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Search Results for " interleukin-5 "

16

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9962	Mepolizumab 美泊利单抗,SB 240563	IL Receptor	Immunology/Inflammation
	Mepolizumab (SB 240563) 是一种中和 IL-5 的人源化单克隆抗体。美泊利单抗可用于严重嗜酸性哮喘和嗜酸性肉芽肿伴多血管炎的研究。
T3133	YM-90709 YM90709,YM 90709	IL Receptor; Interleukin	Immunology/Inflammation
	YM-90709是新型的能够抑制IL-5与IL-5受体结合的拮抗剂, 。
T9537	N'-Nitro-D-arginine N'-Nitro-D-arginine,H-D-Arg(NO2)-OH,(R)-2-Amino-5-(3-nitroguanidino)pentanoic acid,N'-硝基-D-精氨酸	Others	Others
	N'-Nitro-D-arginine (N'-Nitro-D-arginine) 是一种砌块。
T7606	Guanosine 5'-diphosphate disodium salt 5'-二磷酸鸟苷二钠,5'-GDP-Na2,鸟苷-5'-二磷酸二钠盐	Endogenous Metabolite	Metabolism
	Guanosine 5'-diphosphate disodium salt (5'-GDP-Na2) 是一种核苷二磷酸。它是一种潜在的铁动员剂，能够阻断铁调素-铁转运蛋白相互作用，也可以调节白 IL-6/stat-3 途径。
T14367	AZ1495	IRAK; CDK; Haspin Kinase	Cell Cycle/Checkpoint; Immunology/Inflammation; NF-κB
	AZ1495 是一种口服有活性的白介素-1受体相关激酶 4(IRAK4)抑制剂，能够作用于 IRAK4 (IC50:5 nM)和 IRAK1 (IC50:23 nM)。可用于研究突变型 MYD88L265P 弥漫性 B 细胞淋巴瘤 (DLBCL) 。
T10497	Benralizumab BIW-8405,MEDI-563	Apoptosis; IL Receptor; Interleukin	Apoptosis; Immunology/Inflammation
	Benralizumab (MEDI-563) 是一种靶向白介素 5 受体 α (IL-5Rα) 单克隆抗体，通过增强抗体依赖性细胞介导的细胞毒性促使嗜酸性粒细胞快速进行反应。Benralizumab 可用于严重的嗜酸性哮喘，可用于预防慢性阻塞性肺病加重。
T12706	Reslizumab Sch 55700	IL Receptor	Immunology/Inflammation
	Reslizumab is humanized monoclonal antibodies that target interleukin-5 (IL-5) for the treatment of eosinophilic asthma.
T80577	Varokibart
	Varokibart (TEV-53275)为针对IL-5的人源化IgG4λ单克隆抗体。
T70107	Olcorolimus
	Olcorolimus inhibits single allergen-induced allergic inflammation such as eosinophilic and lymphocytic infiltration and mRNA expression for interleukin (IL)-4 and IL-5
T82060	Interleukin-6 fragment (human)
	Interleukin-6 fragment (human) 是一种多效性细胞因子，由淋巴细胞及非淋巴细胞产生。该分子的编码基因位于人类第7号染色体，长度大约为5 kb。Interleukin-6 fragment (human) 在免疫响应、急性相应、炎症过程、癌症治疗及血液造血方面均有重要的潜在应用。
T72120	Guanosine 5'-diphosphate sodium GDP sodium
	Guanosine 5'-diphosphate (GDP) sodium 是一种核苷二磷酸，可激活 5'-三磷酸腺苷敏感的 K+通道。Guanosine 5'-diphosphate sodium 是一种潜在的铁动员剂，可阻断铁调素-铁转运蛋白 (hepcidin-ferroportin) 相互作用并调节 IL-6/stat-3通路。Guanosine 5'-diphosphate sodium 可用于炎症研究，如炎症性贫血 (AI)。
T4186	AC-264613 AC264613	Protease-activated Receptor	GPCR/G Protein
	AC-264613 是一种选择性蛋白酶激活受体 (PAR-2) 激动剂，pEC50为 7.5。
T37554	Oleyl Anilide
	AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol. Oleyl analide (OA) is a weak inhibitor of acylCoA:cholesterol acyltransferase (ACAT) with an IC50 of 26 μM. OA and the related glyceride dioleoyl phenylamino propane 1,2-diol have been linked to a syndrome of eosinophilia, excessive T-cell activation, and elevated interleukin-4 (IL-4), soluble IL-2R, and IL-5. The clinical consequences are an acute pulm...
T38106	JC-171
	JC-171 is a selective NLRP3 inflammasome inhibitor, with an IC50 of 8.45 μM for inhibiting LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages[1]. JC-171 (0-100 μM) blocks NLRP3 inflammasome activation and IL-1β production in primary macrophages dose dependently[1]. ...
T36668	Geranylgeranoic Acid
	Geranylgeranoic acid (GGA) is an isoprenoid that has been found inS. chinensisand has anticancer activity.1It induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes, but not primary mouse hepatocytes, when used at concentrations ranging from 1 to 20 μM. GGA (10 μM) induces apoptosis in Huh7 cellsvialoss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32).2It also...
T37604	ITK inhibitor
	Interleukin-2-inducible T cell kinase (ITK) is a non-receptor tyrosine kinase expressed in T cells, NKT cells and mast cells which plays a crucial role in regulating the T cell receptor (TCR), CD28, CD2, chemokine receptor CXCR4, and FcepsilonR-mediated signaling pathways. ITK inhibitors can be used for the treatment of inflammation and immune-mediated disorders. ITK inhibitor (N-[5-[[3-[(4-Acetylpiperazin-1-yl)carbonyl]-4-methyl-6-methoxy-phenyl]thio]thiazol-2-yl]-4-(N-1,2-dimethylpropylaminome...

