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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T40109 |
APOL1-IN-1
APOL1-IN-1 |
Others | Others |
APOL1-IN-1是一种有效的载脂蛋白 L1(APOL1) 的抑制剂,可用于研究局灶节段性肾小球硬化 (FSGS) 和非糖尿病肾病 (NDKD) 的发病原理,促进对此类疾病的研究。 | |||
T22700 |
Cyclapolin 9
|
PLK | Cell Cycle/Checkpoint |
Cyclapolin 9 是一种具有选择性、有效性和 ATP 竞争性的 polo-like kinase 1 (PLK1) 抑制剂,IC50 为 500 nM,对其他激酶尚未显示出活性。 | |||
T8844 |
Diflapolin
|
Others; FLAP; Epoxide Hydrolase | Immunology/Inflammation; Metabolism; Others |
Diflapolin 是高活性的双 5-脂氧合酶激活蛋白(FLAP)/可溶性环氧化物水解酶抑制剂,具有显著的抗炎作用和较高的靶向选择性。它抑制分离的 sEH 的活性,IC50为20 nM。它还抑制完整人单核细胞和中性粒细胞中 5-LOX 产物的形成,IC50分别为 30 和 170 nM。 | |||
T60171 |
Ibezapolstat hydrochloride
|
Antibacterial | Microbiology/Virology |
Ibezapolstat hydrochloride 是一种抗菌化合物。 | |||
T0307 |
Tyloxapol
四丁酚醇,Triton WR1339,四丁酚醛 |
NF-κB; LPL Receptor | GPCR/G Protein; NF-κB |
Tyloxapol (Triton WR1339) 是一种烷基芳基聚醚醇型非离子液体聚合物,是一种表面活性稳定剂,可诱导动物高脂血症。 | |||
T124075 |
8-epi-Chlorajapolide F
|
||
8-epi-Chlorajapolide F 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124075。 | |||
T33370 |
Metyrapol
SU 5236,SU-5236,SU5236 |
||
Metyrapol is a competitive inhibitor of 11-deoxycorticosterone hydroxylation by 11β-hydroxylase. | |||
T77068 | Lodapolimab | ||
Lodapolimab (LY3300054) 是一种 IgGλ 抗PD-1单克隆抗体。 | |||
T10243 |
Ibezapolstat
ACX-362E |
Others | Others |
ACX-362E is an orally available DNA polymerase IIIC (pol IIIC) inhibitor, acts as an antimicrobial agent to treat Gram-positive infections (MIC50: 2 μg/mL for C. difficile). | |||
T76909 | Apolizumab | ||
Apolizumab (Hu1D10)为人源化单克隆抗体,针对人类白细胞抗原-DR β链。该抗体能够介导慢性淋巴细胞白血病(CLL)细胞在体外的凋亡。 | |||
T125830 |
Chlorajapolide F
|
||
Chlorajapolide F 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T125830。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02956 |
Apolipoprotein L/APOL1 Protein, Human, Recombinant (His)
APOL1,apolipoprotein L1,APOL,FSGS... |
Human | Baculovirus Insect Cells |
APOL1, also known as apolipoprotein L1, is a minor apoprotein component of HDL (High-density lipoprotein) or 'good cholesterol' which is synthesized in the liver and also in many other tissues, including pancreas, kidney, and brain. APOL1 belongs to the apolipoprotein L family. It may play a role in lipid exchange and transport throughout the body. It may also participate in reverse cholesterol transport from peripheral cells to the liver. Defects in APOL1 are the cause of focal segmental glomer... | |||
TMPJ-00137 |
APRIL/TNFSF13 Protein, Human, Recombinant (Flag & His)
TRDL-1,TNF- and APOL-related leukocyte expressed li... |
Human | HEK293 Cells |
APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule. Secreted human APRIL, which consists almost entirely of a single TNF homology domain, shares 85% amino acid sequence identity with mouse and rat APRIL. Both APRIL and its close relative BAFF bind and signal through the TNF superfamily recept... | |||
TMPJ-01391 |
BAFF/TNFSF13B Protein, Mouse, Recombinant (mFc)
TALL-1,Dendritic cell-derived TNF-like molecule,BLyS,Tumor n... |
Mouse | HEK293 Cells |
BAFF/TNFSF13B Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with N-mFc tag. The predicted molecular weight is 45-60 KDa and the accession number is Q9WU72. | |||
TMPJ-00178 |
BAFF/TNFSF13B Protein, Human, Recombinant (His)
B lymphocyte stimulator,TNF- and APOL-related leuko... |
Human | HEK293 Cells |
BAFF/TNFSF13B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 22 KDa and the accession number is Q9Y275. | |||
TMPJ-00177 |
BAFF/TNFSF13B Protein, Human, Recombinant (Avi & hFc), Biotinylated
BAFF,Dendritic cell-derived TNF-like molecule,CD257,B lympho... |
Human | HEK293 Cells |
B-cell activating factor (BAFF), also known as BLyS, TALL-1, THANK, and TNFSF13B, is a transmembrane glycoprotein in the TNF ligand superfamily. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), TNFRSF17 (BCMA), and TNFRSF13C (BAFFR). BAFF can promotes the survival, proliferation and maturation of B lymphocytes, which are key elements in the pathogenesis of systemic lupus erythematosus (SLE). This cytokine is encoded on TNFSF13B gene, and diverse single-nucleotide polymor... | |||
