16
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Cat. No. | Product Name | Target | Signaling Pathways |
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T30935 |
ci-IP3/PM
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CI-IP3 /PM is a cell-permeable caged inositol triphosphate that promotes the release of Ca2+ from internal storage under UV photolysis. | |||
T19266 |
Ins(1,4,5)-P3 hexapotassium salt
1,4,5-IP3 hexapotassium salt,D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt |
Others | Others |
D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt is promotes endoplasmic The second messenger of net calcium ions. | |||
T8867 |
RO2959 Hydrochloride
RO2959 HCl |
IL Receptor; Calcium Channel; Interleukin | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism |
RO2959 Hydrochloride (RO2959 HCl) 是选择性CRAC 通道抑制剂,IC50为 402 nM。它是人IL-2产生的有效抑制剂,有效阻断 T 细胞受体触发的基因表达和 T 细胞功能途径。它是由Orai1/Stim1通道介导的钙存储进入的有效阻滞剂,IC50为 25 nM。 | |||
T41181 | iP300v | ||
iP300v is a negative control for iP300w | |||
T68759 |
OSIP339391
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OSIP339391 is a A2BAR antagonist. | |||
T83733 |
TIP39 (human, bovine) TFA
Tuberoinfundibular Peptide of 39 Residues |
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TIP39作为一种神经肽及甲状旁腺激素受体2型(PTH2R)激动剂,在表达重组人或大鼠PTH2R的COS-7细胞中诱导cAMP积累(EC50分别为0.5和0.8 nM),以及在内源性表达PTH2R的F-11细胞中(EC50 = 1.15 nM)。在CFK2大鼠软骨细胞中,TIP39 (1 nM)诱导细胞周期在G0/G1阶段停滞,并减少软骨分化的主要调控因子Sox9的表达。此外,TIP39 (100 pmol/动物)在小鼠强迫游泳测试中减少了不动时间。 | |||
T4693 |
2-Aminoethyl diphenylborinate
2-Aminoethoxydiphenyl borate,二苯基酸,2-APB |
Calcium Channel; TRP/TRPV Channel | Membrane transporter/Ion channel; Metabolism |
2-Aminoethyl diphenylborinate (2-APB) 是细胞通透性的 IP3R 和 TRP 通道抑制剂,还抑制 store-operated Ca2+(SOC)通道。 | |||
T9031 |
MCU-i4
|
Others; Mitochondrial Metabolism | Metabolism; Others |
MCU-i4 阻断IP3依赖的线粒体 Ca2+的摄取,是一种新型 MCU 负调节剂,可结合 MICU1 并损害肌肉细胞生长。 | |||
T11137 |
(E)-GABAB receptor antagonist 1
|
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
(E)-GABAB receptor antagonist 1 是 GABAB receptor antagonist 1 的反式结构。(E)-GABAB receptor antagonist 1 降低 GABA 诱导的 IP3 (三磷酸肌醇) 产生,IC50 为 37.9 μM。GABAB receptor antagonist 1是选择性的 GABAB (γ-氨基丁酸) 受体的负变构调节剂。 | |||
T83950 |
ARN 11391
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ARN 11391是ITPR1 (Inositol 1,4,5-trisphosphate (IP3) receptor type 1)的增效剂,它直接作用于ITPR1,从而增强细胞内钙离子信号。ARN 11391还能增强表达突变型ITPR1细胞中的钙信号,这与SCA29型脊髓小脑共济失调有关。 | |||
T11350 | GABAB receptor antagonist 1 | GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selective and negative allosteric modulator of GABAB (γ-Aminobutyric acid) receptors. | |||
T14202 | AM-4668 | GPR | Endocrinology/Hormones; GPCR/G Protein |
AM-4668 is a type 2 diabetes GPR40 agonist. For GPR40, in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), the EC50s are 3.6 nM and 36 nM, respectively. | |||
TP1710 |
Calmodulin Binding Peptide 1
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Calmodulin Binding Peptide 1, a potent CaM-binding peptide with picomolar (pM) affinity, originates from smooth muscle myosin light-chain kinase (MLCK peptide). It effectively blocks inositol trisphosphate (IP3)-induced calcium (Ca2+) release [1]. | |||
T14553 |
BHPI
|
Others | Others |
BHPI is a potent inhibitor of nuclear estrogen–ERα-regulated gene expression. Elicits sustained ERα-dependent activation of the endoplasmic reticulum (EnR) stress sensor, the unfolded protein response (UPR), and persistent inhibition of protein synthesis. | |||
T36937 |
PtdIns-(1,2-dioctanoyl) (sodium salt)
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The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) containing C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacyl glycerol (DAG) stereochemistry as that of the natural compound. The short fatty acid chains of this anal... | |||
T37030 |
PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)
PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt) |
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The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4)-P1 (1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound contains the same inositol and diacylglycerol (DAG) stereochemistry as the natural compound. PtdIns-(4)-P1 can be phosphorylated to di- ... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T7190 |
Actein
|
Apoptosis; Akt; JNK; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Actein 是从升麻的根茎中分离的一种三萜糖苷,通过促进ROS/JNK 活化和钝化人膀胱癌中的AKT 途径来抑制细胞增殖,诱导自噬和凋亡。 | |||
T23538 |
Xestospongin C
(-)-Xestospongin C |
Others | Others |
IP3-dependent Ca2+ release inhibitor |