51
13
Cat. No. | Product Name | Target | Signaling Pathways |
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T32075 |
HH-Folic acid
|
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HH-Folic acid derives from vitamin B9. | |||
T31838 |
Folic acid, methyl-
x-Methylfolic acid,x-Methyl folic acid,x-Methylpteroylglutamic acid |
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Folic acid, methyl- is a nutrient that belongs to the vitamin B family. Folate is significant for the easy conversion of carbohydrates into glucose and is essential in red blood cell formation, cell division, detoxification, and the production of some neu | |||
T0699 |
Sulfamonomethoxine
磺胺间甲氧嘧啶,磺胺间甲氧嘧啶钠 |
Antibacterial; Antibiotic | Microbiology/Virology |
Sulfamonomethoxine 是一种磺胺类抗菌剂。它可研究血液动力学,竞争性抑制剂二氢叶酸合成,从而阻断叶酸合成。 | |||
T25999 |
Pteropterin
Teropterin,PTGA,Pteroyl triglutamic acid,Folic acid diglutamate |
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Pteropterin is an antineoplastic agent. | |||
TMIH-0243 |
Folic Acid-d4
|
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Folic Acid-d4 是 Folic Acid 的氘代化合物。 | |||
T0849 |
Pyrimethamine
Pirimecidan,RP 4753,Pirimetamin,乙胺嘧啶 |
DHFR; Antifolate; Parasite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Pyrimethamine (Pirimecidan) 是一种二氢叶酸还原酶的竞争性抑制剂,用作抗疟药。 | |||
T16045 |
Methotrexate metabolite
DAMPA,甲喋呤杂质E |
Antifolate; Drug Metabolite | Cell Cycle/Checkpoint; Metabolism |
Methotrexate metabolite (DAMPA) (DAMPA)是 Methotrexate 的活性代谢物。Methotrexate 具有拮抗叶酸 (folic acid) 的作用,被用作免疫抑制剂。 | |||
T20882 |
4-Nitrobenzoic acid
Kyselina p-nitrobenzoova,4Nitrobenzoic acid,Nitrodracylic acid,4 Nitrobenzoic acid |
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4-Nitrobenzoic acid (4Nitrobenzoic acid) 是一种药物中间体,常在叶酸、DABA、PABA 和染料的生产中出现。 | |||
T20339 |
7-Hydroxymethotrexate
NSC 380963,NSC-380963,NSC380962,NSC380963,NSC 380962,NSC-380962 |
Drug Metabolite | Metabolism |
7-Hydroxymethotrexate 是 Methotrexate 主要的代谢产物。Methotrexate 对叶酸具有抑制作用,抑制二氢叶酸还原酶,从而防止叶酸转化为四氢叶酸,并抑制 DNA 合成。Methotrexate 对代谢也具有抑制作用。 | |||
T7593 |
Levomefolate calcium
左旋甲状腺素钙,L-5-甲基四氢叶酸钙 |
Antifolate | Cell Cycle/Checkpoint |
Levomefolate calcium 是一种人工形式的叶酸。它是叶酸的一种辅酶形式,是膳食补充剂中生物利用度更高的替代品。 | |||
T0930 |
Sulfadiazine
Sulphadiazine,磺胺嘧啶 |
Antibacterial; Antibiotic; Parasite; Autophagy | Autophagy; Microbiology/Virology |
Sulfadiazine (Sulphadiazine) 是一种磺胺类抗生素具有抗疟活性,可研究弓形虫病。 | |||
T21434 |
Sulfacetamide
NSC 63871,磺胺醋酰,NSC-63871,Sebizon,Region,NSC63871,Sulphacetamide,Acetosulfamine |
Others; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Sulfacetamide (NSC-63871) 是一种抗生素,通过限制细菌生存所需的叶酸的存在来治疗睑缘炎或结膜炎,有潜力用于眼部感染的研究。 | |||
T33691 |
Nitrosofolic acid
CCRIS 466,N-Nitrosofolic acid,Glutamic acid, N-nitroso-N-pteroyl-, L- |
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Nitrosofolic acid is a folic acid derivaive. | |||
T31508 |
Diopterin
Folate monoglutamate,Pteroyl diglutamic acid |
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Diopterin is a folic acid analog. | |||
T32100 |
Homofolic acid
NSC-79249,NSC 79249,9-Methylfolic acid,NSC79249,Homofolate |
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Homofolic acid is a folic acid analog. | |||
T68629 |
Lysine-iodoacetylmethotrexate
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Lysine-iodoacetylmethotrexate if a Folic Acid Antagonist. | |||
T34183 |
Pteroylpentaglutamic acid
Pte-penta-glu,NSC372667,NSC 372667,NSC-372667 |
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Pteroylpentaglutamic acid within the folic acid family is a bioactive chemical. | |||
T34822 |
Tetrahydromethotrexate
NSC 526044,NSC-526044,NSC526044 |
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Tetrahydromethotrexate is a folic acid derivative. | |||
T11144 |
EC0488
|
Others | Others |
EC0488 was used to synthesize EC0531, which has folic acid receptor specificity and anti-tumor activity. | |||
