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Search Results for " cct2 "

Targets Recommended: Chk

14

抑制剂 & 化合物

1

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10718L	CCT241533 hydrochloride	Chk	Cell Cycle/Checkpoint
	CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).
T4428	CCT241736	FLT; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	CCT241736 是一种口服生物可利用的双重 FLT3/Aurora 激酶抑制剂，还抑制临床相关的 FLT3 耐药突变体，包括 FLT3-ITD 和 FLT3。它是 CCT137690 的高级类似物，是治疗人类恶性肿瘤的临床前开发候选物。
T14905	CCT251236	HSP	Cytoskeletal Signaling; Metabolism
	CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen. It inhibits HSF1-mediated HSP72 induction (IC50: 19 nM).
T9638	CCT241161	Raf	MAPK
	CCT241161 is an orally active pan-RAF inhibitor, with IC50 values of 3, 6, 10, 15, and 30 nM for LCK, CRAF, SRC, V600E-BRAF, and BRAF, respectively. It displays significant activity against BRAF and NRAS mutant melanomas, as well as demonstrating anticancer cell proliferative effects [1].
T7080	CCT245737 SRA737	Chk	Cell Cycle/Checkpoint
	CCT245737 (SRA737) 是一种具有口服活性的选择性 Chk1 抑制剂，IC50值为 1.3 nM。
T14907	CCT251545	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	CCT251545 是一种有效的、具有口服活性的WNT 抑制剂，在 7dF3 细胞中对 WNT 抑制作用的IC50值为 5 nM。它是选择性化学探针，用于探索 CDK8 和 CDK19 在人类疾病中的作用。
T36704	CCT241533 dihydrochloride CCT 241533 dihydrochloride
	Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes. Caldwell et al (2011) Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J.Med.Chem. 54 580 PMID:21186793
T14906	CCT251455	Kinesin	Cytoskeletal Signaling
	CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM).
T71353	CCT239065
	CCT239065 is a novel, selective, and efficacious nanomolar pyridopyrazinone V600EBRAF and LCK inhibitor.
T22633	CCT251545 analogue, Compound 51	Others	Others
	CCT251545 analog is a potent and selective CDK8/19 inhibitor (IC50: 5.1 nM and 5.6 nM, respectively). Mediator complex-associated kinases CDK8 and CDK19 are involved in the regulation of multiple transcription pathways. CDK8 plays as an oncogene in gastri
T14904	CCT244747	Chk	Cell Cycle/Checkpoint
	CCT244747 is a CHK1 inhibitor (IC50: 7.7 nM) and also abrogates G2 checkpoint (IC50: 29 nM).
T62775	CCT245232
	CCT245232 是一种有效的热激因子 1 (HSF1) 抑制剂。其中 HSF1 是一种热激反应的主要调节因子，能够诱导多个基因以响应温度升高和其他压力。CCT245232 具有潜力进行增殖性疾病（如癌症）的研究。
T70553	CCT245737(S)
	CCT245737(S) is a highly selective oral checkpoint kinase 1 (CHK1) inhibitor.
T10718	CCT241533	Chk	Cell Cycle/Checkpoint
	CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).

化合物

CCT241533 hydrochloride

Cat.No: T10718L

Target: Chk

Cat.No: T4428

Target: FLT, Aurora Kinase

Cat.No: T14905

Target: HSP

Cat.No: T9638

Target: Raf

Cat.No: T7080

Synonym: SRA737

Target: Chk

Cat.No: T14907

Target: Wnt/beta-catenin

CCT241533 dihydrochloride

Cat.No: T36704

Synonym: CCT 241533 dihydrochloride

Cat.No: T14906

Target: Kinesin

Cat.No: T71353

CCT251545 analogue, Compound 51

Cat.No: T22633

Target: Others

Cat.No: T14904

Target: Chk

Cat.No: T62775

Cat.No: T70553

Cat.No: T10718

Target: Chk

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02183	CCT2 Protein, Human, Recombinant (His & SUMO) CCT2,99D8.1,CCT-beta,TCP-1-beta,<...	Human	E. coli
	Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. CCT2 Protein, Human, Recombinant (His & S...

重组蛋白

CCT2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02183

Species: Human

Expression System: E. coli

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