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Search Results for " bacillus subtilis "

13

抑制剂 & 化合物

27

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19717	Cyclo-L-Trp-L-Trp	Antifungal	Microbiology/Virology
	Cyclo-L-Trp-L-Trp 是一种广谱抗真菌剂。它还诱导组蛋白的高度乙酰化。
T61037	Glycosyltransferase-IN-1	Others	Others
	Glycosyltransferase-IN-1 是一种糖基转移酶 (glycosyltransferase) 抑制剂，具有抑菌活性，抑制 MSSA、MRSA 、枯草杆菌和肠杆菌。
T38137	3,5-Dimethylbenzaldehyde	Endogenous Metabolite; Antifungal	Metabolism; Microbiology/Virology
	3,5-Dimethylbenzaldehyde 具有广谱的抗菌活性，对枯草芽孢杆菌、白假丝酵母菌、大肠杆菌、铜绿假单胞菌、金黄色葡萄杆菌和肺炎链球菌具有抑制作用。
T77608	1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl-	Antifungal	Microbiology/Virology
	1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl- 可作为一种广谱抗菌剂，对黑曲霉枯草芽孢杆菌、白假丝酵母、大肠杆菌和金黄色葡萄球菌有抑制作用。1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl- 在体外实验中显示出抗炎活性，可用于治疗细菌感染。
T68203	Tuberine, (+)-
	Tuberine, (+)- is an alkaloid isolated from Haplophyllum tuberculatum that has high antimicrobial activity against Staphylococcus aureus, Bacillus subtilis and Saccharomyces cerevisiae. Tuberine, (+)- is also slightly inhibitory to Escherichia coli .
T82351	Gageotetrin A
	Gageotetrin A为源自海洋细菌Bacillus subtilis的抗菌肽，显示出抗真菌活性，同时对多种人类癌细胞无毒性。
T82350	Gageotetrin C
	Gageotetrin C是一种海洋细菌枯草芽孢杆菌产生的抗菌肽，其对真菌表现出较高的活性，具有MIC值为0.02-0.04 μM。
T68946	Antibiotic MA 144M1
	Antibiotic MA 144M1 is an anthracycline glycoside that inhibits the growth of gram-positive bacteria, e.g. Staphyococcus aureaus, Bacillus subtilis and Sarcina lutea, and inhibits the growth of animal tumors such as leukemia L 1210, P 388 and sarcoma 180. It's produced by fermentation of MA 144-producing strains of streptomyces and by the chemical or enzymatic conversion of aclacinomycin A or cinerubin A.
T68945	Antibiotic MA 144M2
	Antibiotic MA 144M2 is an anthracycline glycoside that inhibits the growth of gram-positive bacteria, e.g. Staphyococcus aureaus, Bacillus subtilis and Sarcina lutea, and inhibits the growth of animal tumors such as leukemia L 1210, P 388 and sarcoma 180. It's produced by fermentation of MA 144-producing strains of streptomyces and by the chemical or enzymatic conversion of aclacinomycin A or cinerubin A.
T78654	MraY-IN-3 hydrochloride
	MraY-IN-1（compound 12a）是一种针对细菌转位酶MraY的有效抑制剂，具有140 μM的IC50值。其对Escherichia coli K12、Bacillus subtilis W23和Pseudomonas fluorescens Pf-5展现出抗菌活性，相应的MIC50为7 µg/mL、12 µg/mL和46 µg/mL。MraY-IN-1适用于抗菌药物的研究领域。
T80368	Im5
	Im5 是一种具有针对 Escherichia coli、Staphylococcus aureus、Bacillus subtilis 的抗菌活性（MIC:10、2.5-5、0.5-1 μM)的抗菌肽，同时表现出溶血性（EC50: 28 μM）。
T64172	MraY-IN-1
	MraY-IN-1 (compound 12a) 是细菌转位酶 MraY 的有效抑制剂 (IC50: 140 μM)。MraY-IN-1 对大肠杆菌 K12 (MIC50: 7 μg/ml)、枯草芽孢杆菌 W23 (MIC50: 12 μg/ml) 和荧光假单胞杆菌 Pf-5 (MIC50: 46 μg/ml) 具有抗菌作用。MraY-IN-1 能够用于抗菌的研究。
T63552	FtsZ-IN-1
	FtsZ-IN-1 是有效的、具有喹啉环的 FtsZ 抑制剂，对革兰氏阳性菌具有较强的抑菌效果 (MIC: 0.5-8 μg/mL)。FtsZ-IN-1 能够提高 FtsZ 聚合作用，明显促进枯草芽孢杆菌 (B. subtilis) 的细胞伸长。FtsZ-IN-1 拥有低溶血毒性和低诱导耐药倾向，表现出抗耐药性细菌效果。