TMPY-04310 |
Apolipoprotein A-IV/APOA4 Protein, Human, Recombinant (His)
apolipoprotein A-IV |
Human | HEK293 Cells |
Apolipoprotein is genetically associated with the risk of Alzheimer's disease (AD). The APOA1, APOC3, and APOA4 genes are closely linked and located on human chromosome 11. There was a decreased trend for levels of APOA1, APOC3, and APOA4 in AD patients. CONCLUSION: Low levels of APOA1, APOC3, and APOA4 are associated with risk of AD. APOA1, APOC3, and APOA4 should be developed as combined drugs for the therapy of AD. SNP(single nucleotide polymorphisms)in APOA1and APOA4 genes influences atherog... | |||
TMPY-02899 |
Apolipoprotein A-I/APOA1 Protein, Mouse, Recombinant (His)
Apoa-1,2-Sep,42248,1-Sep,apolipoprotein A-I,Alp-1,L... |
Mouse | HEK293 Cells |
Apolipoprotein A-I/APOA1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.2 kDa and the accession number is Q00623. | |||
TMPY-02716 |
Apolipoprotein M/APOM Protein, Human, Recombinant (hFc)
apolipoprotein M,NG20,DADB-127H9.5,HSPC336,apo-M,G3... |
Human | HEK293 Cells |
Apolipoprotein M/APOM Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.6 kDa and the accession number is O95445. | |||
TMPY-01278 |
Apolipoprotein H/APOH Protein, Human, Recombinant (His)
BG,apolipoprotein H (beta-2-glycoprotein I),B2G1, |
Human | HEK293 Cells |
Apolipoprotein H/APOH Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.7 kDa and the accession number is A0A384NKM6. | |||
TMPK-01087 |
Apolipoprotein A-V/APOA5 Protein, Mouse, Recombinant (His)
ApoA-V,Apolipoprotein A-V,Rap3,Apoa5,Apo-AV,Apo... |
Mouse | E. coli |
APOA5 is probably the gene with the strongest effect on triglyceride (TG) metabolism. APOA5 is almost exclusively expressed in the liver, and its product apoAV has a very low circulating concentration. New physiological roles of apoAV have been recently elucidated, such as control of chylomicron production in the intestine and TG accumulation in adipose tissue.The key role of APOA5 in TG metabolism has been largely shown through genetic studies in association with either severe or moderate hyper... | |||
TMPK-01328 |
Apolipoprotein H/APOH Protein, Cynomolgus, Recombinant (His)
B2GPI,B2G1,BG,B2GP1,APOH,beta(2)GPI,β(2)GPI,Apo-H |
Cynomolgus | HEK293 Cells |
Apolipoprotein (apo)H (also known as beta 2 glycoprotein-I) is a glycoprotein synthesized by liver cells and it is present in the blood associated with plasma lipoproteins. APOH displays a genetically determined structural polymorphism: three alleles (APOH*1, APOH*2, APOH*3) at a single locus on chromosome 17 code for different isoforms, and population studies have shown that APOH*2 is the most frequent allele. | |||
TMPY-05297 |
Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx)
LPG,apolipoprotein E,ApoE4,APO-E,LDLCQ5,AD2 |
Human | E. coli |
Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx) is expressed in E. coli expression system with His and Trx tag. The predicted molecular weight is 51.3 kDa and the accession number is P02649. | |||
TMPY-05528 |
Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx), Biotinylated
APO-E,LDLCQ5,LPG,ApoE4,AD2,apolipoprotein E |
Human | E. coli |
Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx), Biotinylated is expressed in E. coli expression system with His and Trx tag. The predicted molecular weight is 51.3 kDa and the accession number is P02649. | |||
TMPJ-00757 |
Apolipoprotein A-II/APOA2 Protein, Human, Recombinant (His)
Apolipoprotein A-II,Truncated apolipoprote... |
Human | HEK293 Cells |
