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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0005	Aspirin 阿司匹林,Acetylsalicylate,Acetylsalicylic Acid,邻乙酰水杨酸,ASA	Mitophagy; Virus Protease; COX; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Aspirin (Acetylsalicylic Acid) 是一种选择性 COX 抑制剂，具有多种药理活性。它是组蛋白去乙酰化酶抑制剂，可上调细胞周期阻滞蛋白 p21，抑制携带 COX-1 的卵巢 Y 细胞。它还抑制 HUVEC 和新生大鼠心室心肌细胞中 COX-2 的表达，分别减少 PG 的产生和 ERK 和 NF-KB 的下调。
T20458	Aspirin DL-lysine DL-Lysine acetylsalicylic acid salt,Aspegic,ASL,Aspisol
	Aspirin DL-lysine is a non-steroidal anti-inflammatory drug. It also may inhibit cancer growth. Aspirin DL-lysine is a water-soluble, injectable aspirin derivative.
T13751	L-Threonine derivative-1	Others	Others
	L-Threonine derivative-1 是乙酰水杨酸-L-苏氨酸酯，具有潜在的镇痛活性。
T3276	Benorilate Benortan,贝诺酯,Benoral,Salipran,Benorylate	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Benorilate (Salipran) 是对乙酰氨基酚和乙酰水杨酸的酯化产物，具有抗炎、解热的作用。它还能够抑制前列腺素(PG)的合成，可用于缓解疼痛的研究。
T15447	Guacetisal	Others	Others
	Guacetisal 是从乙酰水杨酸与愈创木酚的酯化反应中提取的，可用于治疗慢性支气管炎的相关研究。

化合物

Aspirin

Cat.No: T0005

Synonym: 阿司匹林,Acetylsalicylate,Acetylsalicylic Acid,邻乙酰水杨酸,ASA

Target: Mitophagy, Virus Protease, COX, Autophagy

Aspirin DL-lysine

Cat.No: T20458

Synonym: DL-Lysine acetylsalicylic acid salt,Aspegic,ASL,Aspisol

Target:

L-Threonine derivative-1

Synonym: Benortan,贝诺酯,Benoral,Salipran,Benorylate

Target: Prostaglandin Receptor

Cat. No.	Product Name	Target	Signaling Pathways
T2735	5-Acetylsalicylic acid 5-乙酰水杨酸(阿司匹林),5-acetyl-2-hydroxybenzoic acid	Others	Others
	5-Acetylsalicylic acid (5-acetyl-2-hydroxybenzoic acid) 是炎症性肠病中的活性剂，具有抗炎活性。
TN6710	Methyl acetylsalicylate ACETYLSALICYLIC ACID METHYL ESTER,乙酰水杨酸甲酯	Others	Others
	Methyl acetylsalicylate (ACETYLSALICYLIC ACID METHYL ESTER) 是一种从豌豆中分离出来的天然产物。抑制胶原蛋白诱导的人富含血小板的血浆聚集。
T5917	2-Hydroxy-6-methoxybenzoic acid 6-甲氧基水杨酸,2-羟基-6-甲氧基苯甲酸,6-Methoxysalicylic acid	Others	Others
	2-Hydroxy-6-methoxybenzoic acid (6-Methoxysalicylic acid) 可用于动物血浆中乙酸水杨酸及其主要代谢物水杨酸含量的测定，表现出较好的抗缓解疼痛活性。
T0335	Sodium salicylate 水杨酸钠,Salicylic acid sodium salt,2-Hydroxybenzoic acid sodium salt	Apoptosis; NF-κB; COX; S6 Kinase; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; MAPK; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling
	Sodium salicylate (2-Hydroxybenzoic acid sodium salt) 是一种S6K 的抑制剂，可抑制COX-2活性。它还是一种NF-κB 抑制剂，可降低炎症基因的表达，促进老化肌肉的修复。
TN4600	Myrianthic acid	PAFR; AChR	GPCR/G Protein; Neuroscience
	Myrianthic acid shows anticancer activity, it shows inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low-density lipoproteins at a 50 uM concentration. Myrianthic acid is equivalently inhibitive as acetylsalicylic acid (IC50: 57.0 microM) on epinephrine induced platelet aggregation.
TN5113	Taxinine B	Others	Others
	Taxinine and taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells. Taxinine B shows stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA).