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Search Results for " atf "

6

抑制剂 & 化合物

1

天然产物

14

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T82952	ATF3 inducer 1
	ATF3 inducer 1, 作为一种高效ATF3诱导剂，能显著提高ATF3蛋白及其mRNA的表达水平，并在小鼠模型中展现出对MetS的抗性活性。
T78121	SSM3 tetraTFA hydrate	Others	Others
	SSM3 tetraTFA hydrate为有效的furin抑制剂，具有54 nM的EC50和12 nM的Ki。该化合物可有效阻断furin依赖的炭疽毒素保护antigen-83在细胞表面的处理。
T83679	Parasin I (catfish) TFA
	Parasin I是来自鲶鱼(P. asotus)组蛋白H2A N端区域的一种抗微生物肽片段，参与宿主防御。它通过在受伤P. asotus的皮肤黏膜中的cathepsin D从组蛋白H2A形成。Parasin I对多种革兰氏阳性和阴性细菌以及真菌具有活性（MICs分别为1-2, 1-4, 和1-2 µg/ml）。
T21865	BC 11-38	PDE	Metabolism
	BC 11-38是一种有效的PDE11生物活性抑制剂，可提高PKA 介导的 ATF-1 磷酸化、 H295R 细胞 cAMP 水平和皮质醇生成。
T11995	Melatonin-d4 N-Acetyl-5-methoxytryptamine D5,Melatonin D5,褪黑素 D5	Others	Others
	Melatonin D5, a deuterium-labeled version of melatonin, is a hormone produced by the pineal gland, known for its role as a selective ATF-6 inhibitor that promotes apoptosis in human hepatoma cells via COX-2 downregulation. Additionally, it activates melatonin receptors and exhibits antioxidative and anti-inflammatory properties.
T63665	EIF2α activator 1
	EIF2α activator 1（Compound 40）为真核生物起始因子2α（eIF2α）磷酸化的激活剂，能够提高EIF2α下游蛋白ATF和CHOP的表达水平。该化合物对K562细胞和PBMC细胞展现出抗增殖活性，其IC50值分别为4.00 μM和19.3 μM。

化合物

ATF3 inducer 1

Cat.No: T82952

SSM3 tetraTFA hydrate

Cat.No: T78121

Target: Others

Parasin I (catfish) TFA

Cat.No: T83679

Cat.No: T21865

Target: PDE

Cat.No: T11995

Synonym: N-Acetyl-5-methoxytryptamine D5,Melatonin D5,褪黑素 D5

Target: Others

EIF2α activator 1

Cat.No: T63665

Cat. No.	Product Name	Target	Signaling Pathways
T1659	Melatonin Melatonine,松果体素,N-Acetyl-5-methoxytryptamine,褪黑素	CaMK; Apoptosis; Mitophagy; Estrogen/progestogen Receptor; Melatonin Receptor; Glutathione Peroxidase; Endogenous Metabolite; ROR; Autophagy	Apoptosis; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Metabolism; Neuroscience
	Melatonin (Melatonine) 是一种由松果体制成的激素，可激活褪黑激素受体。它在睡眠中起作用，有抗氧化和抗炎特性。它是新型选择性ATF-6抑制剂，可诱导细胞凋亡。