Apolipoprotein A-II(Apo-AII for short), also known as Apolipoprotein A2, is a secreted protein which belongs to the apolipoprotein A2 family. It exists as a disulfide-linked homodimer; and also can form a disulfide-linked heterodimer with APOD. APOA2 is the 2nd most abundant protein of the high density lipoprotein particles. This protein may stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. Defects in APOA2 gene might cause apolipop... | |||
TMPY-00337 |
Apolipoprotein M/APOM Protein, Human, Recombinant (His)
DADB-127H9.5,apo-M,apolipoprotein M,NG20,G3a,HSPC33... |
Human | P. pastoris (Yeast) |
Apolipoprotein M/APOM Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 19.9 kDa and the accession number is O95445-1. | |||
TMPJ-01071 |
Apolipoprotein H/APOH Protein, Mouse, Recombinant (His)
Beta-2-glycoprotein 1,Apoh,β-2-glycoprotein 1 |
Mouse | HEK293 Cells |
Apolipoprotein H (APOH), also known as Beta-2-glycoprotein 1, is a glycoprotein synthesized by liver cells and it is present in the blood associated with plasma lipoproteins. Its carbohydrate content is approximately 19% of the molecular weight and it is present in the blood associated with plasma lipoproteins. Mature mouse ApoH shares 76% and 42% aa sequence identity with human and rat ApoH, respectively. The activity of APOH appears to involve the binding of agglutenating, inhibits agglutinati... | |||
TMPY-00667 |
Apolipoprotein A-I/APOA1 Protein, Human, Recombinant (hFc)
Apolipoprotein A-I |
Human | HEK293 Cells |
Apolipoprotein A-I/APOA1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 55 kDa and the accession number is P02647. | |||
TMPY-06955 |
Apolipoprotein A-I/APOA1 Protein, Mouse, Recombinant (hFc)
Alp-1,1-Sep,Ltw-1,Lvtw-1,Apoa-1,42248,apolipoprotei... |
Mouse | HEK293 Cells |
Apolipoprotein A-I/APOA1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.68 kDa and the accession number is Q00623. | |||
TMPJ-00158 |
Apolipoprotein A-I/APOA1 Protein, Human, Recombinant
Apolipoprotein A-I,APOA1,Apo-AI,ApoA-I |
Human | E. coli |
Apolipoprotein A1 (APOA1) is a secreted protein which belongs to the Apolipoprotein A1/A4/E family. APOA1 is the major protein component of high density lipoprotein (HDL) in plasma. APOA1 plays a critical role in various biological processes, such as Cholesterol metabolism, Lipid metabolism and transport, Steroid metabolism. APOA1 promotes cholesterol efflux from tissues to the liver and thus helps to clear cholesterol from arteries. Defects in this gene resulted in HDL deficiencies, including T... | |||
TMPJ-00756 |
Apolipoprotein E/APOE3 Protein, Human, Recombinant (His)
Apolipoprotein E,Apo-E,APOE,ApoE3 |
Human | HEK293 Cells |
ApoE, a glycoprotein, is a structural component of very low density lipoprotein (vLDL) synthesized by the liver and intestinally synthesized chylomicrons . ApoE is also a constituent of a subclass of high density of lipoproteins (HDL) involved in cholesterol transport .ApoE mediates high affinity binding of chylomicrons and vLDL particles to the LDL receptor, allowing for specific uptake of these particles by the liver, preventing the accumulation of cholesterol rich particles in the plasma .Apo... | |||
TMPY-03428 |
Apolipoprotein A-I/APOA1 Protein, Human, Recombinant (His)
Apolipoprotein A-I |
Human | E. coli |
Apolipoprotein A-I/APOA1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 30.7 kDa and the accession number is P02647. | |||
TMPK-00588 |
Apolipoprotein E/APOE4 Protein, Human, Recombinant (hFc)
Apolipoprotein E,Apo-E,apolipo E,APOE4,APO... |
Human | HEK293 Cells |
Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells w... | |||
TMPY-00270 |
Apolipoprotein H/APOH Protein, Rat, Recombinant (His)
apolipoprotein H (β-2-glycoprotein I),apol... |
Rat | HEK293 Cells |
Apolipoprotein H/APOH Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.9 kDa and the accession number is A6HK92. | |||
TMPJ-00783 |
Apolipoprotein D/APOD Protein, Human, Recombinant (His)
ApoD,Apolipoprotein D,Apo-D |
Human | HEK293 Cells |
