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Targets Recommended: Guanylate cyclase

16

抑制剂 & 化合物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T34648	Sinitrodil ITF296,ITF-296,ITF 296	Guanylate cyclase	GPCR/G Protein
	Sinitrodil (ITF-296) 是一种鸟苷酸环化酶兴奋剂，可用于治疗心肌缺血和心绞痛。
T6279L	Givinostat hydrochloride ITF2357 hydrochloride,Givinostat HCl,ITF2357,ITF 2357,ITF-2357,ITF2357 HCl	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Givinostat hydrochloride (ITF2357 hydrochloride) 是一种 HDAC 抑制剂，对 HDAC1 和 HDAC3 的 IC50 分别为 198 和 157 nM。 Givinostat hydrochloride 具有抗炎、抗血管生成和抗肿瘤活性。
T69735	ITF3756	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	ITF3756 是一种选择性 HDAC6 抑制剂。
T6279	Givinostat hydrochloride monohydrate ITF2357,ITF-2357 hydrochloride monohydrate,Givinostat,Gavinostat hydrochloride monohydrate,吉维司他	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Givinostat hydrochloride monohydrate (ITF2357) 是一种HDAC 抑制剂，对HDAC1和HDAC3的IC50分别为 198 nM 和 157 nM。
T27581	Icrocaptide ITF 1697,ITF-1697,ITF1697
	Icrocaptide is used potentially for the treatment of acute myocardial infarction.
T27597	Imidazole Salicylate ITF-182,ITF182,ITF 182,Salizolo,Selezen
	Imidazole Salicylate, a non-steroidal anti-inflammatory drug, has limited inhibitory effects on prostaglandin synthesis.
T71894	AZD3229 Tosylate
	AZD3229 Tosylate is a highly potent inhibitor targeting mutant forms of the pan-KIT enzyme, with a primary application in the treatment of gastrointestinal stromal tumors (GISTs).
T36629	Givinostat
	Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduced IL-1β secretion more than 70%. Givinostat (ITF-2357) suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM Givinostat, but at 1...
T7740	Protease-Activated Receptor-4 diTFA Protease-Activated Receptor-4 diTFA(245443-52-1(free base))	Protease-activated Receptor	GPCR/G Protein
	Protease-Activated Receptor-4 diTFA 是蛋白酶激活受体 4 (PAR4) 激动剂。
T7847	Apelin-13 triTFA(217082-58-1(free base))	Others	Others
	Apelin-13 triTFA(217082-58-1(free base)) 是 APJ 受体的内源性配体，可激活该 G 蛋白偶联受体，EC50 值为 0.37 nM。
T124352	Dihydrocitflavanone
	Dihydrocitflavanone 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124352。
TP1127	Nemifitide diTFA INN 00835 diTFA	5-HT Receptor	GPCR/G Protein; Neuroscience
	Nemifitide diTFA (INN 00835 diTFA) 是一种合成的五肽，是一种可透过血脑屏障的黑色素细胞抑制因子 (MIF) 的肽类似物，具有有效的抗抑郁活性。
T77923	BSJ-03-204 triTFA	CDK; PROTACs	Cell Cycle/Checkpoint; PROTAC
	BSJ-03-204 triTFA是一种融合了Cereblon配体和CDK配体的PROTAC，作为基于Palbociclib的、高效的CDK4/6双重降解剂，选择性地对CDK4/D1和CDK6/D1表现出26.9 nM和10.4 nM的IC50值。它不会引发IKZF1/3的降解，展现了潜在的抗癌活性。
T11330	FTI-2148 diTFA	Others	Others
	FTI-2148 diTFA is a RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 1.4 nM and 1.7 μM, respectively.
T81380	PROTAC EGFR degrader 7 diTFA	PROTACs	PROTAC
	PROTACEGFRdegrader 7 diTFA (compound 13b) 是高效且选择性的 CRBN 招募 PROTACEGFRL858R/T790M 降解剂，DC50 值为 13.2 nM。它在抑制 NCI-H1975 细胞增殖方面表现出强效，IC50 值为 46.82 nM，并且能够显着诱导这些细胞发生凋亡以及 G2/M 期的阻滞。PROTACEGFRdegrader 7 diTFA 展现了潜在的抗肿瘤活性，适合应用于非小细胞肺癌 (NSCLC) 的相关研究。
T81949	Lanreotide diTFA BIM 23014 diTFA
	Lanreotide (BIM 23014) diTFA是一种生长抑素类似物，具抗肿瘤活性，适用于类癌综合症研究。

化合物

Cat.No: T34648

Synonym: ITF296,ITF-296,ITF 296

Target: Guanylate cyclase

Givinostat hydrochloride

Cat.No: T6279L

Synonym: ITF2357 hydrochloride,Givinostat HCl,ITF2357,ITF 2357,ITF-2357,ITF2357 HCl

Target: HDAC

Cat.No: T69735

Target: HDAC

Givinostat hydrochloride monohydrate

Cat.No: T6279

Synonym: ITF2357,ITF-2357 hydrochloride monohydrate,Givinostat,Gavinostat hydrochloride monohydrate,吉维司他

Target: HDAC

Cat.No: T27581

Synonym: ITF 1697,ITF-1697,ITF1697

Imidazole Salicylate

Cat.No: T27597

Synonym: ITF-182,ITF182,ITF 182,Salizolo,Selezen

AZD3229 Tosylate

Cat.No: T71894

Cat.No: T36629

Protease-Activated Receptor-4 diTFA

Cat.No: T7740

Synonym: Protease-Activated Receptor-4 diTFA(245443-52-1(free base))

Target: Protease-activated Receptor

Apelin-13 triTFA(217082-58-1(free base))

Cat.No: T7847

Target: Others

Dihydrocitflavanone

Cat.No: T124352

Nemifitide diTFA

Cat.No: TP1127

Synonym: INN 00835 diTFA

Target: 5-HT Receptor

BSJ-03-204 triTFA

Cat.No: T77923

Target: CDK, PROTACs

Cat.No: T11330

Target: Others

PROTAC EGFR degrader 7 diTFA

Cat.No: T81380

Target: PROTACs

Lanreotide diTFA

Cat.No: T81949

Synonym: BIM 23014 diTFA

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04828	TFF3 Protein, Human, Recombinant (His) trefoil factor 3 (intestinal),ITF,P1B,TFI	Human	HEK293 Cells
	Trefoil factor family (TFF) peptides are involved in the maintenance of epithelial integrity and epithelial restitution. Trefoil factor-3 (TFF3) is an estrogen-regulated gene associated with prognosis in different types of cancer. The presence and localization of TFF3 peptide was associated with the embryonic stage and tissue differentiation. TFF3 peptide distribution specific to the germ layers was not observed. The role of TFF3 peptide in cell migration and differentiation, immune response, an...
TMPJ-01173	TFF3 Protein, Mouse, Recombinant (His) Itf,Trefoil factor 3,Intestinal trefoil factor,m	Mouse	HEK293 Cells
	Trefoil factors (TFF) are secretory products of mucin producing cells. They play a key role in the maintenance of the surface integrity of oral mucosa and enhance healing of the gastrointestinal mucosa by a process called restitution. TFF comprises the gastric peptides (TFF1), spasmolytic peptide (TFF2), and the intestinal trefoil factor (TFF3). They have an important and necessary role in epithelial restitution within the gastrointestinal tract. Members of the trefoil family are characterized b...

重组蛋白

TFF3 Protein, Human, Recombinant (His)

Cat.No: TMPY-04828

Species: Human

Expression System: HEK293 Cells

TFF3 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01173

Species: Mouse

Expression System: HEK293 Cells

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