T30690 |
Calcium dextrofolinate
Calcium (6R)-folinate |
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Calcium dextrofolinate is a calcium salt of a derivative of Folic Acid. | |||
T24972 |
2'-Fluoroaminopterin
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2'-Fluoroaminopterin is a folic acid antagonist agent. | |||
T24976 |
3'-Fluoroaminopterin
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3'-Fluoroaminopterin is a folic acid antagonist agent. | |||
T31851 |
Formiminoglutamic acid
NSC-334078,NSC334078,NSC 334078 |
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Formiminoglutamic acid is used to indicate folic acid deficiency and megaloblastic anemia of pregnancy with the measurement in the urine after oral administration of histidine. | |||
T29461 |
5-Methyltetrahydrofolate triglutamate
5-Me-Thf(glu)3 |
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5-Methyltetrahydrofolate triglutamate is a form of folic acid. | |||
T24535 |
Ninopterin
NSC-107137,NSC107137,9-Me-PGA,NSC 107137,L-Glutamic acid, 9-methylpteroyl- |
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Ninopterin is an experimental antineoplastic and folic acid analog. | |||
T32706 |
Levomefolate calcium pentahydrate
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Levomefolate calcium pentahydrate is the calcium salt of 5-methyltetrahydrofolic acid, a biologically active form of folic acid that functions, in conjunction with Vitamin B12. Levomefolate is included in formulations of certain oral contraceptives to ens | |||
T25208 |
CB 3717
CB3717,CB-3717,N(sup 10)-Propargyl-5,8-dideazafolic acid |
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CB 3717 is an enzyme inhibitor, antineoplastic agent, folic acid antagonist. | |||
T29434 |
4-Desacetylvinblastine hydrazide
DAVLBH,Deacetylvinblastine hydrazide,Desacetylvinblastine hydrazide |
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Deacetylvinblastine hydrazide, a cytotoxic vinca alkaloid often conjugated with folic acid to produce EC145, a novel folate-receptor targeted agent. | |||
T25796 |
Methotrexate 1-methyl ester
Methotrexate related compound I,Methotrexate alpha-methyl ester |
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Methotrexate 1-methyl ester is an impurity of Methotrexate which is a folic acid antagonist. It's used as an antineoplastic and antirheumatic. | |||
T24961 |
10-Deazaaminopterin
NSC 311469,NSC-311469,10-Deaza-aminopterin,NSC311469 |
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10-Deazaaminopterin is a poly-gamma-glutamyl metabolite of the experimental anticancer drug, a folic acid antagonist, antineoplastic agent enzyme inhibitor. | |||
T70080 |
Methasquin
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Methasquin is a folic acid antagonist that has been used in the treatment of experimental leukemia; acts by inhibiting the dihydrofolate reductase in the cell. | |||
T25797 |
Methotrexate 5-methyl ester
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Methotrexate 5-methyl ester is an impurity of Methotrexate which is a folic acid antagonist. It's used as an antineoplastic and antirheumatic. | |||
T0148L |
Folinic Acid Calcium Salt Pentahydrate
Folinic acid,亚叶酸钙五水合物,Leucovorin Calcium Pentahydrate,Leucovorin calcium salt pentahydrate |
Others; Antifolate | Cell Cycle/Checkpoint; Others |
Folinic Acid Calcium Salt Pentahydrate (Leucovorin Calcium Pentahydrate) 是一种还原型叶酸,是一种解毒剂,通常与甲氨蝶呤 (MTX) 联用,以降低 MTX 诱导的毒性。 | |||
T25358 |
EC-17 free acid
EC17,EC 17,EC-17,FTIC-Folate,Folate-FTIC |
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EC17 is a FITC conjugated folic acid, also known as Folate-FITC. It also acts as an FRα-targeting agent that fluoresces at 500nm. EC17 is a conjugate consisting of fluorescein isothiocyanate (FITC) conjugated with folate with potential antineoplastic acti | |||
T34740 |
Sulfacytine
