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44

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22833	H-9 dihydrochloride	EGFR; 5-HT Receptor; PKA	Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Neuroscience; Tyrosine Kinase/Adaptors
	H-9 dihydrochloride 是一种具有有效性的蛋白激酶（ PKA）抑制剂。H-9 Dihydrochloride 在低浓度下显著降低 5-HT 的兴奋性反应。H-9 Dihydrochloride 会对咽部活动产生影响。H-9 Dihydrochloride 对 EGF (表皮生长因子)依赖的上皮细胞系的信号转导和细胞生长有抑制作用。
T21128	Lansoprazole sulfide Lansoprazole impurity C,AG-1777,EC 600-451-9,H 225/18,K-1252
	Lansoprazole sulfide is an impurity of Lansoprazole, which is a gastric pump inhibitor.
T67324	(1'R,3a'R,8a'S,9'S,9a'S)-1'-Methyl-3'-oxo-N,N-diphenyl-3',3a',5',7',8',8a',9',9a'-octahydro-1'H-spiro[[1,3]dioxolane-2,6'-naphtho[2,3-c]furan]-9'-carboxamide
	(1'R,3a'R,8a'S,9'S,9a'S)-1'-Methyl-3'-oxo-N,N-diphenyl-3',3a',5',7',8',8a',9',9a'-octahydro-1'H-spiro[[1,3]dioxolane-2,6'-naphtho[2,3-c]furan]-9'-carboxamide 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67324，CAS号为 900160-98-7。
T7354	H-Val-Pro-Pro-OH	RAAS	Endocrinology/Hormones
	H-Val-Pro-Pro-OH 是一种血管紧张素 I 转化酶(ACE)的抑制剂(IC50:9 μM)。他是一种来源于牛奶的脯氨酸肽衍生物。
T11526	DPP-IV-IN-2 H-Lys(4-nitro-Z)-pyrrolidide	DPP-4	Proteases/Proteasome
	DPP-IV-IN-2 (H-Lys(4-nitro-Z)-pyrrolidide) 是二肽基肽酶 IV 和DP8/9的抑制剂， IC50分别为 0.1 和 0.95 μM。
T33820	ORG 2766 ORG-2766,ORG2766
	ORG 2766 is an ACTH 4-9 (H-Met(O)-Glu-His-Phe-D-Lys-Phe-OH) analog and neurotrophic peptide.
T62156	HIV-1 integrase inhibitor 9
	HIV-1 integrase inhibitor 9 (compound 8a) 是一种 HIV-1 RNase H 的有效抑制剂 (IC50: 12.3 μM)，具有抗病毒作用。
T62297	H-Val-Pro-Pro-OH TFA
	H-Val-Pro-Pro-OH (TFA) 是一种血管紧张素 I 转化酶(ACE)的抑制剂 (IC50: 9 μM)。H-Val-Pro-Pro-OH (TFA) 是一种来源于牛奶的脯氨酸肽衍生物。
T25481	H 77 H77,H-77
	H 77 is a new effective renin inhibitor. H 77 is angiotensinogen (6-13)-octapeptide in which the peptide bond -CO-NH- at the Leu(9)-Leu(11) linkage is replaced by a -CH2-NH- bond.
T67578	H-Glu(OBzl)-OH
	H-Glu(OBzl)-OH 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67578，CAS号为 1676-73-9。
T66595	H-Hyp-OMe hydrochloride
	H-Hyp-OMe hydrochloride 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66595，CAS号为 40216-83-9。
T65925	H-Asp(ome)-OMe HCl
	H-Asp(ome)-OMe HCl 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65925，CAS号为 32213-95-9。
T64955	H-DL-Phg(2-Cl)-OH
	H-DL-Phg(2-Cl)-OH 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T64955，CAS号为 88744-36-9。
T67312	H-DL-Phe(4-NO2)-OH
	H-DL-Phe(4-NO2)-OH 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67312，CAS号为 2922-40-9。
T64776	H-Phe(2,4-DiCl)-OH
	H-Phe(2,4-DiCl)-OH 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T64776，CAS号为 111119-36-9。
T66626	H-D-Allo-Ile-OH
	H-D-Allo-Ile-OH 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66626，CAS号为 1509-35-9。
T63994	MMP-9-IN-4
	MMP-9-IN-4 是 MMP-9 抑制剂，能够与 MMP-9 形成 H-π 相互作用，IC50 值为 7.46 nM。MMP-9-IN-4 还能够抑制 AKT 活性，其 IC50 值为 8.82 nM。MMP-9-IN-4 能够诱导细胞凋亡 (apoptosis)，显示出细胞毒性，能够用于研究癌症。
T67362	H-Glu(OtBu)-OH
	H-Glu(OtBu)-OH 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67362，CAS号为 2419-56-9。
TP1350	H-Val-Pro-Pro-OH TFA (58872-39-2 free base) H-Val-Pro-Pro-OH TFA
	H-Val-Pro-Pro-OH(TFA), a proline peptide derivative from milk, is an ACE inhibitor with IC50 of 9 M.
T74621	STING agonist-9
	STINGagonist-9 (Compound 45) 是一种有效的STING 激动剂，对 h-STING 和 m-STING 的EC50值分别为 1.2 nM 和 32.82 μM。STINGagonist-9 具有抗肿瘤活性。
T65771	1,7'-Dimethyl-2'-propyl-1H,1'H-2,5'-bibenzo[d]imidazole
	1,7'-Dimethyl-2'-propyl-1H,1'H-2,5'-bibenzo[d]imidazole 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65771，CAS号为 152628-02-9。
T66916	H-Cys(Acm)-OH HCl
	H-Cys(Acm)-OH HCl 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66916，CAS号为 28798-28-9。
