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23

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T26674	AT-130 AT 130	HBV; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	AT-130 是一种苯基丙烯酰胺衍生物，是乙型肝炎病毒复制的非核苷抑制剂。它抑制病毒 DNA 的合成，EC50为 0.13 μM。
T9588	JI130	Others	Others
	JI130 能够削弱 Hes1 抑制转录的能力。 JI130 治疗显著减少了小鼠胰腺肿瘤异种移植模型中的肿瘤体积。
T4033	MSX-130 MSX 130	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	MSX-130 是一种CXCR4拮抗剂，可抑制肿瘤转移。
T12532	PQM130	Beta Amyloid	Neuroscience
	PQM130是一种魏罗酮-多奈哌齐杂化化合物，能透过大脑。PQM130是多靶点的候选药物，可用于Aβ1-42低聚物引起的神经毒性，还具有抗炎活性。它是具有神经保护作用的、有潜力的抗 AD 药物。
T6591	Nodinitib-1 ML130,CID-1088438	TNF; NOD-like Receptor (NLR); NOD	Apoptosis; Immunology/Inflammation; NF-κB
	Nodinitib-1 (CID-1088438) 是 NOD1抑制剂(IC50:0.56 μM)。
T4450	GIBH-130	IL Receptor; TNF; Interleukin	Apoptosis; Immunology/Inflammation
	GIBH130 是一种有效的神经炎症抑制剂，可作用于活化的小胶质细胞，明显抑制IL-1β的分泌(IC50:3.4 nM)。
T2646	HA130	PDE	Metabolism
	HA130 是选择性 autotaxin 抑制剂，IC50=28 nM。
TP1305	LEP(116-130)(mouse)	Others	Others
	LEP(116-130)(mouse) 是合成的瘦素肽片段之一。
TP1305L	LEP(116-130)(mouse)TFA(258276-95-8 free base)	Complement System	Immunology/Inflammation
	LEP(116-130)(mouse)TFA(258276-95-8 free base) 是一种合成的瘦素肽片段。
T40332	ZXH-4-130
	ZXH-4-130 is a potent and selective CRBN degrader, functioning as a hetero-PROTAC compound with the inclusion of CRBN-VHL.
T35429	AC-4-130
	AC-4-130, a powerful inhibitor of the SH2 domain of STAT5, effectively hinders STAT5 activation, dimerization, nuclear translocation, and transcription of genes reliant on STAT5. This compound directly binds to STAT5, ultimately leading to cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 exhibits notable anti-cancer properties and effectively suppresses abnormal STAT5 activity in acute myeloid leukemia (AML), making it a promising therapeutic option [1].
T41204	TAT-Gap19(I130A) TAT-Gap19(I130A)
	TAT-Gap19(I130A) is a control peptide for TAT-Gap19, a Cx43 hemichannel blocker. TAT-Gap19(I130A) consists of TAT-GAP19 with a I130A amino acid residue change at a key residue for GAP19 activity. In C6 glioma cells expression Cx43, TAT-GAP19(1130A) does not inhibit [Ca2+]i-triggered ATP release at 200 μM. TAT-Gap19(I130A) is cell permeable.
T76221	Leptin (116-130)
	Leptin(116-130)是一种生物活性的瘦素片段，能促进AMPA受体运输至突触并加强活动依赖性的海马突触可塑性。此外，Leptin(116-130)在抗淀粉样蛋白毒性模型中有效阻止海马突触损伤和神经元细胞死亡，显示出对研究阿尔茨海默病(AD)具有重要潜力。
T62603	NVP-BBD130
	NVP-BBD130 是一种稳定的、ATP 竞争性的、有效的、口服具有活力的 PI3K 和 mTOR 抑制剂。
T78941	Anticancer agent 130	Apoptosis	Apoptosis
	Anticanceragent 130 (化合物 8d) 能有效诱导A549细胞的凋亡，表现出显著的抗癌活性。
T77920	ZXH-4-130 TFA	PROTACs	PROTAC
	ZXH-4-130 TFA为高效、选择性CRBN降解剂，属于CRBN-VHL类(hetero-PROTAC)化合物。在MM1.S细胞中，10 nM ZXH-4-130 TFA可诱导约80%的CRBN降解。
T36208	15(R)-Pinane Thromboxane A2 15(R)-Pinane Thromboxane A2
	15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2 . 15(R)-PTA2 does not inhibit collagen-induced platelet aggregation (IC50s = 120-130 μM). It does not affect gastric tone in isolated rat gastric fundus when used at concentrations of 0.5 or 1.5 μg/ml and is less effective than PTA2 at inhibiting prostaglandin-induced contraction of isolated rat stomach muscle.
T39194	PLX647 dihydrochloride
	PLX647 dihydrochloride is a potent and selective dual inhibitor of FMS and KIT kinases, with IC50 values of 28 nM and 16 nM, respectively. At a concentration of 1 μM, PLX647 dihydrochloride demonstrates superior selectivity against a wide range of 400 kinases, except FLT3 and KDR, where IC50 values are 91 nM and 130 nM, respectively. This orally active compound holds great potential for targeted kinase inhibition.
T38276	Benzomalvin C
	Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/ml in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC50 value of 130 μM for recombinant IDO. It was isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.
T74668	Zicronapine fumarate
	Zicronapine (Lu 31-130) fumarate 是抗精神病药，主要通过拮抗多巴胺D1/D2受体和5-HT2A受体发挥作用，在动物模型中显示出显著的前认知效果，展现出治疗多种神经和精神疾病的可能性。
T35989	CAY10565
	S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low molecular weight species such as S-nitrosoglutathione (GSNO) and S-nitrosocysteine (CysNO). CAY10565 is a member of a new class of S-nitrosothiol species that act as NO donors under acidic conditions. It decomposes with a half-life of 130 minutes in 0.1 M phosphate buffer, pH 5.0,...
T83811	2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate sodium 2'(3')-ANT-ATP
	2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate（2'-ANT-ATP）与3'-ANT-ATP是荧光ATP衍生物，可自发地进行异构化。在水中，2'(3')-ANT-ATP的激发波长为330 nm时，发射最大波长为428 nm。它对哺乳动物腺苷酸环化酶（AC1）、AC2及AC5显示出抑制作用，抑制常数(Kis)分别为130、640和120 nM。此外，它还能抑制百日咳杆菌腺苷酸环化酶毒素CyaA（在锰和镁存在下，Kis分别为1.3和20 µM）、炭疽杆菌腺苷酸环化酶毒素水肿因子（在锰和镁存在下，Kis分别为0.44和5.15 µM）以及大肠杆菌重组酶A（RecA；Ki = 6.3 µM）。
T38077	TLQP-21 TFA
	TLQP-21 TFA, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potent G-protein-coupled receptor complement-3a receptor1 (C3aR1) agonist (EC50: mouse TLQP-21=10.3 μM; human TLQP-21=68.8μM). TLQP-21 TFA activates C3aR1 to induce an increase of intracellular Ca2+. TLQP-21 TFA is used for the research in regulation of nociception and other relevant physiologic functions[1][2]. TLQP-21 TFA is a peptide of 21 amino acids. At a dose of 3 μM TLQP-21 induces up to ~69% of th...

