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20

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T75349	CDP-Star
	CDP-Star 是碱性磷酸酶的化学发光底物。CDP-Star 可用于酶联免疫分析。
T9901A-003	Gemtuzumab CDP-771,CMA-676
	Gemtuzumab(CMA-676) 是一种针对 CD33 抗原且由重组人源化 IgG4 抗体组成的单克隆抗体。Gemtuzumab 可用于合成一种抗体偶联化合物 (ADC)--Gemtuzumab ozogamicin 。Gemtuzumab 可用于研究急性髓性白血病。
T8735	Sulbactum Sodium 5'-CDP,Cytidine-5′-diphosphate,胞苷-5'-二磷酸	Others	Others
	Sulbactum Sodium (5'-CDP) 由胞苷一磷酸 (CMP) 或尿苷一磷酸 (UMP) 通过磷酸基团的转移在尿苷酸激酶 (UMPK) 酶的催化下合成。
T21951	CDP 840 hydrochloride
	CDP-840 (GR259653X) 是一种有效的、选择性和口服活性的phosphodiesterase IV (PDE IV)抑制剂。CDP-840 抑制有意识的松鼠猴中抗原诱导的早期和晚期支气管收缩。
T31163	Cytidine 5'-diphosphate disodium CDP sodium salt,Cytidine 5'-diphosphate disodium salt,胞苷-5'-二磷酸二钠盐,Cytidine diphosphate sodium salt	Others	Others
	Cytidine 5'-diphosphate disodium (CDP sodium salt) 产生 CTP 以支持 DNA 和 RNA 生物合成和核糖核苷酸还原酶以产生 dCMP。
T83816	Cytidine-5'-O-(2-thiodiphosphate) sodium CDP-β-S
	Cytidine-5’-O-(2-thiodiphosphate) (CDP-β-S) 是一种不可水解的CDP衍生物，具有抗氧化活性。在Trolox等效吸收能力(TEAC)测定中，该化合物在5至20 µM的浓度范围内清除自由基。
T82611	Dapirolizumab pegol CDP 7657
	Dapirolizumab pegol (CDP 7657) 是一种针对 CD40LG/TNFSF5 的 Fab'-IgG-κ 型单克隆抗体，其结构上通过偶联了 pegol 基团。该化合物源自最初的克隆物种挪威大鼠 (Rattus norvegicus)。
T13388L	Zaurategrast ethyl ester UCB1184197,CDP323	Others	Others
	Zaurategrast ethyl ester is the ethyl ester prodrug of CT7758 and is an α4β1/α4β7 integrin antagonist. It is used for the treatment of inflammatory and autoimmune disorders.
T13388	Zaurategrast ethyl ester sulfate UCB1184197 sulfate,CDP323 sulfate	Others	Others
	Zaurategrast ethyl ester sulfate is a α4β1/α4β7 integrin antagonist, and used for the treatment of inflammatory and autoimmune disorders.
T72081	CpCDPK1/TgCDPK1-IN-2	Parasite	Microbiology/Virology
	CpCDPK1/TgCDPK1-IN-2 是 CpCDPK1 和 TgCDPK1 双重抑制剂，对 CpCDPK1 和 TgCDPK1 有抑制这样，IC50 值分别为 12 和 5 nM。CpCDPK1/TgCDPK1-IN-2 可用于研究弓形虫 (T. gondii)、细小隐孢子虫 (C. parvum) 和隐孢子虫 (C. hominus) 等顶复门原生动物感染相关疾病。
T72033	pCDPK1/TgCDPK1-IN-3	Parasite	Microbiology/Virology
	CpCDPK1/TgCDPK1-IN-3 是一种 CpCDPK1 和 TgCDPK1双重抑制剂，对 CpCDPK1 的IC50 为 0.003µM ，对TgCDPK1 的IC50 为 0.0036 µM。CpCDPK1/TgCDPK1-IN-3 可用于研究像弓形虫、细小隐孢子虫和隐孢子虫等顶复门原生动物相关疾病感染。
