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Search Results for " alk-7 "

6

抑制剂 & 化合物

12

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T27790	Labradimil RMP-7,ALK-01-040,Receptor-mediated permeabiliser-7,DRG0182,DRG 0182,DRG-0182
	Labradimil is a bradykinin B2 receptor agonist. Labradimil increases the permeability of human brain microvascular endothelial cell monolayers. Labradimil enhances delivery of hydrophilic chemotherapeutics and increases survival in rats with metastatic tu
T1791L	Ceritinib dihydrochloride LDK378 dihydrochloride,双盐酸盐色瑞替尼	IGF-1R; ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	Ceritinib dihydrochloride (LDK378 dihydrochloride) 是一种选择性的、口服具有活性的、ATP 竞争性的ALK 酪氨酸激酶抑制剂 (IC50:200 pM)。它还抑制IGF-1R (IC50:8 nM)，InsR (IC50:7 nM) 和 STK22D (IC50:23 nM)。它显示出良好的抗肿瘤作用。
T1791	Ceritinib 色瑞替尼,LDK378	Serine Protease; IGF-1R; ALK	Angiogenesis; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Ceritinib (LDK378) 是一种选择性，具有口服活性的、ATP 竞争性的 ALK 酪氨酸激酶抑制剂，IC50=200 pM。它还抑制 IGF-1R (IC50:8 nM)，InsR (IC50:7 nM) 和 STK22D (IC50:23 nM)。它显示出良好抗肿瘤效力。
T76858	Ascrinvacumab PF-03446962	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	Ascrinvacumab (PF-03446962) 是一种针对 ALK-1 的高效人源化 IgG2 单克隆抗体。Ascrinvacumab 对人 ALK1 的 Kd 值为 7 nM。Ascrinvacumab 对 TGF-β 有抑制作用，可用于研究肝细胞癌 (HCC)。
T3678	Entrectinib RXDX-101,恩曲替尼,NMS-E628	Trk receptor; ROS; ALK; Autophagy; ROS Kinase	Angiogenesis; Autophagy; Immunology/Inflammation; Tyrosine Kinase/Adaptors
	Entrectinib (RXDX-101) 是一种可口服的 Trk、ROS1和 ALK 抑制剂，具有抗肿瘤和中枢神经活性，抑制 TrkA、TrkB、TrkC、ROS1 和 ALK 的 IC50值分别为 1、3、5、12 和 7 nM。
T61443	Trk-IN-7
	Trk-IN-7 (compound I-6) is a highly potent inhibitor of TRK, exhibiting IC50 values ranging from 0.25-10 nM for TRKA, TRKB, and TRKC, respectively. In addition, Trk-IN-7 demonstrates notable inhibition against EML4-ALK (IC50 <15 nM), as well as ALK G1202R, ALK C1156Y, ALK R1275Q, ALK F1174L, ALK L1197M, and ALK G1269A (IC50 = 5-50 nM) [1].

化合物

Cat.No: T27790

Synonym: RMP-7,ALK-01-040,Receptor-mediated permeabiliser-7,DRG0182,DRG 0182,DRG-0182

