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18

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T31570	DPBX-L-Dopa DPBX L-Dopa
	DPBX-L-Dopa is a boron-containing dopa-derivative, acting as a bladder relaxant through non-catecholamine receptors.
T36122	3-O-methyl-L-DOPA (hydrate)
	3-O-methyl-L-DOPA is a metabolite of L-DOPA , produced by the activity of catechol O-methyltransferase. 3-O-methyl-L-DOPA may have effects of its own or it may compete with the actions of L-DOPA.
T24047	Etilevodopa hydrochloride Levodopa ethyl ester,Etilevodopa HCl, L-DOPA ethyl ester	Others; Dopamine Receptor; Drug Metabolite	GPCR/G Protein; Metabolism; Neuroscience; Others
	Etilevodopa hydrochloride (L-DOPA ethyl ester) 是 Levodopa 的前药，在胃肠道中被非特异性酯酶快速水解产生 Levodopa 和乙醇。Levodopa 是多巴胺的前体，有助于中枢神经系统的渗透和传递多巴胺。Etilevodopa HCl 可用于帕金森病 (PD)的相关研究。
T31823	Fluorodopa F 18 Fluorodopa (18F),6-(18F)Fluoro-L-DOPA,F-DOPA,L-6-(18F)Fluoro-DOPA,6-(18F)Fluorodopamine
	Fluorodopa F 18 can be used as radioactive agent.
T34589	SD-1077 d3-L-DOPA,deuldopa,deuterated levodopa,SD1077
	SD-1077, also known as d3-L-DOPA, is a deuterium containing levodopa. SD-1077 has been shown in preclinical models to improve the half-life of dopamine in the brain resulting in a prolonged treatment effect.
T74180	[18F]-Labeled L-dopa precursor
	[18F]-Labeled L-dopa precursor 是用于合成 18F-labeled L-dopa 的前体。
T1517	Benserazide hydrochloride Benserazide HCl,盐酸苄丝肼,Serazide,Ro 4-4602	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Benserazide hydrochloride (Ro 4-4602) 是一种芳香族 L-氨基酸脱羧酶（AADC）的抑制剂，常用于帕金森病。
TP2050L	CTAP(TFA） (103429-32-9 free base) CTAP(TFA）	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	CTAP(TFA) (103429-32-9 free base) 是一种有效的、高度选择性的、脑渗透性 μ-阿片受体拮抗剂，IC50 为 3.5 nM。它的选择性比 δ 阿片类药物 (IC50=4500 nM) 和生长抑素受体高 1200 倍以上。 CTAP TFA 可用于研究 L-DOPA 诱导的运动障碍 (LID)
T7746	Eltoprazine dihydrochloride	Others	Others
	Eltoprazine dihydrochloride 是一种先前开发用于攻击性的药物，已在帕金森病 (PD) 的动物模型和运动障碍 PD 患者中研究了左旋多巴诱导的运动障碍。
T0115	Idazoxan hydrochloride RX 781094,盐酸咪唑克生	Adrenergic Receptor; Imidazoline Receptor	GPCR/G Protein; Neuroscience
	Idazoxan hydrochloride (RX 781094) 是一种 α2-肾上腺素受体拮抗剂，改善帕金森氏病、L-DOPA 引起的运动障碍和实验性帕金森病的运动症状。它也是咪唑啉受体拮抗剂，可竞争性拮抗唑啉样药物的中枢性降压作用。