T78388	9-Amino-6-chloro-2-methoxyacridine
	9-Amino-6-chloro-2-methoxyacridine为pH敏感荧光探针，常用于监测假定H+/溶质反转运系统介导特定底物穿越液泡膜时的液泡pH变化。
T67086	H-D-Thr(tBu)-OH
	H-D-Thr(tBu)-OH 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67086，CAS号为 201274-81-9。
TP1727	Gp100 (25-33), human
	Gp100 (25-33), human is the amino acids 25-33 fragment of the human melanoma antigen. It is a 9-amino acid (AA) epitope restricted by H-2Db and recognized by the T cells.This is amino acids 25 to 33 fragment of human melanoma antigen gp100. This H-2Db res
TP1416	Gp100 (25-33), human TFA (212370-40-6 free base) Gp100 (25-33), human TFA
	Gp100 (25-33), human TFA is a 25-33 amino acid fragment of human melanoma antigen.Gp100 (25-33), human TFA is a 9-amino acid (AA) epitopes restricted by h-2db and recognized by T cells.
T75766	GP(33-41) TFA
	GP(33-41) TFA 是一种由 9 个氨基酸残基组成的多肽，它是淋巴细胞性脉络丛脑膜炎病毒 GP1 抗原决定基中的序列。GP(33-41) TFA 能够上调 RMA-S (Db Kb) 细胞表面 H-2Db 分子，SC50值为 344 nM。
T78599	CK2-IN-9
	CK2-IN-9是一种有效的CK2 kinase选择性抑制剂，IC50值为3 nM。它能降低Wnt报告因子的活性，达到IC50为75 nM。在大鼠体内显示出低暴露量（AUC=0.36 μM/h）及高清除率（CL=65 mL/min/kg）。
TP1752	GP(33-41)
	GP(33-41), a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus, and can upregulate H-2Db molecules at the RMA-S (Db Kb) cell surface with a SC50 of 344 nM. GP33-41 Epitopeis a strong agonist of CD8 T cells
T37053	Z-(L-Arg)-AMC (hydrochloride)
	Z-(L-Arg)-AMC is a fluorogenic substrate for trypsin, cathepsin B, and cathepsin H.1,2Upon enzymatic cleavage by trypsin, cathepsin B, or cathepsin H, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify trypsin, cathepsin B, and cathepsin H activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. 1.Zimmerman, M., Ashe, B., Yurewicz, E.C., et al.Sensitive assays for trypsin, elastase, and chymotrypsin using new fluorogenic substrat...
T70988	Ibulocydine
	Ibulocydine is a potent CDK inhibitor. Ibulocydine has high activity against Cdk7/cyclin H/Mat1 and Cdk9/cyclin T. Ibulocydine inhibited the growth of HCC cells more effectively than other Cdk inhibitors, including olomoucine and roscovitine, whereas ibulocydine as well as the other Cdk inhibitors and BMK-Y101 minimally influenced the growth of normal hepatocyte cells. Ibulocydine induced apoptosis in HCC cells, most likely by inhibiting Cdk7 and Cdk9. In vitro treatment of HCC cells with ibuloc...
T36443	(R,R)-CXCR2-IN-2 (R,R)-CXCR2-IN-2
	(R,R)-CXCR2-IN-2, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively[1]. [1]. Lu H, et al. Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists. J Med Chem. 2018;61(6):2518-2532.
T36412	Multiflorenol
	Multiflorenol is a triterpene that has been found in T. kirilowii seeds.1 It inhibits in vitro activation of Epstein-Barr virus early antigen (EBV-EA) induced by the tumor promoter phorbol 12-myristate 13-acetate in a concentration-dependent manner. \|1. Akihisa, T., Tokuda, H., Ichiishi, E., et al. Anti-tumor promoting effects of multiflorane-type triterpenoids and cytotoxic activity of karounidiol against human cancer cell lines. Cancer Lett. 173(1), 9-14 (2001).
T35549	Elsinochrome A
	Elsinochrome A is a perylenequinone fungal metabolite that has been found inHypomycesand has anticancer activity.1Photoactivation of elsinochrome A induces the production of singlet oxygen and apoptosis in R366.4 rhesus monkey embryonic stem cells and HCe-8693 colorectal carcinoma cells when used at concentrations ranging from 1 to 100 μM. 1.Ma, L., Tai, H., Li, C., et al.Photodynamic inhibitory effects of three perylenequinones on human colorectal carcinoma cell line and primate embryonic stem ...
T35451	β-Defensin-2 (human) (trifluoroacetate salt)
