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抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T77699	EP4-IN-1	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	EP4-IN-1 是一种有效的前列腺素 EP4 受体抑制剂，具有潜在的抗肿瘤抗炎和镇痛活性，可用于研究免疫疾病和肿瘤疾病。
T11211	EP4 receptor antagonist 1	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	EP4 receptor antagonist 1 是一种有效的特异性前列腺素 EP4受体拮抗剂，对人和小鼠 EP4受体的 IC50分别为6.1 nM 和16.2 nM。 EP4 receptor antagonist 1 可用于癌症免疫治疗的研究。
T38595	EP4 receptor antagonist 3 EP4 receptor antagonist 3
	EP4 receptor antagonist 3 is a highly potent and specific inhibitor of the EP4 receptor. It is intended for research purposes in studying EP4 receptor-mediated diseases such as acute and chronic pain, osteoarthritis, rheumatoid arthritis, and cancer.
T83779	EP4 Antagonist 14 Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14
	EP4 antagonist 14是一种前列腺素E2（PGE2）受体亚型EP4的拮抗剂，其在使用表达人源受体的HEK293细胞的报告基因测定中的IC50值为1.1 nM。它还能抑制PGE2诱导的同种细胞中的β-阿雷斯汀招募（IC50 = 0.9 nM）。EP4 antagonist 14（10 µM）能减少RAW 264.7巨噬细胞中PGE2诱导的mRNA表达，这些mRNA编码Il-4、巨噬细胞甘露糖受体1（Mrc1）、几丁质酶样蛋白3（Chil3）、趋化因子（C-X-C）基序配体1（Cxcl1）、表达在髓样细胞上的触发受体2（Trem2）和精氨酸酶-1（Arg1）。在体内，EP4 antagonist 14（每天30 mg/kg），结合抗PD-1抗体，能够在CT26小鼠结肠癌模型中抑制肿瘤生长并增加CD8+ T细胞对肿瘤的浸润。
T63100	EP4 receptor antagonist 2
	EP4 receptor antagonist 2 (compound 2-13) 是一种 EP4 受体的有效激动剂 (IC50: 7.8 nM)，具有抗肿瘤作用。
T60840	EP4 receptor antagonist 4
	EP4 receptor antagonist 4 是一种EP4受体激动剂 (human pEC50 = 6.3)。
T9622	MF-766	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	MF-766 是高效的、具有口服活性的EP4选择性拮抗剂，Ki 为 0.23 nM。它在功能检测中表现为一种完整的拮抗剂，其 IC50为 1.4 nM (在 10% HS 存在时变成 1.8 nM)。它具有用于癌症和炎症疾病研究的价值。
T5841	Travoprost 曲伏前列素,Flu-Ipr,Fluprostenol isopropyl ester,AL6221	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Travoprost (Fluprostenol isopropyl ester) 是一种异丙基酯前药，是一种高亲和力的，选择性的 FP 前列腺素全受体激动剂。它能够降低眼压，有潜力应用于青光眼和眼高压。
T37701	pep4c pep4c
	pep4c 可用于生命科学领域的相关研究。其产品编号为 T37701，CAS号为 243843-43-8。
TQ0292	Grapiprant AAT-007,RQ-00000007,CJ-023423	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Grapiprant (AAT-007) 是一种选择性EP4 受体拮抗剂，生理配体为前列腺素 E2(PGE2)，有用于骨关节炎疼痛和炎症的研究潜力。它取代 [3H]-PGE2(1 nM) 与狗的重组EP4 受体结合，IC50为 35 nM，Ki 为 24 nM。
TQ0025	E7046	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	E7046 是一种口服有效的特异性 EP4拮抗剂，IC50值为 13.5 nM，Ki 值为 23.14 nM，具有抗肿瘤活性。
T62525	TP-16	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	TP-16是一种新型高效且具有选择性的 EP4 拮抗剂，可阻断IMCs的功能，增强细胞毒性T细胞介导的体内肿瘤消除。
TQ0290	ONO-AE3-208 AE 3-208	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	ONO-AE3-208 (AE 3-208) 是一种 EP4 拮抗剂，可抑制前列腺癌的细胞迁移、侵袭和转移。
T1978	GW627368 GW 627368X	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	GW627368 (GW 627368X) 是一种新型、强效和选择性的前列腺素 EP4 受体拮抗剂，还对血栓素受体TP 有亲和力。对人 EP4 和 TP 的pKi 值分别为 7.0 和 6.8。
T14975	CJ-42794 CJ-042794	Others	Others
	CJ-42794 (CJ-042794)是前列腺素受体 EP4的选择性拮抗剂, 抑制[3H]-PGE2与 EP4受体结合的平均 pKi 为8.5, 对 EP4选择性比 EP1, EP2和 EP3高200多倍。
T8993L	BGC-20-1531 hydrochloride(1186532-61-5 free base) BGC-20-1531 hydrochloride,GTPL3380 hydrochloride,AP-1531 hydrochloride	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	BGC-20-1531 hydrochloride(1186532-61-5 free base) (GTPL3380 hydrochloride) 是一种 EP4 拮抗剂，用于治疗急性偏头痛。
T15681	L-161982	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	L-161982 是选择性的 EP4 受体拮抗剂。L-161982 可以抑制 PGE2 诱导的 HCA-7 细胞 ERK 磷酸化和细胞增殖。L-161982 可以缓解胶原诱导的小鼠关节炎。
T1562	Rebamipide Proamipide,OPC12759,瑞巴派特	Free radical scavengers; COX; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience; oxidation-reduction
	Rebamipide (OPC12759) 是一种粘膜保护剂，可诱导COX-2表达，增加PGE2水平，并以 COX-2 依赖性方式增强胃粘膜防御。
T5482	TG4-155	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	TG4-155 是一种脑渗透性 EP2 拮抗剂，对 EP2 和 DP1 具有低纳摩尔的拮抗活性。它作用于 EP2 的 KB 为 2.4 nM，比对 DP1 受体的选择性高 14 倍，比对 EP1、EP3、EP4 和 IP 的选择性比高 550-4750 倍。
