Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed a strong binding affinity for the EP4 receptor (Ki: 0.7 nM).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,190 | 35日内发货 | ||
5 mg | ¥ 5,280 | 35日内发货 | ||
10 mg | ¥ 9,360 | 35日内发货 | ||
25 mg | ¥ 19,800 | 35日内发货 |
产品描述 | MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed a strong binding affinity for the EP4 receptor (Ki: 0.7 nM). |
体外活性 | MF498 inhibits PGE2-stimulated cAMP accumulation in a dose-dependent manner (IC50: 1.7 and 17 nM in the absence and presence of 10% serum, respectively). MF498 also displays a relatively good selectivity over other prostanoid receptors, does not compromise the mucosal integrity in the gastrointestinal tract. |
体内活性 | MF498 on inflammation in adjuvant-caused arthritis (AIA), a rat model for rheumatoid arthritis (RA), and joint pain in a guinea pig model of iodoacetate-induced osteoarthritis (OA). MF498 relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis. |
分子量 | 603.69 |
分子式 | C32H33N3O7S |
CAS No. | 915191-42-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31 mg/mL (51.35 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.6565 mL | 8.2824 mL | 16.5648 mL | 41.412 mL |
5 mM | 0.3313 mL | 1.6565 mL | 3.313 mL | 8.2824 mL | |
10 mM | 0.1656 mL | 0.8282 mL | 1.6565 mL | 4.1412 mL | |
20 mM | 0.0828 mL | 0.4141 mL | 0.8282 mL | 2.0706 mL | |
50 mM | 0.0331 mL | 0.1656 mL | 0.3313 mL | 0.8282 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
MF498 915191-42-3 Others MF-498 MF 498 Inhibitor inhibitor inhibit