Apolipoprotein-D (ApoD) is an atypical apolipoprotein and, based on its primary structure, it also a member of the lipocalin family. ApoD is mainly associated with high density lipoproteins in human plasma. ApoD is expressed in numerous tissues having high levels of expression in spleen, testes and brain. ApoD plays a role in maintenance and repair within the central and peripheral nervous systems. ApoD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is a multi... | |||
TMPH-00949 |
APOLD1 Protein, Human, Recombinant (His)
Vascular early response gene protein,APOLD1,VERGE,<... |
Human | E. coli |
May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability. APOLD1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 33.4 kDa and the accession number is Q96LR9. | |||
TMPK-00763 |
Apolipoprotein E/APOE3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
APOE3,Apo-E,apolipo E,Apolipoprotein E,APO... |
Human | HEK293 Cells |
Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated i... | |||
TMPY-02553 |
Apolipoprotein A-I/APOA1 Protein, Mouse, Recombinant (aa 1-264, hFc)
apolipoprotein A-I,1-Sep,Apoa-1,Ltw-1,Brp-14,apo-AI... |
Mouse | HEK293 Cells |
Apolipoprotein A-I/APOA1 Protein, Mouse, Recombinant (aa 1-264, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 55.8 kDa and the accession number is Q00623. | |||
TMPK-00764 |
Apolipoprotein A-II/APOA2 Protein, Human, Recombinant (hFc)
Apolipoprotein A-II(1-76),Apolipoprotein A... |
Human | HEK293 Cells |
APOA2 is a protein implicated in triglyceride, fatty acid and glucose metabolism. In pigs, the APOA2 gene is located on pig chromosome 4 (SSC4) in a QTL region affecting fatty acid composition, fatness and growth traits. Apolipoprotein A-II/APOA2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 36.1 kDa and the accession number is P02652. | |||
TMPK-00795 |
Apolipoprotein A-II/APOA2 Protein, Mouse, Recombinant (hFc)
APOA2,Apolipoprotein A-II(1-76),Apolipopro... |
Mouse | HEK293 Cells |
APOA2 is a protein implicated in triglyceride, fatty acid and glucose metabolism. In pigs, the APOA2 gene is located on pig chromosome 4 (SSC4) in a QTL region affecting fatty acid composition, fatness and growth traits. Apolipoprotein A-II/APOA2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 36.2 kDa and the accession number is P09813. | |||
TMPJ-00601 |
Apolipoprotein C-II/APOC2 Protein, Human, Recombinant (His)
Apolipoprotein C2,Apolipoprotein C-II,APC2... |
Human | E. coli |
APOC2 activates the lipoprotein lipase in capillaries, which hydrolyzes triglycerides and thus provides free fatty acids for cells. APOC2 is component of the very low density lipoprotein (VLDL) fraction in plasma. It is also an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly. Defects in APOC2 are the cause of hyperlipoprot... | |||
TMPK-00762 |
Apolipoprotein E/APOE3 Protein, Human, Recombinant (hFc)
APOE,Apo-E,Apolipoprotein E,APOE3,apolipo ... |
Human | HEK293 Cells |
Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells w... | |||
TMPK-00589 |
Apolipoprotein E/APOE4 Protein, Human, Recombinant (His)
APOE,apolipo E,Apo-E,APOE4,Apolipoprotein ... |
Human | HEK293 Cells |
Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells w... | |||
TMPJ-01447 |
Apolipoprotein B-100/APOB Protein, Human, Recombinant (His)
APOB,ApolipoproteinB-100 |
Human | E. coli |
Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | |||
TMPJ-00805 |
Apolipoprotein E/APOE Protein, Mouse, Recombinant (His)
Apo-E,APOE,Apolipoprotein E |
Mouse | HEK293 Cells |
Apolipoprotein E (Apo-E), is a member of the apolipoprotein A1/A4/E family. ApoE is a major protein component of serum LDL, VLDL, HDL, and chylomicrons. APOE may function in mediating the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. APOE is usually secreted in plasma. Phosphorylation sites are present in the extracellular medium. | |||
TMPK-00788 |
Apolipoprotein E/APOE Protein, Mouse, Recombinant (hFc)
apolipo E,Apo-E,Apolipoprotein E,APOE |
Mouse | HEK293 Cells |
Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells wi... |