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21

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T37596	Terevalefim	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Terevalefim 是干细胞生长因子的一种类似物，对c-Met 受体有选择性激活作用。
T7376	Dihexa PNB-0408,Hexanoyl-Tyr-Ile-Ahx-NH2,N-hexanoic-Try-Ile-(6)-amino hexanoic amide	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Dihexa (Hexanoyl-Tyr-Ile-Ahx-NH2) 是肝细胞生长因子/c-Met (HGF/c-Met) 系统的激活剂，它与 HGF (Kd = 65 pM) 结合，是肽血管紧张素 IV 的类似物。
T39507L	Fosgonimeton acetate Fosgonimeton acetate (2093305-05-4 Free base)	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Fosgonimeton acetate 是一种肝细胞生长因子受体激动剂。
T76758	Rilotumumab AMG 102	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Rilotumumab (AMG 102) 是一种针对肝细胞生长因子的单克隆抗体，对 HGF/MET 驱动的信号传导有抑制作用。Rilotumumab 具有抗肿瘤作用，可用于研究去势抵抗性前列腺癌 (CRPC) 和胃癌。
T76780	Onartuzumab RG-3638,PRO-14396,MetMAb	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Onartuzumab (MetMAb) 是一种人源化抗酪氨酸激酶 c-MET 单价单克隆抗体。Onartuzumab 具有抗肿瘤活性，对 HGF 结合、受体磷酸化和信号转导有抑制作用。
T5478	SRI 31215 TFA SRI 31215	c-Met/HGFR	Tyrosine Kinase/Adaptors
	SRI 31215 TFA 是 matriptase、hepsin、肝细胞生长因子激活剂(HGFA)的三重抑制剂，IC50值分别为 0.69 μM、0.65 μM、0.3 μM。它能够阻断 pro-HGF 的活化，模拟 HAI-1/2 的活性。
T76743	Emibetuzumab LY2875358	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Emibetuzumab 是一种有效的人源化二价 MET 抗体 (IgG4 型)。Emibetuzumab 具有抗肿瘤活性，对 HGF 依赖性和非依赖性 MET 通路的激活和肿瘤生长有抑制作用可用于研究晚期去势抵抗性前列腺癌。
T8416	Capmatinib xHCl INCB28060,Capmatinib hydrochloride(free base),INC280	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Capmatinib xHCl (INCB28060) 是一种有效的、口服活性的、选择性的和 ATP 竞争性 c-Met 激酶抑制剂，有效地阻断体外激酶活性 (IC50 = 0.13 nM) 以及在细胞中的组成型或 HGF 刺激活性(IC50 值范围从 0.3 到1.1纳米)。
T2054	Altiratinib DCC-2701	VEGFR; Tie-2; FLT; Trk receptor; c-Met/HGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Altiratinib (DCC-2701) 是一种多靶点激酶抑制剂，能够抑制 MET (IC50:2.7 nM)，TIE2 (IC50:8 nM)，VEGFR2 (IC50:9.2 nM)，FLT3 (IC50:9.3 nM)，Trk1 (IC50:0.85 nM)，Trk2 (IC50:4.6 nM) 和 Trk3 (IC50:0.83 nM)。
T19389	L-Ascorbic acid 2-phosphate magnesium 2-Phospho-L-ascorbic acid magnesium,维生素C磷酸酯镁,维生素 C 磷酸酯镁	Phosphatase; Phosphorylase	Metabolism
	L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) 是长效的维生素 C 衍生物，能够以刺激胶原蛋白的表达和形成。它提高成骨细胞分化过程中 hASC 中的碱性磷酸酶特性和 runx2A 的表达。它能够以作为培养基补充人脂肪干细胞的成骨分化。
T76745	Ficlatuzumab
	Ficlatuzumab 是一种靶向人肝细胞生长因子 (HGF) 的单克隆抗体 (McAb)。Ficlatuzumab 能够阻断HGF/c-Met 信号通路的激活，抑制c-Met 受体介导的癌细胞增殖、迁移和侵袭。
T28899	T-1840383
	T-1840383 is an inhibitor of VEGF-induced VEGFR-2 phosphorylation and HGF-induced c-Met phosphorylation in vascular endothelial cells and cancer epithelial cells.
TP1990	Norleual
	Angiotensin IV analog. Highly potent HGF/c-MET inhibitor (IC50 = 3 pM). Inhibits HGF-induced MDCK cell proliferation and invasion in vitro. Also AT4 receptor antagonist; disrupts LTP stabilization. Antiangiogenic.
T74390	VD2173
	VD2173 是一种HGF 激活丝氨酸蛋白酶的侧链环化大环肽抑制剂。VD2173 有效抑制matriptase 和hepsin。VD2173 可用于肺癌的研究。
T70844	CM-118
	CM-118 is a potent and selective dual inhibitor of c-Met and ALK which potently abrogates hepatocyte growth factor (HGF)-induced c-Met phosphorylation and cell migration, as well as phosphorylation of ALK, EML4-ALK, and ALK resistance mutants in transfected cells.
T70318	AMG-337 monohydrate
	AMG-337 monohydrate is a highly selective small molecule MET inhibitor. Aberrant hepatocyte growth factor (HGF)/MET signaling has been implicated in hepatocarcinogenesis, suggesting that MET may serve as an attractive therapeutic target in hepatocellular carcinoma.
T75940	Norleual TFA
	Norleual TFA 是一种血管紧张素 (Ang) IV 类似物，是一种肝细胞生长因子(HGF)/c-Met 抑制剂，IC50为 3 pM。Norleual TFA 还是一种AT4拮抗剂，具有强大的抗血管生成活性。
T28240	Ono 1301 Ono-1301,Ono1301
	Ono 1301 is a prostaglandin I2 mimetic coumpound with inhibitory activity against thromboxane A2 synthase. Ono 1301 suppresses pancreatic fibrosis in the DBTC-induced CP model by inhibiting monocyte activity not only with induction of HGF but also by Ono
T71187	Foretinib phosphate
	Foretinib phosphate is an orally bioavailable small molecule with potential antineoplastic activity. MET/VEGFR2 inhibitor GSK1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. The proto-oncogene c-MET has been found to be over-expressed in a variety of cancers.
T69599	ABT-510
	ABT-510 is synthetic peptide that mimics the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascularization; these pro-angiogenic growth factors include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF)), hepatocyte growth factor (HGF), and interleukin 8 (IL-8).
T78549	Ethylene glycol dimethacrylate	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Ethylene glycol dimethacrylate 是一种具有细胞毒性和基因毒性作用的甲基丙烯酸酯单体。它可增加人牙龈成纤维细胞 (HGF) 内的活性氧 (ROS) 产生，引发 DNA 损伤和细胞凋亡 (apoptosis)，并使细胞周期在 G1/G0 期停滞。

