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Search Results for " e-cadherin "

Targets Recommended: Apoptosis Phosphatase Gamma-secretase Immunology/Inflammation related

11

抑制剂 & 化合物

24

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T13410	ZLDI-8	Apoptosis; Phosphatase; Gamma-secretase; Immunology/Inflammation related	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience; Proteases/Proteasome; Stem Cells
	ZLDI-8 是 Notch 激活/裂解酶 ADAM-17 的抑制剂，可抑制 Notch 蛋白裂解，并降低促存活/抗凋亡和上皮-间质转化相关蛋白的表达。它还是竞争性不可逆酪氨酸磷酸酶抑制剂，以IC50为 5.32 μM 抑制 MHCC97-H 细胞的生长。
T3144	BML-284 Wnt agonist 1	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	BML-284 (Wnt agonist 1) 是细胞通透性 Wnt 信号激活剂，能够诱导 TCF 依赖的转录活性(EC50>700 nM)。
T8820	BML-284 hydrochloride BML-284 HCL,Wnt agonist 1 HCL	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	BML-284 hydrochloride (Wnt agonist 1 HCL) 是细胞通透性 Wnt 信号激活剂。它能够诱导 TCF 依赖的转录活性(EC50>700 nM)。
T4252	ML327	c-Myc; Autophagy	Autophagy; Cell Cycle/Checkpoint
	ML327 是 MYC 的阻断剂，还可抑制 E-钙粘蛋白转录和逆转上皮间质转化。
T81058	SWELYYPLRANL-NH2 TFA
	SWELYYPLRANL-NH2 TFA 作为E-cadherin和N-cadherin的拮抗剂，显示出对噬菌体克隆与E-或N-cad/Fc嵌合蛋白结合的有效抑制作用，IC50分别为0.7和0.09 μM。此化合物亦能阻碍细胞聚集，有助于促进药物穿越上皮和内皮的渗透性屏障。
T81059	SWELYYPLRANL-NH2
	SWELYYPLRANL-NH2 是一种分别针对E-cadherin和N-cadherin的拮抗剂，能够有效抑制噬菌体克隆与E-或N-cad/Fc嵌合蛋白的结合，其IC50值分别为0.7和0.09 μM。此外，该化合物还可抑制细胞聚集现象，并能促进药物透过上皮和内皮的渗透性屏障，以便于药物递送。
T78532	HDAC-IN-55	Others	Others
	HDAC-IN-55(8j)是一种小分子化合物，能够上调E-钙粘蛋白的表达并抑制癌细胞的增殖。
T60639	SLEC-11
	SLEC-11 可在E-钙粘蛋白缺陷细胞中作为合成致死(SL)的先导化合物出现，具有治疗胃癌的潜力。
T41169	P21d hydrochloride
	P21d hydrochloride is a potent and selective breast tumor Ki nase (Brk) inhibitor (IC50 = 30 nM). Exhibits >650-fold selectively for Brk over Aurora B Ki nase and Lck. Downregulates SNAIL protein, restores E-cadherin expression and suppresses migration in breast cancer cells. Also activein vivoand orally bioavailable.
T62822	CT1-3
	CT1-3 是一种有效的抗癌剂。CT1-3 能够调控 JNK/Bcl-2/Bax/XIAP 通路，进而诱导线粒体介导的细胞凋亡 (apoptosis)。CT1-3 可以调控 E-cadherin/Snail 轴抑制人癌细胞 (HCCs) 的上皮间充质转化 (EMT) 电位，并抑制肿瘤发生。CT1-3 在小鼠模型中具有抗肿瘤作用，且没有表现出明显的肝、肾毒性。
T69685	AGPS-IN-2i	MMP	Proteases/Proteasome
	AGPS-IN-2i 是一种高效且具有很高亲和力的烷基甘油磷酸酯合成酶抑制剂的，可控制着细胞中醚脂的利用和代谢，降低了醚类脂质水平和细胞迁移率，促进癌细胞的增殖和运动。AGPS-IN-2i 在 PC-3和 MDA-MB-231癌细胞中测试时通过调节 E-cadherin、Snail 和 MMP2的表达水平，特异性地损害了上皮向间质转化（EMT）。AGPS-IN-2i 对癌细胞增殖具有抑制作用。

