Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NLX-204 hydrochloride(2170405-10-2 free base)是一种有效且选择性的 ERK1/2 磷酸化偏好 5-HT1A 受体激动剂 (pKi = 10.19)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 879 | 现货 | ||
5 mg | ¥ 1,790 | 现货 | ||
10 mg | ¥ 2,560 | 现货 | ||
25 mg | ¥ 4,290 | 现货 | ||
50 mg | ¥ 6,130 | 现货 | ||
100 mg | ¥ 8,460 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,870 | 现货 |
产品描述 | NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19). |
体内活性 | NLX-204, displayed high selectivity in the SafetyScreen44 panel (including hERG channel), high solubility, metabolic stability, and Caco-2 penetration and did not block CYP3A4, CYP2D6 isoenzymes, or P-glycoprotein.?Preliminary in vivo studies confirmed its promising pharmacokinetic profile.?NLX-204 also robustly stimulated ERK1/2 phosphorylation in rat cortex and showed highly potent (MED = 0.16 mg/kg) and efficacious antidepressant-like activity, totally eliminating immobility in the rat Porsolt test. |
分子量 | 409.13 |
分子式 | C20H23Cl2F2N3O2 |
CAS No. | T22379L |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (26.89 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.4442 mL | 12.2211 mL | 24.4421 mL | 61.1053 mL |
5 mM | 0.4888 mL | 2.4442 mL | 4.8884 mL | 12.2211 mL | |
10 mM | 0.2444 mL | 1.2221 mL | 2.4442 mL | 6.1105 mL | |
20 mM | 0.1222 mL | 0.6111 mL | 1.2221 mL | 3.0553 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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