Ceritinib dihydrochloride

Cat.No: T1791L

Synonym: LDK378 dihydrochloride,双盐酸盐色瑞替尼

Target: IGF-1R, ALK

Cat.No: T1791

Synonym: 色瑞替尼,LDK378

Target: Serine Protease, IGF-1R, ALK

Cat.No: T76858

Synonym: PF-03446962

Target: ALK, TGF-beta/Smad

Cat.No: T3678

Synonym: RXDX-101,恩曲替尼,NMS-E628

Target: Trk receptor, ROS, ALK, Autophagy, ROS Kinase

Cat.No: T61443

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00486	ALK-7 Protein, Human, Recombinant (hFc) ACVRLK7,ALK7,activin A receptor, ...	Human	HEK293 Cells
	ALK-7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 36.6 kDa and the accession number is Q8NER5-1.
TMPY-02253	ENPP7 Protein, Mouse, Recombinant (His) ectonucleotide pyrophosphatase/phosphodiesterase 7,...	Mouse	HEK293 Cells
	ENPP7 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47 kDa and the accession number is Q3TIW9.
TMPY-01070	ENPP7 Protein, Human, Recombinant (His) ectonucleotide pyrophosphatase/phosphodiesterase 7,...	Human	HEK293 Cells
	ENPP7 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49 kDa and the accession number is Q6UWV6.
TMPY-03187	ALK-7 Protein, Rhesus, Recombinant (hFc) activin A receptor, type IC	Rhesus	HEK293 Cells
	ALK-7 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 36.6 kDa and the accession number is F7GDQ6.
TMPY-06036	FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) FGFR-1,FLG,CD331,HH2,FLT2,KAL2,FGFBR,HBGFR,CEK,HRTFDS,fibrob...	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.5 kDa and the accession number is P11362-7.
TMPK-00828	Mucin-1/MUC1 Isoform Y Protein, Human, Recombinant (hFc) PEMT,Episialin,Mucin1,PUM,KL-6,MUC-1,Mucin-1,H23AG,PEM,CA 15...	Human	HEK293 Cells
	MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire variable number of tandem repeat region, are involved in oncogenic processes by enhancing tumour initiation. MUC1/Y is therefore considered a promising target for the identification and treatment of epithelial cancers.
TMPK-00392	FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi) CD331,FGFR-1,FLT-2,BFGFR,N-sam,FGFR1 β (IIIc),bFGF-R-1	Human	HEK293 Cells
	Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors and thus constitutes an attractive molecular target for selective cancer treatment. FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.23 kDa and the accession numb...
TMPK-00394	FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated FGFR1 β (IIIc),N-sam,FLT-2,BFGFR,bFGF-R-1,CD331,FGFR-1	Human	HEK293 Cells
	Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors and thus constitutes an attractive molecular target for selective cancer treatment. FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.23 kDa and the ...
TMPK-01371	IGFBP-7 Protein, Human, Recombinant (hFc) RAMSVPS,TAF,IGFBPRP1,AGM,IBP7,MAC25,IGFBP-7	Human	HEK293 Cells
	IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein that contains three protein domain modules. Human IGFBP-rp1 cDNA encodes 282 amino acid (aa) residue precursor protein with a putative 26 aa signal peptide. IGFBP-7 binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. IGFBP-7 Protein, Human, Recombinant (hFc) is expres...
TMPK-00395	FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated FGF R1a,FGFR1 α,FGFR1 alpha,FGFR1 α (IIIc)	Human	HEK293 Cells
	FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42 kDa and the accession number is P11362-7.
TMPK-00393	FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi) FGFR1 α,FGFR1 alpha,FGF R1a,FGFR1 α (IIIc)	Human	HEK293 Cells
	FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42 kDa and the accession number is P11362-7.
TMPY-06035	FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) KAL2,OGD,N-SAM,CEK,FLT2,HH2,FLG,CD331,BFGFR,HBGFR,FLT-2,FGFB...	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.7 kDa and the accession number is P11362-7.

重组蛋白

ALK-7 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00486

Species: Human

Expression System: HEK293 Cells

ENPP7 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02253

Species: Mouse

Expression System: HEK293 Cells

ENPP7 Protein, Human, Recombinant (His)

Cat.No: TMPY-01070

Species: Human

Expression System: HEK293 Cells

ALK-7 Protein, Rhesus, Recombinant (hFc)

Cat.No: TMPY-03187

Species: Rhesus

Expression System: HEK293 Cells

FGFR1 Protein, Human, Recombinant (alpha (IIIb), His)

Cat.No: TMPY-06036

Species: Human

Expression System: HEK293 Cells

Mucin-1/MUC1 Isoform Y Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00828

Species: Human

Expression System: HEK293 Cells

FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00392

Species: Human

Expression System: HEK293 Cells

FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00394

Species: Human

Expression System: HEK293 Cells

IGFBP-7 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01371

Species: Human

Expression System: HEK293 Cells

FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00395

Species: Human

Expression System: HEK293 Cells

FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00393

Species: Human

Expression System: HEK293 Cells

FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc)

Cat.No: TMPY-06035

Species: Human

Expression System: HEK293 Cells

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