T8637	DMNB 6-Nitroveratraldehyde,6-硝基藜芦醛	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	DMNB (6-Nitroveratraldehyde) 可用于合成no-carrier-added 6-[18F]fluoro-L-DOPA (6-FDOPA)。它可用于研究多巴胺能系统的PET。
T15701	Methyldopa hydrochloride L-(-)-α-Methyldopa hydrochloride,MK-351 hydrochloride	Others	Others
	L-(-)-α-Methyldopa hydrochloride is an alpha-adrenergic agonist psychoactive drug. It is used as a sympatholytic or antihypertensive. Methyldopa has a dual mechanism of action. It is a competitive inhibitor of the enzyme DOPA decarboxylase, which converts
T16279	Nebicapone BIA 3-202	Others	Others
	Nebicapone is a reversible catechol-O-methyltransferase (COMT) inhibitor and is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of CO
T20396	Levadopa Related Compound A 6-Hydroxydopa, L-,L-Hydroxydopa
	Levadopa Related Compound A is the 6-hydroxy derivative of the amino acid L-DOPA with neurotoxic properties. Exogenously administered 6-Hydroxy-L-DOPA is biotransformed by an amino acid decarboxylase to the highly potent and catecholamine-selective neurot
T37605	D-DOPA
	D-DOPA is an enantiomer of the dopamine precursor L-DOPA . It can be converted to L-DOPAviasequential oxidation and transamination, which are mediated by D-amino acid oxidase (DAAO) and DOPA transaminase, respectively, in rat kidney homogenates.1It reduces the number of dopaminergic neurons in primary rat embryonic mesencephalic cultures in a concentration-dependent manner.2Intraventricular administration of D-DOPA (200 μg/animal) increases striatal dopamine levels in rats.3D-DOPA (20 mg/kg, i.p...
T72703	Tyrosinase-IN-11
	Tyrosinase-IN-11 是一种有效的酪氨酸酶 (tyrosinase) 抑制剂，对 L-酪氨酸酶和 L-多巴的 IC50值分别为 50 nM 和 64 nM。Tyrosinase-IN-11 具有显着的抗氧化活性和低细胞毒性。Tyrosinase-IN-11 具有用于皮肤色素沉着过度研究的潜力。
T75917	CTAP TFA
	CTAP TFA 是一种强效、高选择性的、可透过血脑屏障的阿片受体 (μopioid receptor) 拮抗剂，IC50为 3.5 nM。CTAP TFA 对δ opioid 受体 (IC50=4500 nM) 和生长抑素受体 (somatostatin receptors) 具有超过 1200 倍的选择性。CTAP TFA 可用于L -多巴胺诱导的运动障碍 (LID) 和阿片类活性分子过量或成瘾的研究。
T38145	Eltoprazine
	Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro: The binding of [3H]eltoprazine to whole tissue sections was saturable and revealed an apparent dissociation constant (Kd) of 11 nM. Specific [3H]eltoprazine binding was completely displaced by 5-HT; conversely, unlabelled eltoprazine reduced [3H]5-HT binding to the levels of no...

