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21

抑制剂 & 化合物

21

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11929	M2N12	Phosphatase	Metabolism
	M2N12 是一种高度选择性的细胞分裂周期蛋白磷酸酶 25C 抑制剂，IC50值为 0.09 μM。它还抑制 Cdc25A 和 Cdc25B 的活性，IC50值分别为 0.53 μM 和 1.39 μM。它具有抗肿瘤活性，可研究癌症。
T41248	Thiocolchicine	Microtubule Associated	Cytoskeletal Signaling
	Thiocolchicine 是一种有效的微管蛋白聚合抑制剂，IC50 为 2.5 µM，Ki 为 0.7 µM。 Thiocolchicine 诱导细胞凋亡。 Thiocolchicine 可用作 ADC 技术中的 ADC 细胞毒素。
T15129	DiI DiIC18(3)	Others	Others
	DiI (DiIC18(3)) 是一种亲脂性膜染料，通常用作神经元和其它细胞的长期示踪剂。它在进入细胞膜之前荧光非常弱，仅当进入到细胞膜后才可以被激发出很强的橙红色荧光 (λex=549 nm，λem=565 nm)。
T39759	Janelia Fluor® 549 TFA JF549 TFA
	Janelia Fluor 549 TFA (JF549 TFA) is a fluorescent dye with the absorption maximum (λab (max)) of 549 nm and emission maximum (λem (max)) of 571 nm.
T34983	UCM 549 UCM549,UCM-549
	UCM 549 is a bioactive chemical.
T82014	Janelia Fluor® 549, Maleimide TFA JF549, Maleimide TFA
	Janelia Fluor® 549, Maleimide TFA (JF549, Maleimide TFA) 是荧光染料，λab (max) 为549 nm，λem (max) 为571 nm。
T82013	Janelia Fluor® 549, Tetrazine JF549, Tetrazine
	Janelia Fluor® 549, Tetrazine (JF549, Tetrazine) 为具有最大吸收波长 (λab (max)) 549 nm 和最大发射波长 (λem (max)) 571 nm 的荧光染料。
T82015	Janelia Fluor® 549, Azide JF549, Azide
	Janelia Fluor® 549, Azide (JF549, Azide) 是一种标记用荧光染料，其最大吸收波长(λab (max))为549 nm，最大发射波长(λem (max))为571 nm。
T39240	Janelia Fluor® 549, SE JF549, SE,JF549,NHS
	Janelia Fluor 549, SE (JF549, SE) is a fluorescent dye with the absorption maximum (λab (max)) of 549 nm and emission maximum (λem (max)) of 571 nm.
T41149	BOP-JF549 BOP-JF549
	BOP-JF549 is a fluorescent dual α9β1/α4β1 integrin inhibitor. Comprises BOP conjugated to Janelia Fluor® 549. Fluorogenic: fluoresces only once bound to integrins, enabling hassle-free no-wash experiments. Bright and photostable, enabling live cell tracking of integrin receptors over long time-course experiments. Excitation maximum = 549 nm; emission maximum = 571 nm.
T78394	Janelia Fluor® 525, SE JF525, NHS,JF525, SE
	Janelia Fluor 525, SE（JF525, SE）为黄色荧光染料（Ex = 525 nm；Em = 549 nm）。
T32372	Keenamide A
	Keenamide A, a cytotoxic cyclic hexapeptide, exhibits significant activity towards the P-388, A-549, MEL-20, and HT-29 tumor cell lines, but was inactive against the D6 and W2 Plasmodium falciparum malarial clones.
T39241	PA Janelia Fluor® 549, SE PA Janelia Fluor® 549, SE,PA-JF549-NHS
	PA Janelia Fluor 549, SE (PA-JF549-NHS) is a bright photoactivatable fluorophore of JF549, SE (JF549, NHS). JF549, SE (JF549, NHS) is a fluorescent dye with the absorption maximum (λab (max)) of 549 nm and emission maximum (λem (max)) of 571 nm.
T13643	Demethoxydeacetoxypseudolaric acid B analog 脱甲氧基脱乙酰土槿皮乙酸,去甲氧基去乙酰氧基土槿甲酸B类似物	Others	Others
	Demethoxydeacetoxypseudolaric acid B analog 是由 Pseudolaric acid B 半合成得到，能够有效抑制 HMEC-1、HL-60、A-549、MB-MDA-468、BEL-7402、HCT116、Hela 细胞，且 IC50值范围为 0.136-1.162 μM。
T62503	EGFR/BRAFV600E-IN-1
	EGFR/BRAFV600E-IN-1 (Compound 23) 是一种有效的 EGFR (IC50: 0.08 μM) 和 BRAFV600E (IC50: 0.15 μM) 双重抑制剂。EGFR/BRAFV600E-IN-1 在 G1 前和 G2/M 期均诱导细胞凋亡 (apoptosis) 及细胞周期停滞。EGFR/BRAFV600E-IN-1 对 A-549 (IC50: 1.2 μM)、MCF-7 (IC50: 0.79 μM)、Panc-1 (IC50: 1.3 μM)、HT-29 (IC50: 1.23 μM) 表现出抗增殖作用。
T36387	Rhod-2 (sodium salt)
	Rhod-2 (sodium salt) is a water-soluble, red fluorescent calcium indicator. It exhibits a significant shift in fluorescence intensity upon calcium binding (ex max = 549 nm; calcium-free v. ex/em max = 552/581 nm; calcium-bound). [1][2] Unlike the UV-excitable indicators fura-2 and indo-1 , there is no accompanying spectral shift.
T36386	Rhod-2 (potassium salt)
	Rhod-2 (potassium salt) is a water-soluble, red fluorescent calcium indicator. It exhibits a significant shift in fluorescence intensity upon calcium binding (ex max = 549 nm; calcium-free v. ex/em max = 552/581 nm; calcium-bound). Unlike the UV-excitable indicators fura-2 and indo-1 , there is no accompanying spectral shift.
T36847	Coelenterazine hcp
	Coelenterazine hcp is a synthetic bioluminescent luciferin that displays an emission maximum of 445 nm.1It has been used as a calcium indicator and substrate to quantifyRenillaluciferase activity.1,2,3 1.Sabnis, R.W.Handbook of biological dyes and stains: Synthesis and industrial applications(2010) 2.Shimomura, O., Kishi, Y., and Inouye, S.The relative rate of aequorin regeneration from apoaequorin and coelenterazine analoguesBiochemistry Journal296(Pt 3)549-551(1993) 3.Pichler, A., Prior, J.L.,...
T37013	(+/-)-PPCC oxalate
	Selective sigma (σ) receptor ligand. Displays high affinity for σ1; also binds at σ2 sites (Ki = 1.5 nM and 50.8 nM respectively). Selective over a range of receptor types including dopaminergic and muscarinic receptors, DAT and SERT. Prezzavento et al (2007) Novel sigma receptor ligands: synthesis and biological profile. J.Med.Chem. 50 951 PMID:17328523 \|Prezzavento et al (2008) A new sigma ligand, (±)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect. Life Sci. 82 549 PMI...
T36537	Nitrofurantoin-13C3 Nitrofurantoin-13C3
	Nitrofurantoin-13C3is intended for use as an internal standard for the quantification of nitrofurantoin by GC- or LC-MS. Nitrofurantoin is a nitrofuran antibiotic.1In vivo, nitrofurantoin (25-100 mg/kg) reducesE. colireplication and abscess formation in the renal medulla of infected rats in a dose-dependent manner. It prevents kidney and bladder infection in rats following bladder inoculation with clinical isolates ofP. mirabilis. Nitrofurantoin also prevents alkalization of urine, as well as ca...
T35757	Beauvericin A
	Beauvericin A is a cyclodepsipeptide and derivative of beauvericin originally isolated fromB. bassianathat has diverse biological activities.1,2,3It is active againstM. tuberculosis(MIC = 25 μg/ml) andP. falciparum(IC50= 12 μg/ml).2Beauvericin A is toxic to brine shrimp (LD100= 32 μg/ml).3 1.Gupta, S., Montillor, C., and Hwang, Y.-S.Isolation of Novel Beauvericin Analogues from the Fungus Beauveria bassianaJ. Nat. Prod.58(5)733-738(1995) 2.Nilanonta, C., Isaka, M., Kittakoop, P., et al.Antimycob...

