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Cat. No. | Product Name | Target | Signaling Pathways |
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T80057 |
Cytochrome P450 reductase
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Cytochrome P450reductase,一种NADPH-细胞色素还原酶,发挥作用于促进芳香酶构象,以最适合底物结合。 | |||
T4382 |
Proguanil hydrochloride
Paludrine hydrochloride,盐酸氯胍,Chlorguanide hydrochloride,Chloroquanil |
Others; Dehydrogenase; DNA/RNA Synthesis; Antifolate; Parasite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Others |
Proguanil hydrochloride (Chloroquanil) 是一种双胍类抗疟疾剂,在体内代谢形成环胍。它还是一种二氢叶酸还原酶抑制剂。 | |||
T2534 |
Pitavastatin calcium
P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,匹伐他汀钙,NK-104 |
Apoptosis; Mitophagy; Endogenous Metabolite; HMG-CoA Reductase; Autophagy | Apoptosis; Autophagy; Metabolism |
Pitavastatin calcium (NK-104) 是一种羟甲基戊二酰-CoA 还原酶抑制剂。它在 HepG2 细胞中抑制乙酸合成胆固醇的IC50为 5.8 nM。它是高效的肝细胞低密度脂蛋白胆固醇受体诱导剂。具有抗癌活性。 | |||
T35724 |
4-hydroxy Atorvastatin (calcium salt)
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4-hydroxy Atorvastatin is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias. Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin. | |||
T69178 |
Rosuvastatin lactone
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Rosuvastatin lactone is the lactone form of the HMG-CoA reductase inhibitor rosuvastatin. It is found in vivo following rosuvastatin administration. Rosuvastatin lactone is an inhibitor of the cytochrome P450 (CYP) isoforms CYP2C9.1 and CYP2C9.3 (IC50s = 8.52 and 4.1 µM, respectively). | |||
T35718 |
N-desmethyl Rosuvastatin (sodium salt hydrate)
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N-desmethyl Rosuvastatin is an active metabolite of the HMG-CoA reductase inhibitor rosuvastatin .1,2N-desmethyl Rosuvastatin is formed when rosuvastatin undergoes demethylation, primarily by the cytochrome P450 (CYP) isoform CYP2C9 and to a lesser extent by CYP2C19 and CYP3A4.1 1.Macwan, J.S., Ionita, I.A., and Akhlaghi, F.A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography-tand... | |||
T20765 |
Atorvastatin
阿托伐他汀,阿伐他汀 |
HMG-CoA Reductase; Autophagy | Autophagy; Metabolism |
Atorvastatin 是一种具有口服活性的 HMG-CoA 还原酶抑制剂,通过激活肝细胞色素p450加快代谢,具有有效降低血脂的能力。Atorvastatin 以 IC50 值分别为 0.39 μM 和 2.39 μM 来抑制人 SV-SMC 细胞的增殖和侵袭。Atorvastatin 与氯吡格雷同时服用两种可能会导致患者血栓事件增加。 | |||
TMIH-0457 |
Proguanil-d6 HCl
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Proguanil-d6 HCl 是 Proguanil HCl 的氘代化合物。Proguanil HCl 的 CAS 号为 637-32-1。Proguanil hydrochloride 是一种双胍类抗疟疾剂,在体内代谢形成环胍。它还是一种二氢叶酸还原酶抑制剂。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T1153 |
Trimethoprim
NIH 204,BW 56-72,甲氧苄啶,NSC-106568 |
DHFR; DNA/RNA Synthesis; Antifolate; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Trimethoprim (NSC-106568) 是抑菌抗生素,也是具有口服活性的二氢叶酸还原酶抑制剂。它对多种革兰氏阳性和革兰氏阴性需氧细菌具有活性,可用于尿路感染,肺孢子菌肺炎和志贺氏菌病的研究。 | |||
T82305 |
Glucoarabin
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Glucoarabin是一种硫代葡萄糖苷,具备生物活性。在Hepa1c1c7细胞内,Glucoarabin的水解产物能够上调NQO1,而对细胞色素P450 (CYP) 1A1的活性无显著作用。 |