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Search Results for " alk1 "

Targets Recommended: ALK TGF-beta/Smad

15

抑制剂 & 化合物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T1943	ML347 LDN 193719	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	ML347 (LDN 193719) 是一种选择性的 ALK1/ALK2 抑制剂，它们的 IC50 分别为 46/32 nM，比对 ALK3 的抑制性高 300 倍。
T1944	LDN-214117	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	LDN214117 是一种高效的 ALK2 选择性抑制剂(IC50:22nM)，也是一种 BMP6 抑制剂(IC50:100nM)，对ALK5抑制力弱100倍。
T78128	GALK1-IN-1	Others	Others
	GALK1-IN-1（化合物4）是一种IC50为4.2129 μM的半乳糖激酶抑制剂。
T76858	Ascrinvacumab PF-03446962	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	Ascrinvacumab (PF-03446962) 是一种针对 ALK-1 的高效人源化 IgG2 单克隆抗体。Ascrinvacumab 对人 ALK1 的 Kd 值为 7 nM。Ascrinvacumab 对 TGF-β 有抑制作用，可用于研究肝细胞癌 (HCC)。
T1914	K02288 K 02288	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	K 02288是骨形态发生蛋白 (BMP) I 型受体抑制剂，能够抑制 ALK1 (IC50:1.8nM)、ALK2 (IC50:1.1nM)、ALK6 (IC50:6.4nM)。对 ALK3 和 ALK6 的抑制稍弱，IC50在 5-34 nM 之间。
T1900	LDN-212854 LDN212854,BMP Inhibitor III	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	LDN-212854 (BMP Inhibitor III) 是一种新型BMP 抑制剂，抑制 ALK2 的IC50=1.3 nM，比对ALK1，ALK3，ALK4和ALK5的抑制性高2，66，1641和7135倍。
T1935	LDN193189 LDN-193189,DM-3189,LDN 193189	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	LDN193189 (LDN-193189) 是BMPI 型受体的选择性抑制剂，能够抑制 ALK2 (IC50:5 nM)、 ALK3 (IC50:30 nM)。对 ALK4、ALK5 和 ALK7 的作用效果弱 (IC50≥500 nM)。
T35348	LDN-193189 2HCl LDN-193189 2HCl,DM-3189 2HCl	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	LDN-193189 2HCl (DM-3189 2HCl) 是一种选择性 BMP 信号抑制剂，对ALK1,ALK2,ALK3和ALK6有抑制作用，在激酶实验中显示的 IC50 分别为 0.8 nM、0.8 nM、5.3 nM 和 16.7 nM。LDN-193189 2HCl 在C2C12细胞中对BMP I 型受体ALK2和ALK3的转录活性有抑制作用，IC50分别为5 nM 和30 nM，作用于BMP 比作用于TGF-β选择性高200倍。
T1942	DMH-1 DMH1	ALK; Autophagy; TGF-beta/Smad	Angiogenesis; Autophagy; Stem Cells; Tyrosine Kinase/Adaptors
	DMH-1 是一种选择性 BMP 抑制剂，对 ALK1、ALK2、ALK3和 ALK6的 IC50值分别为 27、107.9、<5和 47.6 nM。
T73490	MU1700
	MU1700 是一种具有口服活性的、强效的 ALK1/2抑制剂，IC50分别为 13 nM 和 6 nM，其具有细胞膜通透性以及高脑渗透性。
T70176	P7170
	P7170 is an anti-cancer agent active as an mTORC1/C2 and activin receptor-like kinase 1 (ALK1) inhibitor.
T6158	LDN-193189 HCl LDN193189 Hydrochloride	ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	LDN-193189 HCl (LDN193189 Hydrochloride) 是一种选择性 BMP I 型受体激酶抑制剂。
T74660	M4K2234
	M4K2234 (compound 26b) 是 ALK2的抑制剂。M4K2234 抑制 ALK2和 ALK5的 IC50值分别为 5 和 2144 nM。M4K2234 可用作 ALK1和 ALK2蛋白激酶的化学探针。M4K2234 可用于癌症的研究。
T21637	SB-505124 hydrochloride
	SB-505124 hydrochloride 是TGF-βI 型受体(ALK4，ALK5，ALK7) 的选择性抑制剂，对 ALK4，ALK5 的IC50值分别为 129 nM 和 47 nM，对 ALK1，2，3 或 6 无作用。
T35896	AZ 12799734 AZ12799734	ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	AZ 12799734 是一种具有口服活性、选择性和有效性的 TGFBR1和 ALK5 双重抑制剂，对 BMP 和 TGFβ 有抑制作用，可用于研究肿瘤。