化合物

Cat.No: T11929

Target: Phosphatase

Cat.No: T41248

Target: Microtubule Associated

Cat.No: T15129

Synonym: DiIC18(3)

Target: Others

Janelia Fluor® 549 TFA

Cat.No: T39759

Synonym: JF549 TFA

Cat.No: T34983

Synonym: UCM549,UCM-549

Janelia Fluor® 549, Maleimide TFA

Cat.No: T82014

Synonym: JF549, Maleimide TFA

Janelia Fluor® 549, Tetrazine

Cat.No: T82013

Synonym: JF549, Tetrazine

Janelia Fluor® 549, Azide

Cat.No: T82015

Synonym: JF549, Azide

Janelia Fluor® 549, SE

Cat.No: T39240

Synonym: JF549, SE,JF549,NHS

Cat.No: T41149

Synonym: BOP-JF549

Janelia Fluor® 525, SE

Cat.No: T78394

Synonym: JF525, NHS,JF525, SE

Cat.No: T32372

PA Janelia Fluor® 549, SE

Cat.No: T39241

Synonym: PA Janelia Fluor® 549, SE,PA-JF549-NHS

Demethoxydeacetoxypseudolaric acid B analog

Cat.No: T13643

Synonym: 脱甲氧基脱乙酰土槿皮乙酸,去甲氧基去乙酰氧基土槿甲酸B类似物

Target: Others

EGFR/BRAFV600E-IN-1

Cat.No: T62503

Rhod-2 (sodium salt)

Cat.No: T36387

Rhod-2 (potassium salt)

Cat.No: T36386

Coelenterazine hcp

Cat.No: T36847

(+/-)-PPCC oxalate

Cat.No: T37013

Nitrofurantoin-13C3

Cat.No: T36537

Synonym: Nitrofurantoin-13C3

Cat.No: T35757

Cat. No.	Product Name	Target	Signaling Pathways
T5826	Eupalinolide A	HSP	Cytoskeletal Signaling; Metabolism
	Eupalinolide A 是分离于林泽兰中的一种天然产物，通过抑制 HSF1 与 HSP90 的相互作用，激活 HSF1，诱导 HSP70 的表达。它对 A-549、BGC-823、SMMC-7721 和 HL-60 肿瘤细胞系具有强大的细胞毒性。
T6S2238	Eupalinolide B	Others	Others
	Eupalinolide B 是一种胚芽倍半萜，分离自Eupatorium lindleyanum 中。它对BGC-823、A-549 和 HL-60 等肿瘤细胞具有细胞毒性。
T5S1897	Linderalactone	Apoptosis; Others; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Others; Stem Cells
	Linderalactone 是从乌药中分离出来的一种倍半萜烯内酯，通过调节凋亡相关蛋白的表达和抑制 JAK/STAT 信号通路来抑制癌细胞生长。它以 IC50值为 15 µM 来抑制肺癌 A-549 细胞的增殖。
TN5676	Musellarin B
	Musellarin B is cytotoxic toward several of the human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480).
T75452	Cytoglobosin D
	Cytoglobosin D 是一种细胞松弛素衍生物，对 A-549 细胞系显示毒性活性 (IC50=2.55 μM)。
TN1628	Eupalinilide B	Others	Others
	Eupalinilides B demonstrates potent cytotoxicity against P-388 and A-549 tumor cell lines.
TN4629	Nemoralisin C	Others	Others
	Nemoralisin C shows antiproliferative activity against HepG2, AGS, MCF-7, and A-549 cancer cell lines.
TN3371	Albatrelin G	Others	Others
	Albatrelin G shows weak cytotoxic activity to cell lines HL-60, SMMC-7721, A-549, and MCF-7, in vitro.
TN4630	Nemoralisin	Others	Others
	Nemoralisin exhibits weak cytotoxicities (IC50>10 uM) against HepG2, AGS, MCF-7, and A-549 cancer cell lines.
TN3925	Eichlerianic acid	HSV	Microbiology/Virology
	Eichlerianic acid is a trypanocidal compound with an IC50 value of 10 mg/mL. Eichlerianic acid may have antiviral activity against Herpes simplex virus types I and II in vitro. Eichlerianic acid shows weak cytotoxicity (IC50 6.87 to >40 μM) against human cancer cell (HL-60, SMMC-7721, A-549, MCF-7 and SW480).
TN3646	Chlorovaltrate K	Others	Others
	Chlorovaltrate K shows moderate cytotoxicity against lung adenocarcinoma (A 549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8) and hepatoma (Bel 7402) cell lines with IC50 values of 0.89-9.76 uM.
T75490	27-O-(tert-Butyldimethylsilyl)withaferin A