化合物

Cat.No: T31570

Synonym: DPBX L-Dopa

3-O-methyl-L-DOPA (hydrate)

Cat.No: T36122

Etilevodopa hydrochloride

Cat.No: T24047

Synonym: Levodopa ethyl ester,Etilevodopa HCl, L-DOPA ethyl ester

Target: Others, Dopamine Receptor, Drug Metabolite

Fluorodopa F 18

Cat.No: T31823

Synonym: Fluorodopa (18F),6-(18F)Fluoro-L-DOPA,F-DOPA,L-6-(18F)Fluoro-DOPA,6-(18F)Fluorodopamine

Cat.No: T34589

Synonym: d3-L-DOPA,deuldopa,deuterated levodopa,SD1077

[18F]-Labeled L-dopa precursor

Cat.No: T74180

Benserazide hydrochloride

Cat.No: T1517

Synonym: Benserazide HCl,盐酸苄丝肼,Serazide,Ro 4-4602

Target: Dopamine Receptor

CTAP(TFA） (103429-32-9 free base)

Cat.No: TP2050L

Synonym: CTAP(TFA）

Target: Opioid Receptor

Eltoprazine dihydrochloride

Cat.No: T7746

Target: Others

Idazoxan hydrochloride

Cat.No: T0115

Synonym: RX 781094,盐酸咪唑克生

Target: Adrenergic Receptor, Imidazoline Receptor

Cat.No: T8637

Synonym: 6-Nitroveratraldehyde,6-硝基藜芦醛

Target: DNA-PK

Methyldopa hydrochloride

Cat.No: T15701

Synonym: L-(-)-α-Methyldopa hydrochloride,MK-351 hydrochloride

Target: Others

Cat.No: T16279

Synonym: BIA 3-202

Target: Others

Levadopa Related Compound A

Cat.No: T20396

Synonym: 6-Hydroxydopa, L-,L-Hydroxydopa

Cat.No: T37605

Tyrosinase-IN-11

Cat.No: T72703

Cat.No: T75917

Cat.No: T38145

Cat. No.	Product Name	Target	Signaling Pathways
T0848	L-DOPA 左旋多巴,Levodopa,3,4-Dihydroxyphenylalanine	Dopamine Receptor; Endogenous Metabolite	GPCR/G Protein; Metabolism; Neuroscience
	L-DOPA (Levodopa) 是的神经递质多巴胺的代谢前体，具有口服活性。Levodopa 能够透过血脑屏障，并在大脑中转化为多巴胺。Levodopa 具有抗痛觉过敏作用。Levodopa 还具有帕金森氏病的研究潜力。
T26288	Clovamide trans-Clovamide,N-trans-Caffeoy-L-dopa	Apoptosis; Influenza Virus; ROS; Antibacterial	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	Clovamide (trans-Clovamide) 是一种天然存在的咖啡酰结合物，具有抗菌、抗炎、抗氧化和神经保护作用。它是一种极好的活性氧和氧自由基清除剂。
T15255	Etilevodopa Levodopa ethyl ester,L-DOPA ethyl ester	Others	Others
	Etilevodopa is an ethyl-ester prodrug of Levodopa which is used for the treatment of Parkinson's disease (PD). It is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Levodopa is the direct precursor of dop
T3737	3-(2,4-Dihydroxyphenyl)propanoic acid 3-(2,4-二羟基苯)丙酸,Hydroumbellic acid,2,4-Dihydroxyhydrocinnamic acid	Tyrosinase	Proteases/Proteasome
	3-(2,4-Dihydroxyphenyl)propanoic acid (Hydroumbellic acid) 是竞争性酪氨酸酶 (tyrosinase) 抑制剂，可抑制 L-Tyrosine 和 DL-DOPA，IC50和 Ki 分别为 3.02 μM 和 11.5 μM。
T4S1962	beta-Asarone β-细辛脑,(Z)-1,2,4-三甲氧基-5-丙烯基苯;顺式细辛脑,Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin	NF-κB; JNK	MAPK; NF-κB
	beta-Asarone (Cis-Isoelemicin) 是一种石菖蒲中的主要成分，具有免疫抑制、促进安定、中枢神经系统抑制、降温等功能。它可透过血脑屏障，能够预防帕金森病。
TN1314	6-Hydroxykaempferol	Tyrosinase	Proteases/Proteasome
	6-Hydroxykaempferol is a competitive inhibitor of tyrosinase compared to L-DOPA, it shows also high antioxidant activities.
TMA2419	Catalponol	cAMP	GPCR/G Protein
	Catalponol can enhance dopamine biosynthesis by inducing TH activity and protect against L-DOPA-induced cytotoxicity in PC12 cells, which was mediated by the increased levels of cyclic AMP.
T75563	Vanicoside E
	Vanicoside E 是一种抗氧化和抗癌剂。Vanicoside E 抑制L-Tyrosine 和L-DOPA，IC50为 45.23 μM 和 189.96 μM。
TN3607	Catalpalactone	cAMP	GPCR/G Protein
	Catalpalactone exhibits high antitermitic, and cytotoxic activities, it exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells , with IC50 values of 9.80 microM. Catalpalactone can inhibit dopamine biosynthesis by

天然产物

Cat.No: T0848

Synonym: 左旋多巴,Levodopa,3,4-Dihydroxyphenylalanine

Target: Dopamine Receptor, Endogenous Metabolite

Cat.No: T26288

Synonym: trans-Clovamide,N-trans-Caffeoy-L-dopa

Target: Apoptosis, Influenza Virus, ROS, Antibacterial

Cat.No: T15255

Synonym: Levodopa ethyl ester,L-DOPA ethyl ester

Target: Others

3-(2,4-Dihydroxyphenyl)propanoic acid

Cat.No: T3737

Synonym: 3-(2,4-二羟基苯)丙酸,Hydroumbellic acid,2,4-Dihydroxyhydrocinnamic acid

Target: Tyrosinase

Cat.No: T4S1962

Synonym: β-细辛脑,(Z)-1,2,4-三甲氧基-5-丙烯基苯;顺式细辛脑,Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin

Target: NF-κB, JNK

6-Hydroxykaempferol

Cat.No: TN1314

Target: Tyrosinase

Cat.No: TMA2419

Target: cAMP

Cat.No: T75563

Cat.No: TN3607

Target: cAMP

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