T78605	CpCDPK1/TgCDPK1-IN-1	Bcr-Abl; Src	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	CpCDPK1/TgCDPK1-IN-1 是一种高效的 CpCDPK1 和 TgCDPK1 双重抑制剂，抑制 Abl 和 Src，具有抗寄生虫活性，适用于研究弓形虫感染和隐孢子虫病。
T22641	CDPPB	GluR	Neuroscience
	CDPPB 是选择性和脑渗透性的代谢型谷氨酸受体亚型5 (mGluR5) 阳性变构的调节剂，在表达人类 mGluR5 的中国仓鼠卵巢细胞中的 EC50值为 27 nM。它为开发抗精神病药提供了一种可能性。
T10700	(+)-CBI-CDPI1	Others	Others
	(+)-CBI-CDPI1 is an enhanced functional analog of CC-1065. It is a DNA alkylating agent and an antibody-drug conjugates (ADCs) toxin.
T22543	ACDPP hydrochloride	Others	Others
	mGlu5 receptor antagonist
T10701	(+)-CBI-CDPI2	Others	Others
	(+)-CBI-CDPI2 is an enhanced functional analog of CC-1065.
T36745	cDPCP
	cDPCP is a platinum-containing DNA-crosslinking agent.1Unlike cisplatin or oxaliplatin , cDPCP forms monofunctional DNA adducts. It is transported into cells by organic cation transporter 1 (OCT1) and OCT2, inhibiting proliferation of MDCK cells expressing the human transporters with IC50values of 8.1 and 1.5 μM, respectively. cDPCP inhibits RNA polymerase II-mediated transcription in a reporter assay using HeLa cells. It increases survival in murine S180 sarcoma and P388 leukemia models when ad...
T76753	Olokizumab
	Olokizumab (CDP 6038) 是一种人源化单克隆抗体，靶向白细胞介素-6 (IL-6)，适用于类风湿关节炎 (RA) 的研究。
T36844	Inostamycin A
	Inostamycin A is a bacterial metabolite that has been found inStreptomycesand has anticancer activity.1It is an inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase (IC50= 0.02 μg/ml in A431 cell membranes) and is selective for CDP-diacylglycerol:inositol 3-phosphatidyltransferase over phospholipase C (PLC) and phosphatidylinositol kinase at 10 μg/ml.2Inostamycin A decreases viability of YCU-T892, KCC-TC873, KB, HSC-4, and YCU-T891 oral squamous cell carcinoma (OSCC) cells in a con...
T35416	α-D-Glucose-1-phosphate (sodium salt hydrate)
	α-D-Glucose-1-phosphate is an intermediate in glycogen metabolism.1,2It is a precursor in the biosynthesis of UDP-glucose, the glucose donor in glycogen biosynthesis.2α-D-Glucose-1-phosphate can be formed during glycogen breakdownviaphosphorolytic cleavage of glycogen by glycogen phosphorylase.1It can be converted to glucose-6-phosphate by phosphoglucomutase. α-D-Glucose-1-phosphate is combined with CTP by α-D-glucose-1-phosphate cytidylyltransferase to form CDP-glucose in the first step of CDP-...