Renoquid,CI636,CI-636,CI 636,磺胺西汀,Sulfacitinum |
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Sulfacytine is a short-acting sulfonamides antibiotic that is taken orally to treat bacterial infections. Sulfonamides, a group of antibiotics, work by inhibiting bacterial production of folic acid. | |||
T13672 |
EC0489
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Others | Others |
EC0489, Small molecule-drug conjugate (SMDC) ,a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor. | |||
T78233 |
Sulfamonomethoxine sodium
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Antibiotic | Microbiology/Virology |
Sulfamonomethoxine sodium用作血液动力学研究中的竞争性抑制剂,通过抑制二氢叶酸合成,进而阻断叶酸的生成。 | |||
T13032 |
Sulfamonomethoxine-d4
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Others | Others |
Sulfamonomethoxine D4 is a deuterium labeled Sulfamonomethoxine. Sulfamonomethoxine is an agent of long acting sulfonamide antibacterial, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate. | |||
T37998 |
N-(4-Aminobenzoyl)-L-glutamic Acid (hydrate)
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N-(4-Aminobenzoyl)-L-glutamic acid is an oxidation product and a metabolite of tetrahydrofolate.1Levels of N-(4-aminobenzoyl)-L-glutamic acid are increased in the plasma of mice fed a high folic acid-containing diet.2 1.Reed, L.S., and Archer, M.C.Oxidation of tetrahydrofolic acid by airJ. Agric. Food Chem.28(4)801-805(1980) 2.Burton, M.A., Antoun, E., Penailillo, R.S., et al.Folic acid induces intake-related changes in the mammary tissue transcriptome of C57BL/6 miceNutrients12(9)2821(2020) | |||
T32705 |
Levomefolate magnesium
L-Methylfolate magnesium |
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Levomefolate magnesium is the magnesium salt of the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods and in the blood circulation, accounting for 98% of folates in human plasma. It is transported across th | |||
T63985 |
Trimetrexate glucuronate
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Trimetrexate glucuronate (NSC 352122) 是一种叶酸拮抗剂,能够抑制二氢叶酸还原酶 (dihydrofolate reductase),进而阻断嘌呤核苷酸和胸苷酸的合成,影响 DNA 和 RNA 合成,表现出潜在的抗肿瘤效果。 | |||
T69089 |
Trimethoprim sulfate
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Trimethoprim sulfate is a pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported. | |||
T25496 |
Hexaglutamate folate
Pteglu6 |
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Hexaglutamate folate is a naturally occurring form of folic acid. The bioavailability of dietary folate may be limited by the need for the glutamate moieties to be deconjugated before absorption. Folate deficiency in humans results in anemia, neural tube | |||
T35976 | 6-Formylpterin | ||
Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen. 6-Formylpterin is an oxidized pterin produced by photolytic breakdown of folic acid. It binds to one of two active sites on XO nearly quantitatively and irreversibly and prevents the metabolism of other substrates at the second site, resulting in hetero-substrate" inhibition at nanomolar concentrations. However | |||
T74009 | 1,1,3-Tribromoacetone | ||
1,1,3-Tribromoacetone 是甲氨蝶呤 的杂质。Methotrexate (Amethopterin) 是一种抗代谢 (antimetabolite) 和抗叶酸剂 (antifolate),可抑制二氢叶酸还原酶,从而防止叶酸转化为四氢叶酸并抑制 DNA 合成。 | |||
T35413 |
(6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride)
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(6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism. Its metabolites participate in the synthesis of thymidine for incorporation into DNA or the synthesis of purines, as well as in the formation of methionine, which can be converted to the ubiquitous methyl donor, S-adenosylmethionine . THFA has also been used to study the activation of metabolite-binding ribos... | |||
T77274 | DSPE-PEG-Folate (MW 5000) | ||
DSPE-PEG-Folate (MW 5000) 是一种含叶酸的 PEG 衍生物,能与癌细胞的叶酸受体结合并具有靶向作用。该化合物可形成胶束/脂质双层,适用于靶向给药系统的研究。 | |||