化合物

Cat.No: T13410

Target: Apoptosis, Phosphatase, Gamma-secretase, Immunology/Inflammation related

Cat.No: T3144

Synonym: Wnt agonist 1

Target: Wnt/beta-catenin

BML-284 hydrochloride

Cat.No: T8820

Synonym: BML-284 HCL,Wnt agonist 1 HCL

Target: Wnt/beta-catenin

Cat.No: T4252

Target: c-Myc, Autophagy

SWELYYPLRANL-NH2 TFA

Cat.No: T81058

SWELYYPLRANL-NH2

Cat.No: T81059

Cat.No: T78532

Target: Others

Cat.No: T60639

P21d hydrochloride

Cat.No: T41169

Cat.No: T62822

Cat.No: T69685

Target: MMP

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03762	E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc) cadherin 1, type 1, E-cadherin (epithelial...	Human	HEK293 Cells
	E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 87.1 kDa and the accession number is P12830-1.
TMPY-04041	E-Cadherin/Cadherin-1 Protein, Rat, Recombinant (His) cadherin 1, type 1, E-cadherin (epithelial...	Rat	HEK293 Cells
	E-Cadherin/Cadherin-1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 78.4 kDa and the accession number is Q9R0T4.
TMPY-03244	E-Cadherin/Cadherin-1 Protein, Rat, Recombinant (hFc) cadherin 1, type 1, E-cadherin (epithelial...	Rat	HEK293 Cells
	E-Cadherin/Cadherin-1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 103.8 kDa and the accession number is Q9R0T4.
TMPK-00509	E-Cadherin/Cadherin-1 Protein, Cynomolgus, Recombinant (His) E-Cadherin,Arc-1,L-CAM,E-CAD,Cadherin1,	Cynomolgus	HEK293 Cells
	E-cadherin is the core component of epithelial adherens junctions, essential for tissue development, differentiation, and maintenance. It is also fundamental for tissue barrier formation, a critical function of epithelial tissues.
TMPY-05052	E-Cadherin/Cadherin-1 Protein, Human, Recombinant (His) Arc-1,UVO,CDHE,cadherin 1, type 1, E-cadherin	Human	HEK293 Cells
	E-Cadherin/Cadherin-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62 kDa and the accession number is A0A0U2ZQU7.
TMPY-05656	E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc), Biotinylated E-Cadherin,CD324,Arc-1,UVO,E-cad,cadherin ...	Human	HEK293 Cells
	E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 87.1 kDa and the accession number is P12830-1.
TMPY-02137	E-Cadherin/Cadherin-1 Protein, Mouse, Recombinant (His) AA960649,L-CAM,UVO,cadherin 1, type 1, E-cadher...	Mouse	HEK293 Cells
	E-Cadherin/Cadherin-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 78 kDa and the accession number is P09803.
TMPH-02307	Vinculin Protein, Human, Recombinant (GST)	Human	E. coli
	Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
TMPK-00800	CDH3 Protein, Mouse, Recombinant (His) HJMD,CDHP,CAD3,P-cadherin,Placental cadherin	Mouse	HEK293 Cells
	Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration. CDH3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The ...
TMPK-01306	CDH3 Protein, Cynomolgus, Recombinant (His) PCAD,CDHP,CAD3,Placental cadherin,HJMD,Cadherin...	Cynomolgus	HEK293 Cells
	Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration. CDH3 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag....
TMPH-00331	ALS3 Protein, Candida albicans, Recombinant (B2M & His & Myc) Adhesin 3,3D9 antigen,Agglutinin-like protein 3	Candida albicans	E. coli
	Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys. ALS3 Prot...
TMPK-00851	CDH3 Protein, Human, Recombinant (aa 108-654, His) CAD3,Placental cadherin,PCAD,HJMD,CDH3,P-cadher...	Human	HEK293 Cells
	Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration. CDH3 Protein, Human, Recombinant (aa 108-654, His) is expressed in HEK293 mammalian cells with C-H...
TMPH-01218	DSP Protein, Human, Recombinant (His & SUMO) Desmoplakin,DSP,DP,250/210 kDa paraneoplastic pemphigus anti...	Human	E. coli
	Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. DSP Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 42.1 kDa and the accession number is P15924.
TMPY-00610	RAB2 Protein, Mouse, Recombinant (His) C80220,Rab2,RAB2A, member RAS oncogene family,9330148M11Rik	Mouse	E. coli
	RAB2A, a protein essential for ER-to-Golgi transport, is critical in promoting proteolytic activity and 3D invasiveness of breast cancer (BC) cell lines.RAB2A is amplified and elevated in human BC and is a powerful and independent predictor of disease recurrence in BC patients. Thus, RAB2A is a novel trafficking determinant essential for regulation of a mesenchymal invasive program of BC dissemination. At the cellular levels, RAB2A controls both canonical polarized Golgi-to-Plasma membrane traff...
TMPH-02539	MGAT3 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains, called bisecting N-acetylglucosamine (GlcNAc). It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. The addition of this bisecting GlcNAc residue alters not only the composition,...
TMPY-03795	EIF5A2 Protein, Human, Recombinant (His) eIF5AII,eukaryotic translation initiation factor 5A2,EIF-5A2	Human	E. coli
	Eukaryotic translation initiation factor 5A2 (EIF5A2) has been demonstrated to be upregulated in numerous types of human cancer and is associated with cancer progression. Silencing of EIF5A2 in the NSCLC cells resulted in the downregulation of the tumorigenic proteins, apoptosis regulator Bcl-2 and myc proto-oncogene protein, and upregulation of E-cadherin, suggesting that EIF5A2 promotes proliferation and metastasis through these proteins. EIF5A2 may therefore serve as a novel therapeutic targe...
TMPH-02217	SMARCA4 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor compl...
TMPK-01424	Peptide Ready HLA-E01:03&B2M Monomer Protein, Human, MHC (His & Avi) MHC,HLA-E01:03,Peptide Ready	Human	HEK293 Cells
	HLA-E01:03&B2M&Peptide ready Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-E01:03. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner.
TMPK-01545	HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Monomer Protein, Human, MHC (His & Avi), Biotinylated sHLA-E,MHC,MHC class I antigen E,HLAE,MHC HLA-E alpha-1,MHC ...	Human	HEK293 Cells
	HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ...
TMPK-01423	Peptide Ready HLA-E01:03&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated MHC,Peptide Ready,HLA-E01:03	Human	HEK293 Cells
	HLA-E01:03&B2M&Peptide ready Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-E01:03. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner.
TMPK-01541	HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Tetramer Protein, Human, MHC (His & Avi), Biotinylated QA1,MHC HLA-E alpha-2.1,MHC,HLAE,MHC class I antigen E,MHC H...	Human	HEK293 Cells
	HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ...
TMPK-01544	HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Tetramer Protein, Human, MHC (His & Avi) MHC class I antigen E,HLAE,sHLA-E,QA1,MHC HLA-E alpha-2.1,MH...	Human	HEK293 Cells
	HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ...
TMPK-01452	HLA-E*01:03&B2M&Peptide (VMAPKTLVL) Monomer Negative Control Protein, Human, MHC (His & Avi) HLAE,MHC class I antigen E,MHC,QA1,sHLA-E	Human	HEK293 Cells
	HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ...
TMPK-01514	HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Monomer Protein, Human, MHC (His & Avi) sHLA-E,MHC class I antigen E,MHC HLA-E alpha-1,MHC,HLAE,QA1,...	Human	HEK293 Cells
	HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ...

