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25

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6501	Fludarabine Phosphate NSC 312887 Phosphate,fludara Phosphate,F-ara-A (NSC 312887) Phosphate,F-ara-AMP,磷酸氟达拉滨	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Fludarabine Phosphate (NSC 312887 Phosphate) 是一种腺苷和脱氧腺苷类似物，与 dATP 竞争，并入到 DNA，可以抑制 DNA 聚合酶 α、核糖核苷酸还原酶和 DNA 引发酶，从而中断 DNA 合成并抑制肿瘤细胞生长。
T1038	Fludarabine NSC 118218,Fludarabinum,氟达拉宾,氟达拉滨,F-ara-A	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; STAT	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; JAK/STAT signaling; Stem Cells
	Fludarabine (Fludarabinum) 是一种氟化嘌呤类似物，一种核酸合成抑制剂和 STAT1 激活抑制剂。Fludarabine 具有抗肿瘤活性，可以用于治疗白血病和淋巴瘤。
T10360	AR-A 2 AR-A 000002	Others	Others
	AR-A 2 is a selective 5-HT1B receptor antagonist, with a high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki: 0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki: 5 nM).
T19688	Lodenosine FddA,3'-dideoxyarabinosyladenine,Fddl,2'-F-dd-ara-A,2'-Fluoro-2',DDG-1
	Lodenosine is an inhibitor of RNA-directed DNA polymerase, and potentially for the treatment of HIV.
TNU1171	2’-Fluoro-2’-deoxy-ara-A(Bz)-3’-phosphoramidite
	2'-Fluoro-2'-deoxy-ara-A(Bz)-3'-phosphoramidite is a Nucleoside Phosphoramidite; Nucleoside Derivative - Fluoro-modified nucleoside.
T27342L	Flurocitabine HCl Flurocitabine HCl(37717-21-8 Free base)	Others	Others
	Flurocitabine HCl 是阿糖胞苷的氟化酸酐类似物，在体内部分水解成两种活性抗肿瘤物质 (阿拉伯糖基-氟尿嘧啶 (ara-FC) 和阿拉伯糖基-氟尿嘧啶 (ara-FU))。Flurocitabine HCl 在急性白血病和实体瘤的 I 期研究中具显示出抗肿瘤活性。
T1272L	Cytarabine hydrochloride Ara-C hydrochloride,Cytosine Arabinoside hydrochloride	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Cytarabine hydrochloride (Ara-C hydrochloride) 是一种核苷类似物，可导致 S 期细胞周期停滞并抑制DNA 聚合酶。Cytarabine 抑制DNA 合成，IC50为 16 nM。Cytarabine hydrochloride 对HSV 具有抗病毒作用。
T36944	Ara-G	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Ara-G 是一种脱氧鸟苷 (GdR) 类似物和核苷类似物，可被 T 淋巴谱系细胞迅速转化为其相应的阿拉伯糖基鸟嘌呤核苷酸三磷酸 (araGTP)，从而抑制 DNA 合成和对 T 淋巴母细胞的选择性体外毒性细胞系以及来自 T 细胞急性淋巴细胞白血病 (ALL) 患者的新鲜分离的白血病细胞。
T8308	NL-1	Mitochondrial Metabolism; Autophagy	Autophagy; Metabolism
	NL-1 是一种mitoNEET 抑制剂，具有抗白血病作用。它抑制 REH 和 REH/Ara-C 细胞生长，IC50分别为 47.35 µM 和 56.26 µM。
T74032	Ara-F-NAD+ sodium
	Ara-F-NAD+ sodium 是一种 NAD+的 arabino 类似物。Ara-F-NAD+ sodium 是一种有效的、可逆的、缓慢结合的CD38NADase 抑制剂。
T38730	Ara-F-NAD+
	Ara-F-NAD+, an arabino analogue of NAD + , is a potent, slow-binding CD38 NADase inhibitor, with a K i of 169 nM.
TNU1176	2’-Fluoro-2’-deoxy-ara-C(Bz)-3’-phosphoramidite
	2'-Fluoro-2'-deoxy-ara-C(Bz)-3'-phosphoramidite is a Nucleoside Phosphoramidite; Nucleoside Derivative - Fluoro-modified nucleoside.
T38718	Cytarabine triphosphate Cytarabine triphosphate,Ara-CTP
