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32

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T61553	ATPase-IN-2
	ATPase-IN-2 is a compound that acts as an inhibitor of ATPase, with an IC50 value of 0.9 μM. It also inhibits the glycohydrolase activity of C. difficile toxin B (TcdB) with an AC50 value of 30.91 μM. ATPase-IN-2 is commonly utilized in ATP-related research [1].
T9882	RUVBL1/2 ATPase-IN-1	Others	Others
	RUVBL1/2 ATPase-IN-1 是一种有效的 RUVBL1/2 ATPase 抑制剂，IC50 值分别为 6.0 和 7.7 μM。 RUVBL1/2 ATPase-IN-1 可用于癌症疾病的研究。
T60032	BRM/BRG1 ATP Inhibitor-2	Epigenetic Reader Domain	Chromatin/Epigenetic
	BRM/BRG1 ATP Inhibitor-2 是 BRG1/BRM ATPase 的抑制剂，可用于治疗 BAF 相关疾病的研究。
T0674	Lansoprazole 兰索拉唑,A-65006,AG-1749	Proton pump; Phospholipase; Antibacterial	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Lansoprazole (A-65006) 是一种可抑制胃酸生成的质子泵抑制剂。它是中性鞘磷脂酶的外泌体抑制剂。
T62248	SARS-CoV-2 nsp13-IN-6
	SARS-CoV-2 nsp13-IN-6 (compound C5) 是一种 SARS-CoV-2 非结构蛋白 13 (nsp13) 的有效抑制剂，能够作用于 ssDNA+ATPase (IC50: 27 μM)和 ssDNA-ATPase (IC50: 33 μM)。SARS-CoV-2 nsp13-IN-6 可以用于抗 COVID-19 的研究。
T63615	SARS-CoV-2 nsp13-IN-5
	SARS-CoV-2 nsp13-IN-5 是 SARS-CoV-2 nsp13 的有效抑制剂，能够作用于 ssDNA+ATPase (IC50: 50 μM) 和 ssDNA-ATPase (IC50: 55 μM)。SARS-CoV-2 nsp13-IN-5 能够用于抗 COVID-19 的研究。
T62413	SARS-CoV-2 nsp13-IN-1
	SARS-CoV-2 nsp13-IN-1 (compound C1) 是一种 nsp13 (非结构蛋白 13) 的有效抑制剂。SARS-CoV-2 nsp13-IN-1 只抑制nsp13 ssDNA+ATPase (IC50: 6 μM)，不抑制 ssDNA-ATPase。SARS-CoV-2 nsp13-IN-1 能够用于研究 COVID-19。
T76374	SPAI-1
	SPAI-1，特异性单价阳离子ATP酶抑制剂，源自猪十二指肠。能体外抑制Na+，K+-ATP酶和H+，K+-ATP酶，同时刺激Mg2+-ATP酶。
T62264	SARS-CoV-2 nsp13-IN-2
	SARS-CoV-2 nsp13-IN-2 (Compound C2) 是一种 SARS-CoV-2 非结构蛋白 13（nsp13）小分子抑制剂，能够作用于 nsp13 ssDNA+ATPase (IC50: 42 μM)。
T62375	SARS-CoV-2 nsp13-IN-3
	SARS-CoV-2 nsp13-IN-3 (Compound C3) 是一种 SARS-CoV-2 非结构蛋白 13（nsp13）小分子抑制剂，能够作用于 nsp13 ssDNA+ATPase (IC50: 32 μM)。
T62031	SARS-CoV-2 nsp13-IN-4
	SARS-CoV-2 nsp13-IN -4 (C4 (d)) 是强效的、选择性的 nsp13 helicase 小分子抑制剂。SARS-CoV-2 nsp13-IN -4 抑制 nsp13 的 ssDNA+ ATPase 活性，IC50值为57 μM。SARS-CoV-2 nsp13-IN-4 显示广谱抗病毒作用。
T61740	Esomeprazole hemistrontium
	Esomeprazole hemistrontium, also known as (S)-Omeprazole, is a potent and orally active proton pump inhibitor that effectively reduces acid secretion by inhibiting the H+, K+-ATPase in gastric parietal cells. This compound exhibits promising potential for research in symptomatic gastroesophageal reflux disease [1] [2] [3].
T61667	Esomeprazole potassium salt
	Esomeprazole potassium salt ((S)-Omeprazole potassium salt) is an effective and orally active proton pump inhibitor that works by inhibiting the H+, K+-ATPase enzyme in the gastric parietal cells, leading to a reduction in acid secretion. It is a promising compound for investigating symptomatic gastroesophageal reflux disease [1] [2] [3].
T61467	Esomeprazole magnesium salt
	Esomeprazole magnesium salt is a potent and orally active proton pump inhibitor that effectively reduces acid secretion in gastric parietal cells by inhibiting the H+, K+-ATPase. This compound has shown promise for the research and treatment of symptomatic gastroesophageal reflux disease [1][2][3].
T39255	β-Cyfluthrin beta-Cyfluthrin,β-Cyfluthrin
	β-Cyfluthrin is a type II synthetic pyrethroid compound commonly utilized as an active ingredient in agricultural insecticide products. It exerts its insecticidal properties by acting as a neurotoxicant, primarily impacting the calcium concentration within nervous tissue. This effect is achieved through the inhibition of Ca 2+ ATPase, a crucial component involved in calcium transport.
T35465	(±)16-HETE
	Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure. At a concentration of 2 μM the (S)-enantiomer of 16-HETE inhibits pro...
T35848	16(S)-HETE
	Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that demonstrates stereospecific biological activity. 16(S)-HETE inhibits proximal tubule ATPase activity by as much as 60% at a concentration of 2 μM.
T73645	ARL67156 triethylamine
	ARL67156 (FPL 67156) triethylamine 是一种ecto-ATPase 抑制剂。ARL67156 triethylamine 是竞争性 NTPDase1 (CD39)，NTPDase3 和 NPP1 抑制剂，Ki 分别为 11，18 和 12 μM。ARL67156 triethylamine 可用于钙化性主动脉瓣疾病、哮喘等疾病的研究。