T63349	Treprostinil diethanolamine UT-15C	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Treprostinil diethanolamine (UT-15C) 是EP2、DP1和IP 的有效激动剂，对EP2、DP1、IP、EP1、EP4、EP3 和 FPKi 的值分别为 3.6、4.4、32.1、212、826、2505 和 4680 nM。Treprostinil diethanolamine 能够促使 cAMP 的上调，进而维持血管系统内的稳态，并造成人肺动脉的血管扩张。
T3306	PF-04418948 PF 04418948,PF04418948	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	PF-04418948 是一种可口服的，选择性的前列腺素EP2受体拮抗剂，IC50为16 nM。
T26497	AAT-008 AAT008
	AAT-008 is a PGE2 receptor EP4 antagonist.
T12060	MK-2894 sodium salt	Others	Others
	MK-2894 sodium salt is a highly potent and selective antagonist of second generation EP4.
T71269	ASP7657
	ASP7657 is a novel, potent, and selective prostaglandin EP4 receptor antagonist.
T12061	MK-2894	Others	Others
	MK-2894 is a highly potent and selective antagonist of second generation EP4 .
T15690	L-902688	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	L-902688 is an orally active EP4 receptor agonist (Ki: 0.38 nM; EC50: 0.6 nM). L-902688 displays >4,000-fold selective for EP4 over other EP and prostanoid receptors.
T15642	KAG-308	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	KAG-308 is an effective selective and orally active agonist of the EP4 receptor (Ki: 2.57 nM and EC50: 17 nM for human EP4 receptor), more selective over EP1, EP2, EP3, and IP receptor. KAG-308 suppresses colitis and promotes histological mucosal healing,
T14500	BAY-1316957	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	BAY-1316957 is a highly potent and selective EP4 receptor antagonist. With an IC50 of 15.3 nM. Good oral bioavailability[1].
T23448	TCS 2510	Others	Others
	EP4 agonist
T78710	AMX12006	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	AMX12006为一种口服活性EP4拮抗剂，显示出高度的选择性与有效性，IC50为4.3 nM，并具备细胞毒性和抗肿瘤活性。
T15689	L-798106 CM9,GW671021	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	L-798106 is a highly selective prostanoid EP3 receptor antagonist (Ki=0.3 nM). It also has micromolar activities at EP4, EP1, and EP2 receptors (Ki: 916 nM, >5000 nM, and >5000 nM at EP4, EP1, and EP2, respectively).
T37441	KMN-80
	The prostaglandin E receptor 4 (EP4) is one of four G protein-coupled receptors that mediate the actions of prostaglandin E2 . Binding of PGE2 to the EP4 receptor causes an increase in intracellular cyclic AMP, which plays important roles in bone formation and resorption, cancer, and atherosclerosis. KMN-80 is a substituted γ-lactam (pyrrolidinone) derivative of PGE1 that acts as a selective and potent agonist of EP4 with an IC50 value of 3 nM (IC50 = 1.4 μM for EP3 and > 10 μM for all other pro...
T11499	GSK726701A	Others	Others
	GSK726701A is a new type of prostaglandin E2 receptor 4 (EP4) partial agonist (pEC50: 7.4).
T8993	BGC201531 AP-1531,GTPL3380,BGC-20-1531	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	BGC201531 (AP-1531) 是一种 EP4 拮抗剂，用于治疗急性偏头痛。
T27279	ER819762 ER-819762,ER 819762
	ER819762, an antagonist of the prostaglandin E2 EP4 receptor, inhibits Th1 differentiation and Th17 expansion.
T10046	16,16-Dimethyl prostaglandin E2 16,16-dimethyl PGE2	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	16,16-Dimethyl prostaglandin E2 is an orally active vertebrate Hematopoietic stem cells homeostasis critical regulator. It can act through EP2/EP4 and has an interaction with the Wnt pathway.
T16069	MF498	Others	Others
	MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed a strong binding affinity for the EP4 receptor (Ki: 0.7 nM).
T31054	CP-432 CP432,CP734432,CP 734432,CP-734432
	CP-432 (CP-734432) is an EP4 prostaglandin agonist for the treatment of glaucoma and ocular hypertension.
T79432	NXT-10796	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	NXT-10796为具口服活性且肠道限制性EP4受体激动剂。
T36080	Rivenprost ONO-4819
	Prostaglandin E2 activates four distinct G protein-coupled receptors, EP1-4. Rivenprost is a potent and selective agonist for the EP4 receptor (Ki = 0.7, 56, 620, and >10,000 nM for EP4, EP3, EP2, and EP1, respectively). It has been used to promote EP4-mediated bone formation, prevent bone loss related to osteoporosis, drive osteoblast differentiation, and stabilize bone implants.[1][2][3][4][5] Rivenprost has also been used to support wound healing.[6]
T69590	ONO-AE1-329
	ONO-AE1-329 is a novel agonist of the prostaglandin PGE2 receptor EP4.
T70718	CR-6086
	CR6086 is a novel, potent EP4 antagonist showing favourable immunomodulatory properties, striking DMARD effects in rodents, and anti-inflammatory activity targeted to immune-mediated inflammatory diseases and distinct from the general effects of cyclooxygenase inhibitors. CR6086 showed selectivity and high affinity for the human EP4 receptor (Ki = 16.6 nM) and functioned as a pure antagonist (half-maximal inhibitory concentration, 22 nM) on PGE2-stimulated cAMP production.
T63316	BGC-20-1531 free base
	BGC-20-1531 (PGN 1531) free base 是选择性的、有效的前列腺素 EP4受体拮抗剂 (pKB: 7.6)，表现出偏头痛的研究潜力。
T14139	Aganepag AGN 210937	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Aganepag, a potent Prostanoid EP2 receptor agonist, exhibits remarkable selectivity with an EC50 of 0.19 nM, demonstrating no activity at the EP4 receptor. Its applications are primarily in the fields of wound healing, scar reduction, scar prevention, and the treatment and prevention of wrinkles.
T26925	Butaprost Butaprostum,TR-4979,(R)-Butaprost
	Butaprost is a chemical compound that functions as a selective agonist for the prostaglandin E receptor (EP2). It exhibits an EC50 of 33 nM and a Ki of 2.4 μM when interacting with the murine EP2 receptor. However, Butaprost demonstrates lower activity against murine EP1, EP3, and EP4 receptors. Furthermore, it effectively attenuates fibrosis by inhibiting the TGF-β/Smad2 signaling pathway [1] [2] [3].
T37996	17-phenyl trinor Prostaglandin E2 ethyl amide 17-phenyl trinor Prostaglandin E2 ethyl amide
	17-phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rats (Ki = 25, 4.3, and 54 nM, respectively). 17-phenyl trinor PGE2 causes contraction of guinea pig ileum at a concentration of 11 μM and is 4.4 times more potent than PGE2 as an antifertility agent in hamsters. Modification of the C-1 carboxyl group to an ethyl amide serves to inc...
T78582	15-keto-Prostaglandin E2 15-keto-PGE2	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	15-keto-Prostaglandin E2为内源性代谢产物，通过与STAT3Cys259残基结合，抑制STAT3激活作用。该化合物能够结合并稳定EP2与EP4受体，进而抑制乳腺癌细胞生长与进展，并通过激活PPAR-γ促进真菌生长。
T29907	Alprostadil sodium PGE1 sodium salt,Prostaglandin E1 sodium
	Alprostadil sodium 是一种前列腺素受体配体，对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集，可作为血管扩张剂用于外周血管疾病的研究。
T71510	MF-592
	MF-592 is a potent and selective antagonists of the EP4 receptor. MF-592 demonstrated good functional potency (hEP4 IC50 = 3 nM) and potent inhibition of PGE2 modulated TNFa release in LPS stimulated human whole blood (hWB) (IC50 = 78nM). In addition, it showed an excellent oral pharmacokinetic (PK) profile and in vivo efficacy in a rat chronic adjuvant-induced-arthritis model (ED50 = 0.1 mg/kg/day).. MF-592 has a desirable overall preclinical profile that suggests it is suitable for further de...
T40738	CAY10580 CAY10580
	CAY10580 is a potent and selective prostaglandin EP 4 receptor agonist ( K i =35 nM).