	27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a) 为一种天然茄内酯类化合物，具备诱导细胞凋亡 (apoptosis) 的能力。该化合物对人类癌细胞系HeLa、A-549、MCF-7以及正常Vero细胞展现出抗增殖活性。
TN1498	Cimigenol	Others	Others
	Cimigenol is a potential antitumor compound, combination of it with an autophagy inhibitor may be a valuable strategy for the chemoprevention or treatment of colon cancer. It exerted potent cytotoxic activity against SMMC-7721 (7.87μM) and A-549 (12.16 μM
TN5647	Confluentin
	Confluentin has antimicrobial activity against the gram-positive bacteria.Confluentin significantly inhibits compound 48/80-induced histamine release from rat peritoneal mast cells. Confluentin also shows weak cytotoxicity against four human tumor cell li
TN6014	Norcepharadione B 鱼腥草
	Norcepharadione B shows good inhibitory activity against the replication of HSV-1, it also shows antimalarial activity with EC50 values of 7.5mug/ml. Norcepharadione B exhibits significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3,
TN4264	Isoapetalic acid 胡桐，海棠木	HIV Protease; Antifection	Microbiology/Virology; Proteases/Proteasome
	Isoapetalic acid and apetalic acid exhibit cytotoxic activities towards both cancer cell lines(human breast cancer (MCF-7) and human lung carcinoma (A-549) cell lines) and both Gram-positive bacteria(two Gram-positive bacteria, S. aureus and B. subtilis a
TN3870	Iriflophenone 2-O-Rhamnoside Dimethylmatairesinol	Others	Others
	Dimethylmatairesinol can reduce the amount of Immunoglobulin E (IgE) secreted by human myeloma U266 cells, it has potential as an anti-allergic agent. Dimethylmatairesinol also exhibits significant cytotoxicity against three human tumor cells(A-549 lung c
T35483	19,20-Epoxycytochalasin D
	19,20-Epoxycytochalasin D is a fungal metabolite that has been found in the endophytic fungus Nemania sp. UM10M. It is active against the chloroquine-sensitive and -resistant strains of P. falciparum (MIC = 0.4 ng/ml for both) without inducing cytotoxicity in Vero cells. It is cytotoxic to BT-549, LLC-PK11, and P388 cells (IC50s = 7.84, 8.4, and 0.16 &#181M, respectively) but not SK-MEL, KB, or SKOV3 cells up to a concentration of 10 &#181M.
TN2684	2,3,23-Trihydroxy-12-oleanen-28-oic acid	Others	Others
	2β,3β,23α-Trihydroxy-12-oleanen-28-oic acid shows cytotoxic activities to human lung adenocarcinoma(A-549)cell lines. 2α,3β,23-Trihydroxyolean-12-en-28-oic acid and 2α,3β,23-trihydroxyurs-12-en-28-oic acid exhibit cytotoxicity in vitro against the growth of human cancer cells lines HepG-2,with IC50 values of 16.13 ± 3.83, 15.97 ± 2.47 uM, respectively.
TN1646	Flemiphilippinin A	Others	Others
	Flemiphilippin A has antioxidant activity, it shows DPPH radical scavenging activity with effective half maximal concentration (EC50) of 18.36 ug/mL. Flemiphilippinin A (5 ug/mL) exhibits some level of antitumor activity against human hepatocellular carci
TN3616	Cedrelone	Apoptosis; MMP; Antifection	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Cedrelone 是一种柠檬苦素类化合物，是一种吩嗪生物合成样结构域蛋白 (PBLD) 激活剂。Cedrelone 可诱导癌细胞凋亡 (apoptosis)。Cedrelone 是一种非常有效的细胞凋亡诱导剂，它能导致细胞周期停止。Cedrelone 具有杀虫活性，可抑制 P. saucia 的箭毒生长，并可抑制乳草蝽（Oncopeltus fasciatus）的蜕皮。Cedrelone具有抗肿瘤作用，对SMMC-7721、A-549、MCF-7 和 SW480 等癌细胞株具有显著的细胞毒性。