T35849	17(S)-HETE
	Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites.17-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney.17(S)-HETE inhibits proximal tubule ATPase activity by as much as 70% at a concentration of 2 μM.
T75315	Phenacaine
	Phenacaine (Holocaine)为一种局部麻醉剂，能够在大脑及心脏红细胞中抑制特定的钙调素依赖性Ca2+-ATP酶与环核苷酸磷酸二酯酶刺激产生。
T73644	ARL67156 trisodium hydrate
	ARL67156 (FPL 67156) trisodium hydrate 是一种ecto-ATPase 抑制剂。ARL67156 trisodium hydrate 是竞争性 NTPDase1 (CD39)，NTPDase3 和 NPP1 抑制剂，Ki 分别为 11，18 和 12 μM。ARL67156 trisodium hydrate 可用于钙化性主动脉瓣疾病、哮喘等疾病的研究。
T35523	(±)17-HETE
	Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)17-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. At a concentration of 2 μM the (S)-enantiomer of 17-HETE inhibits proximal tubule ATPase activity by as much as 70%, whereas the (R)-isomer is inactive.
T78218	Ilaprazole sodium hydrate IY-81149 sodium hydrate	Proton pump	Membrane transporter/Ion channel
	Ilaprazole (IY-81149) sodium hydrate是一种具有口服活性的质子泵抑制剂，可以量依赖性地不可逆抑制H+/K+-ATPase，并在兔壁细胞制剂中展示出IC50为6μM的效力。该化合物主要用于胃溃疡的研究，并已证实是一种有效的T细胞起源蛋白激酶(TOPK)抑制剂。
T37708	17(R)-HETE
	Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 17-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. 17(R)-HETE is an inactive isomer of 17-HETE, whereas the (S) enantiomer can inhibit proximal tubule ATPase activity at a concentration of 2 μM.
T35847	16(R)-HETE
	Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that demonstrates stereospecific biological activity. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that...
T61643	Vonoprazan hydrochloride
	Vonoprazan hydrochloride 是一种高效且具口服活性的质子泵抑制剂 (PPI) 和钾竞争性酸阻断剂 (potassium-competitive acid blocker, P-CAB)，展示出优秀的抗分泌活性。在 pH 为 6.5 的条件下，该化合物可抑制猪胃微粒体内 H+,K+-ATPase 的酶活性，呈现出 19 nM 的 IC50 值。Vonoprazan hydrochloride 主要应用于胃酸相关疾病的研究，包括胃食管反流病和消化性溃疡，并可用于根除幽门螺杆菌。
T73935	MsbA-IN-6	Antibiotic	Microbiology/Virology
	MsbA-IN-6作为一种高效的抑制剂，针对革兰氏阴性ATP结合盒(ABC)转运蛋白MsbA具有抗生素作用。MsbA是关键的内膜蛋白，负责将脂多糖从内叶转运至内膜的周质面。MsbA-IN-6通过抑制大肠杆菌MsbA的ATP酶与转运活性实现其杀菌效果，并对多种临床上常见的多药耐药菌株保持有效活性。
T36659	Boromycin
	Boromycin is a boron-containing macrolide antibiotic that has been found in Streptomyces. Boromycin inhibits growth of B. subtilis (MIC = 0.05 μg/ml) and induces efflux of potassium ions from B. subtilis without affecting Na+/K+-ATPase activity. It decreases the synthesis of protein, RNA, and DNA in B. subtilis when used at a concentration of 0.05 μg/ml. It inhibits the growth of B. halodurans (MIC = 10 ng/ml) and inhibits the futalosine pathway of menaquinone synthesis in B. halodurans. Boromyc...
T75656	Calcimycin hemimagnesium
	Calcimycin (A-23187) hemimagnesium，一种具有抗生素功能的独特二价阳离子离子载体（例如钙离子和镁离子），通过提高细胞内钙浓度而诱导Ca2+依赖性细胞死亡。该化合物还能抑制革兰氏阳性细菌和部分真菌生长，同时抑制ATP酶活性并解耦哺乳动物细胞的氧化磷酸化（OXPHOS），触发细胞凋亡（apoptosis）。
T83785	2-Chloroadenosine-5'-O-diphosphate sodium 2-chloro ADP
	2-Chloroadenosine-5'-O-diphosphate是一种腺苷5'二磷酸（ADP）的衍生物。它在浓度依赖性的方式下，促进了人类富含血小板的血浆中的聚集，并抑制了由前列腺素E2（PGE2）诱导的环磷酸腺苷（cAMP）的产生。2-Chloroadenosine-5'-O-diphosphate引起预收缩的孤立的豚鼠taenia coli条带放松（pD2 = 6.74），降低大鼠的动脉血压。此外，它还抑制了热休克蛋白70（Hsp70）家族成员mortalin的ATP酶活性（人类酶的表观Ki = 45.05 µM）。
T36570	KUS121
	KUS121 is a valosin-containing protein (VCP) modulator that inhibits VCP ATPase activity (IC50= 330 nM).1It inhibits cell death, ATP depletion, and upregulation of C/EBP-homologous protein (CHOP) induced by tunicamycin, an inducer of ER stress, in HeLa cells when used at concentrations of 20, 50, and 50 μM, respectively. KUS121 (100 μM) inhibits ATP depletion and cell death induced by oxygen-glucose deprivation (OGD) in rat primary cortical neurons in anin vitromodel of cerebral ischemia.2It red...
T36400	para-amino-Blebbistatin
	para-amino-Blebbistatin is a more water-soluble form of (S)-4'-nitro-blebbistatin , which is a more stable and less phototoxic form of (-)-blebbistatin .1,2,3 (-)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases that rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM).2,3,4 Through these effects, it blocks ap...