化合物

Cat.No: T77699

Target: Prostaglandin Receptor

EP4 receptor antagonist 1

Cat.No: T11211

Target: Prostaglandin Receptor

EP4 receptor antagonist 3

Cat.No: T38595

Synonym: EP4 receptor antagonist 3

EP4 Antagonist 14

Cat.No: T83779

Synonym: Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14

EP4 receptor antagonist 2

Cat.No: T63100

EP4 receptor antagonist 4

Cat.No: T60840

Cat.No: T9622

Target: Prostaglandin Receptor

Cat.No: T5841

Synonym: 曲伏前列素,Flu-Ipr,Fluprostenol isopropyl ester,AL6221

Target: Prostaglandin Receptor

Cat.No: T37701

Synonym: pep4c

Cat.No: TQ0292

Synonym: AAT-007,RQ-00000007,CJ-023423

Target: Prostaglandin Receptor

Cat.No: TQ0025

Target: Prostaglandin Receptor

Cat.No: T62525

Target: Prostaglandin Receptor

Cat.No: TQ0290

Synonym: AE 3-208

Target: Prostaglandin Receptor

Cat.No: T1978

Synonym: GW 627368X

Target: Prostaglandin Receptor

Cat.No: T14975

Synonym: CJ-042794

Target: Others

BGC-20-1531 hydrochloride(1186532-61-5 free base)

Cat.No: T8993L

Synonym: BGC-20-1531 hydrochloride,GTPL3380 hydrochloride,AP-1531 hydrochloride

Target: Prostaglandin Receptor

Cat.No: T15681

Target: Prostaglandin Receptor

Cat.No: T1562

Synonym: Proamipide,OPC12759,瑞巴派特

Target: Free radical scavengers, COX, Prostaglandin Receptor

Cat.No: T5482

Target: Prostaglandin Receptor

Treprostinil diethanolamine

Cat.No: T63349

Synonym: UT-15C

Target: Prostaglandin Receptor

Cat.No: T3306

Synonym: PF 04418948,PF04418948

Target: Prostaglandin Receptor

Cat.No: T26497

Synonym: AAT008

MK-2894 sodium salt

Cat.No: T12060

Target: Others

Cat.No: T71269

Cat.No: T12061

Target: Others

Cat.No: T15690

Target: Prostaglandin Receptor

Cat.No: T15642

Target: Prostaglandin Receptor

Cat.No: T14500

Target: Prostaglandin Receptor

Cat.No: T23448

Target: Others

Cat.No: T78710

Target: Prostaglandin Receptor

Cat.No: T15689

Synonym: CM9,GW671021

Target: Prostaglandin Receptor

Cat.No: T37441

Cat.No: T11499

Target: Others

Cat.No: T8993

Synonym: AP-1531,GTPL3380,BGC-20-1531

Target: Prostaglandin Receptor

Cat.No: T27279

Synonym: ER-819762,ER 819762

16,16-Dimethyl prostaglandin E2

Cat.No: T10046

Synonym: 16,16-dimethyl PGE2

Target: Prostaglandin Receptor

Cat.No: T16069

Target: Others

Cat.No: T31054

Synonym: CP432,CP734432,CP 734432,CP-734432

Cat.No: T79432

Target: Prostaglandin Receptor

Cat.No: T36080

Synonym: ONO-4819

Cat.No: T69590

Cat.No: T70718

BGC-20-1531 free base

Cat.No: T63316

Cat.No: T14139

Synonym: AGN 210937

Target: Prostaglandin Receptor

Cat.No: T26925

Synonym: Butaprostum,TR-4979,(R)-Butaprost

17-phenyl trinor Prostaglandin E2 ethyl amide

Cat.No: T37996

Synonym: 17-phenyl trinor Prostaglandin E2 ethyl amide

15-keto-Prostaglandin E2

Cat.No: T78582

Synonym: 15-keto-PGE2

Target: Prostaglandin Receptor

Alprostadil sodium

Cat.No: T29907

Synonym: PGE1 sodium salt,Prostaglandin E1 sodium

Cat.No: T71510

Cat.No: T40738

Synonym: CAY10580

Cat. No.	Product Name	Target	Signaling Pathways
T1626	Prostaglandin E1 前列地尔,PGE1,列腺素E1,Alprostadil	Endogenous Metabolite; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	Prostaglandin E1 (Alprostadil) 是一种前列腺素受体配体，对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集，可作为血管扩张剂用于外周血管疾病的研究。

天然产物

Prostaglandin E1

Cat.No: T1626

Synonym: 前列地尔,PGE1,列腺素E1,Alprostadil

Target: Endogenous Metabolite, Prostaglandin Receptor

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