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Search Results for " gsts "

Targets Recommended: Glutathione Peroxidase GST

5

抑制剂 & 化合物

6

天然产物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T11505	GSTO1-IN-1	Glutathione Peroxidase; GST	Metabolism; oxidation-reduction
	GSTO1-IN-1 是谷胱甘肽 S-转移酶 omega 1 抑制剂，IC50=31 nM。
T5097	Ezatiostat TER199(free base),TLK199	Apoptosis; Glutathione Peroxidase; GST	Apoptosis; Metabolism; oxidation-reduction
	Ezatiostat (TER199(free base)) 是一种谷胱甘肽的三肽类似物，也是一种选择性的口服活性的谷胱甘肽 S-转移酶 P1-1 (GSTP1) 抑制剂。它通过抑制GSTP1导致 JNK 激活，刺激淋巴细胞生成和骨髓祖细胞增殖，可研究骨髓增生异常综合症。
T4564	Ethacrynic acid Edecrin,利尿酸,Etacrynic Acid,Hydromedin	Others; Calcium Channel; NF-κB; GST	Membrane transporter/Ion channel; Metabolism; NF-κB; Others; oxidation-reduction
	Ethacrynic acid (Edecrin) 是谷胱甘肽 S-转移酶抑制剂，也是NF-κB 信号传导途径的有效抑制剂，并且还调节白三烯的形成。它还可抑制 L 型电压依赖性和储存操作的钙通道，从而导致气道平滑肌细胞松弛。它是利尿剂，具有抗炎特性，可减轻类维生素 A 诱导的小鼠耳部水肿。
T22776	Ezatiostat hydrochloride TLK199 HCl,Ezatiostat盐酸盐,TER199	Glutathione Peroxidase	Metabolism
	Ezatiostat hydrochloride (TLK199 HCl) 是一种新型谷胱甘肽类似物，可刺激淋巴细胞生成和骨髓祖细胞增殖，可用于治疗血细胞减少症和研究骨髓增生异常综合症。它也是口服活性的选择性谷胱甘肽 S-转移酶 P1-1 抑制剂，通过抑制 GSTP1导致 JNK 激活。
T11240	Ethacrynic acid D5	Others	Others
	Ethacrynic acid, a diuretic, functions as an inhibitor of L-type voltage-dependent and store-operated calcium channels, facilitating the relaxation of airway smooth muscle (ASM) cells. It exhibits anti-inflammatory effects, notably reducing retinoid-induced ear edema in mice, and inhibits glutathione S-transferases (GSTs), making it a potent suppressor of the NF-kB signaling pathway. Additionally, ethacrynic acid modulates leukotriene formation. A variant, Ethacrynic acid D5, is distinguished by...

化合物

Cat.No: T11505

Target: Glutathione Peroxidase, GST

Cat.No: T5097

Synonym: TER199(free base),TLK199

Target: Apoptosis, Glutathione Peroxidase, GST

Ethacrynic acid

Cat.No: T4564

Synonym: Edecrin,利尿酸,Etacrynic Acid,Hydromedin

Target: Others, Calcium Channel, NF-κB, GST

Ezatiostat hydrochloride

Cat.No: T22776

Synonym: TLK199 HCl,Ezatiostat盐酸盐,TER199

Target: Glutathione Peroxidase

Ethacrynic acid D5

Cat.No: T11240

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3S0012	coniferyl ferulate	P-gp; GST	Membrane transporter/Ion channel; Neuroscience; oxidation-reduction
	Coniferyl ferulate 是从川芎中提取的一种天然产物，是强效的谷胱甘肽 S-转移酶抑制剂，强抑制人胎盘型谷胱甘肽 S-转移酶，IC50为 0.3 μM。它还可逆转多药耐药性并下调 P-糖蛋白。
TN1078	Seneciphylline 千里光菲灵碱,千里光非灵	P450; GST	Metabolism; oxidation-reduction
	Seneciphylline 是一种有毒的吡咯烷核生物碱，存在于千里光植物中。它显著增加了环氧水合酶和谷胱甘肽-S-转移酶的特性，但导致细胞色素 P-450 和相关单加氧酶特性的抑制。
T7995	α-Angelica lactone α-当归内酯,当归内酯,Alpha-Angelica Lactone	Others; GST	Others; oxidation-reduction
	α-Angelica lactone 是一种乙烯基亲核试剂，也是一种天然存在的抗癌剂。它可以得到手性的 δ-氨基 γ，γ-二取代丁烯醇内酯羰基衍生物，并在 γ-碳上表现出亲电子俘获。它通过选择性增强谷胱甘肽-S-硫转移酶 (GST) 和 UDP-葡糖苷转移酶 (UGT) 解毒酶发挥强大的化学保护作用。
T3S0541	Curzerene 莪术烯,莪术呋喃烯	Apoptosis; GST	Apoptosis; oxidation-reduction
	Curzerene, a sesquiterpene compound derived from the rhizome of Curculigo orchioides Gaertn, possesses potent anti-cancer properties. It is known to induce apoptosis in cells[1] and also suppress the expression of glutathione S-transferase A1 (GSTA1) mRNA and protein.
TN5166	Trans-Methylisoeugenol	Parasite; GST	Microbiology/Virology; oxidation-reduction
	Trans-Methylisoeugenol 是从 Acorus calamus L 中分离得到的具有杀虫活性的化合物。它是一种天然食用香料，具有抗焦虑和抗抑郁等特性，可对谷胱甘肽 S-转移酶（GSTs）产生中度可逆性抑制作用（对人类 GSTs 的抑制浓度为 0.2 至 5.4 毫摩尔，对大鼠 GSTs 的抑制浓度为 0.4 至 4.9 毫摩尔）。
T5S1285	(+)-(3R,8S)-Falcarindiol Falcarindiol,镰叶芹二醇	Others	Others
	(+)-(3R,8S)-Falcarindiol 是一种从胡萝卜中得到的聚乙炔，有抗炎、抗肿瘤和抗脂质过氧化活性。它具有抗分歧杆菌作用，对Mycobacterium tuberculosisH37Ra 的 MIC 和 IC50值分别为 24 μM 和 6 μM。