重组蛋白

E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-03762

Species: Human

Expression System: HEK293 Cells

E-Cadherin/Cadherin-1 Protein, Rat, Recombinant (His)

Cat.No: TMPY-04041

Species: Rat

Expression System: HEK293 Cells

E-Cadherin/Cadherin-1 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-03244

Species: Rat

Expression System: HEK293 Cells

E-Cadherin/Cadherin-1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00509

Species: Cynomolgus

Expression System: HEK293 Cells

E-Cadherin/Cadherin-1 Protein, Human, Recombinant (His)

Cat.No: TMPY-05052

Species: Human

Expression System: HEK293 Cells

E-Cadherin/Cadherin-1 Protein, Human, Recombinant (hFc), Biotinylated

Cat.No: TMPY-05656

Species: Human

Expression System: HEK293 Cells

E-Cadherin/Cadherin-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02137

Species: Mouse

Expression System: HEK293 Cells

Vinculin Protein, Human, Recombinant (GST)

Cat.No: TMPH-02307

Species: Human

Expression System: E. coli

CDH3 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00800

Species: Mouse

Expression System: HEK293 Cells

CDH3 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01306

Species: Cynomolgus

Expression System: HEK293 Cells

ALS3 Protein, Candida albicans, Recombinant (B2M & His & Myc)

Cat.No: TMPH-00331

Species: Candida albicans

Expression System: E. coli

CDH3 Protein, Human, Recombinant (aa 108-654, His)

Cat.No: TMPK-00851

Species: Human

Expression System: HEK293 Cells

DSP Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01218

Species: Human

Expression System: E. coli

RAB2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00610

Species: Mouse

Expression System: E. coli

MGAT3 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02539

Species: Mouse

Expression System: E. coli

EIF5A2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03795

Species: Human

Expression System: E. coli

SMARCA4 Protein, Human, Recombinant (His)

Cat.No: TMPH-02217

Species: Human

Expression System: P. pastoris (Yeast)

Peptide Ready HLA-E*01:03&B2M Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01424

Species: Human

Expression System: HEK293 Cells

HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01545

Species: Human

Expression System: HEK293 Cells

Peptide Ready HLA-E*01:03&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01423

Species: Human

Expression System: HEK293 Cells

HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Tetramer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01541

Species: Human

Expression System: HEK293 Cells

HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01544

Species: Human

Expression System: HEK293 Cells

HLA-E*01:03&B2M&Peptide (VMAPKTLVL) Monomer Negative Control Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01452

Species: Human

Expression System: HEK293 Cells

HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01514

Species: Human

Expression System: HEK293 Cells

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