化合物

Cyclo-L-Trp-L-Trp

Cat.No: T19717

Target: Antifungal

Glycosyltransferase-IN-1

Cat.No: T61037

Target: Others

3,5-Dimethylbenzaldehyde

Cat.No: T38137

Target: Endogenous Metabolite, Antifungal

1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl-

Cat.No: T77608

Target: Antifungal

Cat.No: T68203

Cat.No: T82351

Cat.No: T82350

Antibiotic MA 144M1

Cat.No: T68946

Antibiotic MA 144M2

Cat.No: T68945

MraY-IN-3 hydrochloride

Cat.No: T78654

Cat.No: T80368

Cat.No: T64172

Cat.No: T63552

Cat. No.	Product Name	Target	Signaling Pathways
T5084	Xanthosine dihydrate 黄苷二水合物	Others; Endogenous Metabolite	Metabolism; Others
	Xanthosine dihydrate 是衍生自黄嘌呤和核糖的核苷，能够提高牛和山羊的乳腺干细胞数量和产奶量。
T21552	5-deoxy Thymidine 5'-脱氧胸苷,5'-Deoxythymidine,Thymidine, 5'-deoxy-1-[(2R,4S,5R)-4-hydroxy-5-methyloxolan-2-yl]-5-methylpyrimidine-2,4-dione	Others	Others
	5-deoxy Thymidine (5'-Deoxythymidine) 是5'位被氢取代的胸苷形式。它对枯草芽孢杆菌和金黄色葡萄球菌的活性有效。
TN6675	Cyclo(Pro-Val) Cyclo(prolylvalyl)	Antibacterial; Antifungal	Microbiology/Virology
	Cyclo(Pro-Val) (Cyclo(prolylvalyl)) 是从海洋真菌中获得的，具有中等的抗真菌活性和较弱的抗肿瘤活性。 Cyclo(Pro-Val) 抑制枯草芽孢杆菌的生长，MIC 为 0.8 g/L。
T4788	L-Norvaline	Others; Endogenous Metabolite	Metabolism; Others
	L-Norvaline 是一种精氨酸酶抑制剂，也是一种非蛋白支链氨基酸。 L-Norvaline 先前已被报道为枯草芽孢杆菌抗真菌肽的天然成分。 L-Norvaline 和其他修饰的支链氨基酸在研究中受到了关注，因为它们似乎被掺入到大肠杆菌中发现的一些重组蛋白中。
TN4851	Pterodondiol	Antifection	Microbiology/Virology
	Pterodondiol has moderate activity against bacteria including Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Mycobacteium phlei and Bacillus circulans.
T75549	(2E,4E)-Decadienoic acid
	(2E,4E)-Decadienoic acid 是一种抗卵菌脂肪族化合物，存在于 Bacillus subtilis 和 Trichoderma asperellum 的共培养物中。
TN4028	Euchrestaflavanone B	PARP; Antifection	Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
	Euchrestaflavanone B shows antibacterial activity against Gram positive bacteria, Staphylococcus aureus, Bacillus subtilis and Bacillus cereus. Euchrestaflavanone B may function by inhibiting oncogenic disease, at least in part, through the inhibition of
TN4852	Pterodontic acid	Antifection	Microbiology/Virology
	Pterodontic acid and pterodondiol showed moderate activity against bacteria including Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis.
T75578	Apigravin
	Apigravin 是一种有效的抗菌剂。Apigravin 对 Bacillus subtilis 具有抗菌活性，MIC 值为 61 μM。
T15349	Fraxidin	Others	Others
	Fraxidin is a class of coumarin. It is isolated from the roots of Jatropha podagrica. It also shows antibacterial activity against Bacillus subtilis with an inhibition zone of 12 mm at a concentration of 20 µg/disk.
TN1695	Globulol	Antifection	Microbiology/Virology
	Globulol shows antimicrobial activity against Xanthomonas vesicatoria and Bacillus subtilis, the IC50 value of 158.0 microg/ mLand 737.2 microg/ mL, respectively.
TN2032	Pachypodol 霍香黃酮醇	Antifection	Microbiology/Virology
	Pachypodol has antibacterial and antifungal activities against Bacillus subtilis, Staphylococcus aureus, Staphylococcus faecalis, Echerichia coli, Pseudomonas aeruginosa, Candida albicans, Candida krusei and Candida galabrata.
T81344	Pycnophorin
	碧萝芷以25μM的最小抑菌浓度（MIC）显著抑制枯草芽孢杆菌和金黄色葡萄球菌的生长。
TN4579	Monomethylsulochrin	Antifection	Microbiology/Virology
	Monomethylsulochrin shows antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus. It shows moderately inhibitory effects on the human bacterial pathogen Helicobacter pylori with the MIC value of 28.9+/-0.1 microM.
TN3400	Altechromone A	Antifection	Microbiology/Virology
	Altechromone A has antimicrobial activity, it is active against Bacillus subtilis, Escherichia coli, Pseudomonas fluorescens and Candida albicans with the MICs of 3.9, 3.9, 1.8, and 3.9 ug/ml, respectively.
T66935	1-Aminopropan-2-ol	Endogenous Metabolite	Metabolism
	1-Aminopropan-2-ol 参与枯草芽孢杆菌菌株中的苏氨酸代谢，可作为真菌培养基上的氮源。
T80351	Maximin 28
	Maximin 28为源自蟾蜍大脑的抗菌肽，对金黄色葡萄球菌(Staphylococcus aureus)、大肠杆菌(Escherichia coli)及枯草芽孢杆菌(Bacillus subtilis)表现出抗菌活性，其MIC值分别为4.7、9.4、75 μg/mL。
TN2392	9,17-Octadecadiene-12,14-diyne-1,11,16-triol	Antifection	Microbiology/Virology
	9,17-Octadecadiene-12,14-diyne-1,11,16-triol shows antibacterial activity against Bacillus subtilis and Pseudomonas fluorescens, antifungal activity against Cladosporium cucumerinum, moiluscicidal activity against Biomphalaria glabrata at low concentratio
T75684	Monascorubrin
	Monascorubrin 是一种从红曲菌菌丝体中纯化获得的化合物，对枯草芽孢杆菌和拟假丝酵母显示出显著的抗生素活性。
TN2626	14-Norpseurotin A	Antifection	Microbiology/Virology
	14-Norpseurotin A shows good antileishmanial and moderate anticancer activities. It also displays significant antimicrobial activities against Escherichia coli, Bacillus subtilis, and Micrococcus lysoleikticus with MICs of 3.74, 14.97, and 7.49 microM , r
TN4594	Murraol	Antifection	Microbiology/Virology
	Murraol shows the significant proliferative activities on osteoblast-like UMR106 cells lines at the concentration of 1 × 10-10 mol/L. It and auraptenol show 63 ug/mL MIC value against Klebsiella pneumoniae ATCC 4352 and Bacillus subtilis ATCC 9372.
T80350	Maximin 15
	Maximin 15为源自蟾蜍大脑的抗菌肽，具有针对金黄色葡萄球菌、大肠杆菌和枯草芽孢杆菌的活性，其最小抑菌浓度(MIC)值依次为9.4, 18.8, 75 μg/mL。
T82859	Blepharotriol
	Blepharotriol为Maytenus blepharodes中发现的一种酚类三萜化合物。该化合物具有抗菌特性，对Bacillus subtilis的最小抑菌浓度（MIC）为8-4 µg/ml。此外，Blepharotriol在HeLa、Hep-2、Vero细胞上的半数抑制浓度（IC50）分别为12.2、>20、>20 µM，表明其具有一定的细胞毒性。
T75686	Enfumafungin
	Enfumafungin，一种从Hormonema carpetanum菌提取的三萜糖苷，具有抗真菌特性，主要通过作为(1,3)-beta-D-葡聚糖合酶抑制剂影响真菌细胞壁发挥作用。其对酵母和多数真菌（除隐球菌外）有效，但不会抑制枯草芽孢杆菌的生长。
TN6674	Cyclo-(Pro-Gly) Cyclo(Pro-Gly)
	Cyclo(Pro-Gly) is an active metabolite of piracetam-N-phenylacetyl-L-prolylglycine (GWS-111), it shows a greater resistance to an enzymatic effect than natural neuropeptides. Cyclo-(Gly-Pro) shows cytotoxicity at the concentration of 10 umol/L, it inhibit
TN4670	Norlichexanthone	Antibacterial; Parasite	Microbiology/Virology
	Norlichexanthone 具有治疗和/或预防生活方式相关疾病的潜力，例如 2 型糖尿病、代谢综合征、动脉粥样硬化和心血管疾病。它具有抗菌和抗疟活性，对枯草芽孢杆菌有很强的活性，IC50范围为1-5uM，对耐甲氧西林金黄色葡萄球菌的生长也有很强的抑制作用，IC50为20.95±1.56uM。
TN5153	Torilin	MMP; ERK; IκB/IKK; p38 MAPK; NF-κB; Tyrosinase; Reductase; DNA/RNA Synthesis; JNK	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Endocrinology/Hormones; MAPK; Metabolism; NF-κB; Proteases/Proteasome
	Torilin 是一种睾酮5α还原酶抑制剂，它（IC50=31.7+/-4.23μM）对5α还原酶的抑制作用强于α-亚麻酸（IC50=160.3+/-24.62μM），但弱于非那雄胺（IC50=0.38+/-0.06μM）。Torilin 具有免疫调节、肝脏保护和抗炎特性，它通过限制 TAK1介导的 MAP 激酶和 NF-βB 活化来抑制炎症，它可以减轻关节炎的严重程度，改变 dLN 或关节中的白细胞活化，并恢复血清和脾细胞细胞因子失衡。托利林抑制α-黑素细胞刺激激素激活的 B16黑色素瘤细胞中的黑色素生成，IC（50）值为25μM。Torilin 对枯草芽孢杆菌 ATCC 6633孢子和营养细胞表现出优异的抗菌活性。Torilin 在体内和体外都具有强大的抗血管生成活性，它可能通过抑制肿瘤侵袭来抑制肿瘤发生，逆转癌细胞的多药耐药性，它可以增强阿霉素、长春碱、紫杉醇和秋水仙碱对多药耐药 KB-V1和 MCF7/ADR 细胞的细胞毒性。