	β-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius.2β-Defensin-2 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.3It also stimulates calcium mobilization, migration, and proliferation of keratinocytes whe...
T35426	β-Defensin-1 (human) (trifluoroacetate salt)
	β-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth ofB. adolescentis,L. acidophilus,B. breve,B. vulgatus,L. fermentum,B. longum, andS. thermophilusin an antimicrobial radial diffusion assay.2β-Defensin-1 also inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius, and of susceptibleM. tuberculosisH37Rv but no...
T35504	(±)10-HDHA
	(±)10-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.[1][2] It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.[3][4][5] (±)10-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid. Reference：[1]. VanRollins, M., and Murphy, R.C. Autooxidation of docosahexaenoic acid: Analysis of ten isomers of hydroxydocosahexaenoate. J. Lipid Res. 25(5), 507-517 (1984).[2]. Reynaud, ...
T35800	MD001
	MD001 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ.1 It binds to PPARα and PPARγ (Kds = 9.55 and 0.14 μM, respectively) but does not bind to PPARβ/δ at concentrations up to 500 μM. It increases transcriptional activity of PPARα and PPARγ in a cell-based luciferase reporter assay when used at a concentration of 10 μM. MD001 (10 μM) increases expression of PPARα, PPARγ, and retinoid X receptor (RXR), as well as PPARα and PPARγ target genes, in HepG2 cells. It...
T37847	Zonisamide-13C2,15N Zonisamide-13C2,15N
	Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium...
T35799	MBX-8025 (sodium salt)
	MBX-8025 is an agonist of peroxisome proliferator-activated receptor δ (PPARδ).1 It is greater than 750- and 2,500-fold selective for PPARδ over PPARα and PPARγ. MBX-8025 (10 mg/kg per day for eight weeks) reduces increases in fasting blood glucose and serum insulin levels, and decreases insulin resistance in Alms1 mutant (foz/foz) mice fed an atherogenic diet as a model of diet-induced obesity, type 2 diabetes, and non-alcoholic steatohepatitis (NASH).2 It also decreases serum alanine transamin...
T38042	Resolvin D4 Resolvin D4,RvD4
	Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid . [1] It has been detected in human milk, in the dorsal pouch of mice before and after infection with S. aureus, and in untreated tissues from humans, mice, and sardines.[2][3] RvD4, at 10 ng/mouse, reduces neutrophil infiltration in zymosan A-induced peritonitis and, at 200 ng/mouse, diminishes neutrophil infiltration in response to S. aureus infection. [3] With isolated cells, RvD4 promotes phagocytosi...
T38145	Eltoprazine
	Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro: The binding of [3H]eltoprazine to whole tissue sections was saturable and revealed an apparent dissociation constant (Kd) of 11 nM. Specific [3H]eltoprazine binding was completely displaced by 5-HT; conversely, unlabelled eltoprazine reduced [3H]5-HT binding to the levels of no...
T37741	N-hexadecanoyl-L-Homoserine lactone C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone
	Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which...
T36570	KUS121
	KUS121 is a valosin-containing protein (VCP) modulator that inhibits VCP ATPase activity (IC50= 330 nM).1It inhibits cell death, ATP depletion, and upregulation of C/EBP-homologous protein (CHOP) induced by tunicamycin, an inducer of ER stress, in HeLa cells when used at concentrations of 20, 50, and 50 μM, respectively. KUS121 (100 μM) inhibits ATP depletion and cell death induced by oxygen-glucose deprivation (OGD) in rat primary cortical neurons in anin vitromodel of cerebral ischemia.2It red...

