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Search Results for " ct2 "

Targets Recommended: Chk

16

抑制剂 & 化合物

1

天然产物

5

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10718L	CCT241533 hydrochloride	Chk	Cell Cycle/Checkpoint
	CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).
T4428	CCT241736	FLT; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	CCT241736 是一种口服生物可利用的双重 FLT3/Aurora 激酶抑制剂，还抑制临床相关的 FLT3 耐药突变体，包括 FLT3-ITD 和 FLT3。它是 CCT137690 的高级类似物，是治疗人类恶性肿瘤的临床前开发候选物。
T14905	CCT251236	HSP	Cytoskeletal Signaling; Metabolism
	CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen. It inhibits HSF1-mediated HSP72 induction (IC50: 19 nM).
T9638	CCT241161	Raf	MAPK
	CCT241161 is an orally active pan-RAF inhibitor, with IC50 values of 3, 6, 10, 15, and 30 nM for LCK, CRAF, SRC, V600E-BRAF, and BRAF, respectively. It displays significant activity against BRAF and NRAS mutant melanomas, as well as demonstrating anticancer cell proliferative effects [1].
T7080	CCT245737 SRA737	Chk	Cell Cycle/Checkpoint
	CCT245737 (SRA737) 是一种具有口服活性的选择性 Chk1 抑制剂，IC50值为 1.3 nM。
T14907	CCT251545	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	CCT251545 是一种有效的、具有口服活性的WNT 抑制剂，在 7dF3 细胞中对 WNT 抑制作用的IC50值为 5 nM。它是选择性化学探针，用于探索 CDK8 和 CDK19 在人类疾病中的作用。
T36704	CCT241533 dihydrochloride CCT 241533 dihydrochloride
	Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes. Caldwell et al (2011) Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J.Med.Chem. 54 580 PMID:21186793
T32136	ICT2700 de OH CPI MI,deOHCPIMI,de-OH-CPI-MI,ICT 2700,ICT-2700
	ICT2700 is a potent cytotoxin selectively by CYP1A1 as a tumor-selective treatment for human bladder cancers.
T14904	CCT244747	Chk	Cell Cycle/Checkpoint
	CCT244747 is a CHK1 inhibitor (IC50: 7.7 nM) and also abrogates G2 checkpoint (IC50: 29 nM).
T62775	CCT245232
	CCT245232 是一种有效的热激因子 1 (HSF1) 抑制剂。其中 HSF1 是一种热激反应的主要调节因子，能够诱导多个基因以响应温度升高和其他压力。CCT245232 具有潜力进行增殖性疾病（如癌症）的研究。
T70553	CCT245737(S)
	CCT245737(S) is a highly selective oral checkpoint kinase 1 (CHK1) inhibitor.
T10718	CCT241533	Chk	Cell Cycle/Checkpoint
	CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).
T14906	CCT251455	Kinesin	Cytoskeletal Signaling
	CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM).
T71353	CCT239065
	CCT239065 is a novel, selective, and efficacious nanomolar pyridopyrazinone V600EBRAF and LCK inhibitor.
T22633	CCT251545 analogue, Compound 51	Others	Others
	CCT251545 analog is a potent and selective CDK8/19 inhibitor (IC50: 5.1 nM and 5.6 nM, respectively). Mediator complex-associated kinases CDK8 and CDK19 are involved in the regulation of multiple transcription pathways. CDK8 plays as an oncogene in gastri
T63830	Anticancer agent 76
	Anticancer agent 76 (Compound CT2-3) 是一种能够明显抑制人 NSCLC 细胞增殖、诱导细胞周期阻滞、ROS 生成和细胞凋亡（apoptosis）的抗癌剂。

化合物

CCT241533 hydrochloride

Cat.No: T10718L

Target: Chk

Cat.No: T4428

Target: FLT, Aurora Kinase

Cat.No: T14905

Target: HSP

Cat.No: T9638

Target: Raf

Cat.No: T7080

Synonym: SRA737

Target: Chk

Cat.No: T14907

Target: Wnt/beta-catenin

CCT241533 dihydrochloride

Cat.No: T36704

Synonym: CCT 241533 dihydrochloride

Cat.No: T32136

Synonym: de OH CPI MI,deOHCPIMI,de-OH-CPI-MI,ICT 2700,ICT-2700

Cat.No: T14904

Target: Chk

Cat.No: T62775

Cat.No: T70553

Cat.No: T10718

Target: Chk

Cat.No: T14906

Target: Kinesin

Cat.No: T71353

CCT251545 analogue, Compound 51

Cat.No: T22633

Target: Others

Anticancer agent 76

Cat.No: T63830

Cat. No.	Product Name	Target	Signaling Pathways
T4702	(3-Carboxypropyl)trimethylammonium chloride γ-Butyrobetaine hydrochloride,(3-羧丙基)三甲基氯化铵,(3-Carboxypropyl)trimethylammonium chlor	Endogenous Metabolite	Metabolism
	(3-Carboxypropyl)trimethylammonium chloride ((3-Carboxypropyl)trimethylammonium chlor) 一种血管病变性中间代谢物，是由肠道微生物代谢产生，这些微生物以红肉中的肉碱为食。

天然产物

(3-Carboxypropyl)trimethylammonium chloride

Cat.No: T4702

Synonym: γ-Butyrobetaine hydrochloride,(3-羧丙基)三甲基氯化铵,(3-Carboxypropyl)trimethylammonium chlor

Target: Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00714	CD5L Protein, Mouse, Recombinant (His) 42010,AAC-11,Sp-alpha,Pdp,Api6,AI047839,CT...	Mouse	HEK293 Cells
	CD5L Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is Q9QWK4.
TMPH-02183	CCT2 Protein, Human, Recombinant (His & SUMO) CCT2,99D8.1,CCT-beta,TCP-1-beta,C...	Human	E. coli
	Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. CCT2 Protein, Human, Recombinant (His & S...
TMPH-02756	LECT2 Protein, Mouse, Recombinant (His & Myc)	Mouse	P. pastoris (Yeast)
	LECT2 Protein, Mouse, Recombinant (His & Myc) is expressed in Yeast.
TMPY-03811	KCT2 Protein, Human, Recombinant (His) chromosome 5 open reading frame 15,KCT2,HT...	Human	HEK293 Cells
	C5orf15 (Chromosome 5 Open Reading Frame 15, also known as KCT2) is a Protein Coding gene. KCT2 gene maps to human chromosome 5q31.1 and is conserved in human, chimpanzee, cow, rat, and chicken. KCT2 is a 265 amino acid single-pass type I membrane protein that is widely expressed in the thyroid, kidney, and other tissues. Chromosome 5 is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. ...
TMPH-02755	LECT2 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation. LECT2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 20.7 kDa and the accession number is O88803.

重组蛋白

CD5L Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00714

Species: Mouse

Expression System: HEK293 Cells

CCT2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02183

Species: Human

Expression System: E. coli

LECT2 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02756

Species: Mouse

Expression System: P. pastoris (Yeast)

KCT2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03811

Species: Human

Expression System: HEK293 Cells

LECT2 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02755

Species: Mouse

Expression System: E. coli

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