复杂电压和依赖性的钠通道。它通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长，迁移和侵袭。Lidocaine 是一种酰胺衍生物，是一种研究室性心律失常的药物和有效的肿瘤抑制剂。
T1144L	Lidocaine Hydrochloride hydrate	EGFR; Sodium Channel	Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors
	Lidocaine Hydrochloride hydrate 是一种酰胺类局部麻醉剂，具有抗炎作用。
T23213	QX-222 chloride QX 222,Lidocaine N-Methyl Hydrochloride	Sodium Channel	Membrane transporter/Ion channel
	QX-222 chloride (Lidocaine N-Methyl Hydrochloride) 是 Lignocaine 的一种三甲基类似物，是有效的 Na+通道阻滞剂。
T25720	Lidocaine methiodide Methyllidocaine iodide,N-Methyllidocaine
	Lidocaine methiodide is an antiarrythmic. It is also exhibiting arrythmogenic effects in subjects.
T8341	QX 314 QX-314	Others	Others
	QX 314 (Lidocaine N-ethyl bromide) 是一种非膜渗透性阻滞剂，可抑制酸诱导的食管伤害性 C 纤维神经元活化。
T13177L	Tocainide	Sodium Channel	Membrane transporter/Ion channel
	Tocainide 是口服有活性的 sodium channel 阻滞剂，阻断产生疼痛的病灶中(神经膜上)的钠通道。它是利多卡因 (lignocaine) 的伯胺类似物，可用于研究心律不齐。
T10679	Carcainium chloride 卡氯铵,QX 572,Carcainium (chloride),Carcainiumchloride,RSD 931	Others	Others
	Carcainium chloride (Carcainium (chloride)) 是利多卡因的衍生物，具有镇咳作用。
T9530	W 36017	Others	Others
	W36017 是利多卡因的一种杂质，其阻滞神经活性的pKa 为 7.4。
T26287	Transcainide R54718,R 54718,R-54718	Sodium Channel	Membrane transporter/Ion channel
	Transcainide(R 54718) 是一种新的利多卡因类似物，是具有口服活性的抗心律失常剂。Transcainide 可阻断牛心脏和大鼠骨骼肌中 BTX 激活的钠通道的开放状态。
T13177	Taquidil
	Tocainide hydrochloride 是一种sodium channel 阻滞剂，它阻断神经膜中产生疼痛的病灶中的钠通道。Tocainide hydrochloride 是利多卡因 (lignocaine) 的一种伯胺类似物，可有效抑制各种情况下的室性心律失常。
T1098	Denatonium benzoate 苯甲地那铵,THS-839	Others	Others
	Denatonium benzoate (THS-839) 是一种已知的最苦的化合物，可作为厌恶剂(苦味剂)，加入到工业酒精、防冻液、咬指甲癖预防、呼吸器面罩配合测试、动物驱虫剂、液体皂和洗发水中，防止不适当的摄取。
T34253	Rad 242 Rad242,Rad-242
	Rad 242 is a hydrophobic lidocaine derivative.
T30861	CH 200 CH-200,CH200,06-14C
	CH 200 is a novel antiarrhythmic drug that inhibits arrhythmias in beagles more effectively than procainamide and lidocaine.
T20732	Lignocaine N-oxide
	Lignocaine N-oxide is a metabolite of Lidocaine, which is an antiarrhythmic and anesthetic agent.
T80638	Glycinexylidide GX	MEK	MAPK
	Glycinexylidide (GX) 是一种 Lidocaine 的活性代谢物。作为有效的局部麻醉药，Lidocaine 可以通过阻断复杂电压依赖性的钠通道来发挥作用。此外，它还能抑制胃癌细胞生长、迁移和侵袭。GX 显示出在麻醉、癌症治疗和心血管疾病研究中的应用潜力。
T37670	CAY10568
	Most local anesthetics act by abolishing voltage gated sodium channel currents indiscriminately in all populations of neurons. Selective analgesia through TRPV1-mediated entry of a cationic lidocaine derivative, QX314, was recently reported. CAY10568 is a physically smaller, less hydrophobic version of QX314 designed to be even more permeable to TRPV1 ion channel when activated by agonists such as capsaicin and N-oleoyl dopamine. CAY10568 when given in combination with suitable TRPV1 agonists sh...

化合物

Cat.No: T0468

Synonym: Lignocaine,Alphacaine,Xylocaine,利多卡因

Target: Apoptosis, ERK, NF-κB, MEK, Sodium Channel, Histamine Receptor

Lidocaine hydrochloride

Cat.No: T1144

Synonym: Lidocaine HCL,盐酸利多卡因,Lignocaine hydrochloride,Xyloneural,Lidothesin

Target: Apoptosis, ERK, NF-κB, MEK, Sodium Channel

Lidocaine Hydrochloride hydrate

Cat.No: T1144L

Target: EGFR, Sodium Channel

QX-222 chloride

Cat.No: T23213

Synonym: QX 222,Lidocaine N-Methyl Hydrochloride

Target: Sodium Channel

Lidocaine methiodide

Cat.No: T25720

Synonym: Methyllidocaine iodide,N-Methyllidocaine

Cat.No: T8341

Synonym: QX-314

Target: Others

Cat.No: T13177L

Target: Sodium Channel

Carcainium chloride

Cat.No: T10679

Synonym: 卡氯铵,QX 572,Carcainium (chloride),Carcainiumchloride,RSD 931

Target: Others

Cat.No: T9530

Target: Others

Cat.No: T26287

Synonym: R54718,R 54718,R-54718

Target: Sodium Channel

Cat.No: T13177

Denatonium benzoate

Cat.No: T1098

Synonym: 苯甲地那铵,THS-839

Target: Others

Cat.No: T34253

Synonym: Rad242,Rad-242

Cat.No: T30861

Synonym: CH-200,CH200,06-14C

Lignocaine N-oxide

Cat.No: T20732

Glycinexylidide

Cat.No: T80638

Synonym: GX

Target: MEK

Cat.No: T37670

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