化合物

H-9 dihydrochloride

Cat.No: T22833

Target: EGFR, 5-HT Receptor, PKA

Lansoprazole sulfide

Cat.No: T21128

Synonym: Lansoprazole impurity C,AG-1777,EC 600-451-9,H 225/18,K-1252

(1'R,3a'R,8a'S,9'S,9a'S)-1'-Methyl-3'-oxo-N,N-diphenyl-3',3a',5',7',8',8a',9',9a'-octahydro-1'H-spiro[[1,3]dioxolane-2,6'-naphtho[2,3-c]furan]-9'-carboxamide

Cat.No: T67324

H-Val-Pro-Pro-OH

Cat.No: T7354

Target: RAAS

Cat.No: T11526

Synonym: H-Lys(4-nitro-Z)-pyrrolidide

Target: DPP-4

Cat.No: T33820

Synonym: ORG-2766,ORG2766

HIV-1 integrase inhibitor 9

Cat.No: T62156

H-Val-Pro-Pro-OH TFA

Cat.No: T62297

Cat.No: T25481

Synonym: H77,H-77

Cat.No: T67578

H-Hyp-OMe hydrochloride

Cat.No: T66595

H-Asp(ome)-OMe HCl

Cat.No: T65925

H-DL-Phg(2-Cl)-OH

Cat.No: T64955

H-DL-Phe(4-NO2)-OH

Cat.No: T67312

H-Phe(2,4-DiCl)-OH

Cat.No: T64776

H-D-Allo-Ile-OH

Cat.No: T66626

Cat.No: T63994

Cat.No: T67362

H-Val-Pro-Pro-OH TFA (58872-39-2 free base)

Cat.No: TP1350

Synonym: H-Val-Pro-Pro-OH TFA

STING agonist-9

Cat.No: T74621

1,7'-Dimethyl-2'-propyl-1H,1'H-2,5'-bibenzo[d]imidazole

Cat.No: T65771

H-Cys(Acm)-OH HCl

Cat.No: T66916

9-Amino-6-chloro-2-methoxyacridine

Cat.No: T78388

H-D-Thr(tBu)-OH

Cat.No: T67086

Gp100 (25-33), human

Cat.No: TP1727

Gp100 (25-33), human TFA (212370-40-6 free base)