	Cytarabine triphosphate (Ara-CTP), a competitive inhibitor of DNA synthesis and an active metabolite of Cytarabine, exhibits predictive potential for leukemic blasts' chemosensitivity to Cytarabine through intracellular levels.
T30117	Ara-fluorocytosine NSC529180,NSC 529180,NSC-529180
	Ara-fluorocytosine is a biochemical.
TNU0493	2’-Deoxy-2’-fluoro-6-S-Methyl-6-thio-ara-guanosine
	2'-Deoxy-2'-fluoro-6-S-Methyl-6-thio-ara-guanosine is a Nucleoside Derivative - 6-Modified purine nucleoside; Thio-nucleoside; Fluoro-modified nucleoside.
TNU1422	2'-F-2'-ara-N2-ibu-dG Phosphoramidite
	2'-F-2'-ara-N2-ibu-dG Phosphoramidite is a Nucleoside Phosphoramidite.
TNU1173	2'-Fluoro-2'-deoxy-ara-U-3'-phosphoramidite
	2'-Fluoro-2'-deoxy-ara-U-3'-phosphoramidite is a Nucleoside Phosphoramidite; Nucleoside Derivative - Fluoro-modified nucleoside.
T13907	Sulfo-ara-F-NMN CZ-48	Others	Others
	Sulfo-ara-F-NMN 是一种具有细胞渗透性的烟酰胺单核苷酸 (NMN) 的类似物。Sulfo-ara-F-NMN 对激活 SARM1具有选择性，对 CD38具有抑制作用， IC50 约为 10 μM。Sulfo-ara-F-NMN 对具有更高的环化酶活性 CZ-48或 NMN 的激活会引起 SARM1的构象变化，导致 cADPR 的产生、NAD 的消耗和非凋亡细胞死亡。
TNU1558	2’-Deoxy-2’-fluoro-ara-uridine
	2'-Deoxy-2'-fluoro-ara-uridine is a Nucleoside Derivative - 2'-Modified nucleoside, Fluoro-modified nucleoside, N-Methylated/ alkylated nucleoside.
T83261	6-Methoxypurine arabinoside Ara-m
	6-Methoxypurine arabinoside (Ara-m) 是一种抗水痘-带状疱疹病毒（VZV）活性物质，具有对8株VZV 50%抑制浓度差异，在0.5 - 3 microM范围内。
T17059	Tetrahydrouridine NSC 112907,NSC112907,四氢尿苷,NSC-112907	DNA Methyltransferase	Chromatin/Epigenetic
	Tetrahydrouridine (NSC-112907; THU) 是一种多药耐药调节剂。它可用于癌症治疗，使肿瘤细胞对放射治疗更加敏感。它是一种竞争性胞苷脱氨酶 (CDA) 抑制剂，可抑制 ara-C 和吉西他滨等细胞毒性脱氧胞苷类似物分解代谢中的脱氨作用。
T79224	Ara-SH	Apoptosis	Apoptosis
	Ara-SH为Cytarabine巯基丙酸取代的衍生物，应用于通过自组装技术制造携带Cytarabine和Venetoclax的智能共负载纳米颗粒(AV-NP)的触发器。在体外和体内实验中，Ara-SH展现出显著的协同抗白血病效果。
T11957	MBC-11 trisodium	Others	Others
	MBC-11 trisodium has potential to treat tumor-induced bone disease (TIBD).It is a first-in-class conjugate of the bone-targeting bisphosphonate HEDP covalently linked to the antimetabolite Ara-C.
T74088	Fludarabine triphosphate trisodium
	Fludarabine triphosphate (F-ara-ATP) trisodium 是Fludarabine 的活性代谢物，是一种有效的、非竞争性的、特异性的DNA 引发酶 (DNA primase) 抑制剂，其IC50为 2.3 μM，Ki 为 6.1 μM。Fludarabine triphosphate trisodium 通过阻断 DNA 引发酶和引物 RNA 形成抑制 DNA 合成 (DNA synthesis)。Fludarabine triphosphate trisodium 可抑制核糖核苷酸还原酶和DNA 聚合酶，导致细胞凋亡 (apoptosis)。
T71361	CHS-828 nicotinate
	CHS-828 nicotinate is a CHS-828 salt with Nicotinic acid.. CHS-828 also known as GMX-1778, is a potent and selective NAMPT inhibitor. CHS-828 inhibits cellular synthesis of NAD. CHS 828 kill tumour cells by inhibiting the nuclear factor-kappaB translocation but unlikely through down-regulation of proteasome. CHS 828 has shown promising anticancer activity in experimental tumor models and primary cultures of cancer cells from patients. CHS 828 showed a synergistic effect with melphalan in 67%, ...

化合物

Fludarabine Phosphate

Cat.No: T6501

Synonym: NSC 312887 Phosphate,fludara Phosphate,F-ara-A (NSC 312887) Phosphate,F-ara-AMP,磷酸氟达拉滨

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Cat.No: T1038

Synonym: NSC 118218,Fludarabinum,氟达拉宾,氟达拉滨,F-ara-A

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, STAT

Cat.No: T10360

Synonym: AR-A 000002

Target: Others

Cat.No: T19688

Synonym: FddA,3'-dideoxyarabinosyladenine,Fddl,2'-F-dd-ara-A,2'-Fluoro-2',DDG-1

2’-Fluoro-2’-deoxy-ara-A(Bz)-3’-phosphoramidite

Cat.No: TNU1171

Flurocitabine HCl

Cat.No: T27342L

Synonym: Flurocitabine HCl(37717-21-8 Free base)

Target: Others

Cytarabine hydrochloride

Cat.No: T1272L

Synonym: Ara-C hydrochloride,Cytosine Arabinoside hydrochloride

Target: DNA/RNA Synthesis

Cat.No: T36944

Target: Nucleoside Antimetabolite/Analog

Cat.No: T8308

Target: Mitochondrial Metabolism, Autophagy

Ara-F-NAD+ sodium

Cat.No: T74032

Cat.No: T38730

2’-Fluoro-2’-deoxy-ara-C(Bz)-3’-phosphoramidite

Cat.No: TNU1176

Cytarabine triphosphate

Cat.No: T38718

Synonym: Cytarabine triphosphate,Ara-CTP

Ara-fluorocytosine

Cat.No: T30117

Synonym: NSC529180,NSC 529180,NSC-529180

2’-Deoxy-2’-fluoro-6-S-Methyl-6-thio-ara-guanosine

Cat.No: TNU0493

2'-F-2'-ara-N2-ibu-dG Phosphoramidite

Cat.No: TNU1422

2'-Fluoro-2'-deoxy-ara-U-3'-phosphoramidite

Cat.No: TNU1173

Sulfo-ara-F-NMN

Cat.No: T13907

Synonym: CZ-48

Target: Others

2’-Deoxy-2’-fluoro-ara-uridine

Cat.No: TNU1558

6-Methoxypurine arabinoside

Cat.No: T83261

Synonym: Ara-m

Tetrahydrouridine

Cat.No: T17059

Synonym: NSC 112907,NSC112907,四氢尿苷,NSC-112907

Target: DNA Methyltransferase

Cat.No: T79224

Target: Apoptosis

MBC-11 trisodium

Cat.No: T11957

Target: Others

Fludarabine triphosphate trisodium

Cat.No: T74088

CHS-828 nicotinate

Cat.No: T71361

Cat. No.	Product Name	Target	Signaling Pathways
T1506	Vidarabine Adenine Arabinoside,阿糖腺苷,9-β-D-Arabinofuranosyladenine,Vira-A,Arabinosyladenine,Ara-A	Nucleoside Antimetabolite/Analog; Tyrosine Kinases; DNA/RNA Synthesis; Antibiotic; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Vidarabine (Adenine Arabinoside) 是从链霉菌分离的核苷类抗生素，能抗单纯性疱疹和水痘-带状疱疹病毒。它对 HSV-1 和 HSV-2 的 IC50值分别为 9.3 μg/ml 和 11.3 μg/ml。
T1272	Cytarabine 阿糖胞苷,Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Endogenous Metabolite; Autophagy; HSV	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Cytarabine (Ara-C) 是一种核苷类似物，一种 DNA 合成抑制剂 (IC50=16 nM)。Cytarabine 可以抑制 DNA 聚合酶，诱导细胞周期阻滞、细胞自噬和凋亡。Cytarabine 具有抗肿瘤活性。

天然产物

Cat.No: T1506

Synonym: Adenine Arabinoside,阿糖腺苷,9-β-D-Arabinofuranosyladenine,Vira-A,Arabinosyladenine,Ara-A

Target: Nucleoside Antimetabolite/Analog, Tyrosine Kinases, DNA/RNA Synthesis, Antibiotic, HSV

Cat.No: T1272

Synonym: 阿糖胞苷,Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Endogenous Metabolite, Autophagy, HSV

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