化合物

Cat.No: T37596

Target: c-Met/HGFR

Cat.No: T7376

Synonym: PNB-0408,Hexanoyl-Tyr-Ile-Ahx-NH2,N-hexanoic-Try-Ile-(6)-amino hexanoic amide

Target: c-Met/HGFR

Fosgonimeton acetate

Cat.No: T39507L

Synonym: Fosgonimeton acetate (2093305-05-4 Free base)

Target: c-Met/HGFR

Cat.No: T76758

Synonym: AMG 102

Target: c-Met/HGFR

Cat.No: T76780

Synonym: RG-3638,PRO-14396,MetMAb

Target: c-Met/HGFR

Cat.No: T5478

Synonym: SRI 31215

Target: c-Met/HGFR

Cat.No: T76743

Synonym: LY2875358

Target: c-Met/HGFR

Capmatinib xHCl

Cat.No: T8416

Synonym: INCB28060,Capmatinib hydrochloride(free base),INC280

Target: c-Met/HGFR

Cat.No: T2054

Synonym: DCC-2701

Target: VEGFR, Tie-2, FLT, Trk receptor, c-Met/HGFR

L-Ascorbic acid 2-phosphate magnesium

Cat.No: T19389

Synonym: 2-Phospho-L-ascorbic acid magnesium,维生素C磷酸酯镁,维生素 C 磷酸酯镁

Target: Phosphatase, Phosphorylase

Cat.No: T76745

Cat.No: T28899

Cat.No: TP1990

Cat.No: T74390

Cat.No: T70844

AMG-337 monohydrate

Cat.No: T70318

Cat.No: T75940

Cat.No: T28240

Synonym: Ono-1301,Ono1301

Foretinib phosphate

Cat.No: T71187

Cat.No: T69599

Ethylene glycol dimethacrylate

Cat.No: T78549

Target: Reactive Oxygen Species

Cat. No.	Product Name	Target	Signaling Pathways
T5S1331	Herbacetin	c-Met/HGFR; Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Herbacetin 是一种亚麻籽中的天然类黄酮，具有多种药理活性，如抗氧化、抗炎、抗癌作用。它是鸟氨酸脱羧酶Ornithine decarboxylase (ODC)变构抑制剂，能够直接与 ODC 上的 Asp44，Asp243 和 Glu384 结合。其中鸟氨酸脱羧酶是多胺生物合成中的限速酶。
TN1549	Damnacanthal 丹宁卡	IL Receptor; Akt; Syk	Angiogenesis; Cytoskeletal Signaling; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma through its inhibitory effects on the HGF/c-Met axis.
TN4023	Eucalyptin	Antifection	Microbiology/Virology
	Eucalyptin has antioxidant and antimicrobial properties, it exhibits potent antimicrobial activities against seven micro-organisms with minimum inhibitory concentrations (MIC) ranging from 1.0 to 31 mg/L. Eucalyptin A exhibits potent inhibition on HGF/c-M
TN2177	Sanggenol L	c-Myc; NF-κB	Cell Cycle/Checkpoint; NF-κB
	Sanggenol L shows higher cytotoxicity against human oral tumor cell lines (HSC-2 and HSG) than against normal human gingival fibroblasts (HGF), it induces apoptosis via caspase activation and inhibition of NF-κB/IκBα± phosphorylation as a potent chemother

天然产物

Cat.No: T5S1331

Target: c-Met/HGFR, Akt

Cat.No: TN1549

Synonym: 丹宁卡

Target: IL Receptor, Akt, Syk

Cat.No: TN4023

Target: Antifection

Cat.No: TN2177

Target: c-Myc, NF-κB

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