Cat.No: TP1416

Synonym: Gp100 (25-33), human TFA

Cat.No: T75766

Cat.No: T78599

Cat.No: TP1752

Z-(L-Arg)-AMC (hydrochloride)

Cat.No: T37053

Cat.No: T70988

(R,R)-CXCR2-IN-2

Cat.No: T36443

Synonym: (R,R)-CXCR2-IN-2

Cat.No: T36412

Cat.No: T35549

β-Defensin-2 (human) (trifluoroacetate salt)

Cat.No: T35451

β-Defensin-1 (human) (trifluoroacetate salt)

Cat.No: T35426

Cat.No: T35504

Cat.No: T35800

Zonisamide-13C2,15N

Cat.No: T37847

Synonym: Zonisamide-13C2,15N

MBX-8025 (sodium salt)

Cat.No: T35799

Cat.No: T38042

Synonym: Resolvin D4,RvD4

Cat.No: T38145

N-hexadecanoyl-L-Homoserine lactone

Cat.No: T37741

Synonym: C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone

Cat.No: T36570

Cat. No.	Product Name	Target	Signaling Pathways
T3S1641	Esculentoside H	TNF; NF-κB; JNK	Apoptosis; MAPK; NF-κB
	Esculentoside H 是一种皂苷，分离自多年生植物 Phytolacca esculent 的根提取物中，具有抗肿瘤作用。它的机制与 TNF 释放能力有关。它能够阻断 JNK1/2和 NF-κB 信号介导的基质金属蛋白酶-9 (MMP-9) 表达，抑制结肠癌细胞迁移。
T36914	2-Hydroxyanthraquinone	Others	Others
	2-Hydroxyanthraquinone 是一种天然产物，显示出抗肿瘤和免疫抑制活性。
TN4378	Kanshone H	Others	Others
	Kanshone H 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4378，CAS号为 1445952-33-9。
TN3318	9-Hydroxy-alpha-lapachone	Antifection	Microbiology/Virology
	9-Hydroxy-alpha-lapachone can highly inhibit the growth of H. pylori, it exhibits potent inhibitory activity against H. pylori Cystathionine gamma-synthase, with IC(50) values of 4.64 microM. It may have anti-inflammatory activity, it exhibits potent inhi
T36438	Sporogen-AO 1
	Sporogen-AO 1 is a fungal metabolite originally isolated fromA. oryzaethat has diverse biological activities.1,2,3,4,5It inhibits HIV-1 Tat transactivation in a cell-based assay with an IC50value of 15.8 μM.4Sporogen-AO 1 is cytotoxic to HeLa, KB, and NCI H187 cancer cells (IC50s = 8.3, 9, and 5.1 μM, respectively).2,5It is active againstC. albicans(MIC = 4 mM).3 1.Tanaka, S., Wada, K., Marumo, S., et al.Structure of sporogen-ao 1, a sporogenic substance of Aspergillus oryzaeTetrahedron Lett.25(...
T36348	Cerebroside C
	Cerebroside C is a fungal metabolite and glycosphingolipid that has been found in the rice pathogenic fungusM. grisea.1It induces production of the phytoalexin momilactone A when applied to wounded rice leaves, indicating that cerebroside C is an elicitor of the hypersensitive response in rice. Cerebroside C increases germination rate and reduces germination time in wheat seeds in a concentration-dependent manner at 4°C.2It also increases root length, fresh weight, and dry weight of wheat seedli...

天然产物

Esculentoside H

Cat.No: T3S1641

Target: TNF, NF-κB, JNK

2-Hydroxyanthraquinone

Cat.No: T36914

Target: Others

Cat.No: TN4378

Target: Others

9-Hydroxy-alpha-lapachone

Cat.No: TN3318

Target: Antifection

Cat.No: T36438

Cat.No: T36348

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