化合物

Cat.No: T9962

Synonym: 美泊利单抗,SB 240563

Target: IL Receptor

Cat.No: T3133

Synonym: YM90709,YM 90709

Target: IL Receptor, Interleukin

N'-Nitro-D-arginine

Cat.No: T9537

Synonym: N'-Nitro-D-arginine,H-D-Arg(NO2)-OH,(R)-2-Amino-5-(3-nitroguanidino)pentanoic acid,N'-硝基-D-精氨酸

Target: Others

Guanosine 5'-diphosphate disodium salt

Cat.No: T7606

Synonym: 5'-二磷酸鸟苷二钠,5'-GDP-Na2,鸟苷-5'-二磷酸二钠盐

Target: Endogenous Metabolite

Cat.No: T14367

Target: IRAK, CDK, Haspin Kinase

Cat.No: T10497

Synonym: BIW-8405,MEDI-563

Target: Apoptosis, IL Receptor, Interleukin

Cat.No: T12706

Synonym: Sch 55700

Target: IL Receptor

Cat.No: T80577

Cat.No: T70107

Interleukin-6 fragment (human)

Cat.No: T82060

Guanosine 5'-diphosphate sodium

Cat.No: T72120

Synonym: GDP sodium

Cat.No: T4186

Synonym: AC264613

Target: Protease-activated Receptor

Cat.No: T37554

Cat.No: T38106

Geranylgeranoic Acid

Cat.No: T36668

Cat.No: T37604

Cat. No.	Product Name	Target	Signaling Pathways
T6S1538	Neochlorogenic acid 新绿原酸,trans-5-O-Caffeoylquinic acid,Neochlorogenate,金银花,5-O-Caffeoylquinic acid	TNF; NF-κB; COX; Antibacterial; Interleukin	Apoptosis; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB
	Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) 是在干果和其他植物中发现的一种多酚类天然产物，可抑制iNOS 和COX-2蛋白表达，抑制TNF-α和IL-1β产生，还抑制磷酸化的NF-κB p65和p38 MAPK 活化。
TN1291	7,3',4'-Tri-O-methylluteolin 5-Hydroxy-3',4',7-trimethoxyflavone,木犀草素-7,3',4'-三甲醚	TNF; COX; Interleukin	Apoptosis; Immunology/Inflammation; Neuroscience
	7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) 是来自草药马鞭草科的一种类黄酮，具有抗炎，解热，镇咳，抗糖尿病、抗癌和抗黑素生成特性。它以浓度依赖方式明显抑制促炎细胞因子，可显著降低在转录水平的诱导型一氧化氮合酶和环加氧酶-2 的 mRNA 表达。
T7210	Guanosine 5'-diphosphate GDP,鸟苷-5ˊ-二磷酸	Endogenous Metabolite	Metabolism
	Guanosine 5'-diphosphate (GDP) 是核苷二磷酸，是潜在的铁动员剂，能够阻断铁调素-铁转运蛋白相互作用并调节白细胞介素-6 (IL-6)/stat-3 途径。

天然产物

Neochlorogenic acid

Cat.No: T6S1538

Synonym: 新绿原酸,trans-5-O-Caffeoylquinic acid,Neochlorogenate,金银花,5-O-Caffeoylquinic acid

Target: TNF, NF-κB, COX, Antibacterial, Interleukin

7,3',4'-Tri-O-methylluteolin

Cat.No: TN1291

Synonym: 5-Hydroxy-3',4',7-trimethoxyflavone,木犀草素-7,3',4'-三甲醚

Target: TNF, COX, Interleukin

Guanosine 5'-diphosphate

Cat.No: T7210

Synonym: GDP,鸟苷-5ˊ-二磷酸

Target: Endogenous Metabolite

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