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10

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T5858	Sertindole Lu 23-174,舍吲哚	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Sertindole (Lu 23-174) 是一种非典型抗精神病药，可与多巴胺 D2 受体和血清素受体亚型 5-HT1D、5-HT2A 和 5-HT2C 结合，Kd 值分别为 2.7、20、0.14 和 6 nM。
T41133	Ursonic acid methyl ester
	Ursonic acid methyl ester, an esterified derivative of Ursolic acid, exhibits growth inhibitory activity against four tumor cell lines: HL-60, BGC, Bel-7402, and Hela, and the ED50 values for inhibition are >100 μg/ml.
T63653	AKT-IN-11
	AKT-IN-11 是有效的抗人肝癌 Bel-7402 细胞株抗菌剂之一 (IC50: 1.15 μM)。
T79541	HDAC-IN-61	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC-IN-61（compound 12k）为口服生效的HDAC抑制剂，表现出针对Bel-7402细胞线的明显抗癌活性，其IC50值仅为30 nM，适用于癌症研究领域。
T64002	Anticancer agent 61
	Anticancer agent 61 是一种口服具有活力的抗癌剂。Anticancer agent 61 能够抗 HepG2、Bel-7402 和 MCF-7 癌细胞的增殖，他们的 IC50 值分别为 1.12、1.97 和 1.08 μM。Anticancer agent 61 能够抑制肿瘤生长。
T13643	Demethoxydeacetoxypseudolaric acid B analog 脱甲氧基脱乙酰土槿皮乙酸,去甲氧基去乙酰氧基土槿甲酸B类似物	Others	Others
	Demethoxydeacetoxypseudolaric acid B analog 是由 Pseudolaric acid B 半合成得到，能够有效抑制 HMEC-1、HL-60、A-549、MB-MDA-468、BEL-7402、HCT116、Hela 细胞，且 IC50值范围为 0.136-1.162 μM。
T63787	Anticancer agent 62
	Anticancer agent 62 是有效的抗癌剂。Anticancer agent 62 对 HepG2、Bel-7402 和 MCF-7 癌细胞表现出抗增殖作用，其 IC50值分别为 0.019、0.060 和 0.016 μM。Anticancer agent 62 能够抑制肿瘤生长。
T35558	KAAD-Cyclopamine
	Cyclopamine-KAAD is a potent inhibitor of hedgehog signaling with an IC50 value of 20 nM in a Shh-LIGHT2 assay. It blocks binding of BODIPY-cyclopamine to cells expressing Smoothened (Smo) in a dose-dependent manner. Cyclopamine-KAAD is cell-permeable and binds to SmoA1 to promote its exit from the endoplasmic reticulum. It inhibits the invasion and migration (45.9 and 43.3% inhibition, respectively) of Bel-7402 hepatocarcinoma cells and decreases the expression of nuclear glioma-associated onco...
T36882	CAY10773
	CAY10773 is a derivative of the ferroptosis inducer sorafenib .1It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 μM, respectively) over non-cancerous HCV-29 cells (IC50= 23.19 μM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 μM but induces ferroptosis at concentrations greater than or equal to 6 μM with 10 hour or longer incubation times. It increases the production of reactive oxygen ...
T36848	Combretastatin A-1 Combretastatin A1	Akt; Microtubule Associated	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Combretastatin A-1 是一种有效的微管抑制剂，具有抗肿瘤和抗血管活性，通过微管蛋白解聚介导的 AKT 失活抑制 Wnt/β-catenin 通路发挥作用，可用于研究肝癌。

化合物

Cat.No: T5858

Synonym: Lu 23-174,舍吲哚

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Autophagy

Ursonic acid methyl ester

Cat.No: T41133

Cat.No: T63653

Cat.No: T79541

Target: HDAC

Anticancer agent 61

Cat.No: T64002

Demethoxydeacetoxypseudolaric acid B analog

Cat.No: T13643

Synonym: 脱甲氧基脱乙酰土槿皮乙酸,去甲氧基去乙酰氧基土槿甲酸B类似物

Target: Others

Anticancer agent 62

Cat.No: T63787

KAAD-Cyclopamine

Cat.No: T35558

Cat.No: T36882

Combretastatin A-1

Cat.No: T36848

Synonym: Combretastatin A1

Target: Akt, Microtubule Associated

Cat. No.	Product Name	Target	Signaling Pathways
T3S2325	Ardisiacrispin A 百两金素,Saxifragifolin B,LTS-4,Deglucocyclamin	HSV	Microbiology/Virology
	Ardisiacrispin A (Deglucocyclamin) 是一种常见的三萜皂苷，来自于紫金牛属物种。它与来自紫金牛属的 A. crenata 中的一些三萜皂苷具有相似的生物学特性，如对肿瘤细胞具有细胞毒活性、免疫调节和抗病毒活性。
TN2590	11alpha,12alpha-Oxidotaraxerol palmitate	Others	Others
	11alpha,12alpha-Oxidotaraxerol palmitate shows selective cytotoxicity against HCT-8, Bel-7402, BGC-823, A549 and A2780.
TN4496	Marginatoxin	Caspase; Fas/FasL	Apoptosis; Proteases/Proteasome
	Marginatoxin may be a promising chemopreventive agent for treating hepatocellular carcinoma, it induces human hepatoma BEL-7402 cells apoptosis in vitro and in vivo via activation of Fas/FasL-mediated apoptotic pathway.
TN2184	Schisanlactone E 五内脂	Others	Others
	Schisanlactone E may show moderate cytotoxic activity against the human tumor cell lines Bel-7402, BGC-823, MCF-7 and HL-60.
TN3429	Aphagranin A	Others	Others
	Aphagranin A exhibits strong antiproliferative activity against the growth of six lines of human cancer cells (MCF-7, A549, HepG2, Bel-7402, SGC-7901, and BGC-823.
T82741	Changnanic acid
	Changnanic acid（五味子酸）是一种具有潜在抗肿瘤活性的三萜化合物。在Bel-7402、MCF-7和HL-60人类肿瘤细胞系中，Changnanic acid展现了中等水平的细胞毒性，其IC50s分别是100 μM，100 μM和50.51 μM。
TN3646	Chlorovaltrate K	Others	Others
	Chlorovaltrate K shows moderate cytotoxicity against lung adenocarcinoma (A 549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8) and hepatoma (Bel 7402) cell lines with IC50 values of 0.89-9.76 uM.
TN1646	Flemiphilippinin A	Others	Others
	Flemiphilippin A has antioxidant activity, it shows DPPH radical scavenging activity with effective half maximal concentration (EC50) of 18.36 ug/mL. Flemiphilippinin A (5 ug/mL) exhibits some level of antitumor activity against human hepatocellular carci

天然产物

Ardisiacrispin A

Cat.No: T3S2325

Synonym: 百两金素,Saxifragifolin B,LTS-4,Deglucocyclamin

Target: HSV

11alpha,12alpha-Oxidotaraxerol palmitate

Cat.No: TN2590

Target: Others

Cat.No: TN4496

Target: Caspase, Fas/FasL

Schisanlactone E

Cat.No: TN2184

Synonym: 五内脂

Target: Others

Cat.No: TN3429

Target: Others

Changnanic acid

Cat.No: T82741

Chlorovaltrate K

Cat.No: TN3646

Target: Others

Flemiphilippinin A

Cat.No: TN1646

Target: Others

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