化合物

Cat.No: T1943

Synonym: LDN 193719

Target: ALK, TGF-beta/Smad

Cat.No: T1944

Target: ALK, TGF-beta/Smad

Cat.No: T78128

Target: Others

Cat.No: T76858

Synonym: PF-03446962

Target: ALK, TGF-beta/Smad

Cat.No: T1914

Synonym: K 02288

Target: ALK, TGF-beta/Smad

Cat.No: T1900

Synonym: LDN212854,BMP Inhibitor III

Target: ALK, TGF-beta/Smad

Cat.No: T1935

Synonym: LDN-193189,DM-3189,LDN 193189

Target: ALK, TGF-beta/Smad

LDN-193189 2HCl

Cat.No: T35348

Synonym: LDN-193189 2HCl,DM-3189 2HCl

Target: ALK, TGF-beta/Smad

Cat.No: T1942

Synonym: DMH1

Target: ALK, Autophagy, TGF-beta/Smad

Cat.No: T73490

Cat.No: T70176

Cat.No: T6158

Synonym: LDN193189 Hydrochloride

Target: ALK

Cat.No: T74660

SB-505124 hydrochloride

Cat.No: T21637

Cat.No: T35896

Synonym: AZ12799734

Target: ALK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01168	ALK-1 Protein, Human, Recombinant (His) ALK1,ALK-1,activin A rec...	Human	HEK293 Cells
	ALK-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 12.3 kDa and the accession number is A0A0S2Z310.
TMPK-00924	SLPI Protein, Mouse, Recombinant (hFc) WAP4,BLPI,SLPI,HUSI-1,HUSI,MPI,ALP,WFDC4,ALK	Mouse	HEK293 Cells
	Elafin and SLPI (secretory leucocyte protease inhibitor) have multiple important roles both in normal homoeostasis and at sites of inflammation. These include antiprotease and antimicrobial activity as well as modulation of the response to LPS (lipopolysaccharide) stimulation. Elafin and SLPI are members of larger families of proteins secreted predominantly at mucosal sites, and have been shown to be modulated in multiple pathological conditions. SLPI Protein, Mouse, Recombinant (hFc) is express...
TMPY-00662	ALK-1 Protein, Mouse, Recombinant (His & hFc) AI115505,AI427544,activin A receptor type ...	Mouse	HEK293 Cells
	ALK-1 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 39 kDa and the accession number is Q61288.
TMPK-00767	SLPI Protein, Human, Recombinant (hFc) WFDC4,HUSI,SLPI,WAP4,MPI,BLPI,ALK1,HUSI-	Human	HEK293 Cells
	Elafin and SLPI (secretory leucocyte protease inhibitor) have multiple important roles both in normal homoeostasis and at sites of inflammation. These include antiprotease and antimicrobial activity as well as modulation of the response to LPS (lipopolysaccharide) stimulation. Elafin and SLPI are members of larger families of proteins secreted predominantly at mucosal sites, and have been shown to be modulated in multiple pathological conditions. SLPI Protein, Human, Recombinant (hFc) is express...
TMPY-00650	ALK-1 Protein, Human, Recombinant (hFc) SKR3,ORW2,TSR-I,ALK1,activin A receptor ty...	Human	HEK293 Cells
	ALK-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 37.4 kDa and the accession number is A0A0S2Z310.
TMPJ-00304	ALK-1 Protein, Mouse, Recombinant (hFc) TSR-I,Serine/threonine-protein kinase receptor R3,ALK	Mouse	HEK293 Cells
	Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1...
TMPY-04464	GALK1 Protein, Human, Recombinant (His & GST) galactokinase 1,HEL-S-19,GALK,GK<...	Human	Baculovirus Insect Cells
	Galactokinase, also known as Galactose kinase, GALK and GALK1, is a protein which belongs to theGHMP kinase family and GalK subfamily. Galactokinase / GALK1 is a major enzyme for galactose metabolism. Galactokinase (GALK) deficiency is an autosomal recessive disorder characterized by elevation of blood galactose concentration and diminished galactose-1-phosphate, leading to the production of galactitol. Defects in GALK1 are the cause of galactosemia II ( GALCT2 ) which II is an autosomal ...
TMPJ-00997	GALK1 Protein, Human, Recombinant (His) Galactokinase,Galactose Kinase,GALK1,G...	Human	E. coli
	Galactokinase belongs to the GHMP kinase family and GalK subfamily. Galactokinase is more important to the galactose metabolism pathway. It modifies galactose to create a similar molecule called Galactose-1-Phosphate.Thus, a series of additional steps converts Galactose-1-Phosphate to another simple sugar Glucose, which is the main energy source for most cells. Galactokinase deficiency results in Galactosemia II, an autosomal recessive deficiency characterized by congenital cataracts during infa...

重组蛋白

ALK-1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01168

Species: Human

Expression System: HEK293 Cells

SLPI Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00924

Species: Mouse

Expression System: HEK293 Cells

ALK-1 Protein, Mouse, Recombinant (His & hFc)

Cat.No: TMPY-00662

Species: Mouse

Expression System: HEK293 Cells

SLPI Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00767

Species: Human

Expression System: HEK293 Cells

ALK-1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00650

Species: Human

Expression System: HEK293 Cells

ALK-1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00304

Species: Mouse

Expression System: HEK293 Cells

GALK1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04464

Species: Human

Expression System: Baculovirus Insect Cells

GALK1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00997

Species: Human

Expression System: E. coli

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