天然产物

coniferyl ferulate

Cat.No: T3S0012

Target: P-gp, GST

Cat.No: TN1078

Synonym: 千里光菲灵碱,千里光非灵

Target: P450, GST

α-Angelica lactone

Cat.No: T7995

Synonym: α-当归内酯,当归内酯,Alpha-Angelica Lactone

Target: Others, GST

Cat.No: T3S0541

Synonym: 莪术烯,莪术呋喃烯

Target: Apoptosis, GST

Trans-Methylisoeugenol

Cat.No: TN5166

Target: Parasite, GST

(+)-(3R,8S)-Falcarindiol

Cat.No: T5S1285

Synonym: Falcarindiol,镰叶芹二醇

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04077	HPGDS/PGD2 Protein, Human, Recombinant (His) hematopoietic prostaglandin D synthase,PGD2,GSTS1-1...	Human	E. coli
	HPGDS/PGD2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 24.2 kDa and the accession number is O60760.
TMPJ-00690	PGDS Protein, Human, Recombinant Glutathione-Requiring Prostaglandin D Synthase,PGDS,Glutathi...	Human	E. coli
	Hematopoietic Prostaglandin D Synthase (HPGDS) belongs to the GST superfamily and Sigma family. HPGDS contains one GST C-terminal domain and one GST N-terminal domain. HPGDS is highly expressed in adipose tissue, macrophages, and placenta, and it exists in the form of homodimer in living body. HPGDS is a cytosolic enzyme that isomerizes PGH(2). HPGDS is a bifunctional enzyme that catalyzes both the conversion of PGH2 to PGD2 and also shows low glutathione-peroxidase activity towards cumenehydrop...
TMPY-00539	GSTA1 Protein, Human, Recombinant (His) glutathione S-transferase alpha 1,GTH1,GST2,glutathione S-tr...	Human	HEK293 Cells
	GSTA1 (Glutathione S-Transferase Alpha 1) is a Protein Coding gene. This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds. Glutathione S-transferases (GSTs) are involved in the detoxification of carcinogens and may be linked to carcinogenesis. As a vital component of GSTs, GSTA1 plays an important role in carcinogenesis. GSTA1 expression may be a target molecule in the early diagnosis and treatment of lung cancer. Human colonic adeno...
TMPJ-00499	GSTP1 Protein, Human, Recombinant GSTP1,GST3,GST class-pi,Glutathione S-transferase P,FAEES3,G...	Human	E. coli
	Glutathione S-transferase P (GSTP1) is an enzyme that contains 1 GST C-terminal domain, 1 GST N-terminal domain. GSTP1 belongs to the GST superfamily, the GSTs are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione ...
TMPY-02223	GSTM2 Protein, Human, Recombinant (His) GSTM2-2,GTHMUS,glutathione S-transferase mu 2 (muscle),GSTM,...	Human	E. coli
	Glutathione S-transferase Mu 2, also known as GST class-mu 2, GSTM2-2, and GSTM2, is a cytoplasm protein that belongs to the GST superfamily and Mu family. GSTM2 / GST4 contains one GST C-terminal domain and one GST N-terminal domain. The glutathione S-transferases (GSTs) are a multigene family of enzymes largely involved in the detoxification of chemicals. Eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, si...
TMPY-03450	GSTK1 Protein, Human, Recombinant glutathione S-transferase κ1,GST,glutathione S-transferase k...	Human	E. coli
	GSTK1 gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. Glutathione S-transferases (GSTs) are a family of enzymes that catalyze a variety of reactions in both eukaryotes and prokaryotes. They catalyze the conjugation of reduced glutathione with potentially toxic, xenobiotic substrates, thus aiding excretion from the body. GSTK1(glutathione S-transferase kappa 1) is localized to the peroxisome and catalyzes the...
TMPY-03338	GSTZ1 Protein, Human, Recombinant (His) MAI,GSTZ1-1,glutathione S-transferase ζ 1,MAAI,GSTZ1,glutath...	Human	E. coli
	GSTZ1 (Glutathione S-Transferase Zeta 1) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. GSTZ1 gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. GSTZ1 is a bifunctional protein that has minimal glutathione-conjugating activity with ethacrynic acid ...

重组蛋白

HPGDS/PGD2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04077

Species: Human

Expression System: E. coli

PGDS Protein, Human, Recombinant

Cat.No: TMPJ-00690

Species: Human

Expression System: E. coli

GSTA1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00539

Species: Human

Expression System: HEK293 Cells

GSTP1 Protein, Human, Recombinant

Cat.No: TMPJ-00499

Species: Human

Expression System: E. coli

GSTM2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02223

Species: Human

Expression System: E. coli

GSTK1 Protein, Human, Recombinant

Cat.No: TMPY-03450

Species: Human

Expression System: E. coli

GSTZ1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03338

Species: Human

Expression System: E. coli

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