化合物

Cat.No: T26674

Synonym: AT 130

Target: HBV, DNA/RNA Synthesis

Cat.No: T9588

Target: Others

Cat.No: T4033

Synonym: MSX 130

Target: CXCR

Cat.No: T12532

Target: Beta Amyloid

Cat.No: T6591

Synonym: ML130,CID-1088438

Target: TNF, NOD-like Receptor (NLR), NOD

Cat.No: T4450

Target: IL Receptor, TNF, Interleukin

Cat.No: T2646

Target: PDE

LEP(116-130)(mouse)

Cat.No: TP1305

Target: Others

LEP(116-130)(mouse)TFA(258276-95-8 free base)

Cat.No: TP1305L

Target: Complement System

Cat.No: T40332

Cat.No: T35429

TAT-Gap19(I130A)

Cat.No: T41204

Synonym: TAT-Gap19(I130A)

Leptin (116-130)

Cat.No: T76221

Cat.No: T62603

Anticancer agent 130

Cat.No: T78941

Target: Apoptosis

ZXH-4-130 TFA

Cat.No: T77920

Target: PROTACs

15(R)-Pinane Thromboxane A2

Cat.No: T36208

Synonym: 15(R)-Pinane Thromboxane A2

PLX647 dihydrochloride

Cat.No: T39194

Cat.No: T38276

Zicronapine fumarate

Cat.No: T74668

Cat.No: T35989

2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate sodium

Cat.No: T83811

Synonym: 2'(3')-ANT-ATP

Cat.No: T38077

Cat. No.	Product Name	Target	Signaling Pathways
T37751	Streptazolin
	Streptazolin is a fungal metabolite originally isolated from S. viridochromogenes. It increases NF-κB activity when used at concentrations ranging from 60 to 130 μg/ml, at least in part, via PI3K signaling. Streptazolin enhances TNF-α secretion induced by LPS and enhances IL-8 secretion when used alone or in combination with LPS in THP-1 Blue cells.

天然产物

Cat.No: T37751

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