天然产物

Cat.No: T1659

Synonym: Melatonine,松果体素,N-Acetyl-5-methoxytryptamine,褪黑素

Target: CaMK, Apoptosis, Mitophagy, Estrogen/progestogen Receptor, Melatonin Receptor, Glutathione Peroxidase, Endogenous Metabolite, ROR, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00904	Urokinase/uPA Protein, Human, Recombinant (His) u-PA,QPD,BDPLT5,ATF,UPA,plasminogen activator, urok...	Human	HEK293 Cells
	Urokinase/uPA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46 kDa and the accession number is A0A024QZM9.
TMPK-00782	PLAU/uPA Protein, Mouse, Recombinant (His & Avi) PLAU,UPA,BDPLT5,ATF,u-PA,QPD,Urokinase,URK	Mouse	HEK293 Cells
	Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. PLAU inhibition could suppress tumor growth. Collectively, PLAU is necessary for tumor progression and can be a diagnostic and prognostic biomarker in HNSCC. PLAU/uPA Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 49.00 kDa and the accession number is P06869.
TMPH-01164	ATF-3 Protein, Human, Recombinant (His) ATF3,cAMP-dependent transcription factor ATF	Human	E. coli
	ATF3 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-03274	ATF-4 Protein, Rat, Recombinant (His & Myc) cAMP-dependent transcription factor ATF-4,Activatin...	Rat	E. coli
	ATF-4 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 43.2 kDa and the accession number is Q9ES19.
TMPH-02613	ATF-5 Protein, Mouse, Recombinant (His & Myc) Transcription factor ATFx,Transcription factor-like...	Mouse	E. coli
	Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcrip...
TMPJ-00886	ATF1 Protein, Human, Recombinant (His) Cyclic AMP-dependent transcription factor ATF-1,Act...	Human	E. coli
	Cyclic AMP-dependent transcription factor ATF-1(ATF1) which contains 1 bZIP (basic-leucine zipper) domain and 1 KID (kinase-inducible) domain, belongs to the bZIP family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. ATF1 binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It also binds to the ...
TMPY-02792	GDNF Protein, Human, Recombinant (HEK293) HSCR3,ATF2,HFB1-GDNF,ATF1,glial cell deriv...	Human	HEK293 Cells
	GDNF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.1 kDa and the accession number is P39905-2.
TMPK-00783	PLAU/uPA Protein, Mouse, Recombinant (His & Avi), Biotinylated ATF,URK,Urokinase,PLAU,u-PA,UPA,QPD,BDPLT5	Mouse	HEK293 Cells
	Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. PLAU inhibition could suppress tumor growth. Collectively, PLAU is necessary for tumor progression and can be a diagnostic and prognostic biomarker in HNSCC. PLAU/uPA Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 49.00 kDa and the accession number is P06869.
TMPK-00274	PLAU/uPA Protein (active form), Human, Recombinant (His & Avi), Biotinylated QPD,Urokinase,BDPLT5,UPA,ATF,URK,u-PA,PLAU	Human	HEK293 Cells
	Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. PLAU inhibition could suppress tumor growth. Collectively, PLAU is necessary for tumor progression and can be a diagnostic and prognostic biomarker in HNSCC. PLAU/uPA Protein (active form), Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 49.3 kDa and the accession number is P0074...
TMPK-00539	PLAU/uPA Protein (active form), Cynomolgus, Recombinant (His) URK,ATF,UPA,u-PA,Urokinase,QPD,PLAU,BDPLT5	Cynomolgus	HEK293 Cells
	Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. PLAU inhibition could suppress tumor growth. Collectively, PLAU is necessary for tumor progression and can be a diagnostic and prognostic biomarker in HNSCC. PLAU/uPA Protein (active form), Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 47.23 kDa and the accession number is A0A2K5WND1.
TMPH-02609	CREBZF Protein, Mouse, Recombinant (His) Tyrosine kinase-associated leucine zipper protein LAZip,Zf,H...	Mouse	Baculovirus Insect Cells
	Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells.
TMPY-06970	GDNF Protein, Human, Recombinant ATF1,ATF2,HSCR3,胶质细胞生长因子,HFB1-GDNF,glial c...	Human	E. coli
	GDNF Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.2 kDa and the accession number is P39905-1.
TMPY-02444	ATF2 Protein, Human, Recombinant (His & GST) CREB2,CRE-BP1,CREB-2,TREB7,activating transcription factor 2...	Human	Baculovirus Insect Cells
	Activating transcription factor 2, also known as ATF2, is a member of the leucine zipper family of DNA-binding proteins that binds to the cAMP response element. Its activity is enhanced after phosphorylation by stress-activated protein kinases such as c-Jun N-terminal kinase and p38. ATF2 has been found to be a target of the JNK signal transduction pathway and mediate adenovirus E1A-inducible transcriptional activation. ATF2 is also been reported playing roles in TGF-β signaling pathway. It has ...
TMPH-00886	ATF7IP2 Protein, Human, Recombinant (His) MCAF2,ATF7-interacting protein 2,Activating transcr...	Human	E. coli
	Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable). AT...

重组蛋白

Urokinase/uPA Protein, Human, Recombinant (His)

Cat.No: TMPY-00904

Species: Human

Expression System: HEK293 Cells

PLAU/uPA Protein, Mouse, Recombinant (His & Avi)

Cat.No: TMPK-00782

Species: Mouse

Expression System: HEK293 Cells

ATF-3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01164

Species: Human

Expression System: E. coli

ATF-4 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03274

Species: Rat

Expression System: E. coli

ATF-5 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02613

Species: Mouse

Expression System: E. coli

ATF1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00886

Species: Human

Expression System: E. coli

GDNF Protein, Human, Recombinant (HEK293)

Cat.No: TMPY-02792

Species: Human

Expression System: HEK293 Cells

PLAU/uPA Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00783

Species: Mouse

Expression System: HEK293 Cells

PLAU/uPA Protein (active form), Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00274

Species: Human

Expression System: HEK293 Cells

PLAU/uPA Protein (active form), Cynomolgus, Recombinant (His)

Cat.No: TMPK-00539

Species: Cynomolgus

Expression System: HEK293 Cells

CREBZF Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02609

Species: Mouse

Expression System: Baculovirus Insect Cells

GDNF Protein, Human, Recombinant

Cat.No: TMPY-06970

Species: Human

Expression System: E. coli

ATF2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02444

Species: Human

Expression System: Baculovirus Insect Cells

ATF7IP2 Protein, Human, Recombinant (His)

Cat.No: TMPH-00886

Species: Human

Expression System: E. coli

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