天然产物

Cat.No: T5826

Target: HSP

Cat.No: T6S2238

Target: Others

Cat.No: T5S1897

Target: Apoptosis, Others, JAK

Cat.No: TN5676

Cat.No: T75452

Cat.No: TN1628

Target: Others

Cat.No: TN4629

Target: Others

Cat.No: TN3371

Target: Others

Cat.No: TN4630

Target: Others

Eichlerianic acid

Cat.No: TN3925

Target: HSV

Chlorovaltrate K

Cat.No: TN3646

Target: Others

27-O-(tert-Butyldimethylsilyl)withaferin A

Cat.No: T75490

Cat.No: TN1498

Target: Others

Cat.No: TN5647

Norcepharadione B

Cat.No: TN6014

Synonym: 鱼腥草

Isoapetalic acid

Cat.No: TN4264

Synonym: 胡桐，海棠木

Target: HIV Protease, Antifection

Iriflophenone 2-O-Rhamnoside

Cat.No: TN3870

Synonym: Dimethylmatairesinol

Target: Others

19,20-Epoxycytochalasin D

Cat.No: T35483

2,3,23-Trihydroxy-12-oleanen-28-oic acid

Cat.No: TN2684

Target: Others

Flemiphilippinin A

Cat.No: TN1646

Target: Others

Cat.No: TN3616

Target: Apoptosis, MMP, Antifection

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