天然产物

Xanthosine dihydrate

Cat.No: T5084

Synonym: 黄苷二水合物

Target: Others, Endogenous Metabolite

5-deoxy Thymidine

Cat.No: T21552

Synonym: 5'-脱氧胸苷,5'-Deoxythymidine,Thymidine, 5'-deoxy-1-[(2R,4S,5R)-4-hydroxy-5-methyloxolan-2-yl]-5-methylpyrimidine-2,4-dione

Target: Others

Cat.No: TN6675

Synonym: Cyclo(prolylvalyl)

Target: Antibacterial, Antifungal

Cat.No: T4788

Target: Others, Endogenous Metabolite

Cat.No: TN4851

Target: Antifection

(2E,4E)-Decadienoic acid

Cat.No: T75549

Euchrestaflavanone B

Cat.No: TN4028

Target: PARP, Antifection

Pterodontic acid

Cat.No: TN4852

Target: Antifection

Cat.No: T75578

Cat.No: T15349

Target: Others

Cat.No: TN1695

Target: Antifection

Cat.No: TN2032

Synonym: 霍香黃酮醇

Target: Antifection

Cat.No: T81344

Monomethylsulochrin

Cat.No: TN4579

Target: Antifection

Cat.No: TN3400

Target: Antifection

1-Aminopropan-2-ol

Cat.No: T66935

Target: Endogenous Metabolite

Cat.No: T80351

9,17-Octadecadiene-12,14-diyne-1,11,16-triol

Cat.No: TN2392

Target: Antifection

Cat.No: T75684

14-Norpseurotin A

Cat.No: TN2626

Target: Antifection

Cat.No: TN4594

Target: Antifection

Cat.No: T80350

Cat.No: T82859

Cat.No: T75686

Cyclo-(Pro-Gly)

Cat.No: TN6674

Synonym: Cyclo(Pro-Gly)

Norlichexanthone

Cat.No: TN4670

Target: Antibacterial, Parasite

Cat.No: TN5153

Target: MMP, ERK, IκB/IKK, p38 MAPK, NF-κB, Tyrosinase, Reductase, DNA/RNA Synthesis, JNK

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