化合物

Cat.No: T75349

Cat.No: T9901A-003

Synonym: CDP-771,CMA-676

Sulbactum Sodium

Cat.No: T8735

Synonym: 5'-CDP,Cytidine-5′-diphosphate,胞苷-5'-二磷酸

Target: Others

CDP 840 hydrochloride

Cat.No: T21951

Cytidine 5'-diphosphate disodium

Cat.No: T31163

Synonym: CDP sodium salt,Cytidine 5'-diphosphate disodium salt,胞苷-5'-二磷酸二钠盐,Cytidine diphosphate sodium salt

Target: Others

Cytidine-5'-O-(2-thiodiphosphate) sodium

Cat.No: T83816

Synonym: CDP-β-S

Dapirolizumab pegol

Cat.No: T82611

Synonym: CDP 7657

Zaurategrast ethyl ester

Cat.No: T13388L

Synonym: UCB1184197,CDP323

Target: Others

Zaurategrast ethyl ester sulfate

Cat.No: T13388

Synonym: UCB1184197 sulfate,CDP323 sulfate

Target: Others

CpCDPK1/TgCDPK1-IN-2

Cat.No: T72081

Target: Parasite

pCDPK1/TgCDPK1-IN-3

Cat.No: T72033

Target: Parasite

CpCDPK1/TgCDPK1-IN-1

Cat.No: T78605

Target: Bcr-Abl, Src

Cat.No: T22641

Target: GluR

(+)-CBI-CDPI1

Cat.No: T10700

Target: Others

ACDPP hydrochloride

Cat.No: T22543

Target: Others

(+)-CBI-CDPI2

Cat.No: T10701

Target: Others

Cat.No: T36745

Cat.No: T76753

Cat.No: T36844

α-D-Glucose-1-phosphate (sodium salt hydrate)

Cat.No: T35416

Cat. No.	Product Name	Target	Signaling Pathways
T0136	Citicoline CDP-Choline,Citicholine,尼古林,cytidine 5'-diphosphocholine,cytidine diphosphate-choline	Apoptosis; Dopamine Receptor; Endogenous Metabolite	Apoptosis; GPCR/G Protein; Metabolism; Neuroscience
	Citicoline (CDP-Choline) 是一种合成细胞膜组分磷脂酰胆碱的中间体，有神经保护作用。
T40426	Cytidine 5'-diphosphate trisodium salt CDP,胞苷5'-二磷酸三钠盐水合物,胞苷-5-二磷酸三钠盐,胞苷-5'-二磷酸三钠盐	Others	Others
	Cytidine 5'-diphosphate trisodium salt (CDP) 可通过尿苷单磷酸激酶 (UMPK) 催化将磷酸基从 ATP 转移到胞苷一磷酸 (CMP) 生成用于合成 DNA 和 RNA 的胞苷三磷酸。
T1208	Citicoline sodium Citicoline sodium salt,CDP-choline,胞磷胆碱钠	Apoptosis; Others; Endogenous Metabolite	Apoptosis; Metabolism; Others
	Citicoline sodium (CDP-choline) 是一种合成细胞膜组分磷脂酰胆碱的中间体，有神经保护作用。
T4972	2'-Deoxycytidine-5'-diphosphate trisodium dCDP,2'-脱氧胞苷-5'-二磷酸三钠盐	Endogenous Metabolite	Metabolism
	2'-Deoxycytidine-5'-diphosphate trisodium (dCDP) 是内源性代谢产物的一种。
T5288	Cytidine-5'-triphosphate disodium 胞苷 5'-三磷酸二钠盐,CTP,Cytidine 5'-triphosphate (disodium salt)	Others; Endogenous Metabolite	Metabolism; Others
	Cytidine-5'-triphosphate disodium (CTP) 是内源性代谢产物的一种。

天然产物

Cat.No: T0136

Synonym: CDP-Choline,Citicholine,尼古林,cytidine 5'-diphosphocholine,cytidine diphosphate-choline

Target: Apoptosis, Dopamine Receptor, Endogenous Metabolite

Cytidine 5'-diphosphate trisodium salt

Cat.No: T40426

Synonym: CDP,胞苷5'-二磷酸三钠盐水合物,胞苷-5-二磷酸三钠盐,胞苷-5'-二磷酸三钠盐

Target: Others

Citicoline sodium

Cat.No: T1208

Synonym: Citicoline sodium salt,CDP-choline,胞磷胆碱钠

Target: Apoptosis, Others, Endogenous Metabolite

2'-Deoxycytidine-5'-diphosphate trisodium

Cat.No: T4972

Synonym: dCDP,2'-脱氧胞苷-5'-二磷酸三钠盐

Target: Endogenous Metabolite

Cytidine-5'-triphosphate disodium

Cat.No: T5288

Synonym: 胞苷 5'-三磷酸二钠盐,CTP,Cytidine 5'-triphosphate (disodium salt)

Target: Others, Endogenous Metabolite

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