化合物

Cat.No: T61553

RUVBL1/2 ATPase-IN-1

Cat.No: T9882

Target: Others

BRM/BRG1 ATP Inhibitor-2

Cat.No: T60032

Target: Epigenetic Reader Domain

Cat.No: T0674

Synonym: 兰索拉唑,A-65006,AG-1749

Target: Proton pump, Phospholipase, Antibacterial

SARS-CoV-2 nsp13-IN-6

Cat.No: T62248

SARS-CoV-2 nsp13-IN-5

Cat.No: T63615

SARS-CoV-2 nsp13-IN-1

Cat.No: T62413

Cat.No: T76374

SARS-CoV-2 nsp13-IN-2

Cat.No: T62264

SARS-CoV-2 nsp13-IN-3

Cat.No: T62375

SARS-CoV-2 nsp13-IN-4

Cat.No: T62031

Esomeprazole hemistrontium

Cat.No: T61740

Esomeprazole potassium salt

Cat.No: T61667

Esomeprazole magnesium salt

Cat.No: T61467

Cat.No: T39255

Synonym: beta-Cyfluthrin,β-Cyfluthrin

Cat.No: T35465

Cat.No: T35848

ARL67156 triethylamine

Cat.No: T73645

Cat.No: T35849

Cat.No: T75315

ARL67156 trisodium hydrate

Cat.No: T73644

Cat.No: T35523

Ilaprazole sodium hydrate

Cat.No: T78218

Synonym: IY-81149 sodium hydrate

Target: Proton pump

Cat.No: T37708

Cat.No: T35847

Vonoprazan hydrochloride

Cat.No: T61643

Cat.No: T73935

Target: Antibiotic

Cat.No: T36659

Calcimycin hemimagnesium

Cat.No: T75656

2-Chloroadenosine-5'-O-diphosphate sodium

Cat.No: T83785

Synonym: 2-chloro ADP

Cat.No: T36570

para-amino-Blebbistatin

Cat.No: T36400

Cat. No.	Product Name	Target	Signaling Pathways
T5S0890	Oleandrin Neriostene,Folinerin,Foliandrin,欧夹竹桃苷	Apoptosis; ATPase; Potassium Channel; Sodium Channel	Apoptosis; Membrane transporter/Ion channel
	Oleandrin (Folinerin) 是夹竹桃属中的一种类固醇，可抑制Na+/K+-ATPase 活性，IC50为 620 nM。
T5S1982	Periplocin Periplocoside,杠柳毒苷	Apoptosis; Others	Apoptosis; Others
	Periplocin (Periplocoside) 是从黑龙骨中分离出的一种强心类固醇。它可促进肿瘤细胞凋亡并抑制肿瘤生长。它通过激活 Na/K-ATPase 介导的 Src/ERK 和 PI3K/Akt 途径，具有促进伤口愈合的潜力。
T35779	Oosporein
	Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ...

天然产物

Cat.No: T5S0890

Synonym: Neriostene,Folinerin,Foliandrin,欧夹竹桃苷

Target: Apoptosis, ATPase, Potassium Channel, Sodium Channel

Cat.No: T5S1982

Synonym: Periplocoside,杠柳毒苷

Target: Apoptosis, Others

Cat.No: T35779

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