T68232 |
Epofolate
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Epofolate is folate receptor-targeting antimitotic agent with potential antineoplastic activity. Folate receptor-targeted epothilone BMS753493 contains an epothilone moiety linked to a single folate molecule. Mediated through the folate moiety, this agent delivers the antimitotic epothilone component into cells expressing folic acid receptors, frequently upregulated in many types of tumor cells. After ligand-receptor internalization, the epothilone moiety induces microtubule polymerization and s... | |||
T74308 |
DSPE-PEG-Folate
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DSPE-PEG-Folate (Mw 3350) 是一种含有叶酸的 PEG 衍生物。DSPE-PEG-Folate 具有靶向作用并能与癌细胞中的叶酸受体结合。DSPE-PEG-Folate 形成胶束/脂质双层,可用于靶向给药系统的研究。 | |||
T79632 |
Antileishmanial agent-21
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Parasite | Microbiology/Virology |
Antileishmanial agent-21 (compound 4e),是靶向利什曼原虫蝶啶还原酶1 (Lm-PTR1) 的抗利什曼虫试剂。该化合物通过抗叶酸机制发挥作用,且其抗利什曼活性能被叶酸和亚叶酸逆转。Antileishmanial agent-21 还能抑制对 Chloroquine 抗性的恶性疟原虫菌株 (RKL9),IC50 范围为0.0198-0.096 μM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T0062 |
Folic acid
Folate,Vitamin B9,Pteroylglutamic acid,Vitamin M,叶酸,Folacin |
DNA/RNA Synthesis; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Folic acid (Vitamin B9) 是维生素B9,是合成DNA/RNA,新细胞产生和维持的必要成分。 | |||
T7730 |
Aminopterin
APGA,氨基蝶呤,4-Aminofolic acid |
Antifolate | Cell Cycle/Checkpoint |
Aminopterin (4-Aminofolic acid) 是叶酸的 4-氨基衍生物,是叶酸拮抗剂,具有抗癌和免疫抑制活性,用于研究儿童白血病。它催化叶酸还原为四氢叶酸,竞争性抑制二氢叶酸还原酶,Ki 值为 3.7 pM。 | |||
T7094 |
Levomefolic Acid
L-5-甲基四氢叶酸,5-MTHF,5-甲基四氢叶酸 |
Reactive Oxygen Species; Endogenous Metabolite | Immunology/Inflammation; Metabolism; NF-κB |
Levomefolic Acid (5-MTHF) 是一种具有口服活性、可穿过血脑屏障的天然活性叶酸,是广泛使用的叶酸食品补充剂。 | |||
T31836 |
Folate sodium
Folic acid, monosodium salt,Folvite sodium |
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Folate sodium, as a member of the vitamin B family, can stimulate the hematopoietic system. Folic acid can be used in the treatment and prevention of folate deficiencies and megaloblastic anemia. | |||
T0148 |
Folinic acid calcium
亚叶酸钙,Wellcovorin,Calcium folinate,Leucovorin Calcium,Folinic acid calcium salt |
DNA/RNA Synthesis; Endogenous Metabolite; Antifolate | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Folinic acid calcium (Leucovorin Calcium) 是叶酸的活性代谢物,是一种解毒剂,通常与甲氨蝶呤 (MTX) 联用,以降低 MTX 诱导的毒性。 | |||
T8854 |
PTEROIC ACID
|
Others | Others |
PTEROIC ACID 是叶酸结构的一部分 | |||
TN6988 |
Pterine-6-carboxylic acid
6-Carboxypterin |
DNA; PDE | DNA Damage/DNA Repair; Metabolism |
Pterine-6-carboxylic acid (6-Carboxypterin) 是叶酸的光降解产物,可被用作光敏感剂研究UVA 破环DNA 结构的分子机制。 | |||
T13516 |
5-Methyltetrahydrofolic acid
甲基叶酸盐,5-Methyl THF |
Endogenous Metabolite | Metabolism |
5-Methyltetrahydrofolic acid (5-Methyl THF) 是四氢叶酸的甲基化衍生物,具有生物活性。5-Methyltetrahydrofolic acid 是主要的天然膳食叶酸,是血浆和脑脊液中叶酸的主要形式。 | |||
T1040 |
Vitamin B12
Cyanocobalamin,Cobalamin,维生素B12 |
Endogenous Metabolite | Metabolism |
Vitamin B12 (Cobalamin) 是一种维生素,在维持血流形成和脑、神经系统正常功能等方面发挥关键作用。 | |||
T13969 |
Xanthopterin (hydrate)
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Others; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
Xanthopterin hydrate 是东方大黄蜂翅膀中黄色颗粒的主要成分,是一种非共轭的蝶啶天然产物,在 386/456 nm 处产生特征性的激发光。 它可抑制 RNA 合成,引起大鼠肾脏生长和肥大。 | |||
T4877 |
L-Homocystine
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Endogenous Metabolite | Metabolism |
L-Homocystine 是一种 L-homocysteine 的氧化物。其中 L-homocysteine 是抗血栓因子、血管舒张损害剂、促炎因子,也是研究心血管疾病发生机制的内质网应激反应的诱导剂。 | |||
T29477 |
6R-Leucovorin
(6R,2'S)-Folinic acid,Dextrofolinic acid |
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6R-Leucovorin is a derivative of Folic Acid. | |||
T15128 |
Dihydrofolic acid
7,8-Dihydrofolic acid,Dihydrofolate |
Others | Others |
Dihydrofolic acid (7,8-Dihydrofolic acid) 是一种叶酸衍生物,在二氢叶酸还原酶的作用下生成四氢叶酸。 |